Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 6 30153743 30153743 + Silent SNP G G A TCGA-XF-A9SJ-01A-11D-A391-08 TCGA-XF-A9SJ-10A-01D-A394-08 g.chr6:30153743G>A c.1530C>T c.(1528-1530)ctC>ctT p.L510L BLCA 6 30154266 30154266 + Missense_Mutation SNP G G A TCGA-BL-A0C8-01A-11D-A10S-08 TCGA-BL-A0C8-10A-01D-A10S-08 g.chr6:30154266G>A c.1007C>T c.(1006-1008)aCc>aTc p.T336I BLCA 6 30164394 30164394 + Missense_Mutation SNP C C T TCGA-E7-A7XN-01A-11D-A34U-08 TCGA-E7-A7XN-10A-01D-A34X-08 g.chr6:30164394C>T c.664G>A c.(664-666)Gag>Aag p.E222K BRCA 6 30153672 30153672 + Missense_Mutation SNP C C T TCGA-AN-A0AK-01A-21W-A019-09 TCGA-AN-A0AK-10A-01W-A021-09 g.chr6:30153672C>T c.1601G>A c.(1600-1602)cGc>cAc p.R534H BRCA 6 30153878 30153878 + Silent SNP G G C TCGA-A2-A3XT-01A-11D-A22X-09 TCGA-A2-A3XT-10A-01D-A22X-09 g.chr6:30153878G>C c.1395C>G c.(1393-1395)ctC>ctG p.L465L BRCA 6 30157808 30157808 + Missense_Mutation SNP G G A TCGA-AN-A03Y-01A-21W-A019-09 TCGA-AN-A03Y-10A-01W-A021-09 g.chr6:30157808G>A c.770C>T c.(769-771)aCg>aTg p.T257M CESC 6 30153705 30153705 + Missense_Mutation SNP A A G TCGA-C5-A7UE-01A-11D-A33O-09 TCGA-C5-A7UE-10A-01D-A33O-09 g.chr6:30153705A>G c.1568T>C c.(1567-1569)gTc>gCc p.V523A COAD 6 30153716 30153716 + Silent SNP G G T TCGA-AA-3496-01A-21D-1835-10 TCGA-AA-3496-11A-01D-1835-10 g.chr6:30153716G>T c.1557C>A c.(1555-1557)acC>acA p.T519T COAD 6 30153888 30153888 + Missense_Mutation SNP G G A TCGA-D5-6540-01A-11D-1719-10 TCGA-D5-6540-10A-01D-1719-10 g.chr6:30153888G>A c.1385C>T c.(1384-1386)gCg>gTg p.A462V COAD 6 30153935 30153936 + Frame_Shift_Del DEL CA CA - TCGA-CK-6747-01A-11D-1835-10 TCGA-CK-6747-10A-01D-1835-10 g.chr6:30153935_30153936delCA c.1337_1338delTG c.(1336-1338)gtgfs p.V446fs COAD 6 30154049 30154049 + Silent SNP G G A TCGA-DM-A1HB-01A-21D-A183-10 TCGA-DM-A1HB-10A-01D-A183-10 g.chr6:30154049G>A c.1224C>T c.(1222-1224)gaC>gaT p.D408D COAD 6 30154075 30154075 + Missense_Mutation SNP C C T TCGA-AA-3947-01A-01W-0995-10 TCGA-AA-3947-10A-01W-0995-10 g.chr6:30154075C>T c.1198G>A c.(1198-1200)Gag>Aag p.E400K COAD 6 30157242 30157242 + Missense_Mutation SNP A A C TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr6:30157242A>C c.857T>G c.(856-858)tTc>tGc p.F286C COAD 6 30157302 30157302 + Missense_Mutation SNP C C T TCGA-A6-6651-01A-21D-1835-10 TCGA-A6-6651-10A-01D-1835-10 g.chr6:30157302C>T c.797G>A c.(796-798)cGg>cAg p.R266Q COAD 6 30164371 30164371 + Silent SNP G G A TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr6:30164371G>A c.687C>T c.(685-687)gtC>gtT p.V229V COAD 6 30166518 30166518 + Silent SNP G G A TCGA-AA-3713-01A-21D-1719-10 TCGA-AA-3713-11A-01D-1719-10 g.chr6:30166518G>A c.363C>T c.(361-363)tgC>tgT p.C121C COAD 6 30166603 30166603 + Missense_Mutation SNP G G T TCGA-DM-A1D8-01A-11D-A152-10 TCGA-DM-A1D8-10A-01D-A152-10 g.chr6:30166603G>T c.278C>A c.(277-279)aCc>aAc p.T93N COAD 6 30166679 30166679 + Missense_Mutation SNP C C T TCGA-AA-A00R-01A-01W-A005-10 TCGA-AA-A00R-10A-01W-A005-10 g.chr6:30166679C>T c.202G>A c.(202-204)Gtg>Atg p.V68M COAD 6 30166680 30166680 + Silent SNP G G A TCGA-AA-A00U-01A-01W-A005-10 TCGA-AA-A00U-10A-01W-A005-10 g.chr6:30166680G>A c.201C>T c.(199-201)ccC>ccT p.P67P COAD 6 30166772 30166772 + Missense_Mutation SNP G G A TCGA-CK-4948-01B-11D-1650-10 TCGA-CK-4948-10A-01D-1650-10 g.chr6:30166772G>A c.109C>T c.(109-111)Cgc>Tgc p.R37C COADREAD 6 30153716 30153716 + Silent SNP G G T TCGA-AA-3496-01A-21D-1835-10 TCGA-AA-3496-11A-01D-1835-10 g.chr6:30153716G>T c.1557C>A c.(1555-1557)acC>acA p.T519T COADREAD 6 30153888 30153888 + Missense_Mutation SNP G G A TCGA-D5-6540-01A-11D-1719-10 TCGA-D5-6540-10A-01D-1719-10 g.chr6:30153888G>A c.1385C>T c.(1384-1386)gCg>gTg p.A462V COADREAD 6 30153935 30153936 + Frame_Shift_Del DEL CA CA - TCGA-CK-6747-01A-11D-1835-10 TCGA-CK-6747-10A-01D-1835-10 g.chr6:30153935_30153936delCA c.1337_1338delTG c.(1336-1338)gtgfs p.V446fs COADREAD 6 30154049 30154049 + Silent SNP G G A TCGA-DM-A1HB-01A-21D-A183-10 TCGA-DM-A1HB-10A-01D-A183-10 g.chr6:30154049G>A c.1224C>T c.(1222-1224)gaC>gaT p.D408D COADREAD 6 30154075 30154075 + Missense_Mutation SNP C C T TCGA-AA-3947-01A-01W-0995-10 TCGA-AA-3947-10A-01W-0995-10 g.chr6:30154075C>T c.1198G>A c.(1198-1200)Gag>Aag p.E400K COADREAD 6 30157242 30157242 + Missense_Mutation SNP A A C TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr6:30157242A>C c.857T>G c.(856-858)tTc>tGc p.F286C COADREAD 6 30157302 30157302 + Missense_Mutation SNP C C T TCGA-A6-6651-01A-21D-1835-10 TCGA-A6-6651-10A-01D-1835-10 g.chr6:30157302C>T c.797G>A c.(796-798)cGg>cAg p.R266Q COADREAD 6 30164371 30164371 + Silent SNP G G A TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr6:30164371G>A c.687C>T c.(685-687)gtC>gtT p.V229V COADREAD 6 30166518 30166518 + Silent SNP G G A TCGA-AA-3713-01A-21D-1719-10 TCGA-AA-3713-11A-01D-1719-10 g.chr6:30166518G>A c.363C>T c.(361-363)tgC>tgT p.C121C COADREAD 6 30166603 30166603 + Missense_Mutation SNP G G T TCGA-DM-A1D8-01A-11D-A152-10 TCGA-DM-A1D8-10A-01D-A152-10 g.chr6:30166603G>T c.278C>A c.(277-279)aCc>aAc p.T93N COADREAD 6 30166679 30166679 + Missense_Mutation SNP C C T TCGA-AA-A00R-01A-01W-A005-10 TCGA-AA-A00R-10A-01W-A005-10 g.chr6:30166679C>T c.202G>A c.(202-204)Gtg>Atg p.V68M COADREAD 6 30166680 30166680 + Silent SNP G G A TCGA-AA-A00U-01A-01W-A005-10 TCGA-AA-A00U-10A-01W-A005-10 g.chr6:30166680G>A c.201C>T c.(199-201)ccC>ccT p.P67P COADREAD 6 30166772 30166772 + Missense_Mutation SNP G G A TCGA-CK-4948-01B-11D-1650-10 TCGA-CK-4948-10A-01D-1650-10 g.chr6:30166772G>A c.109C>T c.(109-111)Cgc>Tgc p.R37C ESCA 6 30154080 30154082 + In_Frame_Del DEL TCC TCC - TCGA-VR-A8Q7-01A-11D-A37C-09 TCGA-VR-A8Q7-10A-01D-A37F-09 g.chr6:30154080_30154082delTCC c.1191_1193delGGA c.(1189-1194)gaggaa>gaa p.397_398EE>E ESCA 6 30166680 30166680 + Silent SNP G G T TCGA-VR-A8EY-01A-11D-A36J-09 TCGA-VR-A8EY-10A-01D-A36M-09 g.chr6:30166680G>T c.201C>A c.(199-201)ccC>ccA p.P67P GBM 6 30153775 30153775 + Missense_Mutation SNP C C A TCGA-41-2572-01A-01D-1353-08 TCGA-41-2572-10A-01D-1353-08 g.chr6:30153775C>A c.1498G>T c.(1498-1500)Gtg>Ttg p.V500L GBM 6 30164404 30164404 + Silent SNP C C T TCGA-28-5215-01A-01D-1486-08 TCGA-28-5215-10A-01D-1486-08 g.chr6:30164404C>T c.654G>A c.(652-654)acG>acA p.T218T GBMLGG 6 30153775 30153775 + Missense_Mutation SNP C C A TCGA-41-2572-01A-01D-1353-08 TCGA-41-2572-10A-01D-1353-08 g.chr6:30153775C>A c.1498G>T c.(1498-1500)Gtg>Ttg p.V500L GBMLGG 6 30164404 30164404 + Silent SNP C C T TCGA-28-5215-01A-01D-1486-08 TCGA-28-5215-10A-01D-1486-08 g.chr6:30164404C>T c.654G>A c.(652-654)acG>acA p.T218T HNSC 6 30154334 30154334 + Splice_Site SNP C C T TCGA-CV-7095-01A-21D-2012-08 TCGA-CV-7095-10A-01D-2013-08 g.chr6:30154334C>T c.939G>A c.(937-939)gtG>gtA p.V313V HNSC 6 30166209 30166209 + Silent SNP C C T TCGA-CN-5356-01A-01D-1434-08 TCGA-CN-5356-10A-01D-1434-08 g.chr6:30166209C>T c.531G>A c.(529-531)gcG>gcA p.A177A HNSC 6 30166498 30166498 + Missense_Mutation SNP C C G TCGA-BA-6871-01A-11D-1870-08 TCGA-BA-6871-10A-01D-1870-08 g.chr6:30166498C>G c.383G>C c.(382-384)cGg>cCg p.R128P HNSC 6 30166570 30166570 + Missense_Mutation SNP C C T TCGA-BB-A5HY-01A-11D-A28R-08 TCGA-BB-A5HY-10A-01D-A28U-08 g.chr6:30166570C>T c.311G>A c.(310-312)cGa>cAa p.R104Q LIHC 6 30156977 30156977 + Splice_Site SNP C C A TCGA-UB-A7MD-01A-12D-A34Z-10 TCGA-UB-A7MD-10A-01D-A34Z-10 g.chr6:30156977C>A c.e9-1 LIHC 6 30166750 30166750 + Missense_Mutation SNP C C T TCGA-UB-AA0V-01A-11D-A382-10 TCGA-UB-AA0V-10A-01D-A385-10 g.chr6:30166750C>T c.131G>A c.(130-132)cGc>cAc p.R44H LUAD 6 30153775 30153775 + Missense_Mutation SNP C C A TCGA-55-8302-01A-11D-2323-08 TCGA-55-8302-10A-01D-2323-08 g.chr6:30153775C>A c.1498G>T c.(1498-1500)Gtg>Ttg p.V500L LUAD 6 30153924 30153924 + Missense_Mutation SNP C C G TCGA-44-6144-01A-11D-1753-08 TCGA-44-6144-10A-01D-1753-08 g.chr6:30153924C>G c.1349G>C c.(1348-1350)gGa>gCa p.G450A LUAD 6 30153984 30153984 + Missense_Mutation SNP T T A TCGA-78-7220-01A-11D-2036-08 TCGA-78-7220-10A-01D-2036-08 g.chr6:30153984T>A c.1289A>T c.(1288-1290)gAg>gTg p.E430V LUAD 6 30164347 30164347 + Silent SNP C C A TCGA-44-6778-01A-11D-1855-08 TCGA-44-6778-10A-01D-1855-08 g.chr6:30164347C>A c.711G>T c.(709-711)ctG>ctT p.L237L LUAD 6 30166684 30166684 + Missense_Mutation SNP C C A TCGA-95-7039-01A-11D-1945-08 TCGA-95-7039-10A-01D-1946-08 g.chr6:30166684C>A c.197G>T c.(196-198)cGa>cTa p.R66L LUSC 6 30166457 30166457 + Missense_Mutation SNP C C T TCGA-37-4135-01A-01D-1352-08 TCGA-37-4135-10A-01D-1352-08 g.chr6:30166457C>T c.424G>A c.(424-426)Gcc>Acc p.A142T LUSC 6 30166844 30166844 + Missense_Mutation SNP C C T TCGA-33-4583-01A-01D-1441-08 TCGA-33-4583-11A-01D-1441-08 g.chr6:30166844C>T c.37G>A c.(37-39)Gag>Aag p.E13K OV 6 30164385 30164385 + Missense_Mutation SNP T T G TCGA-13-1512-01A-01W-0545-08 TCGA-13-1512-10A-01W-0546-08 g.chr6:30164385T>G c.673A>C c.(673-675)Aag>Cag p.K225Q OV 6 30164453 30164453 + Missense_Mutation SNP C C T TCGA-13-1497-01A-01W-0549-09 TCGA-13-1497-10A-01W-0549-09 g.chr6:30164453C>T c.605G>A c.(604-606)cGg>cAg p.R202Q PAAD 6 30166741 30166741 + Missense_Mutation SNP G G A TCGA-IB-7885-01A-11D-2154-08 TCGA-IB-7885-10A-01D-2154-08 g.chr6:30166741G>A c.140C>T c.(139-141)tCa>tTa p.S47L PAAD 6 30166750 30166750 + Missense_Mutation SNP C C T TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:30166750C>T c.131G>A c.(130-132)cGc>cAc p.R44H PRAD 6 30164320 30164320 + Silent SNP C C T TCGA-WW-A8ZI-01A-11D-A377-08 TCGA-WW-A8ZI-10A-01D-A37A-08 g.chr6:30164320C>T c.738G>A c.(736-738)gcG>gcA p.A246A SARC 6 30153712 30153712 + Missense_Mutation SNP G G A TCGA-3B-A9HT-01A-11D-A38Z-09 TCGA-3B-A9HT-10A-01D-A38Z-09 g.chr6:30153712G>A c.1561C>T c.(1561-1563)Cgc>Tgc p.R521C SARC 6 30154038 30154038 + Missense_Mutation SNP G G A TCGA-WK-A8XS-01A-11D-A37C-09 TCGA-WK-A8XS-10E-01D-A37F-09 g.chr6:30154038G>A c.1235C>T c.(1234-1236)aCg>aTg p.T412M SKCM 6 30153703 30153703 + Missense_Mutation SNP G G A TCGA-EE-A2GU-06A-11D-A196-08 TCGA-EE-A2GU-10A-01D-A198-08 g.chr6:30153703G>A c.1570C>T c.(1570-1572)Ccc>Tcc p.P524S SKCM 6 30164359 30164359 + Silent SNP G G A TCGA-D3-A3MV-06A-11D-A21A-08 TCGA-D3-A3MV-10A-01D-A21A-08 g.chr6:30164359G>A c.699C>T c.(697-699)gcC>gcT p.A233A SKCM 6 30164453 30164453 + Missense_Mutation SNP C C T TCGA-D3-A51E-06A-11D-A25O-08 TCGA-D3-A51E-10A-01D-A25O-08 g.chr6:30164453C>T c.605G>A c.(604-606)cGg>cAg p.R202Q SKCM 6 30164463 30164463 + Silent SNP G G A TCGA-EE-A29N-06A-12D-A197-08 TCGA-EE-A29N-10A-01D-A199-08 g.chr6:30164463G>A c.595C>T c.(595-597)Ctg>Ttg p.L199L SKCM 6 30166464 30166464 + Silent SNP C C T TCGA-DA-A1IC-06A-11D-A197-08 TCGA-DA-A1IC-10A-01D-A199-08 g.chr6:30166464C>T c.417G>A c.(415-417)gaG>gaA p.E139E SKCM 6 30166566 30166566 + Silent SNP G G A TCGA-EE-A182-06A-11D-A196-08 TCGA-EE-A182-10A-01D-A198-08 g.chr6:30166566G>A c.315C>T c.(313-315)caC>caT p.H105H SKCM 6 30166681 30166681 + Missense_Mutation SNP G G A TCGA-EE-A2M5-06A-12D-A197-08 TCGA-EE-A2M5-10A-01D-A199-08 g.chr6:30166681G>A c.200C>T c.(199-201)cCc>cTc p.P67L SKCM 6 30166830 30166830 + Silent SNP G G A TCGA-EE-A29S-06A-11D-A197-08 TCGA-EE-A29S-10A-01D-A199-08 g.chr6:30166830G>A c.51C>T c.(49-51)tcC>tcT p.S17S

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand PD4196a COSM4809764 c.9G>A p.T3T Substitution - coding silent 6:30199095-30199095 - TCGA-F5-6814-01 COSM3430455 c.1182G>A p.E394E Substitution - coding silent 6:30186314-30186314 - AD22 COSM5966313 c.943G>A p.V315I Substitution - Missense 6:30186553-30186553 - HCT116 COSM3251219 c.296C>T p.A99V Substitution - Missense 6:30198808-30198808 - TCGA-A5-A0GH-01 COSM1077324 c.1002C>T p.C334C Substitution - coding silent 6:30186494-30186494 - TCGA-28-5215-01 COSM3410905 c.654G>A p.T218T Substitution - coding silent 6:30196627-30196627 - B66-Tumor COSM4006276 c.138C>T p.I46I Substitution - coding silent 6:30198966-30198966 - PTC-515C COSM4160547 c.1354C>G p.L452V Substitution - Missense 6:30186142-30186142 - Pat_06_B COSM1442992 c.845delA p.K282fs*16 Deletion - Frameshift 6:30189477-30189477 - 2171663 COSM4423093 c.689G>A p.G230E Substitution - Missense 6:30196592-30196592 - TCGA-HU-A4H8-01 COSM3861382 c.1581G>A p.W527* Substitution - Nonsense 6:30185915-30185915 - T20 COSM4736007 c.1314G>A p.M438I Substitution - Missense 6:30186182-30186182 - 16617 COSM5615660 c.374G>T p.R125L Substitution - Missense 6:30198730-30198730 - S01864 COSM5671822 c.1253C>T p.S418L Substitution - Missense 6:30186243-30186243 - TCGA-BS-A0TJ-01 COSM76815 c.605G>A p.R202Q Substitution - Missense 6:30196676-30196676 - pfg127T COSM4751952 c.1390C>T p.R464C Substitution - Missense 6:30186106-30186106 - TCGA-EE-A29N-06 COSM3624216 c.595C>T p.L199L Substitution - coding silent 6:30196686-30196686 - TCGA-D3-A51E-06 COSM76815 c.605G>A p.R202Q Substitution - Missense 6:30196676-30196676 - Pat_06_A COSM1442992 c.845delA p.K282fs*16 Deletion - Frameshift 6:30189477-30189477 - Pat_59_A COSM1442992 c.845delA p.K282fs*16 Deletion - Frameshift 6:30189477-30189477 - T613 COSM4736011 c.382C>T p.R128W Substitution - Missense 6:30198722-30198722 - ESCC_123 COSM5640930 c.160C>T p.P54S Substitution - Missense 6:30198944-30198944 - TCGA-EE-A2M5-06 COSM3624222 c.200C>T p.P67L Substitution - Missense 6:30198904-30198904 - TCGA-A5-A0GH-01 COSM1077331 c.311G>A p.R104Q Substitution - Missense 6:30198793-30198793 - CHC1742T COSM4792283 c.198A>G p.R66R Substitution - coding silent 6:30198906-30198906 - TCGA-UB-A7MD-01 COSM4933006 c.905-1G>T p.? Unknown 6:30189200-30189200 - T3064 COSM1442992 c.845delA p.K282fs*16 Deletion - Frameshift 6:30189477-30189477 - TCGA-41-2572-01 COSM3410903 c.1498G>T p.V500L Substitution - Missense 6:30185998-30185998 - CHC1742T COSM4792283 c.198A>G p.R66R Substitution - coding silent 6:30198906-30198906 - 18 COSM5744874 c.796C>T p.R266W Substitution - Missense 6:30189526-30189526 - TCGA-13-1497-01 COSM76815 c.605G>A p.R202Q Substitution - Missense 6:30196676-30196676 - TCGA-EE-A2GU-06 COSM3624209 c.1570C>T p.P524S Substitution - Missense 6:30185926-30185926 - LP6005334-DNA_E03 COSM4412962 c.1378G>A p.V460M Substitution - Missense 6:30186118-30186118 - HCC103T COSM3662348 c.148C>T p.R50C Substitution - Missense 6:30198956-30198956 - TCGA-A2-A3XT-01 COSM3829989 c.1395C>G p.L465L Substitution - coding silent 6:30186101-30186101 - TCGA-CC-A7IF-01 COSM4915426 c.1103T>A p.V368D Substitution - Missense 6:30186393-30186393 - pfg181T COSM4751950 c.1561C>T p.R521C Substitution - Missense 6:30185935-30185935 - HCC103 COSM3662348 c.148C>T p.R50C Substitution - Missense 6:30198956-30198956 - C086 COSM5540804 c.372C>T p.C124C Substitution - coding silent 6:30198732-30198732 - TCGA-13-1512-01 COSM73062 c.673A>C p.K225Q Substitution - Missense 6:30196608-30196608 - TCGA-DM-A1D8-01 COSM1442998 c.278C>A p.T93N Substitution - Missense 6:30198826-30198826 - TCGA-BR-8487-01 COSM3861390 c.1160A>G p.D387G Substitution - Missense 6:30186336-30186336 - BCB167T COSM4798921 c.502G>A p.A168T Substitution - Missense 6:30198461-30198461 - TCGA-AN-A03Y-01 COSM1487575 c.770C>T p.T257M Substitution - Missense 6:30190031-30190031 - TCGA-AN-A0AK-01 COSM3829987 c.1601G>A p.R534H Substitution - Missense 6:30185895-30185895 - TCGA-BR-8361-01 COSM3861392 c.374G>A p.R125Q Substitution - Missense 6:30198730-30198730 - BD72T COSM5512214 c.1127G>T p.R376M Substitution - Missense 6:30186369-30186369 - BN37T COSM1621381 c.905-2A>T p.? Unknown 6:30189201-30189201 - NCI-H2009 COSM24031 c.1315G>T p.V439L Substitution - Missense 6:30186181-30186181 - T3535 COSM4736009 c.392G>T p.R131M Substitution - Missense 6:30198712-30198712 - ESO-2143 COSM1268522 c.842A>C p.K281T Substitution - Missense 6:30189480-30189480 - TCGA-BR-8382-01 COSM3861384 c.1559G>A p.R520Q Substitution - Missense 6:30185937-30185937 - BCB167T COSM4798921 c.502G>A p.A168T Substitution - Missense 6:30198461-30198461 - TCGA-CG-5728-01 COSM3861393 c.202G>A p.V68M Substitution - Missense 6:30198902-30198902 - TCGA-FS-A1ZN-01 COSM3624211 c.905G>A p.G302E Substitution - Missense 6:30189199-30189199 - TCGA-CA-6717-01 COSM1442991 c.857T>G p.F286C Substitution - Missense 6:30189465-30189465 - TCGA-B7-5816-01 COSM3251215 c.310C>T p.R104* Substitution - Nonsense 6:30198794-30198794 - M006 COSM1739216 c.383G>T p.R128L Substitution - Missense 6:30198721-30198721 - TARGET-20-PASVYL-09A-01D COSM5487588 c.100G>A p.V34I Substitution - Missense 6:30199004-30199004 - S00472 COSM5657947 c.206G>A p.W69* Substitution - Nonsense 6:30198898-30198898 - TCGA-EE-A29S-06 COSM3624224 c.51C>T p.S17S Substitution - coding silent 6:30199053-30199053 - TCGA-D5-6540-01 COSM1442987 c.1385C>T p.A462V Substitution - Missense 6:30186111-30186111 - BN37 COSM1621381 c.905-2A>T p.? Unknown 6:30189201-30189201 - SS6003314 COSM3982150 c.600G>A p.R200R Substitution - coding silent 6:30196681-30196681 - TCGA-C5-A7UE-01 COSM4856460 c.1568T>C p.V523A Substitution - Missense 6:30185928-30185928 - TCGA-BR-4257-01 COSM3861388 c.1185G>A p.E395E Substitution - coding silent 6:30186311-30186311 - PD18285a COSM3770565 c.1395C>A p.L465L Substitution - coding silent 6:30186101-30186101 - TCGA-37-4135-01 COSM1647943 c.424G>A p.A142T Substitution - Missense 6:30198680-30198680 - 1_RESISTANT COSM1720769 c.447C>T p.I149I Substitution - coding silent 6:30198516-30198516 - TCGA-AP-A051-01 COSM1077326 c.883C>T p.R295* Substitution - Nonsense 6:30189439-30189439 - 2521244 COSM5887332 c.905-5C>T p.? Unknown 6:30189204-30189204 - 1_PRE-TREATMENT COSM1720769 c.447C>T p.I149I Substitution - coding silent 6:30198516-30198516 - TCGA-A6-6651-01 COSM1442994 c.797G>A p.R266Q Substitution - Missense 6:30189525-30189525 - PD18285a COSM3770567 c.1394T>A p.L465H Substitution - Missense 6:30186102-30186102 - Pat_26_B COSM5540802 c.373C>T p.R125W Substitution - Missense 6:30198731-30198731 - TCGA-D3-A3MV-06 COSM3624214 c.699C>T p.A233A Substitution - coding silent 6:30196582-30196582 - TCGA-BR-6802-01 COSM3251215 c.310C>T p.R104* Substitution - Nonsense 6:30198794-30198794 - TCGA-AX-A0J1-01 COSM1077322 c.1493G>A p.G498D Substitution - Missense 6:30186003-30186003 - 2318492 COSM4776993 c.1171G>C p.E391Q Substitution - Missense 6:30186325-30186325 - ESO-859 COSM1240515 c.1460G>A p.R487Q Substitution - Missense 6:30186036-30186036 - TCGA-DA-A1IC-06 COSM3624218 c.417G>A p.E139E Substitution - coding silent 6:30198687-30198687 - B66-Tumor COSM4006274 c.140C>T p.S47L Substitution - Missense 6:30198964-30198964 - RK145_C01 COSM3702966 c.863A>G p.D288G Substitution - Missense 6:30189459-30189459 - TCGA-CD-A4MI-01 COSM3861397 c.9G>T p.T3T Substitution - coding silent 6:30199095-30199095 - TCGA-AA-3713-01 COSM1442996 c.363C>T p.C121C Substitution - coding silent 6:30198741-30198741 - TCGA-33-4583-01 COSM1647942 c.37G>A p.E13K Substitution - Missense 6:30199067-30199067 - TCGA-BR-8081-01 COSM3861395 c.67C>A p.L23M Substitution - Missense 6:30199037-30199037 - S02255 COSM5680889 c.459G>T p.L153L Substitution - coding silent 6:30198504-30198504 - T3024 COSM1442992 c.845delA p.K282fs*16 Deletion - Frameshift 6:30189477-30189477 - C086 COSM5540802 c.373C>T p.R125W Substitution - Missense 6:30198731-30198731 - B66-Tumor COSM4006272 c.165C>T p.L55L Substitution - coding silent 6:30198939-30198939 - TCGA-CK-4948-01 COSM1443000 c.109C>T p.R37C Substitution - Missense 6:30198995-30198995 - TCGA-EE-A182-06 COSM3624220 c.315C>T p.H105H Substitution - coding silent 6:30198789-30198789 - TCGA-BL-A0C8-01 COSM4811287 c.1007C>T p.T336I Substitution - Missense 6:30186489-30186489 - PT40 COSM5923758 c.397C>T p.H133Y Substitution - Missense 6:30198707-30198707 - TCGA-BR-4292-01 COSM3861386 c.1225G>A p.D409N Substitution - Missense 6:30186271-30186271 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.731863 6p21.3 600830 2392148|CGAP|BC024039|C/T|non-coding||3324|Validated; 2392148|CGAP|BC032297|C/T|non-coding||3107|Validated; 1509587|dbSNP|BC024039|C/T|non-coding||3246|Validated; 1509587|dbSNP|BC032297|C/T|non-coding||3029|Validated

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G IntronicSNV . c.938-410T>C 6 30154745 CM C A Missense p.R125L c.374G>T 6 30166507 NSCLC C A Missense p.V500L c.1498G>T 6 30153775 GBM C A Nonsense p.E76* c.226G>T 6 30166655 CM C A Synonymous p.L237L c.711G>T 6 30164347 LUAD C G IntronicSNV . c.788+61G>C 6 30157729 MB C G Missense p.G450A c.1349G>C 6 30153924 LUAD C G Missense p.R128P c.383G>C 6 30166498 HNSC C T Missense p.A142T c.424G>A 6 30166457 LUSC C T Missense p.D409N c.1225G>A 6 30154048 STAD C T Missense p.E13K c.37G>A 6 30166844 LUSC C T Missense p.G302E c.905G>A 6 30156976 CM C T Missense p.R104Q c.311G>A 6 30166570 UCEC C T Missense p.R125Q c.374G>A 6 30166507 CM C T Missense p.R202Q c.605G>A 6 30164453 OV C T Missense p.R202Q c.605G>A 6 30164453 UCEC C T Missense p.R487Q c.1460G>A 6 30153813 ESCA C T Missense p.V68M c.202G>A 6 30166679 COREAD C T Missense p.V68M c.202G>A 6 30166679 STAD C T Nonsense p.W69* c.206G>A 6 30166675 SCLC C T Synonymous p.A177A c.531G>A 6 30166209 HNSC C T Synonymous p.E139E c.417G>A 6 30166464 CM C T Synonymous p.E395E c.1185G>A 6 30154088 STAD C T Synonymous p.Q167Q c.501G>A 6 30166239 HNSC C T Synonymous p.T218T c.654G>A 6 30164404 GBM C T Synonymous p.T3T c.9G>A 6 30166872 BRCA C T Synonymous p.V313V c.939G>A 6 30154334 HNSC G A Missense p.L291F c.871C>T 6 30157228 CM G A Missense p.P524S c.1570C>T 6 30153703 CM G A Missense p.P67L c.200C>T 6 30166681 CM G A Missense p.S453F c.1358C>T 6 30153915 CM G A Missense p.T257M c.770C>T 6 30157808 BRCA G A Missense p.T336I c.1007C>T 6 30154266 BLCA G A Nonsense p.R104* c.310C>T 6 30166571 STAD G A Nonsense p.R66* c.196C>T 6 30166685 CM G A Synonymous p.A233A c.699C>T 6 30164359 CM G A Synonymous p.C334C c.1002C>T 6 30154271 UCEC G A Synonymous p.H105H c.315C>T 6 30166566 CM G A Synonymous p.L199L c.595C>T 6 30164463 CM G A Synonymous p.L217L c.651C>T 6 30164407 CM G A Synonymous p.P67P c.201C>T 6 30166680 COREAD G A Synonymous p.S17S c.51C>T 6 30166830 CM T C IntronicSNV . c.1-3949A>G 6 30170829 CLL T - Frameshift p.K282Rfs*16 c.845delA 6 30157254 THCA T G Missense p.K225Q c.673A>C 6 30164385 OV T G Missense p.K281T c.842A>C 6 30157257 ESCA