PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PPP6R2 WDR92 24255178 biogrid,intact exp P P P P P P P P P P PMVK WDR92 22939629 biogrid exp P P P P P P P P P P P P P P P P P P P P P P AREG, AREGB WDR92 23844004 biogrid exp P P P P P P P P P P P P P P P P P P P P P P PPP1R3A WDR92 24366813 biogrid exp ZNF316 WDR92 22939629 biogrid exp PPP3CB WDR92 22863883 biogrid exp P P P P P P P P P P P P P P P P P P P P WDR92 POLR3E 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P S100A10 WDR92 22939629 biogrid exp P P P P P P P P P P P P P P P P P P P PPP1CC WDR92 26186194,26496610,24366813 biogrid,intact exp P P P P P P P P P P P P P P P P P P P WDR92 THG1L 22863883 biogrid exp P P P P P P P P P P P P P P P P P P P P P P CCT6B WDR92 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P P P P WDR92 RPAP3 19450687,25036637,18538670,26344197 biogrid,mint,intact exp P P P P P P P P P P P P P P P P P P P P P P ATG7 WDR92 22863883 biogrid exp P P P P P P P P P P P P P P P P P P P P P P WDR92 PFDN2 26344197 biogrid exp P P P P P P P P P P P P P P P P P P P P P P WDR92 VPS25 22863883 biogrid exp P P P P P P P P P P P P P P P P P P P P P P POLR1A WDR92 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P WDR92 PIH1D1 26186194,21078300 biogrid exp P P P P P P P P P P P P P P P P P P P P P P SEC16A WDR92 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P WDR92 PARD6A 14676191 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P PPP1CB WDR92 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P CCT3 WDR92 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P P P P WDR4 WDR92 22863883 biogrid exp P P P P P P P P P PPP1CA WDR92 26186194 biogrid exp P P P P P P P P P P P P P P P P P P HERC2 WDR92 25476789 biogrid exp P P P P P P P P P P P P P P P P P P P P P P OFD1 WDR92 26638075 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P EXOSC8 WDR92 23844004 biogrid exp P P P P P P P P P P P P P P P P P P P P P P WDR92 TERF2IP 22863883 biogrid exp P P P P P P P P P P P P P P P P P P P P P FKBP6 WDR92 25036637 intact exp P P P P P P P P P NPHP1 WDR92 26638075 biogrid,intact exp P P P P P P P P P P P P P P P P P UBE3C WDR92 22863883 biogrid exp P P P P P P P P P P P P P P P P P P P WDR92 MAP3K3 14743216 mint,intact exp P P P P P P P P P P P P XPO1 WDR92 26673895 biogrid exp P P P P P P P P P P P P P P P P P P P P P WDR92 WDR12 22863883 biogrid exp P P P P P P P P P P P P P P P P P P P P P ECD WDR92 ortho P P P P P P P P P P P P P P P P P P EFTUD2 WDR92 ortho P P P P P P P P P P P P P P P P P P P P P P PRPF8 WDR92 ortho P P P P P P P P P P P P P P P P P P P P P P TADA2A WDR92 ortho TTI1 WDR92 ortho P P P P P P P P P P P P P P P P P P WDR5 WDR92 23023127 pred RAB3D WDR92 23023127 pred P P P P P P P P P P P P P P P P RBBP5 WDR92 23023127 pred P P P P P P P P P P P P P P P P P P P P P P RAB6A WDR92 23023127 pred P P P P P P P P P P P P P P P P P P P WDR82 WDR92 23023127 pred POLR2B WDR92 25402006 pred P P P P P P P P P P P P P P P P P P P P P WDR92 GPN1 25402006 pred P P P P P P P P P P P P P P P P P P P WDR92 RUVBL2 25402006 pred P P P P P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96MX6 - 14676191 - C 13 P60903 Q96MX6 biochemical 22939629 colocalization X 2 Q15386 Q96MX6 biochemical 22863883 colocalization X 2 Q96MX6 O95352 biochemical 22863883 colocalization X 2 Q96MX6 P16298-3 biochemical 22863883 colocalization X 2 Q96MX6 Q9NYB0 biochemical 22863883 colocalization X 2 Q96MX6 P57081 biochemical 22863883 colocalization X 2 Q96MX6 Q96B26 affinity chromatography technology 23844004 physical association X 2 Q9NWX6 Q96MX6 biochemical 22863883 colocalization X 2 A0A024R1X3 Q96MX6 biochemical 22863883 colocalization X 2 Q53T99 Q96MX6 biochemical 22863883 colocalization X 2 P0CG48 Q96MX6 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q96MX6 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q96MX6 affinity chromatography technology 21906983 physical association X 2 Q15126 Q96MX6 biochemical 22939629 colocalization X 2 Q96MX6 Q9H6T3 affinity chromatography technology 19450687 physical association X 2 Q96MX6 Q9H6T3 affinity chromatography technology 18538670 physical association X 2 Q96MX6 Q9H6T3 affinity chromatography technology 18538670 physical association X 2 Q96MX6 proximity labelling technology 24255178 physical association X 2 Q96MX6 Q9H6T3 affinity chromatography technology 25036637 physical association X 2 Q96MX6 Q9H6T3 affinity chromatography technology 25036637 physical association X 2 Q96MX6 affinity chromatography technology 14676191 physical association X 2 A6NFI3 Q96MX6 biochemical 22939629 colocalization X 2 Q96MX6 anti tag coimmunoprecipitation 25036637 association C 17 Q96MX6 proximity-dependent biotin identification 24255178 colocalization C 18 Q96MX6 anti tag coimmunoprecipitation 24366813 association C 44 O75344 Q96MX6 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q96MX6 anti tag coimmunoprecipitation 14676191 association C 13 Q96MX6 Q9H6T3 pull down 18538670 physical association X 2 Q96MX6 Q9H6T3 pull down 18538670 physical association X 2 Q96MX6 Q9H6T3 anti tag coimmunoprecipitation 18538670 physical association X 2 Q96MX6 Q9H6T3 anti bait coimmunoprecipitation 18538670 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B WDR92 VPS25 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_305026 prey bait PPP6R2 WDR92 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 24255178 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_131118|UniProt_176964|BIOGRID_293202 bait|bait|bait prey|prey|prey WDR4 WDR92 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_305016 prey bait PPP3CB WDR92 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302170 prey bait S100A10 WDR92 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243471 bait prey WDR92 ZNF316 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238710 bait prey WDR92 WDR12 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304976 bait prey WDR92 RPAP3 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18538670,19450687 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint) UniProt_95938|UniProt_95939|MINT_36127|MINT_65243|MINT_65245|BIOGRID_210107|UniProt_95941|MINT_65246|MINT_65247|UniProt_95940|MINT_36129|BIOGRID_226873|BIOGRID_226872|MINT_36130|MINT_36131 bait|bait|bait|bait|bait|prey|prey|prey|prey|prey|bait|bait|bait|prey|prey prey|prey|prey|prey|prey|bait|bait|bait|bait|bait|prey|prey|prey|bait|bait PMVK WDR92 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243257 bait prey WDR92 TERF2IP MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304326 bait prey WDR92 THG1L MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304351 bait prey WDR92 PARD6A MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 14676191 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_73668|BIOGRID_150456 prey|prey bait|bait UBC WDR92 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_178611|BIOGRID_169297 bait|bait prey|prey UBE3C WDR92 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304766 prey bait ATG7 WDR92 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298665 prey bait

PPI - HINT Gene A Gene B PMID Method Quality ZNF316 WDR92 22939629 0401 HT SEC16A WDR92 26496610,26496610 0007,0004 HT NPHP1 WDR92 26638075,26638075 1314,1313 HT PPP6R2 WDR92 24255178,24255178 1313,1314 HT OFD1 WDR92 26638075,26638075 1314,1313 HT ATG7 WDR92 22863883 0401 HT POLR1A WDR92 26496610 0007 HT PPP3CB WDR92 22863883 0401 HT PPP1CC WDR92 26496610,26186194,26496610,24366813 0007,0004,0004,0007 HT WDR4 WDR92 22863883 0401 HT S100A10 WDR92 22939629 0401 HT PPP1CA WDR92 26186194,27173435 0004,0676 HT PPP1CB WDR92 26496610,27173435 0007,0676 HT PMVK WDR92 22939629 0401 HT UBE3C WDR92 22863883 0401 HT PPP1R7 WDR92 27173435 0676 HT PPP1R3A WDR92 24366813 0004 HT Q59H77 WDR92 26186194 0004 HT CCT6B WDR92 26186194 0004 HT WDR92 VPS25 22863883 0401 HT WDR92 WDR12 22863883 0401 HT WDR92 Q9H6T2 26496610 0004 HT WDR92 RPAP3 18538670,26344197,19450687,18538670,25036637,18538670,18538670,25036637 0004,0401,0004,0096,0007,0007,0006,0004 LC,HT WDR92 DNAAF2 27173435 0676 HT WDR92 POLR3E 26496610,26496610 0007,0004 HT WDR92 PIH1D1 26186194,21078300 0004,0004 HT,LC WDR92 THG1L 22863883 0401 HT WDR92 TERF2IP 22863883 0401 HT WDR92 PFDN2 26344197 0401 HT WDR92 HEL-S-80P 26496610 0004 HT ZNF316 WDR92 22939629 0401 HT SEC16A WDR92 26496610,26496610 0007,0004 HT NPHP1 WDR92 26638075,26638075 1314,1313 HT PPP6R2 WDR92 24255178,24255178 1313,1314 HT OFD1 WDR92 26638075,26638075 1314,1313 HT ATG7 WDR92 22863883 0401 HT POLR1A WDR92 26496610 0007 HT PPP3CB WDR92 22863883 0401 HT PPP1CC WDR92 26496610,26186194,26496610,24366813 0007,0004,0004,0007 HT WDR4 WDR92 22863883 0401 HT S100A10 WDR92 22939629 0401 HT PPP1CA WDR92 26186194,27173435 0004,0676 HT PPP1CB WDR92 26496610,27173435 0007,0676 HT PMVK WDR92 22939629 0401 HT UBE3C WDR92 22863883 0401 HT PPP1R7 WDR92 27173435 0676 HT PPP1R3A WDR92 24366813 0004 HT Q59H77 WDR92 26186194 0004 HT CCT6B WDR92 26186194 0004 HT WDR92 VPS25 22863883 0401 HT WDR92 WDR12 22863883 0401 HT WDR92 Q9H6T2 26496610 0004 HT WDR92 RPAP3 26344197 0401 HT WDR92 DNAAF2 27173435 0676 HT WDR92 POLR3E 26496610,26496610 0007,0004 HT WDR92 PIH1D1 26186194 0004 HT WDR92 THG1L 22863883 0401 HT WDR92 TERF2IP 22863883 0401 HT WDR92 PFDN2 26344197 0401 HT WDR92 HEL-S-80P 26496610 0004 HT WDR92 RPAP3 18538670,19450687,18538670,25036637,18538670,18538670,25036637 0004,0004,0096,0007,0007,0006,0004 LC WDR92 PIH1D1 21078300 0004 LC ZNF316 WDR92 22939629 0401 LC FKBP6 WDR92 25036637 0729 HT ATG7 WDR92 22863883 0401 LC PPP3CB WDR92 22863883 0401 LC WDR4 WDR92 22863883 0401 LC S100A10 WDR92 22939629 0401 LC PMVK WDR92 22939629 0401 LC UBE3C WDR92 22863883 0401 LC WDR92 VPS25 22863883 0401 LC WDR92 WDR12 22863883 0401 LC WDR92 RPAP3 26344197 0401 LC WDR92 THG1L 22863883 0401 LC WDR92 TERF2IP 22863883 0401 LC WDR92 PFDN2 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96MX6 P60903 WDR92 S100A10 0.081 22939629 Q96MX6 P62136 WDR92 PPP1CA 0.332 unassigned1312,26186194,27173435 Q96MX6 O15259 WDR92 NPHP1 0.126 26638075 Q96MX6 O75344 WDR92 FKBP6 0.126 25036637 Q96MX6 Q6P5F9 WDR92 XPO1 0.126 26673895 Q96MX6 O95714 WDR92 HERC2 0.126 25476789 Q9NPB6 Q96MX6 PARD6A WDR92 0.236 14676191 Q9NVR5 Q96MX6 DNAAF2 WDR92 0.236 27173435,unassigned1312 Q9NVU0 Q96MX6 POLR3E WDR92 0.236 26496610 Q9WTM5 Q96MX6 RUVBL2 WDR92 0.236 26496610 Q96MX6 P15514 WDR92 AREGB 0.454 23844004 Q96MX6 O15027 WDR92 SEC16A 0.236 26496610 Q9CSU0 Q96MX6 RPRD1B WDR92 0.236 26496610 Q96MX6 P80313 WDR92 CCT7 0.236 26496610 Q96MX6 P80314 WDR92 CCT2 0.236 26496610 Q96MX6 P80315 WDR92 CCT4 0.236 26496610 Q96MX6 P80318 WDR92 CCT3 0.236 26496610 Q96MX6 P42932 WDR92 CCT8 0.236 26496610 Q96MX6 O95602 WDR92 POLR1A 0.236 26496610 Q96MX6 O70591 WDR92 PFDN2 0.236 26496610 Q96MX6 O75170 WDR92 PPP6R2 0.196 24255178 Q96MX6 P60122 WDR92 RUVBL1 0.236 26496610 Q96MX6 O75665 WDR92 OFD1 0.236 26638075 Q96MX6 P62141 WDR92 PPP1CB 0.236 26496610 Q9H6T3 Q96MX6 RPAP3 WDR92 0.784 18538670,26344197,25036637,19450687 Q96MX6 A6NFI3 WDR92 ZNF316 0.081 22939629 Q96MX6 Q15435 WDR92 PPP1R7 0.236 27173435,unassigned1312 Q96MX6 P49368 WDR92 CCT3 0.126 26186194 Q96MX6 P36873 WDR92 PPP1CC 0.416 26186194,24366813,26496610 Q96MX6 O95352 WDR92 ATG7 0.081 22863883 Q96MX6 Q15386 WDR92 UBE3C 0.081 22863883 Q96MX6 P62140 WDR92 PPP1CB 0.416 27173435,unassigned1312,26496610 Q96MX6 P57081 WDR92 WDR4 0.081 22863883 Q9GZL7 Q96MX6 WDR12 WDR92 0.081 22863883 Q96MX6 Q92526 WDR92 CCT6B 0.126 26186194 Q96MX6 Q96B26 WDR92 EXOSC8 0.21 23844004 Q9NWS0 Q96MX6 PIH1D1 WDR92 0.454 21078300,26186194 Q9NWX6 Q96MX6 THG1L WDR92 0.081 22863883 Q9NYB0 Q96MX6 TERF2IP WDR92 0.081 22863883 Q9BRG1 Q96MX6 VPS25 WDR92 0.081 22863883 Q9UHV9 Q96MX6 PFDN2 WDR92 0.081 26344197 Q96MX6 Q15126 WDR92 PMVK 0.081 22939629 Q96MX6 Q16821 WDR92 PPP1R3A 0.126 24366813

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 WDR92 MI:0045 experimental interaction detection MI:0461 interaction database SEC16A WDR92 MI:0045 experimental interaction detection MI:0461 interaction database NPHP1 WDR92 MI:0045 experimental interaction detection MI:0461 interaction database TTI1 WDR92 MI:0362 inference MI:0461 interaction database PPP6R2 WDR92 MI:0045 experimental interaction detection MI:0461 interaction database FKBP6 WDR92 MI:0045 experimental interaction detection MI:0461 interaction database TADA2A WDR92 MI:0362 inference MI:0461 interaction database OFD1 WDR92 MI:0045 experimental interaction detection MI:0461 interaction database POLR1A WDR92 MI:0045 experimental interaction detection MI:0461 interaction database HERC2 WDR92 MI:0045 experimental interaction detection MI:0461 interaction database ECD WDR92 MI:0362 inference MI:0461 interaction database UBC WDR92 MI:0045 experimental interaction detection MI:0461 interaction database AREG WDR92 MI:0045 experimental interaction detection MI:0461 interaction database PPP1CC WDR92 MI:0045 experimental interaction detection MI:0461 interaction database CCT3 WDR92 MI:0045 experimental interaction detection MI:0461 interaction database ST13 WDR92 MI:0362 inference MI:0461 interaction database CCT8 WDR92 MI:0362 inference MI:0461 interaction database CCT4 WDR92 MI:0362 inference MI:0461 interaction database PPP1CA WDR92 MI:0045 experimental interaction detection MI:0461 interaction database PPP1CB WDR92 MI:0045 experimental interaction detection MI:0461 interaction database CCT2 WDR92 MI:0362 inference MI:0461 interaction database CHAF1A WDR92 MI:0362 inference MI:0461 interaction database EFTUD2 WDR92 MI:0362 inference MI:0461 interaction database PPP1R7 WDR92 MI:0045 experimental interaction detection MI:0461 interaction database PPP1R3A WDR92 MI:0045 experimental interaction detection MI:0461 interaction database PRPF8 WDR92 MI:0362 inference MI:0461 interaction database CCT6B WDR92 MI:0045 experimental interaction detection MI:0461 interaction database EXOSC8 WDR92 MI:0045 experimental interaction detection MI:0461 interaction database WDR92 CCT7 MI:0362 inference MI:0461 interaction database WDR92 RPAP3 MI:0045 experimental interaction detection MI:0461 interaction database WDR92 PARD6A MI:0045 experimental interaction detection MI:0461 interaction database WDR92 RPRD1B MI:0362 inference MI:0461 interaction database WDR92 DNAAF2 MI:0045 experimental interaction detection MI:0461 interaction database WDR92 POLR3E MI:0045 experimental interaction detection MI:0461 interaction database WDR92 PIH1D1 MI:0045 experimental interaction detection MI:0461 interaction database WDR92 PFDN2 MI:0362 inference MI:0461 interaction database WDR92 RUVBL2 MI:0362 inference MI:0461 interaction database WDR92 RUVBL1 MI:0362 inference MI:0461 interaction database