PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RNF103 DERL1 18675248 biogrid exp G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2Z 19690564 biogrid,intact exp G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G G GP G G GP G GP GP G RNF103 VCP 18675248 biogrid exp G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2W 19690564 biogrid,intact exp G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2D2 19690564, 23023127 biogrid,intact exp, pred G G G G GP GP G G GP G GP G GP GP G G GP GP GP G G GP G G G G GP GP G RNF103 UBE2D4 19690564, 23023127 biogrid,intact exp, pred G G G G GP GP G G GP G GP G GP GP G G GP GP GP G G GP G G G G GP GP G RNF103 UBE2E1 18615712, 23023127 biogrid exp, pred G GP G G G GP G G GP G GP G G GP G GP GP GP G G G G G G GP G GP GP G RNF103 UBE2L3 18615712, 23023127 biogrid exp, pred G G G G G GP G G GP G GP G G G G GP GP G GP G G G G G GP G GP GP G RNF103 UBE2N 16215985,18615712,19690564, 23023127 biogrid,intact exp, pred G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G G GP G G GP G GP GP G RNF103 UBE2D1 19690564, 23023127 biogrid,intact exp, pred G G G G GP GP G G GP G GP G GP GP G G GP GP GP G G GP G G G G GP GP G RNF103 UBE2H 19690564, 23023127 biogrid,intact exp, pred G GP G G GP GP G G G G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2E2 18615712,25224329, 23023127 biogrid exp, pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2D3 19690564, 23023127 biogrid,intact exp, pred G G G G GP GP G G GP G GP G GP GP G G GP GP GP G G GP G G G G GP GP G RNF103 UBE2C 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 AMFR 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2V1 23023127 pred RNF103 PSMD10 23023127 pred G G G G G GP G G GP G G G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 TRIM37 23023127 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G G GP G G GP G GP GP G RNF103 UBE2G1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 PAX6 23023127 pred G GP P G P GP GP GP G GP GP GP RNF103 USP45 23023127 pred G P G GP GP G G GP G GP G P GP G GP GP G GP G G GP G GP G GP P RNF103 RNF14 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 GJB6 23023127 pred G P G G GP GP P G P P P P GP P P P P P P G RNF103 RNF41 23023127 pred G GP G G G GP G G GP G GP P G G GP GP P P G G G GP G GP P RNF103 TRIM62 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G RNF103 TRIM63 23023127 pred G G G G RNF103 SYVN1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 AKTIP 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 CHFR 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF103 LRP2 23023127 pred G G G G G G G G GP G G G G G G RNF103 TRIM17 23023127 pred P P P P P P P P P P P P P GP RNF103 PJA1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 NHLRC1 23023127 pred RNF103 MYCBP2 23023127 pred G GP G G G GP G G GP G G G GP GP G GP GP G GP G G GP G G GP G G GP G RNF103 TRAF6 23023127 pred G GP G G GP G G G GP G GP G GP G G GP G GP G G G GP G G GP G GP GP G RNF103 UBQLN1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 MYLIP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF103 BARD1 23023127 pred P G GP P GP P P GP G GP P G P GP G P G GP GP G RNF103 BMI1 23023127 pred P P P P P P P P P P P P P P P RNF103 RPS6KC1 23023127 pred G GP G G GP GP G G GP G GP G G GP G GP GP G GP G G G G G GP G GP GP G RNF103 RCHY1 23023127 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G G G G G GP G GP G G RNF103 RBX1 23023127 pred G G G G G GP G G G G G G GP G G G GP G GP G G GP G G G G G GP G RNF103 CUL1 23023127 pred G G G G G GP G G GP G GP G GP G G GP GP GP GP G G GP G G GP G GP GP G RNF103 RNF8 23023127 pred G GP G G G GP G G GP G GP G G G G GP GP G GP G G G G G GP G GP GP G RNF103 FBXO31 23023127 pred G GP G P GP G G GP G GP G GP GP G GP GP G GP G G GP G G GP G GP GP G RNF103 ARIH1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBQLN2 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2NL 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF103 RNF220 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP G GP G G GP G G G G GP G G RNF103 UBE2G2 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G G GP G G GP G GP GP G RNF103 TRIM9 23023127 pred G G G G G G G G G G G RNF103 UBE2T 23023127 pred G G G GP G GP P P P GP GP P G P G GP P GP G RNF103 RNF5 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G G GP G G GP G GP GP G RNF103 RNF4 23023127 pred G G G G G GP G G GP G GP G G G G G GP GP G G G GP G G G G GP GP G RNF103 RNF146 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 STUB1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 RNF2 23023127 pred P P P GP P P P P P P P P RNF103 WDSUB1 23023127 pred G G G G GP G G G G G GP G G G G G G G G G G G G G G G G GP G RNF103 RNF13 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 TTC14 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G G GP G G GP G GP GP G RNF103 YOD1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP P G G GP G G GP G GP GP G RNF103 UBE2B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF103 CUL2 23023127 pred G GP G G G GP G G GP G GP G GP GP G G GP GP GP G G GP G G G G GP GP G RNF103 UBOX5 23023127 pred G GP G G G GP G G P G G G GP GP G P GP G G G G G G GP G GP G G RNF103 SH3GL2 23023127 pred G GP G G G GP GP G G RNF103 USP44 23023127 pred P P P P P P P P P P GP G P P P GP RNF103 UBE2A 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF103 TTC3 23023127 pred P P P P P RNF103 DNAJB2 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP GP GP G G GP G G GP G GP GP G RNF103 OS9 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 RLIM 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 SMAD7 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP P G RNF103 UBE4A 23023127 pred G GP G G G GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 MIB1 23023127 pred G GP G G GP GP G G GP G GP G G GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 RNF144A 23023127 pred G GP G G GP GP G G GP G GP GP GP G GP GP GP GP G G G G GP G GP P G RNF103 CBLB 23023127 pred G GP G G G GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 ITCH 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 ANKRD39 23023127 pred G GP G G GP GP G G GP G GP G GP GP GP GP GP GP G GP G G GP G GP GP G RNF103 CALN1 23023127 pred GP G P GP P G P P G P GP P P P P P RNF103 HUWE1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2V2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF103 RNF135 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G G GP G G GP G GP GP G RNF103 RING1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 RNF182 23023127 pred P G G GP GP P G P GP P P GP P G G G P GP RNF103 UBE2R2 23023127 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G G GP G G RNF103 BAG5 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 DZIP3 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP G G GP G GP GP G TRIM75P RNF103 23023127 pred RNF103 UBE2S 23023127 pred G G G G G G G G GP G G G GP G G G G G G G G G G G GP G RNF103 USP14 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 KLK6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF103 PRKCG 23023127 pred G G G G G GP G G G G G G G GP G G G G G G G G RNF103 TRIM13 23023127 pred G GP G G G GP G G GP G G G GP G G GP GP G G G G GP G G GP G GP GP G RNF103 FBXO7 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 PTCD3 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 CUL3 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 ASB8 23023127 pred G GP G G GP GP G G G G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 COPS5 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 CDC34 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2I 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 EFHB 23023127 pred G RNF103 UBE2K 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2E3 23023127 pred G GP G G G GP G G GP G GP G G GP G GP GP GP G G G G G G GP G GP GP G RNF103 SPOCK1 23023127 pred G GP G G GP GP G G GP G GP G P GP G GP GP G GP G G GP G G GP G GP GP G RNF103 UBE2M 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G G G G GP G GP GP G RNF103 BIRC6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF103 UBE2L6 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 RNF11 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 TOPORS 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RNF103 UBE2F 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G G GP G G GP G GP GP G RNF103 SOCS7 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O00237 P61088 two hybrid 16215985 direct interaction X 2 O00237 P61088 two hybrid 18615712 direct interaction X 2 O00237 P62837 two hybrid 19690564 direct interaction X 2 O00237 P61077-3 two hybrid 19690564 direct interaction X 2 O00237 A0A024RA90 two hybrid 19690564 direct interaction X 2 O00237 two hybrid 19690564 direct interaction X 2 O00237 P61088 two hybrid 19690564 direct interaction X 2 O00237 Q9H832 two hybrid 19690564 direct interaction X 2 A0A024R1A4 O00237 two hybrid 18615712 direct interaction X 2 Q9BUN8-2 O00237 affinity chromatography technology 18675248 physical association X 2 O00237 A0A024R2Q2 two hybrid 18615712 direct interaction X 2 O00237 A0A024R2K3 two hybrid 18615712 direct interaction X 2 O00237 A0A024R2Q2 two hybrid 25224329 direct interaction X 2 O00237 Q96FI0 two hybrid 19690564 direct interaction X 2 A0A087WW00 O00237 two hybrid 19690564 direct interaction X 2 P0CG48 O00237 affinity chromatography technology 18675248 physical association X 2 P0CG48 O00237 affinity chromatography technology 21906983 physical association X 2 P55072 O00237 affinity chromatography technology 18675248 physical association X 2 O00237 in vivo 18675248 - C 3 O00237 in vivo 18675248 - C 3 O00237 in vivo 18675248 - C 3 O00237 A0A024RA90 two hybrid array 19690564 physical association X 2 O00237 P61088 two hybrid array 19690564 physical association X 2 O00237 Q9H832 two hybrid array 19690564 physical association X 2 O00237 P62837 two hybrid array 19690564 physical association X 2 A0A024QZJ2 O00237 two hybrid array 19690564 physical association X 2 O00237 A0A024RDH2 two hybrid array 19690564 physical association X 2 O00237 A4D1L5 two hybrid array 19690564 physical association X 2 O00237 Q81L21 two hybrid pooling approach 20711500 physical association X 2 Q96B02 O00237 two hybrid array 19690564 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RNF103 UBE2D2 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123446|UniProt_102434 prey|prey bait|bait RNF103 UBE2D4 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123512|UniProt_102500 prey|prey bait|bait RNF103 UBE2D1 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102407|BIOGRID_123418 prey|prey bait|bait RNF103 UBE2E1 MI:0018(two hybrid) 18615712 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_201350 bait prey RNF103 DERL1 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 18675248 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_116576|HPRD_40062 bait|- prey|- RNF103 UBE2Z MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102701|BIOGRID_123713 prey|prey bait|bait RNF103 VCP MI:0493(in vivo)|MI:0004(affinity chromatography technology) 18675248 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_40062|BIOGRID_116577 -|bait -|prey RNF103 UBE2L3 MI:0018(two hybrid) 18615712 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_201348 bait prey RNF103 UBE2W MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102684|BIOGRID_123696 prey|prey bait|bait RNF103 UBE2E2 MI:0018(two hybrid) 18615712 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_201349 bait prey RNF103 UBE2H MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123585|UniProt_102574 prey|prey bait|bait RNF103 UBE2N MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16215985,18615712,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_102600|BIOGRID_201347|BIOGRID_194171|BIOGRID_123611 prey|bait|prey|prey bait|prey|bait|bait RNF103 UBE2D3 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123480|UniProt_102469 prey|prey bait|bait RNF103 UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18675248,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_116578|BIOGRID_177420 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality RNF103 UBE2D1 19690564,19690564 0397,0018 HT RNF103 UBE2E1 18615712 0018 LC RNF103 UBE2D3 19690564,19690564 0397,0018 HT RNF103 UBE2N 16215985,19690564,19690564 0018,0397,0018 LC,HT RNF103 UBE2H 19690564,19690564 0397,0018 HT RNF103 UBE2D2 19690564,19690564 0397,0018 HT RNF103 UBE2L3 18615712 0018 LC RNF103 UBE2W 19690564,19690564 0397,0018 HT RNF103 UBE2E2 25224329,18615712 0018,0018 LC RNF103 UBE2Z 19690564,19690564 0397,0018 HT RNF103 UBE2D4 19690564,19690564 0397,0018 HT RNF103 HEL-S-71 16215985,18615712,19690564 0018,0018,0018 LC,HT

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 RNF103 UBB MI:0362 inference MI:1106 pathways database RNF103 UBC MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF103 UBE2D1 MI:0045 experimental interaction detection MI:0461 interaction database RNF103 UBE2E1 MI:0045 experimental interaction detection MI:0461 interaction database RNF103 VCP MI:0045 experimental interaction detection MI:0461 interaction database RNF103 UBE2D3 MI:0045 experimental interaction detection MI:0461 interaction database RNF103 UBE2N MI:0045 experimental interaction detection MI:0461 interaction database RNF103 UBE2H MI:0045 experimental interaction detection MI:0461 interaction database RNF103 UBE2D2 MI:0045 experimental interaction detection MI:0461 interaction database RNF103 RPS27A MI:0362 inference MI:1106 pathways database RNF103 UBA52 MI:0362 inference MI:1106 pathways database RNF103 UBE2L3 MI:0045 experimental interaction detection MI:0461 interaction database RNF103 OS9 MI:0362 inference MI:1106 pathways database RNF103 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database RNF103 UBE2E2 MI:0045 experimental interaction detection MI:0461 interaction database RNF103 DERL1 MI:0045 experimental interaction detection MI:0461 interaction database RNF103 DERL2 MI:0362 inference MI:1106 pathways database RNF103 UBE2Z MI:0045 experimental interaction detection MI:0461 interaction database RNF103 SEL1L MI:0362 inference MI:1106 pathways database RNF103 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database