Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 15 65369395 65369395 + Missense_Mutation SNP C C T TCGA-OR-A5J2-01A-11D-A29I-10 TCGA-OR-A5J2-10A-01D-A29L-10 g.chr15:65369395C>T c.242C>T c.(241-243)gCc>gTc p.A81V ACC 15 65369395 65369395 + Missense_Mutation SNP C C T TCGA-OR-A5JL-01A-11D-A29I-10 TCGA-OR-A5JL-10A-01D-A29L-10 g.chr15:65369395C>T c.242C>T c.(241-243)gCc>gTc p.A81V ACC 15 65369395 65369395 + Missense_Mutation SNP C C T TCGA-OR-A5JP-01A-11D-A29I-10 TCGA-OR-A5JP-10A-01D-A29L-10 g.chr15:65369395C>T c.242C>T c.(241-243)gCc>gTc p.A81V ACC 15 65369395 65369395 + Missense_Mutation SNP C C T TCGA-OR-A5KT-01A-11D-A29I-10 TCGA-OR-A5KT-10A-01D-A29L-10 g.chr15:65369395C>T c.242C>T c.(241-243)gCc>gTc p.A81V ACC 15 65369395 65369395 + Missense_Mutation SNP C C T TCGA-OR-A5KV-01A-11D-A29I-10 TCGA-OR-A5KV-10A-01D-A29L-10 g.chr15:65369395C>T c.242C>T c.(241-243)gCc>gTc p.A81V ACC 15 65369395 65369395 + Missense_Mutation SNP C C T TCGA-OR-A5L5-01A-11D-A29I-10 TCGA-OR-A5L5-10A-01D-A29L-10 g.chr15:65369395C>T c.242C>T c.(241-243)gCc>gTc p.A81V ACC 15 65369395 65369395 + Missense_Mutation SNP C C T TCGA-OR-A5L9-01A-11D-A29I-10 TCGA-OR-A5L9-10B-01D-A29L-10 g.chr15:65369395C>T c.242C>T c.(241-243)gCc>gTc p.A81V ACC 15 65369395 65369395 + Missense_Mutation SNP C C T TCGA-OR-A5LP-01A-11D-A29I-10 TCGA-OR-A5LP-10A-01D-A29L-10 g.chr15:65369395C>T c.242C>T c.(241-243)gCc>gTc p.A81V ACC 15 65369531 65369531 + Silent SNP G G T TCGA-OR-A5JP-01A-11D-A29I-10 TCGA-OR-A5JP-10A-01D-A29L-10 g.chr15:65369531G>T c.378G>T c.(376-378)gcG>gcT p.A126A ACC 15 65369531 65369531 + Silent SNP G G T TCGA-OR-A5JW-01A-11D-A29I-10 TCGA-OR-A5JW-10A-01D-A29L-10 g.chr15:65369531G>T c.378G>T c.(376-378)gcG>gcT p.A126A ACC 15 65369531 65369531 + Silent SNP G G T TCGA-OR-A5K2-01A-11D-A29I-10 TCGA-OR-A5K2-10B-01D-A29L-10 g.chr15:65369531G>T c.378G>T c.(376-378)gcG>gcT p.A126A ACC 15 65369531 65369531 + Silent SNP G G T TCGA-OR-A5L5-01A-11D-A29I-10 TCGA-OR-A5L5-10A-01D-A29L-10 g.chr15:65369531G>T c.378G>T c.(376-378)gcG>gcT p.A126A ACC 15 65369947 65369947 + Missense_Mutation SNP G G A TCGA-OR-A5JY-01A-31D-A29I-10 TCGA-OR-A5JY-10A-01D-A29L-10 g.chr15:65369947G>A c.794G>A c.(793-795)gGc>gAc p.G265D BLCA 15 65370401 65370401 + Silent SNP C C T TCGA-DK-AA75-01A-11D-A391-08 TCGA-DK-AA75-10A-01D-A394-08 g.chr15:65370401C>T c.1248C>T c.(1246-1248)atC>atT p.I416I BRCA 15 65370332 65370332 + Silent SNP C C T TCGA-E2-A574-01A-11D-A29N-09 TCGA-E2-A574-10A-01D-A29N-09 g.chr15:65370332C>T c.1179C>T c.(1177-1179)ctC>ctT p.L393L COAD 15 65369924 65369924 + Silent SNP C C T TCGA-G4-6309-01A-21D-1835-10 TCGA-G4-6309-10A-01D-1835-10 g.chr15:65369924C>T c.771C>T c.(769-771)gaC>gaT p.D257D COADREAD 15 65369924 65369924 + Silent SNP C C T TCGA-G4-6309-01A-21D-1835-10 TCGA-G4-6309-10A-01D-1835-10 g.chr15:65369924C>T c.771C>T c.(769-771)gaC>gaT p.D257D DLBC 15 65370255 65370255 + Missense_Mutation SNP G G A TCGA-GS-A9TT-01A-11D-A382-10 TCGA-GS-A9TT-10A-01D-A385-10 g.chr15:65370255G>A c.1102G>A c.(1102-1104)Gcc>Acc p.A368T GBMLGG 15 65369306 65369306 + Silent SNP C C T TCGA-S9-A6WL-01A-21D-A33T-08 TCGA-S9-A6WL-10A-01D-A33W-08 g.chr15:65369306C>T c.153C>T c.(151-153)ggC>ggT p.G51G HNSC 15 65369216 65369216 + Frame_Shift_Del DEL C C - TCGA-CR-7392-01A-11D-2012-08 TCGA-CR-7392-10A-01D-2013-08 g.chr15:65369216delC c.63delC c.(61-63)gacfs p.D21fs HNSC 15 65370387 65370387 + Missense_Mutation SNP C C A TCGA-IQ-A6SG-01A-12D-A34J-08 TCGA-IQ-A6SG-10A-01D-A34M-08 g.chr15:65370387C>A c.1234C>A c.(1234-1236)Ctg>Atg p.L412M HNSC 15 65370407 65370407 + Silent SNP C C T TCGA-CN-5369-01A-01D-1434-08 TCGA-CN-5369-10A-01D-1434-08 g.chr15:65370407C>T c.1254C>T c.(1252-1254)ggC>ggT p.G418G KIPAN 15 65369367 65369367 + Silent SNP C C T TCGA-B9-A5W8-01A-11D-A28G-10 TCGA-B9-A5W8-10A-01D-A28G-10 g.chr15:65369367C>T c.214C>T c.(214-216)Ctg>Ttg p.L72L KIRP 15 65369367 65369367 + Silent SNP C C T TCGA-B9-A5W8-01A-11D-A28G-10 TCGA-B9-A5W8-10A-01D-A28G-10 g.chr15:65369367C>T c.214C>T c.(214-216)Ctg>Ttg p.L72L LGG 15 65369306 65369306 + Silent SNP C C T TCGA-S9-A6WL-01A-21D-A33T-08 TCGA-S9-A6WL-10A-01D-A33W-08 g.chr15:65369306C>T c.153C>T c.(151-153)ggC>ggT p.G51G LIHC 15 65370197 65370197 + Silent SNP C C A TCGA-EP-A2KB-01A-11D-A183-10 TCGA-EP-A2KB-10A-01D-A183-10 g.chr15:65370197C>A c.1044C>A c.(1042-1044)gcC>gcA p.A348A LUSC 15 65370042 65370042 + Missense_Mutation SNP G G A TCGA-22-4593-01A-21D-1817-08 TCGA-22-4593-11A-01D-1817-08 g.chr15:65370042G>A c.889G>A c.(889-891)Ggc>Agc p.G297S PRAD 15 65370349 65370349 + Missense_Mutation SNP G G A TCGA-XK-AAIW-01A-11D-A41K-08 TCGA-XK-AAIW-10A-01D-A41N-08 g.chr15:65370349G>A c.1196G>A c.(1195-1197)cGc>cAc p.R399H SKCM 15 65369261 65369261 + Silent SNP C C T TCGA-EE-A3J3-06A-11D-A20D-08 TCGA-EE-A3J3-10A-01D-A20D-08 g.chr15:65369261C>T c.108C>T c.(106-108)ttC>ttT p.F36F SKCM 15 65369922 65369922 + Missense_Mutation SNP G G A TCGA-D3-A51N-06A-11D-A25O-08 TCGA-D3-A51N-10A-01D-A25O-08 g.chr15:65369922G>A c.769G>A c.(769-771)Gac>Aac p.D257N SKCM 15 65370117 65370117 + Missense_Mutation SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr15:65370117G>A c.964G>A c.(964-966)Gag>Aag p.E322K SKCM 15 65370228 65370228 + Missense_Mutation SNP G G C TCGA-D3-A3MU-06A-11D-A21A-08 TCGA-D3-A3MU-10A-01D-A21A-08 g.chr15:65370228G>C c.1075G>C c.(1075-1077)Gga>Cga p.G359R SKCM 15 65370276 65370276 + Missense_Mutation SNP G G A TCGA-EE-A29M-06A-11D-A196-08 TCGA-EE-A29M-10A-01D-A198-08 g.chr15:65370276G>A c.1123G>A c.(1123-1125)Gcc>Acc p.A375T SKCM 15 65370324 65370324 + Missense_Mutation SNP G G A TCGA-EE-A3J5-06A-11D-A20D-08 TCGA-EE-A3J5-10A-01D-A20D-08 g.chr15:65370324G>A c.1171G>A c.(1171-1173)Gga>Aga p.G391R SKCM 15 65370431 65370431 + Silent SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr15:65370431G>A c.1278G>A c.(1276-1278)gaG>gaA p.E426E

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BRCA-EU 15 65366887 65366887 single base substitution C A upstream_gene_variant BRCA-EU 15 65367559 65367559 single base substitution G A upstream_gene_variant BRCA-EU 15 65368084 65368084 single base substitution C T upstream_gene_variant BRCA-EU 15 65368878 65368878 single base substitution G A upstream_gene_variant BRCA-EU 15 65369770 65369770 single base substitution C T missense_variant T206M 617C>T BRCA-EU 15 65369856 65369856 single base substitution G A missense_variant G235S 703G>A BRCA-EU 15 65371434 65371434 single base substitution A G 3_prime_UTR_variant BRCA-EU 15 65371601 65371601 single base substitution C A 3_prime_UTR_variant BRCA-EU 15 65372029 65372029 single base substitution T C 3_prime_UTR_variant BRCA-EU 15 65372088 65372088 single base substitution C T 3_prime_UTR_variant BRCA-EU 15 65372138 65372138 single base substitution C T 3_prime_UTR_variant BRCA-EU 15 65372723 65372723 single base substitution T A downstream_gene_variant BRCA-EU 15 65373233 65373233 single base substitution T C downstream_gene_variant BRCA-EU 15 65375297 65375297 single base substitution G A downstream_gene_variant BRCA-EU 15 65375504 65375504 single base substitution C T downstream_gene_variant BRCA-EU 15 65376596 65376596 single base substitution C T downstream_gene_variant BRCA-EU 15 65377254 65377254 single base substitution G C downstream_gene_variant BRCA-KR 15 65370156 65370156 single base substitution G A missense_variant E335K 1003G>A BRCA-US 15 65370332 65370332 single base substitution C T synonymous_variant L393L 1179C>T BTCA-JP 15 65369638 65369638 single base substitution C T missense_variant T162M 485C>T BTCA-JP 15 65369669 65369669 single base substitution C G missense_variant D172E 516C>G BTCA-JP 15 65370122 65370122 single base substitution C T synonymous_variant Y323Y 969C>T BTCA-JP 15 65370163 65370163 single base substitution G A missense_variant R337Q 1010G>A BTCA-JP 15 65370446 65370446 single base substitution G A synonymous_variant P431P 1293G>A COAD-US 15 65369395 65369395 single base substitution C T missense_variant A81V 242C>T COAD-US 15 65369531 65369531 single base substitution G T synonymous_variant A126A 378G>T COAD-US 15 65369951 65369951 single base substitution A G synonymous_variant E266E 798A>G COAD-US 15 65370353 65370353 single base substitution T C synonymous_variant G400G 1200T>C COCA-CN 15 65369405 65369405 single base substitution C T synonymous_variant C84C 252C>T COCA-CN 15 65369630 65369630 single base substitution C T synonymous_variant A159A 477C>T COCA-CN 15 65369921 65369921 single base substitution C T synonymous_variant F256F 768C>T COCA-CN 15 65370203 65370203 single base substitution C T synonymous_variant R350R 1050C>T ESAD-UK 15 65365381 65365381 deletion of <=200bp A - upstream_gene_variant ESAD-UK 15 65365392 65365392 single base substitution C G upstream_gene_variant ESAD-UK 15 65367518 65367518 single base substitution G A upstream_gene_variant ESAD-UK 15 65368643 65368643 single base substitution C G upstream_gene_variant ESAD-UK 15 65369115 65369115 single base substitution C G upstream_gene_variant ESAD-UK 15 65369528 65369528 single base substitution C T synonymous_variant A125A 375C>T ESAD-UK 15 65371298 65371298 single base substitution C A 3_prime_UTR_variant ESAD-UK 15 65372457 65372457 single base substitution T A downstream_gene_variant ESAD-UK 15 65373665 65373665 single base substitution C T downstream_gene_variant ESAD-UK 15 65375859 65375859 single base substitution C A downstream_gene_variant ESAD-UK 15 65376825 65376825 single base substitution C T downstream_gene_variant ESCA-CN 15 65369195 65369195 single base substitution C T synonymous_variant G14G 42C>T ESCA-CN 15 65369483 65369483 single base substitution C T synonymous_variant C110C 330C>T ESCA-CN 15 65369543 65369543 single base substitution C T synonymous_variant C130C 390C>T LAML-KR 15 65367924 65367924 single base substitution T C upstream_gene_variant LAML-KR 15 65368047 65368047 single base substitution T C upstream_gene_variant LAML-KR 15 65368084 65368084 single base substitution C T upstream_gene_variant LICA-FR 15 65368746 65368746 single base substitution T C upstream_gene_variant LICA-FR 15 65369546 65369546 single base substitution C T synonymous_variant D131D 393C>T LICA-FR 15 65370158 65370168 deletion of <=200bp GCTGCGGCGTC - frameshift_variant ELRRP335 LICA-FR 15 65370788 65370788 single base substitution A G 3_prime_UTR_variant LIHC-US 15 65369217 65369217 single base substitution C T missense_variant R22C 64C>T LINC-JP 15 65364917 65364917 single base substitution C T upstream_gene_variant LIRI-JP 15 65365300 65365300 single base substitution C A upstream_gene_variant LIRI-JP 15 65369696 65369696 single base substitution C T synonymous_variant D181D 543C>T LIRI-JP 15 65372365 65372365 single base substitution T C downstream_gene_variant LIRI-JP 15 65372483 65372483 single base substitution T C downstream_gene_variant LIRI-JP 15 65373966 65373966 single base substitution T A downstream_gene_variant LIRI-JP 15 65375721 65375721 single base substitution T C downstream_gene_variant LIRI-JP 15 65376369 65376369 single base substitution A G downstream_gene_variant LIRI-JP 15 65376376 65376376 single base substitution T G downstream_gene_variant LIRI-JP 15 65376864 65376864 single base substitution C A downstream_gene_variant LIRI-JP 15 65377271 65377271 single base substitution G C downstream_gene_variant LUSC-KR 15 65374834 65374834 single base substitution C A downstream_gene_variant LUSC-US 15 65370042 65370042 single base substitution G A missense_variant G297S 889G>A MALY-DE 15 65366035 65366035 single base substitution A T upstream_gene_variant MALY-DE 15 65366980 65366980 single base substitution C A upstream_gene_variant MELA-AU 15 65364290 65364290 single base substitution G A upstream_gene_variant MELA-AU 15 65364965 65364965 single base substitution C T upstream_gene_variant MELA-AU 15 65365251 65365251 single base substitution G A upstream_gene_variant MELA-AU 15 65365409 65365409 single base substitution C T upstream_gene_variant MELA-AU 15 65365492 65365492 single base substitution C T upstream_gene_variant MELA-AU 15 65365546 65365546 single base substitution G A upstream_gene_variant MELA-AU 15 65365588 65365588 single base substitution T A upstream_gene_variant MELA-AU 15 65365871 65365871 single base substitution G A upstream_gene_variant MELA-AU 15 65366079 65366079 single base substitution C T upstream_gene_variant MELA-AU 15 65366343 65366343 single base substitution C T upstream_gene_variant MELA-AU 15 65366464 65366464 single base substitution G A upstream_gene_variant MELA-AU 15 65366715 65366715 single base substitution G A upstream_gene_variant MELA-AU 15 65366759 65366759 single base substitution C T upstream_gene_variant MELA-AU 15 65367551 65367551 single base substitution C T upstream_gene_variant MELA-AU 15 65367646 65367646 single base substitution C T upstream_gene_variant MELA-AU 15 65367797 65367797 single base substitution G A upstream_gene_variant MELA-AU 15 65368004 65368004 single base substitution G A upstream_gene_variant MELA-AU 15 65368450 65368450 single base substitution C T upstream_gene_variant MELA-AU 15 65369015 65369015 single base substitution C T upstream_gene_variant MELA-AU 15 65369045 65369045 single base substitution G A upstream_gene_variant MELA-AU 15 65369382 65369382 single base substitution G A missense_variant E77K 229G>A MELA-AU 15 65369876 65369876 single base substitution C T synonymous_variant F241F 723C>T MELA-AU 15 65370229 65370229 single base substitution G A missense_variant G359E 1076G>A MELA-AU 15 65370311 65370311 single base substitution C T synonymous_variant F386F 1158C>T MELA-AU 15 65370324 65370324 single base substitution G A missense_variant G391R 1171G>A MELA-AU 15 65370452 65370452 single base substitution C T synonymous_variant P433P 1299C>T MELA-AU 15 65370966 65370966 single base substitution C T 3_prime_UTR_variant MELA-AU 15 65371201 65371202 multiple base substitution (>=2bp and <=200bp) GG AA 3_prime_UTR_variant MELA-AU 15 65371250 65371251 multiple base substitution (>=2bp and <=200bp) GG AA 3_prime_UTR_variant MELA-AU 15 65371288 65371289 multiple base substitution (>=2bp and <=200bp) CC TT 3_prime_UTR_variant MELA-AU 15 65371460 65371460 single base substitution G A 3_prime_UTR_variant MELA-AU 15 65371661 65371661 single base substitution C T 3_prime_UTR_variant MELA-AU 15 65371710 65371710 single base substitution C T 3_prime_UTR_variant MELA-AU 15 65371830 65371830 single base substitution C T 3_prime_UTR_variant MELA-AU 15 65372218 65372218 single base substitution C T 3_prime_UTR_variant MELA-AU 15 65372326 65372326 single base substitution G A downstream_gene_variant MELA-AU 15 65372856 65372856 single base substitution G A downstream_gene_variant MELA-AU 15 65372873 65372873 single base substitution G C downstream_gene_variant MELA-AU 15 65372891 65372891 single base substitution G A downstream_gene_variant MELA-AU 15 65373017 65373017 single base substitution C T downstream_gene_variant MELA-AU 15 65373382 65373382 single base substitution G A downstream_gene_variant MELA-AU 15 65373401 65373401 single base substitution G A downstream_gene_variant MELA-AU 15 65373461 65373461 single base substitution C T downstream_gene_variant MELA-AU 15 65373736 65373736 single base substitution C T downstream_gene_variant MELA-AU 15 65373820 65373820 single base substitution G A downstream_gene_variant MELA-AU 15 65374042 65374042 single base substitution C T downstream_gene_variant MELA-AU 15 65374044 65374044 single base substitution G A downstream_gene_variant MELA-AU 15 65374058 65374058 single base substitution C T downstream_gene_variant MELA-AU 15 65374480 65374480 single base substitution G A downstream_gene_variant MELA-AU 15 65374795 65374795 single base substitution G C downstream_gene_variant MELA-AU 15 65374898 65374898 single base substitution C T downstream_gene_variant MELA-AU 15 65374952 65374952 single base substitution T A downstream_gene_variant MELA-AU 15 65375952 65375952 single base substitution C T downstream_gene_variant MELA-AU 15 65376045 65376045 single base substitution C T downstream_gene_variant MELA-AU 15 65376071 65376071 single base substitution G A downstream_gene_variant MELA-AU 15 65376072 65376072 single base substitution G A downstream_gene_variant MELA-AU 15 65376255 65376255 single base substitution C T downstream_gene_variant MELA-AU 15 65376827 65376827 single base substitution C T downstream_gene_variant MELA-AU 15 65376910 65376910 single base substitution C T downstream_gene_variant MELA-AU 15 65376981 65376981 single base substitution G A downstream_gene_variant MELA-AU 15 65377115 65377115 single base substitution G A downstream_gene_variant ORCA-IN 15 65366669 65366669 single base substitution A G upstream_gene_variant ORCA-IN 15 65368695 65368695 single base substitution A G upstream_gene_variant ORCA-IN 15 65369832 65369832 single base substitution C A missense_variant L227M 679C>A ORCA-IN 15 65371075 65371075 deletion of <=200bp A - 3_prime_UTR_variant OV-AU 15 65365066 65365066 single base substitution G C upstream_gene_variant OV-AU 15 65366608 65366608 single base substitution A G upstream_gene_variant OV-AU 15 65370650 65370650 single base substitution G C 3_prime_UTR_variant PACA-AU 15 65366140 65366140 single base substitution G T upstream_gene_variant PACA-AU 15 65367403 65367403 single base substitution C T upstream_gene_variant PACA-CA 15 65366842 65366842 single base substitution G A upstream_gene_variant PACA-CA 15 65369263 65369263 single base substitution G A missense_variant R37H 110G>A PACA-CA 15 65369331 65369331 single base substitution G A missense_variant A60T 178G>A PACA-CA 15 65369936 65369936 single base substitution C T synonymous_variant Y261Y 783C>T PACA-CA 15 65372292 65372292 single base substitution T A downstream_gene_variant PAEN-AU 15 65367660 65367660 single base substitution C T upstream_gene_variant PBCA-DE 15 65368768 65368768 single base substitution C T upstream_gene_variant PRAD-UK 15 65369306 65369306 single base substitution C T synonymous_variant G51G 153C>T READ-US 15 65369395 65369395 single base substitution C T missense_variant A81V 242C>T READ-US 15 65369951 65369951 single base substitution A G synonymous_variant E266E 798A>G READ-US 15 65370204 65370204 single base substitution G A missense_variant D351N 1051G>A RECA-EU 15 65364858 65364858 single base substitution G A upstream_gene_variant RECA-EU 15 65365748 65365748 single base substitution G T upstream_gene_variant RECA-EU 15 65374847 65374847 single base substitution G T downstream_gene_variant SKCA-BR 15 65364430 65364430 single base substitution G A upstream_gene_variant SKCA-BR 15 65364944 65364944 single base substitution G A upstream_gene_variant SKCA-BR 15 65366635 65366636 deletion of <=200bp AC - upstream_gene_variant SKCA-BR 15 65369848 65369848 single base substitution A C missense_variant D232A 695A>C SKCA-BR 15 65370014 65370014 single base substitution C T synonymous_variant F287F 861C>T SKCA-BR 15 65371710 65371710 single base substitution C T 3_prime_UTR_variant SKCM-US 15 65369261 65369261 single base substitution C T synonymous_variant F36F 108C>T SKCM-US 15 65369922 65369922 single base substitution G A missense_variant D257N 769G>A SKCM-US 15 65370117 65370117 single base substitution G A missense_variant E322K 964G>A SKCM-US 15 65370276 65370276 single base substitution G A missense_variant A375T 1123G>A SKCM-US 15 65370324 65370324 single base substitution G A missense_variant G391R 1171G>A SKCM-US 15 65370431 65370431 single base substitution G A synonymous_variant E426E 1278G>A STAD-US 15 65369263 65369263 single base substitution G A missense_variant R37H 110G>A STAD-US 15 65369317 65369317 single base substitution C T missense_variant A55V 164C>T STAD-US 15 65370228 65370228 single base substitution G A missense_variant G359R 1075G>A

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand P04-1790 COSM245130 c.937C>T p.R313W Substitution - Missense 15:65077752-65077752 + TCGA-D5-6926-01 COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + PTC-54C COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + CSCC-27-T COSM4564003 c.9G>A p.R3R Substitution - coding silent 15:65076824-65076824 + LUAD-S01467 COSM399315 c.762C>G p.A254A Substitution - coding silent 15:65077577-65077577 + TCGA-AY-6196-01 COSM3754413 c.378G>T p.A126A Substitution - coding silent 15:65077193-65077193 + TCGA-AY-6386-01 COSM3754413 c.378G>T p.A126A Substitution - coding silent 15:65077193-65077193 + 587220 COSM1211371 c.563G>A p.R188H Substitution - Missense 15:65077378-65077378 + PCSI_0083_Pa_P_526 COSM3786550 c.178G>A p.A60T Substitution - Missense 15:65076993-65076993 + PCSI_0112_Pa_P COSM3377624 c.110G>A p.R37H Substitution - Missense 15:65076925-65076925 + TCGA-AY-6386-01 COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + TCGA-F1-6874-01 COSM3377624 c.110G>A p.R37H Substitution - Missense 15:65076925-65076925 + SNU-175 COSM4650354 c.252C>T p.C84C Substitution - coding silent 15:65077067-65077067 + ESCC_BICR_017T COSM5158924 c.42C>T p.G14G Substitution - coding silent 15:65076857-65076857 + ESCC_BICR_042T COSM5443673 c.330C>T p.C110C Substitution - coding silent 15:65077145-65077145 + sysucc-311T COSM5478949 c.768C>T p.F256F Substitution - coding silent 15:65077583-65077583 + OSCC-GB_00650111 COSM4890537 c.679C>A p.L227M Substitution - Missense 15:65077494-65077494 + TCGA-AA-3662-01 COSM3754414 c.1200T>C p.G400G Substitution - coding silent 15:65078015-65078015 + BD144T COSM4694112 c.1010G>A p.R337Q Substitution - Missense 15:65077825-65077825 + TCGA-D3-A51N-06 COSM231328 c.769G>A p.D257N Substitution - Missense 15:65077584-65077584 + TCGA-G4-6298-01 COSM3749304 c.798A>G p.E266E Substitution - coding silent 15:65077613-65077613 + TCGA-CD-A4MG-01 COSM4056266 c.1075G>A p.G359R Substitution - Missense 15:65077890-65077890 + sysucc-880T COSM4650354 c.252C>T p.C84C Substitution - coding silent 15:65077067-65077067 + sysucc-1397T COSM5473637 c.1050C>T p.R350R Substitution - coding silent 15:65077865-65077865 + TCGA-BC-A112-01 COSM4936612 c.64C>T p.R22C Substitution - Missense 15:65076879-65076879 + S01494 COSM5668652 c.556G>A p.A186T Substitution - Missense 15:65077371-65077371 + TCGA-EI-6917-01 COSM3420530 c.1051G>A p.D351N Substitution - Missense 15:65077866-65077866 + TCGA-AA-3713-01 COSM3749304 c.798A>G p.E266E Substitution - coding silent 15:65077613-65077613 + TCGA-AY-6196-01 COSM3749304 c.798A>G p.E266E Substitution - coding silent 15:65077613-65077613 + CSCC-45-T COSM4530448 c.169G>T p.G57C Substitution - Missense 15:65076984-65076984 + 0006_CRUK_PC_0006_T4_DNA COSM3849545 c.153C>T p.G51G Substitution - coding silent 15:65076968-65076968 + ME100L COSM231328 c.769G>A p.D257N Substitution - Missense 15:65077584-65077584 + BD87T COSM5505381 c.516C>G p.D172E Substitution - Missense 15:65077331-65077331 + Gp5D COSM2256270 c.1095G>A p.L365L Substitution - coding silent 15:65077910-65077910 + PCSI_0224_Pa_P_526 COSM3786551 c.783C>T p.Y261Y Substitution - coding silent 15:65077598-65077598 + RK308_C01 COSM3744705 c.543C>T p.D181D Substitution - coding silent 15:65077358-65077358 + PTC-7C COSM3754413 c.378G>T p.A126A Substitution - coding silent 15:65077193-65077193 + TCGA-CI-6624-01 COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + ESCC_BICR_028T COSM5431704 c.390C>T p.C130C Substitution - coding silent 15:65077205-65077205 + PTC-10C COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + TCGA-FW-A3R5-06 COSM3887309 c.1278G>A p.E426E Substitution - coding silent 15:65078093-65078093 + KPOPBR-27-T COSM5965994 c.1003G>A p.E335K Substitution - Missense 15:65077818-65077818 + ESCC_170 COSM5649227 c.869A>C p.D290A Substitution - Missense 15:65077684-65077684 + TCGA-AH-6644-01 COSM3749304 c.798A>G p.E266E Substitution - coding silent 15:65077613-65077613 + TCGA-AA-3663-01 COSM3749304 c.798A>G p.E266E Substitution - coding silent 15:65077613-65077613 + SC_9103 COSM5554891 c.607G>A p.G203R Substitution - Missense 15:65077422-65077422 + TCGA-AA-3713-01 COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + TCGA-DY-A0XA-01 COSM3749304 c.798A>G p.E266E Substitution - coding silent 15:65077613-65077613 + T2940 COSM4694110 c.162C>T p.S54S Substitution - coding silent 15:65076977-65076977 + TCGA-CA-6717-01 COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + I2L-P7-Tumor-Organoid COSM5363162 c.776G>A p.R259H Substitution - Missense 15:65077591-65077591 + TCGA-AZ-5407-01 COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + TCGA-G5-6233-01 COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + TCGA-AU-6004-01 COSM3749304 c.798A>G p.E266E Substitution - coding silent 15:65077613-65077613 + LS174T COSM4645901 c.791G>A p.G264D Substitution - Missense 15:65077606-65077606 + 446 COSM4434959 c.334G>A p.A112T Substitution - Missense 15:65077149-65077149 + TCGA-E2-A574-01 COSM3816555 c.1179C>T p.L393L Substitution - coding silent 15:65077994-65077994 + CHC322T COSM3754413 c.378G>T p.A126A Substitution - coding silent 15:65077193-65077193 + ESO-717 COSM1242401 c.1140G>A p.T380T Substitution - coding silent 15:65077955-65077955 + ESCC_158 COSM5646655 c.415G>A p.E139K Substitution - Missense 15:65077230-65077230 + TCGA-CM-6680-01 COSM3749304 c.798A>G p.E266E Substitution - coding silent 15:65077613-65077613 + I2L-P19Tb-Tumor-Organoid COSM5362970 c.844G>A p.A282T Substitution - Missense 15:65077659-65077659 + TCGA-AU-6004-01 COSM3749303 c.242C>T p.A81V Substitution - Missense 15:65077057-65077057 + TCGA-EE-A29M-06 COSM3503140 c.1123G>A p.A375T Substitution - Missense 15:65077938-65077938 + TCGA-AD-6965-01 COSM3754413 c.378G>T p.A126A Substitution - coding silent 15:65077193-65077193 + SC_9080 COSM5549746 c.1175C>T p.A392V Substitution - Missense 15:65077990-65077990 + T1772 COSM4694111 c.604G>A p.A202T Substitution - Missense 15:65077419-65077419 + T3658 COSM4694112 c.1010G>A p.R337Q Substitution - Missense 15:65077825-65077825 + Gp2D COSM2256270 c.1095G>A p.L365L Substitution - coding silent 15:65077910-65077910 + CHC1715T COSM5347673 c.1005_1015del11 p.E335fs*63 Deletion - Frameshift 15:65077820-65077830 + BD57T COSM5510741 c.485C>T p.T162M Substitution - Missense 15:65077300-65077300 + LUAD-B00416 COSM355384 c.1306T>G p.L436V Substitution - Missense 15:65078121-65078121 + PTC-7C COSM3754414 c.1200T>C p.G400G Substitution - coding silent 15:65078015-65078015 + TCGA-G4-6321-01 COSM3754414 c.1200T>C p.G400G Substitution - coding silent 15:65078015-65078015 + CHC320T COSM3667741 c.393C>T p.D131D Substitution - coding silent 15:65077208-65077208 + TCGA-AY-6197-01 COSM3754414 c.1200T>C p.G400G Substitution - coding silent 15:65078015-65078015 + sysucc-1370T COSM5470374 c.477C>T p.A159A Substitution - coding silent 15:65077292-65077292 + BD236T COSM5519324 c.1293G>A p.P431P Substitution - coding silent 15:65078108-65078108 + ESCC_103 COSM5638147 c.249G>A p.E83E Substitution - coding silent 15:65077064-65077064 + AD17 COSM5966257 c.55C>A p.Q19K Substitution - Missense 15:65076870-65076870 + T4 COSM5342613 c.145C>T p.R49C Substitution - Missense 15:65076960-65076960 + BD144T COSM5507324 c.969C>T p.Y323Y Substitution - coding silent 15:65077784-65077784 + TCGA-EE-A3J5-06 COSM3503141 c.1171G>A p.G391R Substitution - Missense 15:65077986-65077986 + C086 COSM5532995 c.1120C>T p.L374L Substitution - coding silent 15:65077935-65077935 + TCGA-AZ-5407-01 COSM3749304 c.798A>G p.E266E Substitution - coding silent 15:65077613-65077613 + 587332 COSM1211372 c.103C>T p.L35F Substitution - Missense 15:65076918-65076918 + I2L-P19Tb-Tumor-Biopsy COSM5362970 c.844G>A p.A282T Substitution - Missense 15:65077659-65077659 + TCGA-FW-A3R5-06 COSM3887308 c.964G>A p.E322K Substitution - Missense 15:65077779-65077779 + TCGA-EE-A3J3-06 COSM3887307 c.108C>T p.F36F Substitution - coding silent 15:65076923-65076923 + TCGA-CD-A4MG-01 COSM4056265 c.164C>T p.A55V Substitution - Missense 15:65076979-65076979 + Gp2D COSM4627333 c.23T>C p.L8P Substitution - Missense 15:65076838-65076838 + TCGA-22-4593-01 COSM700696 c.889G>A p.G297S Substitution - Missense 15:65077704-65077704 + CHC320T COSM3667741 c.393C>T p.D131D Substitution - coding silent 15:65077208-65077208 + ML_79_T_01 COSM5034348 c.695A>C p.D232A Substitution - Missense 15:65077510-65077510 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.586880;Hs.586881;Hs.586884;Hs.586890 15q22.31 613727

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer C - Frameshift p.R22Afs*32 c.64delC 15 65369216 HNSC C T 3-UTRSNV . c.1374+1595C>T 15 65372122 ALL C T Synonymous p.F36F c.108C>T 15 65369261 CM C T Synonymous p.G418G c.1254C>T 15 65370407 HNSC C T Synonymous p.I369I c.1107C>T 15 65370260 CM G A Missense p.A375T c.1123G>A 15 65370276 CM G A Missense p.G297S c.889G>A 15 65370042 LUSC G A Missense p.G391R c.1171G>A 15 65370324 CM