Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 6 30297383 30297383 + Missense_Mutation SNP G G A TCGA-OR-A5L2-01A-11D-A30A-10 TCGA-OR-A5L2-10A-01D-A30A-10 g.chr6:30297383G>A c.289G>A c.(289-291)Gtc>Atc p.V97I ACC 6 30303702 30303702 + Missense_Mutation SNP G G C TCGA-OR-A5J4-01A-11D-A29I-10 TCGA-OR-A5J4-10A-01D-A29L-10 g.chr6:30303702G>C c.730G>C c.(730-732)Gct>Cct p.A244P BLCA 6 30297275 30297275 + Missense_Mutation SNP G G C TCGA-XF-AAMG-01A-11D-A42E-08 TCGA-XF-AAMG-10A-01D-A42H-08 g.chr6:30297275G>C c.181G>C c.(181-183)Gag>Cag p.E61Q BLCA 6 30297321 30297321 + Missense_Mutation SNP G G A TCGA-XF-A9SY-01A-21D-A42E-08 TCGA-XF-A9SY-10A-01D-A42H-08 g.chr6:30297321G>A c.227G>A c.(226-228)cGc>cAc p.R76H BLCA 6 30297475 30297475 + Missense_Mutation SNP G G C TCGA-4Z-AA7Q-01A-11D-A391-08 TCGA-4Z-AA7Q-10A-01D-A394-08 g.chr6:30297475G>C c.381G>C c.(379-381)ttG>ttC p.L127F BLCA 6 30309568 30309568 + Missense_Mutation SNP G G C TCGA-UY-A8OB-01A-12D-A42E-08 TCGA-UY-A8OB-11A-12D-A42H-08 g.chr6:30309568G>C c.1089G>C c.(1087-1089)gaG>gaC p.E363D BLCA 6 30309573 30309573 + Missense_Mutation SNP G G A TCGA-XF-A9T6-01A-11D-A42E-08 TCGA-XF-A9T6-10A-01D-A42H-08 g.chr6:30309573G>A c.1094G>A c.(1093-1095)aGa>aAa p.R365K BRCA 6 30297549 30297549 + Splice_Site SNP T T G TCGA-A8-A0A6-01A-12W-A071-09 TCGA-A8-A0A6-10A-01W-A071-09 g.chr6:30297549T>G c.e2+2 BRCA 6 30298612 30298612 + Missense_Mutation SNP C C T TCGA-A1-A0SN-01A-11D-A142-09 TCGA-A1-A0SN-10B-01D-A142-09 g.chr6:30298612C>T c.508C>T c.(508-510)Cgc>Tgc p.R170C BRCA 6 30309645 30309645 + Missense_Mutation SNP C C T TCGA-AN-A0AK-01A-21W-A019-09 TCGA-AN-A0AK-10A-01W-A021-09 g.chr6:30309645C>T c.1166C>T c.(1165-1167)aCc>aTc p.T389I BRCA 6 30309911 30309911 + Frame_Shift_Del DEL T T - TCGA-BH-A0HF-01A-11W-A071-09 TCGA-BH-A0HF-10A-01W-A071-09 g.chr6:30309911delT c.1432delT c.(1432-1434)tctfs p.S478fs CESC 6 30297275 30297275 + Missense_Mutation SNP G G C TCGA-C5-A1BM-01A-11D-A13W-08 TCGA-C5-A1BM-10A-01D-A13W-08 g.chr6:30297275G>C c.181G>C c.(181-183)Gag>Cag p.E61Q CESC 6 30303588 30303588 + Missense_Mutation SNP G G A TCGA-C5-A7UH-01A-11D-A351-09 TCGA-C5-A7UH-10A-01D-A351-09 g.chr6:30303588G>A c.616G>A c.(616-618)Gaa>Aaa p.E206K CESC 6 30309562 30309562 + Silent SNP C C T TCGA-FU-A3HZ-01A-11D-A20U-09 TCGA-FU-A3HZ-10A-01D-A20U-09 g.chr6:30309562C>T c.1083C>T c.(1081-1083)ttC>ttT p.F361F CHOL 6 30297399 30297399 + Missense_Mutation SNP G G T TCGA-W5-AA2G-01A-11D-A417-09 TCGA-W5-AA2G-10A-01D-A41A-09 g.chr6:30297399G>T c.305G>T c.(304-306)cGg>cTg p.R102L CHOL 6 30303613 30303613 + Missense_Mutation SNP G G A TCGA-ZH-A8Y2-01A-11D-A417-09 TCGA-ZH-A8Y2-10A-01D-A41A-09 g.chr6:30303613G>A c.641G>A c.(640-642)cGa>cAa p.R214Q COAD 6 30297230 30297230 + Missense_Mutation SNP C C T TCGA-AD-6895-01A-11D-1924-10 TCGA-AD-6895-10A-01D-1924-10 g.chr6:30297230C>T c.136C>T c.(136-138)Cac>Tac p.H46Y COAD 6 30297398 30297398 + Missense_Mutation SNP C C T TCGA-AA-3877-01A-01W-0995-10 TCGA-AA-3877-10A-01W-0995-10 g.chr6:30297398C>T c.304C>T c.(304-306)Cgg>Tgg p.R102W COAD 6 30297399 30297399 + Missense_Mutation SNP G G A TCGA-A6-2676-01A-01W-0833-10 TCGA-A6-2676-10A-01W-0833-10 g.chr6:30297399G>A c.305G>A c.(304-306)cGg>cAg p.R102Q COAD 6 30303707 30303707 + Silent SNP C C T TCGA-CK-4948-01B-11D-1650-10 TCGA-CK-4948-10A-01D-1650-10 g.chr6:30303707C>T c.735C>T c.(733-735)gcC>gcT p.A245A COAD 6 30308344 30308344 + Missense_Mutation SNP G G A TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr6:30308344G>A c.956G>A c.(955-957)aGc>aAc p.S319N COAD 6 30309622 30309622 + Silent SNP C C T TCGA-AD-6964-01A-11D-1924-10 TCGA-AD-6964-10A-01D-1924-10 g.chr6:30309622C>T c.1143C>T c.(1141-1143)tgC>tgT p.C381C COAD 6 30309622 30309622 + Silent SNP C C T TCGA-D5-6928-01A-11D-1924-10 TCGA-D5-6928-10A-01D-1924-10 g.chr6:30309622C>T c.1143C>T c.(1141-1143)tgC>tgT p.C381C COAD 6 30309786 30309786 + Missense_Mutation SNP G G T TCGA-G4-6293-01A-11D-1719-10 TCGA-G4-6293-10A-01D-1719-10 g.chr6:30309786G>T c.1307G>T c.(1306-1308)gGg>gTg p.G436V COAD 6 30309849 30309849 + Missense_Mutation SNP G G A TCGA-CK-4952-01A-01D-1719-10 TCGA-CK-4952-10A-01D-1719-10 g.chr6:30309849G>A c.1370G>A c.(1369-1371)cGg>cAg p.R457Q COAD 6 30309925 30309925 + Silent SNP C C A TCGA-AD-5900-01A-11D-1650-10 TCGA-AD-5900-10A-01D-1650-10 g.chr6:30309925C>A c.1446C>A c.(1444-1446)acC>acA p.T482T COADREAD 6 30297230 30297230 + Missense_Mutation SNP C C T TCGA-AD-6895-01A-11D-1924-10 TCGA-AD-6895-10A-01D-1924-10 g.chr6:30297230C>T c.136C>T c.(136-138)Cac>Tac p.H46Y COADREAD 6 30297398 30297398 + Missense_Mutation SNP C C T TCGA-AA-3877-01A-01W-0995-10 TCGA-AA-3877-10A-01W-0995-10 g.chr6:30297398C>T c.304C>T c.(304-306)Cgg>Tgg p.R102W COADREAD 6 30297399 30297399 + Missense_Mutation SNP G G A TCGA-A6-2676-01A-01W-0833-10 TCGA-A6-2676-10A-01W-0833-10 g.chr6:30297399G>A c.305G>A c.(304-306)cGg>cAg p.R102Q COADREAD 6 30303707 30303707 + Silent SNP C C T TCGA-CK-4948-01B-11D-1650-10 TCGA-CK-4948-10A-01D-1650-10 g.chr6:30303707C>T c.735C>T c.(733-735)gcC>gcT p.A245A COADREAD 6 30308344 30308344 + Missense_Mutation SNP G G A TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr6:30308344G>A c.956G>A c.(955-957)aGc>aAc p.S319N COADREAD 6 30309622 30309622 + Silent SNP C C T TCGA-AD-6964-01A-11D-1924-10 TCGA-AD-6964-10A-01D-1924-10 g.chr6:30309622C>T c.1143C>T c.(1141-1143)tgC>tgT p.C381C COADREAD 6 30309622 30309622 + Silent SNP C C T TCGA-D5-6928-01A-11D-1924-10 TCGA-D5-6928-10A-01D-1924-10 g.chr6:30309622C>T c.1143C>T c.(1141-1143)tgC>tgT p.C381C COADREAD 6 30309786 30309786 + Missense_Mutation SNP G G T TCGA-G4-6293-01A-11D-1719-10 TCGA-G4-6293-10A-01D-1719-10 g.chr6:30309786G>T c.1307G>T c.(1306-1308)gGg>gTg p.G436V COADREAD 6 30309849 30309849 + Missense_Mutation SNP G G A TCGA-CK-4952-01A-01D-1719-10 TCGA-CK-4952-10A-01D-1719-10 g.chr6:30309849G>A c.1370G>A c.(1369-1371)cGg>cAg p.R457Q COADREAD 6 30309925 30309925 + Silent SNP C C A TCGA-AD-5900-01A-11D-1650-10 TCGA-AD-5900-10A-01D-1650-10 g.chr6:30309925C>A c.1446C>A c.(1444-1446)acC>acA p.T482T ESCA 6 30298569 30298569 + Missense_Mutation SNP G G T TCGA-V5-AASX-01A-11D-A387-09 TCGA-V5-AASX-10A-01D-A38A-09 g.chr6:30298569G>T c.465G>T c.(463-465)caG>caT p.Q155H ESCA 6 30309814 30309814 + Frame_Shift_Del DEL T T - TCGA-L5-A893-01A-11D-A36J-09 TCGA-L5-A893-11A-21D-A36M-09 g.chr6:30309814delT c.1335delT c.(1333-1335)cctfs p.P445fs GBMLGG 6 30309546 30309546 + Missense_Mutation SNP G G A TCGA-DU-A5TY-01A-11D-A289-08 TCGA-DU-A5TY-10A-01D-A289-08 g.chr6:30309546G>A c.1067G>A c.(1066-1068)cGt>cAt p.R356H HNSC 6 30297129 30297129 + Missense_Mutation SNP C C T TCGA-CV-6961-01A-21D-1912-08 TCGA-CV-6961-10A-01D-1912-08 g.chr6:30297129C>T c.35C>T c.(34-36)tCt>tTt p.S12F HNSC 6 30297214 30297214 + Silent SNP C C T TCGA-CR-7398-01A-11D-2012-08 TCGA-CR-7398-10A-01D-2013-08 g.chr6:30297214C>T c.120C>T c.(118-120)gtC>gtT p.V40V HNSC 6 30297275 30297275 + Missense_Mutation SNP G G A TCGA-CV-6935-01A-11D-1912-08 TCGA-CV-6935-10A-01D-1912-08 g.chr6:30297275G>A c.181G>A c.(181-183)Gag>Aag p.E61K HNSC 6 30308120 30308120 + Missense_Mutation SNP T T C TCGA-F7-A624-01A-22D-A30E-08 TCGA-F7-A624-10A-01D-A30H-08 g.chr6:30308120T>C c.875T>C c.(874-876)tTa>tCa p.L292S HNSC 6 30309588 30309588 + Missense_Mutation SNP C C T TCGA-CN-5360-01A-01D-1434-08 TCGA-CN-5360-10A-01D-1434-08 g.chr6:30309588C>T c.1109C>T c.(1108-1110)cCt>cTt p.P370L HNSC 6 30309645 30309645 + Missense_Mutation SNP C C T TCGA-CN-4726-01A-01D-1434-08 TCGA-CN-4726-10A-01D-1434-08 g.chr6:30309645C>T c.1166C>T c.(1165-1167)aCc>aTc p.T389I HNSC 6 30309967 30309967 + Silent SNP C C T TCGA-CV-7568-01A-11D-2229-08 TCGA-CV-7568-10A-01D-2229-08 g.chr6:30309967C>T c.1488C>T c.(1486-1488)taC>taT p.Y496Y HNSC 6 30309968 30309968 + Missense_Mutation SNP C C T TCGA-CV-7568-01A-11D-2229-08 TCGA-CV-7568-10A-01D-2229-08 g.chr6:30309968C>T c.1489C>T c.(1489-1491)Cca>Tca p.P497S KIPAN 6 30303731 30303752 + Splice_Site DEL GTCAGGCTTCGAGATGCTTAAG GTCAGGCTTCGAGATGCTTAAG - TCGA-P4-A5E8-01A-11D-A28G-10 TCGA-P4-A5E8-11A-12D-A28G-10 g.chr6:30303731_30303752delGTCAGGCTTCGAGATGCTTAAG c.759_780delGTCAGGCTTCGAGATGCTTAAG c.(757-780)cagtcaggcttcgagatgcttaag>ca p.QSGFEMLK253fs KIPAN 6 30308093 30308093 + Missense_Mutation SNP C C T TCGA-B0-5115-01A-01D-1421-08 TCGA-B0-5115-11A-01D-1421-08 g.chr6:30308093C>T c.848C>T c.(847-849)cCa>cTa p.P283L KIRC 6 30308093 30308093 + Missense_Mutation SNP C C T TCGA-B0-5115-01A-01D-1421-08 TCGA-B0-5115-11A-01D-1421-08 g.chr6:30308093C>T c.848C>T c.(847-849)cCa>cTa p.P283L KIRP 6 30303731 30303752 + Splice_Site DEL GTCAGGCTTCGAGATGCTTAAG GTCAGGCTTCGAGATGCTTAAG - TCGA-P4-A5E8-01A-11D-A28G-10 TCGA-P4-A5E8-11A-12D-A28G-10 g.chr6:30303731_30303752delGTCAGGCTTCGAGATGCTTAAG c.759_780delGTCAGGCTTCGAGATGCTTAAG c.(757-780)cagtcaggcttcgagatgcttaag>ca p.QSGFEMLK253fs LGG 6 30309546 30309546 + Missense_Mutation SNP G G A TCGA-DU-A5TY-01A-11D-A289-08 TCGA-DU-A5TY-10A-01D-A289-08 g.chr6:30309546G>A c.1067G>A c.(1066-1068)cGt>cAt p.R356H LIHC 6 30297109 30297109 + Silent SNP T T C TCGA-DD-A119-01A-11D-A12Z-10 TCGA-DD-A119-10A-01D-A12Z-10 g.chr6:30297109T>C c.15T>C c.(13-15)agT>agC p.S5S LIHC 6 30298592 30298593 + Frame_Shift_Del DEL AG AG - TCGA-RC-A6M6-01A-11D-A32G-10 TCGA-RC-A6M6-10A-01D-A32G-10 g.chr6:30298592_30298593delAG c.488_489delAG c.(487-489)cagfs p.Q163fs LIHC 6 30303626 30303626 + Silent SNP G G A TCGA-DD-AAEB-01A-11D-A40R-10 TCGA-DD-AAEB-10A-01D-A40U-10 g.chr6:30303626G>A c.654G>A c.(652-654)gaG>gaA p.E218E LUAD 6 30297117 30297117 + Missense_Mutation SNP A A T TCGA-NJ-A55A-01A-11D-A25L-08 TCGA-NJ-A55A-10A-01D-A25L-08 g.chr6:30297117A>T c.23A>T c.(22-24)gAg>gTg p.E8V LUAD 6 30297202 30297202 + Silent SNP G G A TCGA-44-A47G-01A-21D-A24D-08 TCGA-44-A47G-10A-01D-A24F-08 g.chr6:30297202G>A c.108G>A c.(106-108)ctG>ctA p.L36L LUAD 6 30297350 30297350 + Missense_Mutation SNP A A C TCGA-05-4382-01A-01D-1931-08 TCGA-05-4382-10A-01D-1265-08 g.chr6:30297350A>C c.256A>C c.(256-258)Agt>Cgt p.S86R LUAD 6 30297376 30297376 + Silent SNP C C G TCGA-55-8302-01A-11D-2323-08 TCGA-55-8302-10A-01D-2323-08 g.chr6:30297376C>G c.282C>G c.(280-282)ctC>ctG p.L94L LUAD 6 30297471 30297471 + Missense_Mutation SNP G G C TCGA-05-4415-01A-22D-1855-08 TCGA-05-4415-10A-01D-1855-08 g.chr6:30297471G>C c.377G>C c.(376-378)tGc>tCc p.C126S LUAD 6 30298598 30298598 + Missense_Mutation SNP T T C TCGA-62-A46O-01A-11D-A24D-08 TCGA-62-A46O-10A-01D-A24F-08 g.chr6:30298598T>C c.494T>C c.(493-495)cTg>cCg p.L165P LUAD 6 30303750 30303750 + Missense_Mutation SNP A A C TCGA-75-5146-01A-01D-1625-08 TCGA-75-5146-10A-01D-1625-08 g.chr6:30303750A>C c.778A>C c.(778-780)Aag>Cag p.K260Q LUAD 6 30308286 30308286 + Missense_Mutation SNP G G A TCGA-69-8255-01A-11D-2284-08 TCGA-69-8255-10A-01D-2284-08 g.chr6:30308286G>A c.898G>A c.(898-900)Gaa>Aaa p.E300K LUAD 6 30309601 30309601 + Silent SNP G G A TCGA-49-4490-01A-21D-1855-08 TCGA-49-4490-11A-01D-1855-08 g.chr6:30309601G>A c.1122G>A c.(1120-1122)agG>agA p.R374R LUAD 6 30309955 30309955 + Missense_Mutation SNP G G T TCGA-50-6593-01A-11D-1753-08 TCGA-50-6593-11A-01D-1753-08 g.chr6:30309955G>T c.1476G>T c.(1474-1476)tgG>tgT p.W492C LUSC 6 30297303 30297303 + Missense_Mutation SNP G G A TCGA-34-2600-01A-01D-1522-08 TCGA-34-2600-11A-01D-1522-08 g.chr6:30297303G>A c.209G>A c.(208-210)cGa>cAa p.R70Q LUSC 6 30309598 30309598 + Silent SNP A A T TCGA-33-4586-01A-01D-1441-08 TCGA-33-4586-11A-01D-1441-08 g.chr6:30309598A>T c.1119A>T c.(1117-1119)ccA>ccT p.P373P LUSC 6 30309968 30309968 + Missense_Mutation SNP C C T TCGA-66-2791-01A-01D-0983-08 TCGA-66-2791-11A-01D-0983-08 g.chr6:30309968C>T c.1489C>T c.(1489-1491)Cca>Tca p.P497S LUSC 6 30310025 30310025 + Missense_Mutation SNP G G C TCGA-66-2744-01A-01D-0983-08 TCGA-66-2744-11A-01D-0983-08 g.chr6:30310025G>C c.1546G>C c.(1546-1548)Gat>Cat p.D516H OV 6 30297548 30297548 + Splice_Site SNP G G T TCGA-36-2543-01A-01D-1526-09 TCGA-36-2543-10A-01D-1526-09 g.chr6:30297548G>T c.e2+1 OV 6 30308086 30308086 + Missense_Mutation SNP A A G TCGA-25-1316-01A-01W-0494-09 TCGA-25-1316-10A-01W-0494-09 g.chr6:30308086A>G c.841A>G c.(841-843)Atc>Gtc p.I281V OV 6 30309530 30309530 + Missense_Mutation SNP G G C TCGA-04-1362-01A-01W-0494-09 TCGA-04-1362-10A-01W-0494-09 g.chr6:30309530G>C c.1051G>C c.(1051-1053)Gtc>Ctc p.V351L OV 6 30309785 30309785 + Missense_Mutation SNP G G A TCGA-13-0920-01A-01W-0421-09 TCGA-13-0920-10A-01W-0421-09 g.chr6:30309785G>A c.1306G>A c.(1306-1308)Ggg>Agg p.G436R OV 6 30309877 30309877 + Silent SNP C C T TCGA-29-2429-01A-01D-1526-09 TCGA-29-2429-10A-01D-1526-09 g.chr6:30309877C>T c.1398C>T c.(1396-1398)gcC>gcT p.A466A PAAD 6 30297258 30297258 + Missense_Mutation SNP G G A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:30297258G>A c.164G>A c.(163-165)cGc>cAc p.R55H PAAD 6 30309622 30309622 + Silent SNP C C T TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:30309622C>T c.1143C>T c.(1141-1143)tgC>tgT p.C381C PRAD 6 30308085 30308085 + Silent SNP G G A TCGA-KC-A7F6-01A-11D-A33T-08 TCGA-KC-A7F6-10A-01D-A33W-08 g.chr6:30308085G>A c.840G>A c.(838-840)acG>acA p.T280T SKCM 6 30297489 30297489 + Missense_Mutation SNP C C T TCGA-EE-A29T-06A-11D-A197-08 TCGA-EE-A29T-10A-01D-A199-08 g.chr6:30297489C>T c.395C>T c.(394-396)tCc>tTc p.S132F SKCM 6 30298623 30298623 + Silent SNP C C T TCGA-EE-A2MI-06A-11D-A197-08 TCGA-EE-A2MI-10A-01D-A199-08 g.chr6:30298623C>T c.519C>T c.(517-519)tcC>tcT p.S173S SKCM 6 30308352 30308352 + Missense_Mutation SNP C C T TCGA-EE-A29M-06A-11D-A196-08 TCGA-EE-A29M-10A-01D-A198-08 g.chr6:30308352C>T c.964C>T c.(964-966)Ccc>Tcc p.P322S SKCM 6 30309545 30309545 + Missense_Mutation SNP C C T TCGA-D3-A51T-06A-11D-A25O-08 TCGA-D3-A51T-10A-01D-A25O-08 g.chr6:30309545C>T c.1066C>T c.(1066-1068)Cgt>Tgt p.R356C SKCM 6 30309562 30309562 + Missense_Mutation SNP C C G TCGA-D3-A51G-06A-11D-A25O-08 TCGA-D3-A51G-10A-01D-A25O-08 g.chr6:30309562C>G c.1083C>G c.(1081-1083)ttC>ttG p.F361L SKCM 6 30309586 30309586 + Silent SNP C C T TCGA-D3-A2J9-06A-11D-A196-08 TCGA-D3-A2J9-10A-01D-A198-08 g.chr6:30309586C>T c.1107C>T c.(1105-1107)ctC>ctT p.L369L SKCM 6 30309717 30309717 + Missense_Mutation SNP C C T TCGA-EE-A181-06A-11D-A196-08 TCGA-EE-A181-10A-01D-A198-08 g.chr6:30309717C>T c.1238C>T c.(1237-1239)tCc>tTc p.S413F SKCM 6 30309876 30309876 + Missense_Mutation SNP C C T TCGA-FW-A3TU-06A-11D-A23B-08 TCGA-FW-A3TU-10A-01D-A23B-08 g.chr6:30309876C>T c.1397C>T c.(1396-1398)gCc>gTc p.A466V

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand SCC-9 COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + CSCC-44-T COSM4511432 c.868C>T p.L290F Substitution - Missense 6:30340336-30340336 + WSU-HN12 COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + TCGA-A8-A0A6-01 COSM3829990 c.453+2T>G p.? Unknown 6:30329772-30329772 + MO_1176 COSM5557581 c.300G>C p.K100N Substitution - Missense 6:30329617-30329617 + 2205 COSM5011598 c.1264C>A p.P422T Substitution - Missense 6:30341966-30341966 + TCGA-HU-A4GN-01 COSM3861419 c.1201G>A p.D401N Substitution - Missense 6:30341903-30341903 + PT34 COSM5910541 c.1457C>T p.T486I Substitution - Missense 6:30342159-30342159 + UD-SCC-2 COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + PTC-7C COSM3761798 c.435T>C p.D145D Substitution - coding silent 6:30329752-30329752 + TCGA-FW-A3TU-06 COSM3624243 c.1397C>T p.A466V Substitution - Missense 6:30342099-30342099 + pfg043T COSM4751958 c.313A>G p.S105G Substitution - Missense 6:30329630-30329630 + Pat_41_B COSM5870038 c.943G>A p.E315K Substitution - Missense 6:30340554-30340554 + WSU-HN13 COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + TCGA-D3-A2J9-06 COSM3624237 c.1107C>T p.L369L Substitution - coding silent 6:30341809-30341809 + PTC-14C COSM4160554 c.932C>G p.S311C Substitution - Missense 6:30340543-30340543 + TCGA-BR-8589-01 COSM3861400 c.67T>G p.L23V Substitution - Missense 6:30329384-30329384 + TCGA-EE-A181-06 COSM3624240 c.1238C>T p.S413F Substitution - Missense 6:30341940-30341940 + TCGA-25-1316-01 COSM76817 c.841A>G p.I281V Substitution - Missense 6:30340309-30340309 + DN1401D COSM5961974 c.823G>A p.G275R Substitution - Missense 6:30340291-30340291 + T3262 COSM3624231 c.1066C>T p.R356C Substitution - Missense 6:30341768-30341768 + B22-Tumor COSM4006278 c.523G>A p.E175K Substitution - Missense 6:30330850-30330850 + PT50 COSM3251277 c.811C>T p.P271S Substitution - Missense 6:30340279-30340279 + CSCC-27-T COSM4492762 c.402C>T p.T134T Substitution - coding silent 6:30329719-30329719 + TCGA-AN-A0AK-01 COSM3829993 c.1166C>T p.T389I Substitution - Missense 6:30341868-30341868 + 1_RESISTANT COSM1720770 c.1474T>G p.W492G Substitution - Missense 6:30342176-30342176 + TCGA-BR-8589-01 COSM3861406 c.293A>G p.K98R Substitution - Missense 6:30329610-30329610 + 8052570 COSM3394046 c.640C>T p.R214* Substitution - Nonsense 6:30335835-30335835 + TCGA-D3-A51G-06 COSM3624234 c.1083C>G p.F361L Substitution - Missense 6:30341785-30341785 + T2959 COSM4654074 c.1289G>A p.R430Q Substitution - Missense 6:30341991-30341991 + TCGA-BR-4370-01 COSM3861411 c.731C>T p.A244V Substitution - Missense 6:30335926-30335926 + PTC-7C COSM4160548 c.411C>T p.A137A Substitution - coding silent 6:30329728-30329728 + RKO COSM4648980 c.442C>T p.Q148* Substitution - Nonsense 6:30329759-30329759 + SNU-C4 COSM4654074 c.1289G>A p.R430Q Substitution - Missense 6:30341991-30341991 + C086 COSM3624231 c.1066C>T p.R356C Substitution - Missense 6:30341768-30341768 + NOKSI COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + sysucc-1365T COSM3624231 c.1066C>T p.R356C Substitution - Missense 6:30341768-30341768 + PT45 COSM5927441 c.100G>A p.E34K Substitution - Missense 6:30329417-30329417 + TCGA-C5-A1BM-01 COSM4826411 c.181G>C p.E61Q Substitution - Missense 6:30329498-30329498 + TCGA-A1-A0SN-01 COSM1487577 c.508C>T p.R170C Substitution - Missense 6:30330835-30330835 + CSCC-49-T COSM4489711 c.351C>T p.F117F Substitution - coding silent 6:30329668-30329668 + TCGA-EE-A2MI-06 COSM3624225 c.519C>T p.S173S Substitution - coding silent 6:30330846-30330846 + PTC-7C COSM4160551 c.565C>A p.R189S Substitution - Missense 6:30335760-30335760 + LOVO COSM3251277 c.811C>T p.P271S Substitution - Missense 6:30340279-30340279 + TCGA-CK-4948-01 COSM1443004 c.735C>T p.A245A Substitution - coding silent 6:30335930-30335930 + TCGA-FY-A3R9-01 COSM3374187 c.434A>G p.D145G Substitution - Missense 6:30329751-30329751 + T3724 COSM4736076 c.1074C>T p.S358S Substitution - coding silent 6:30341776-30341776 + BN30T COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + TCGA-G4-6320-01 COSM3697728 c.768C>T p.F256F Substitution - coding silent 6:30335963-30335963 + TCGA-CG-4442-01 COSM3861403 c.208C>T p.R70* Substitution - Nonsense 6:30329525-30329525 + TCGA-29-2429-01 COSM1329111 c.1398C>T p.A466A Substitution - coding silent 6:30342100-30342100 + 1_PRE-TREATMENT COSM1720770 c.1474T>G p.W492G Substitution - Missense 6:30342176-30342176 + TCGA-04-1362-01 COSM76818 c.1051G>C p.V351L Substitution - Missense 6:30341753-30341753 + 148632 COSM1645079 c.116C>G p.P39R Substitution - Missense 6:30329433-30329433 + TCGA-AD-6895-01 COSM1443002 c.136C>T p.H46Y Substitution - Missense 6:30329453-30329453 + UM-SCC-2 COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + TCGA-AM-5820-01 COSM3761801 c.1029T>C p.P343P Substitution - coding silent 6:30341731-30341731 + OSCC-GB_01110111 COSM4884626 c.164G>T p.R55L Substitution - Missense 6:30329481-30329481 + PT41 COSM5924409 c.967C>T p.R323* Substitution - Nonsense 6:30340578-30340578 + 103 COSM5011595 c.425C>T p.P142L Substitution - Missense 6:30329742-30329742 + TCGA-C5-A7UH-01 COSM4856890 c.616G>A p.E206K Substitution - Missense 6:30335811-30335811 + TCGA-CD-8536-01 COSM3861414 c.851G>A p.R284Q Substitution - Missense 6:30340319-30340319 + TCGA-BH-A0HF-01 COSM5835172 c.1432delT p.S478fs*>41 Deletion - Frameshift 6:30342134-30342134 + CSCC-56-T COSM3624231 c.1066C>T p.R356C Substitution - Missense 6:30341768-30341768 + Pat_41_B COSM5870036 c.799G>A p.E267K Substitution - Missense 6:30339926-30339926 + RKO COSM3251254 c.432C>T p.D144D Substitution - coding silent 6:30329749-30329749 + ccRCC-46 COSM1664684 c.49G>A p.A17T Substitution - Missense 6:30329366-30329366 + TCGA-06-0877 COSM2152168 c.37_39delGCA p.A14delA Deletion - In frame 6:30329354-30329356 + CSCC-44-T COSM4552446 c.559G>A p.E187K Substitution - Missense 6:30335754-30335754 + Pat_41_B COSM5870044 c.1270C>T p.P424S Substitution - Missense 6:30341972-30341972 + pfg121T COSM4751961 c.315C>A p.S105R Substitution - Missense 6:30329632-30329632 + TCGA-AD-5900-01 COSM1443014 c.1446C>A p.T482T Substitution - coding silent 6:30342148-30342148 + TCGA-CA-6717-01 COSM1443006 c.956G>A p.S319N Substitution - Missense 6:30340567-30340567 + TCGA-DU-A5TY-01 COSM3928302 c.1067G>A p.R356H Substitution - Missense 6:30341769-30341769 + 93VU147T COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + TCGA-B7-5816-01 COSM3251262 c.566G>A p.R189H Substitution - Missense 6:30335761-30335761 + TCGA-FU-A3HZ-01 COSM3251283 c.1083C>T p.F361F Substitution - coding silent 6:30341785-30341785 + BD22T COSM5508829 c.308A>G p.D103G Substitution - Missense 6:30329625-30329625 + TCGA-D3-A51T-06 COSM3624231 c.1066C>T p.R356C Substitution - Missense 6:30341768-30341768 + ATL012 COSM5710022 c.115C>T p.P39S Substitution - Missense 6:30329432-30329432 + AOCS-165-1-X COSM4153208 c.366G>T p.Q122H Substitution - Missense 6:30329683-30329683 + TCGA-D5-6928-01 COSM1443008 c.1143C>T p.C381C Substitution - coding silent 6:30341845-30341845 + TCGA-BR-8591-01 COSM3251251 c.304C>T p.R102W Substitution - Missense 6:30329621-30329621 + TCGA-36-2543-01 COSM1329113 c.453+1G>T p.? Unknown 6:30329771-30329771 + TCGA-13-0920-01 COSM76819 c.1306G>A p.G436R Substitution - Missense 6:30342008-30342008 + TCGA-AP-A056-01 COSM1077334 c.822C>T p.F274F Substitution - coding silent 6:30340290-30340290 + TCGA-AD-6964-01 COSM1443008 c.1143C>T p.C381C Substitution - coding silent 6:30341845-30341845 + pfg019T COSM1642980 c.1429C>T p.R477C Substitution - Missense 6:30342131-30342131 + S00501 COSM5658500 c.1400G>T p.G467V Substitution - Missense 6:30342102-30342102 + TCGA-AM-5820-01 COSM3761798 c.435T>C p.D145D Substitution - coding silent 6:30329752-30329752 + TCGA-CK-4952-01 COSM1443012 c.1370G>A p.R457Q Substitution - Missense 6:30342072-30342072 + CAL33 COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + BICR_22 COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 + TCGA-EE-A29M-06 COSM3624228 c.964C>T p.P322S Substitution - Missense 6:30340575-30340575 + BD57T COSM5510133 c.53C>T p.A18V Substitution - Missense 6:30329370-30329370 + ESCC_BICR_036T COSM5432218 c.1032G>C p.E344D Substitution - Missense 6:30341734-30341734 + Pat_32_B COSM5870041 c.1099C>T p.R367W Substitution - Missense 6:30341801-30341801 + TCGA-HU-8602-01 COSM3861416 c.963T>C p.F321F Substitution - coding silent 6:30340574-30340574 + sysucc-1317T COSM5450226 c.220C>T p.R74C Substitution - Missense 6:30329537-30329537 + SCC-15 COSM1621382 c.1292T>G p.V431G Substitution - Missense 6:30341994-30341994 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.413493 6p21.3 605700 2487594|CGAP|BC007661|A/G|non-coding||2878|Candidate; 2487594|CGAP|BC034985|A/G|non-coding||3294|Candidate

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A C Missense p.K260Q c.778A>C 6 30303750 LUAD A G Missense p.D145G c.434A>G 6 30297528 THCA A G Missense p.I281V c.841A>G 6 30308086 OV C T Missense p.A244V c.731C>T 6 30303703 STAD C T Missense p.P283L c.848C>T 6 30308093 RCCC C T Missense p.P322S c.964C>T 6 30308352 CM C T Missense p.P370L c.1109C>T 6 30309588 HNSC C T Missense p.P380L c.1139C>T 6 30309618 CM C T Missense p.P497S c.1489C>T 6 30309968 LUSC C T Missense p.R170C c.508C>T 6 30298612 BRCA C T Missense p.R367W c.1099C>T 6 30309578 CM C T Missense p.R477C c.1429C>T 6 30309908 STAD C T Missense p.S12F c.35C>T 6 30297129 HNSC C T Missense p.S132F c.395C>T 6 30297489 CM C T Missense p.S213L c.638C>T 6 30303610 CM C T Missense p.S413F c.1238C>T 6 30309717 CM C T Missense p.T389I c.1166C>T 6 30309645 HNSC C T Nonsense p.R227* c.679C>T 6 30303651 CM C T Synonymous p.V40V c.120C>T 6 30297214 HNSC G A Missense p.E61K c.181G>A 6 30297275 HNSC G A Missense p.G436R c.1306G>A 6 30309785 OV G A Missense p.R189H c.566G>A 6 30303538 STAD G A Missense p.R70Q c.209G>A 6 30297303 LUSC G C Missense p.C126S c.377G>C 6 30297471 LUAD G C Missense p.D516H c.1546G>C 6 30310025 LUSC G C Missense p.V351L c.1051G>C 6 30309530 OV G T Missense p.G467V c.1400G>T 6 30309879 SCLC G T Missense p.W492C c.1476G>T 6 30309955 LUAD T A Missense p.F446Y c.1337T>A 6 30309816 CM