PTM - CPLM Gene Name UniProt ID Type Position Code ERCC6; CSB Q03468 Methylation 170 K ERCC6; CSB Q03468 Methylation 297 K ERCC6; CSB Q03468 Methylation 1054 K ERCC6; CSB Q03468 Methylation 448 K ERCC6; CSB Q03468 Ubiquitination 1457 K ERCC6; CSB Q03468 Ubiquitination 783 K

PTM - dbPAF Gene Name UniProt ID Position Type Species ERCC6; CSB Q03468 1009 S Homo sapiens(Human) ERCC6; CSB Q03468 1067 T Homo sapiens(Human) ERCC6; CSB Q03468 1068 S Homo sapiens(Human) ERCC6; CSB Q03468 1139 S Homo sapiens(Human) ERCC6; CSB Q03468 1142 S Homo sapiens(Human) ERCC6; CSB Q03468 1146 S Homo sapiens(Human) ERCC6; CSB Q03468 124 S Homo sapiens(Human) ERCC6; CSB Q03468 1276 S Homo sapiens(Human) ERCC6; CSB Q03468 1279 Y Homo sapiens(Human) ERCC6; CSB Q03468 1337 S Homo sapiens(Human) ERCC6; CSB Q03468 1340 S Homo sapiens(Human) ERCC6; CSB Q03468 1345 S Homo sapiens(Human) ERCC6; CSB Q03468 1346 S Homo sapiens(Human) ERCC6; CSB Q03468 1347 T Homo sapiens(Human) ERCC6; CSB Q03468 1348 S Homo sapiens(Human) ERCC6; CSB Q03468 1350 T Homo sapiens(Human) ERCC6; CSB Q03468 1379 S Homo sapiens(Human) ERCC6; CSB Q03468 1380 S Homo sapiens(Human) ERCC6; CSB Q03468 1381 S Homo sapiens(Human) ERCC6; CSB Q03468 1388 S Homo sapiens(Human) ERCC6; CSB Q03468 1461 S Homo sapiens(Human) ERCC6; CSB Q03468 158 S Homo sapiens(Human) ERCC6; CSB Q03468 429 S Homo sapiens(Human) ERCC6; CSB Q03468 430 S Homo sapiens(Human) ERCC6; CSB Q03468 438 S Homo sapiens(Human) ERCC6; CSB Q03468 486 S Homo sapiens(Human) ERCC6; CSB Q03468 489 S Homo sapiens(Human) ERCC6; CSB Q03468 624 S Homo sapiens(Human) ERCC6; CSB Q03468 625 Y Homo sapiens(Human) ERCC6; CSB Q03468 893 S Homo sapiens(Human) ERCC6; CSB Q03468 932 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q03468 K170-me Methylation TSRDINRkLDsVKRQ Q03468 K297-me Methylation CNKRAARkAPAPVtP Q03468 K448-me Methylation EGGGGGRkVGRYRDD Q03468 K1054-me Methylation DHDVPKRkKFPASNI Q03468 S35-p Phosphorylation EMAIKQEsGGDGEVE Q03468 S124-p Phosphorylation IHEASRAsQLVDVEK Q03468 S158-p Phosphorylation NKIIEQLsPQAATSR Q03468 S173-p Phosphorylation DINRkLDsVKRQKYN Q03468 T242-p Phosphorylation AWEELIRtGQMtPFG Q03468 T246-p Phosphorylation LIRtGQMtPFGtQIP Q03468 T250-p Phosphorylation GQMtPFGtQIPQKQE Q03468 T303-p Phosphorylation RkAPAPVtPPAPVQN Q03468 S429-p Phosphorylation IDDDFFPssGEEAEA Q03468 S430-p Phosphorylation DDDFFPssGEEAEAA Q03468 S486-p Phosphorylation RLKLEDDsEEsDAEF Q03468 S489-p Phosphorylation LEDDsEEsDAEFDEG Q03468 S624-p Phosphorylation CHGILITsySYIRLM Q03468 Y625-p Phosphorylation HGILITsySYIRLMQ Q03468 S893-p Phosphorylation DGTTTIAsRQPLITR Q03468 Y932-p Phosphorylation GANRVVIyDPDWNPS Q03468 S1142-p Phosphorylation TGKTSMPsGDEsIDE Q03468 S1146-p Phosphorylation SMPsGDEsIDEKLGL Q03468 S1189-p Phosphorylation KSKTKHHsVAEEETL Q03468 S1276-p Phosphorylation DAIMDGAsPDyVLVE Q03468 Y1279-p Phosphorylation MDGAsPDyVLVEAEA Q03468 S1337-p Phosphorylation RFGKKRNsNFsVQHP Q03468 S1340-p Phosphorylation KKRNsNFsVQHPsst Q03468 S1345-p Phosphorylation NFsVQHPsstsPtEK Q03468 S1346-p Phosphorylation FsVQHPsstsPtEKC Q03468 T1347-p Phosphorylation sVQHPsstsPtEKCQ Q03468 S1348-p Phosphorylation VQHPsstsPtEKCQD Q03468 T1350-p Phosphorylation HPsstsPtEKCQDGI Q03468 S1381-p Phosphorylation AEDADSSsGPLASSS Q03468 S1461-p Phosphorylation FESkLSAsQSCVFRE Q03468 K262-sm Sumoylation KQEKKPRkIMLNEAS Q03468 K1254-ub Ubiquitination NDDYVLEkLFKKSVG Q03468 K1295-ub Ubiquitination RVAQDALkALRLSRQ Q03468 K1392-ub Ubiquitination ASSSLLAkMRARNHL Q03468 K1457-ub Ubiquitination ILQEFESkLSAsQSC

PTM - dbPTM UniProt ID Position Code Type Resources References Q03468 158 S Phosphorylation Swiss-Prot 1010711 16964243;17924679;18669648;18691976;19007248 Q03468 170 K Methylation Swiss-Prot 1010711 18438403 Q03468 297 K Methylation Swiss-Prot 1010711 18438403 Q03468 429 S Phosphorylation Swiss-Prot 1010711 18669648 Q03468 430 S Phosphorylation Swiss-Prot 1010711 18669648 Q03468 448 K Methylation Swiss-Prot 1010711 18438403 Q03468 486 S Phosphorylation Swiss-Prot 1010711 16565220;18669648 Q03468 489 S Phosphorylation Swiss-Prot 1010711 18669648 Q03468 1054 K Methylation Swiss-Prot 1010711 18438403 Q03468 1142 S Phosphorylation Swiss-Prot 1010711 18669648;19413330 Q03468 1348 S Phosphorylation Swiss-Prot 1010711 18669648 Q03468 1461 S Phosphorylation Swiss-Prot 1010711 17525332 Q03468 158 S Phosphorylation PhosphoELM.10011 18669648;16964243 Q03468 429 S Phosphorylation PhosphoELM.10011 18669648 Q03468 430 S Phosphorylation PhosphoELM.10011 18669648 Q03468 486 S Phosphorylation PhosphoELM.10011 18669648;16565220 Q03468 489 S Phosphorylation PhosphoELM.10011 18669648;16565220 Q03468 1009 S Phosphorylation PhosphoELM.10011 18669648 Q03468 1142 S Phosphorylation PhosphoELM.10011 18669648 Q03468 1348 S Phosphorylation PhosphoELM.10011 18669648 Q03468 1461 S Phosphorylation PhosphoELM.10011 17525332 Q03468 1347 T Phosphorylation PhosphoELM.10011 18669648 Q03468 1350 T Phosphorylation PhosphoELM.10011 18669648 Q03468 1457 K Ubiquitylation Phosphositeplus.1010730 21890473 Q03468 1054 K Methylation Phosphositeplus.1010730 18438403 Q03468 170 K Methylation Phosphositeplus.1010730 18438403 Q03468 297 K Methylation Phosphositeplus.1010730 18438403 Q03468 448 K Methylation Phosphositeplus.1010730 18438403 Q03468 1142 S Phosphorylation Phosphositeplus.1010730 18669648;22115753 Q03468 124 S Phosphorylation Phosphositeplus.1010730 20068231 Q03468 1345 S Phosphorylation Phosphositeplus.1010730 19276368 Q03468 1348 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;21659604 Q03468 1461 S Phosphorylation Phosphositeplus.1010730 17525332 Q03468 158 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;18691976;19415658;19691289;20068231;21659604 Q03468 429 S Phosphorylation Phosphositeplus.1010730 18669648;20363803;21406692;21659604;22115753 Q03468 430 S Phosphorylation Phosphositeplus.1010730 18669648;20363803;21406692;21659604;22115753 Q03468 486 S Phosphorylation Phosphositeplus.1010730 16565220;18669648;20068231;20363803;21406692;21659604;22115753 Q03468 489 S Phosphorylation Phosphositeplus.1010730 16565220;18669648;20068231;20363803;21406692;21659604;22115753 Q03468 1347 T Phosphorylation Phosphositeplus.1010730 18669648;21659604 Q03468 932 Y Phosphorylation Phosphositeplus.1010730 17626041 Q03468 124 S Phosphorylation HPRD 9.0 20068231 Q03468 158 S Phosphorylation HPRD 9.0 18669648,19415658,18691976,17924679,19007248,19691289,16964243,18452278,20068231 Q03468 429 S Phosphorylation HPRD 9.0 18669648,18452278 Q03468 430 S Phosphorylation HPRD 9.0 17081983,18669648,18452278 Q03468 438 S Phosphorylation HPRD 9.0 17081983 Q03468 486 S Phosphorylation HPRD 9.0 16565220,18669648,18452278,20068231 Q03468 489 S Phosphorylation HPRD 9.0 16565220,18669648,18452278,20068231 Q03468 893 S Phosphorylation HPRD 9.0 18452278 Q03468 1009 S Phosphorylation HPRD 9.0 18669648 Q03468 1142 S Phosphorylation HPRD 9.0 18669648,19413330 Q03468 1345 S Phosphorylation HPRD 9.0 20068231 Q03468 1348 S Phosphorylation HPRD 9.0 18669648,18452278,20068231 Q03468 1461 S Phosphorylation HPRD 9.0 17525332 Q03468 1347 T Phosphorylation HPRD 9.0 18669648,20068231 Q03468 1350 T Phosphorylation HPRD 9.0 18669648 Q03468 158 S Phosphorylation SysPTM 1.1 16964243;18691976;18669648 Q03468 429 S Phosphorylation SysPTM 1.1 18669648 Q03468 430 S Phosphorylation SysPTM 1.1 18669648;17081983 Q03468 438 S Phosphorylation SysPTM 1.1 17081983 Q03468 486 S Phosphorylation SysPTM 1.1 18669648;16565220 Q03468 489 S Phosphorylation SysPTM 1.1 18669648;16565220 Q03468 1142 S Phosphorylation SysPTM 1.1 18669648 Q03468 1348 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References ERCC6 1009 S Phosphorylation 18669648 ERCC6 1142 S Phosphorylation 18669648,19413330 ERCC6 124 S Phosphorylation 20068231 ERCC6 1345 S Phosphorylation 20068231 ERCC6 1347 T Phosphorylation 18669648,20068231 ERCC6 1348 S Phosphorylation 18669648,18452278,20068231 ERCC6 1350 T Phosphorylation 18669648 ERCC6 1461 S Phosphorylation 17525332 ERCC6 158 S Phosphorylation 18669648,19415658,18691976,17924679,19007248,19691289,16964243,18452278,20068231 ERCC6 429 S Phosphorylation 18669648,18452278 ERCC6 430 S Phosphorylation 17081983,18669648,18452278 ERCC6 438 S Phosphorylation 17081983 ERCC6 486 S Phosphorylation 16565220,18669648,18452278,20068231 ERCC6 489 S Phosphorylation 16565220,18669648,18452278,20068231 ERCC6 893 S Phosphorylation 18452278

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q03468 1142 S 18669648 HTP Phosphorylation Q03468 1461 S 17525332 HTP Phosphorylation Q03468 486 S 18669648 HTP Phosphorylation Q03468 486 S 16565220 HTP Phosphorylation Q03468 1009 S 18669648 HTP Phosphorylation Q03468 1348 S 18669648 HTP Phosphorylation Q03468 1347 T 18669648 HTP Phosphorylation Q03468 1350 T 18669648 HTP Phosphorylation Q03468 430 S 18669648 HTP Phosphorylation Q03468 429 S 18669648 HTP Phosphorylation Q03468 489 S 18669648 HTP Phosphorylation Q03468 489 S 16565220 HTP Phosphorylation Q03468 158 S 18669648 HTP Phosphorylation Q03468 158 S 16964243 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q03468 158 Phosphoserine 16964243;18669648;18691976;20068231;23186163 Q03468 170 N6-methylated lysine; by EHMT2 18438403 Q03468 297 N6-methylated lysine; by EHMT2 18438403 Q03468 429 Phosphoserine 18669648;21406692 Q03468 430 Phosphoserine 18669648;21406692 Q03468 448 N6-methylated lysine; by EHMT2 18438403 Q03468 486 Phosphoserine 21406692 Q03468 489 Phosphoserine 21406692 Q03468 1054 N6-methylated lysine; by EHMT2 18438403 Q03468 1142 Phosphoserine 18669648 Q03468 1348 Phosphoserine 18669648;23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type ERCC6 IPI00414779 S 124 HEASRApSQLVDVE phosphorylation ERCC6 IPI00414779 S 1345 FSVQHPpSSTSPTE phosphorylation ERCC6 IPI00414779 S 1348 QHPSSTpSPTEKCQ phosphorylation ERCC6 IPI00414779 S 158 KIIEQLpSPQAATS phosphorylation ERCC6 IPI00414779 S 486 LKLEDDpSEESDAE phosphorylation ERCC6 IPI00414779 S 489 EDDSEEpSDAEFDE phosphorylation ERCC6 IPI00414779 S 893 GTTTIApSRQPLIT phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 2074 108386 - K Ubiquitination 21987572 2074 108386 - K Sumoylation 21693764 2074 108386 - K Ubiquitination 21139048 2074 108386 - K Ubiquitination 21890473 2074 108386 - K Sumoylation 19471022 2074 108386 - K Ubiquitination 21756275 2074 108386 - K Ubiquitination 21963094 2074 108386 - K Ubiquitination 23000965 2074 108386 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID ERCC6 Homo sapiens (Human) 1457 "1457,LQEFESKLSASQS" 1457:21890473 ERCC6 Homo sapiens (Human) 1457 "1457,LQEFESKLSASQS" 1457:21890473 ERCC6 Homo sapiens (Human) 1457 "1457,LQEFESKLSASQS" 1457:21890473 ERCC6 Homo sapiens (Human) 834 "834,LQEFESKLSASQS" 834:21890473