PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KLHL41 ESR2 25604459 intact exp G G GP P G G GP G G KLHL41 KLHL41 15983046 biogrid exp G G GP P G G G GP G G KLHL41 CUL3 15983046 biogrid exp G G GP P G G G GP G G KLHL41 MYBPC1 23414517 intact exp G G G G G GP G G TCAP KLHL41 23414517 intact exp GP G GP G G KLHL41 TRIM10 26186194 biogrid exp G G G G G G GP G G KLHL41 RBX1 15983046 biogrid exp G G GP P G G G G G G KLHL41 RCHY1 25416956 biogrid,intact exp G G GP P G G G G G G KLHL41 NEB 23414517 intact exp G G G P G G G GP G G KLHL41 UTP11L 26186194 biogrid exp G G GP P G G G GP G G KLHL41 POMP 23414517 intact exp G G GP P G G G GP G G KLHL41 NRAP 12692149,23414517 hprd,intact exp, ortho GP GP G KLHL41 SLC2A4 16396496, 25402006 hprd,biogrid exp, ortho, pred P P P KLHL41 KLHL40 ortho GP G KLHL41 WNT1 23023127 pred KLHL41 TGFBR1 23023127 pred G G GP P G G G G G G MTSS1 KLHL41 23023127 pred G G G G G G G G G KLHL41 TNNI3 23023127 pred G GP G G G G G KLHL41 KCNA1 16082366 pred G G GP P G G GP G G KLHL41 KCNB2 16082366 pred G G G G G G KLHL41 NCK1 23023127 pred G G GP P G G G G G G ARHGEF11 KLHL41 23023127 pred G G GP P G G G GP G G KLHL41 DTNA 23023127 pred G G GP P G G G GP G G KLHL41 MYBPH 23023127 pred G KLHL41 CDC42 23023127 pred G G GP P G G G GP G G KLHL41 MYBPC3 23023127 pred G GP G G G G G G KLK8 KLHL41 23023127 pred G G G G G G G G G KLHL41 CHRNA1 23023127 pred G GP P G GP G KLHL41 ATG4B 23023127 pred G G GP P G G G GP G G KLHL41 KIT 23023127 pred G G G P G G G G G KLHL41 RAB25 23023127 pred P G G P G KLHL41 SLIT2 23023127 pred G G GP P G G G GP G G KLHL41 TPM1 23023127 pred G G GP G G G GP G G KLHL41 TTN 23023127 pred G G GP G G G GP G G KLHL41 BAIAP2 23023127 pred G G GP P G G G P G KLHL41 SKIL 23023127 pred G G G P G G G GP G G KLHL41 ADRBK1 23023127 pred G G GP P G G G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O60662 P14672 affinity chromatography technology 16396496 physical association X 2 O60662 A0A024R475 enzymatic study 15983046 direct interaction X 2 O60662 A0A024R475 affinity chromatography technology 15983046 physical association X 2 P0CG48 O60662 affinity chromatography technology 21890473 physical association X 2 O60662 Q96PM5-2 two hybrid 25416956 direct interaction X 2 O60662 P62877 enzymatic study 15983046 direct interaction X 2 O60662 P62877 affinity chromatography technology 15983046 physical association X 2 O60662 P14672 in vivo 16396496 - X 2 O60662 P14672 in vivo 16396496 - X 2 O60662 Q86VF7-4 two hybrid 12692149 - X 2 O60662 Q86VF7-4 in vitro 12692149 - X 2 O60662 Q86VF7-4 in vitro 12692149 - X 2 O60662 Q86VF7-4 two hybrid 12692149 - X 2 O60662 tandem affinity purification 25604459 association C 141 A2TDC0 O60662 two hybrid fragment pooling approach 23414517 physical association X 2 Q00872 O60662 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929 proximity ligation assay 23414517 physical association X 2 O60662 P20929 proximity ligation assay 23414517 physical association X 2 O60662 P20929 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929 two hybrid fragment pooling approach 23414517 physical association X 2 Q96PM5 O60662 two hybrid prey pooling approach 25416956 physical association X 2 Q96PM5 O60662 two hybrid array 25416956 physical association X 2 Q96PM5 O60662 validated two hybrid 25416956 physical association X 2 Q86VF7 O60662 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 Q9Y244 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929-4 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929-4 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929-4 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929-4 two hybrid fragment pooling approach 23414517 physical association X 2 O60662 P20929-4 two hybrid fragment pooling approach 23414517 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B KBTBD10 UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15983046,21890473 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_127425|BIOGRID_174521 bait|prey prey|bait KBTBD10 MYBPC1 MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_127159 bait prey KBTBD10 RBX1 MI:0004(affinity chromatography technology) 15983046 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_127424 bait prey KBTBD10 POMP MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_127302 prey bait KBTBD10 NRAP MI:0492(in vitro)|MI:0663(confocal microscopy) 12692149,23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(intact) HPRD_3914|UniProt_127171 -|bait -|prey KBTBD10 NEB MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy)|MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_127165|UniProt_127166|UniProt_127163|UniProt_127164|UniProt_127169|UniProt_127167|UniProt_127168|UniProt_126748|UniProt_126751|UniProt_127160|UniProt_127162|UniProt_127170|UniProt_127161 bait|bait|bait|bait|bait|bait|bait|neutral component|neutral component|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|neutral component|neutral component|prey|prey|prey|prey TCAP KBTBD10 MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_127437 bait prey KBTBD10 CUL3 MI:0004(affinity chromatography technology) 15983046 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_127423 bait prey KBTBD10 SLC2A4 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16396496 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_189818|HPRD_824 prey|- bait|-

PPI - HINT Gene A Gene B PMID Method Quality KLHL41 TRIM10 26186194 0004 HT KLHL41 UTP11L 26186194 0004 HT KLHL41 TRIM10 26186194 0004 HT KLHL41 UTP11L 26186194 0004 HT TCAP KLHL41 23414517 0399 HT KLHL41 KLHL41 15983046 0415 LC KLHL41 NEB 23414517,23414517 0813,0399 HT KLHL41 MYBPC1 23414517 0399 HT KLHL41 NRAP 12692149,23414517 0018,0399 LC,HT KLHL41 RCHY1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KLHL41 POMP 23414517 0399 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O60662 O15273 KLHL41 TCAP 0.126 23414517 O60662 O60662 KLHL41 KLHL41 0.332 15983046 P62877 O60662 RBX1 KLHL41 0.21 15983046 Q00872 O60662 MYBPC1 KLHL41 0.126 23414517 Q13618 O60662 CUL3 KLHL41 0.21 15983046 Q9Y244 O60662 POMP KLHL41 0.126 23414517 Q9Y3A2 O60662 UTP11L KLHL41 0.126 26186194 Q86VF7 O60662 NRAP KLHL41 0.126 23414517 P20929 O60662 NEB KLHL41 0.416 23414517 Q96LM5 O60662 C4ORF45 KLHL41 0.236 unassigned1304 Q92731 O60662 ESR2 KLHL41 0.126 25604459 Q96PM5 O60662 RCHY1 KLHL41 0.454 25416956 Q9UDY6 O60662 TRIM10 KLHL41 0.126 26186194 P14672 O60662 SLC2A4 KLHL41 0.126 16396496

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TCAP KLHL41 MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 UBC MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 SLC2A4 MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 NEB MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 RBX1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KLHL41 MYBPC1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 CUL3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KLHL41 KLHL40 MI:0362 inference MI:0461 interaction database KLHL41 NRAP MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 ESR2 MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 RCHY1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 TRIM10 MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 POMP MI:0045 experimental interaction detection MI:0461 interaction database KLHL41 UTP11 MI:0045 experimental interaction detection MI:0461 interaction database