PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus USP51 PJA1 22626734 biogrid exp, ortho GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP USP51 USP28 22626734 biogrid exp, ortho GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP USP51 USP15 22626734 biogrid exp, ortho G GP G G GP GP G G P G GP P GP G P GP GP GP G GP GP P P GP P GP USP51 USP21 22626734, 23023127 biogrid exp, ortho, pred GP GP G G G GP G GP P G GP P G G P GP G GP G GP GP P P G P GP USP51 GPSM1 ortho GP GP G G G GP G GP P G GP P G G P GP GP GP G GP GP P G P GP SNCA USP51 ortho G G G G GP GP G GP P G GP G G GP GP G G G G GP GP PEX5 USP51 ortho GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP RAD23B USP51 ortho GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP NUAK1 USP51 ortho GP GP G G GP GP G G P G GP P GP G P GP G GP G GP GP P P G P GP UBC USP51 ortho GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP USP51 EPN1 ortho GP GP G G G GP G G P G GP GP G P GP G GP G GP GP P P G P GP VCP USP51 ortho GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP SUMO2 USP51 23023127 pred GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP USP51 USP3 23023127 pred G G G G G G G G G G G G G G G G G G G G USP34 USP51 23023127 pred GP GP G G GP GP G GP P G GP P GP G P GP GP G G GP GP P P GP P GP USP51 USP44 23023127 pred P P P P P P P P P P P P GP G P P P P P GP DDI2 USP51 23023127 pred P P P P P P P P P P P P P P USP51 KAT2A 25402006 pred GP GP G G GP GP G GP P G GP P GP G P GP G GP G GP GP P GP P GP USP51 FAF1 23023127 pred GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP PARK2 USP51 23023127 pred P GP G P GP G GP P G GP P G P GP GP P G P P P P GP SQSTM1 USP51 23023127 pred GP GP G G GP G G G P G GP P GP G P G GP GP G GP GP P P GP P GP USP51 USP40 23023127 pred GP GP G G GP GP G GP P G GP P GP G P GP G GP G GP G P GP P GP USP51 USP7 23023127 pred GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP UBXN2B USP51 23023127 pred G GP G G G G G G P G GP P G G P G GP G G G GP P G P GP RAD23A USP51 23023127 pred GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP USP14 USP51 23023127 pred GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP USP51 USP48 23023127 pred GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q70EK9 Q8NG27 enzymatic study 22626734 direct interaction X 2 Q70EK9 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q70EK9 Q9Y4E8-2 enzymatic study 22626734 direct interaction X 2 Q70EK9 Q96RU2 enzymatic study 22626734 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B USP51 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223069 prey bait USP51 USP28 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223111 prey bait USP51 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222981 prey bait USP51 USP15 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223093 prey bait

PPI - HINT Gene A Gene B PMID Method Quality USP51 PJA1 22626734 0415 HT USP51 USP28 22626734 0415 HT USP51 USP21 22626734 0415 HT USP51 USP15 22626734 0415 HT

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYH7B USP51 MI:0362 inference MI:0461 interaction database EIF3CL USP51 MI:0362 inference MI:0461 interaction database DDX39A USP51 MI:0362 inference MI:0461 interaction database SUPT5H USP51 MI:0362 inference MI:0461 interaction database CHD1 USP51 MI:0362 inference MI:0461 interaction database CHD2 USP51 MI:0362 inference MI:0461 interaction database BTAF1 USP51 MI:0362 inference MI:0461 interaction database KPNA5 USP51 MI:0362 inference MI:0461 interaction database POLR1C USP51 MI:0362 inference MI:0461 interaction database CETN3 USP51 MI:0362 inference MI:0461 interaction database TIMM44 USP51 MI:0362 inference MI:0461 interaction database NARS USP51 MI:0362 inference MI:0461 interaction database ACSL4 USP51 MI:0362 inference MI:0461 interaction database HIST1H2BK USP51 MI:0362 inference MI:0461 interaction database CLUH USP51 MI:0362 inference MI:0461 interaction database TADA2A USP51 MI:0362 inference MI:0461 interaction database DNAJB5 USP51 MI:0362 inference MI:0461 interaction database ALDH1A2 USP51 MI:0362 inference MI:0461 interaction database GFPT2 USP51 MI:0362 inference MI:0461 interaction database ACSL3 USP51 MI:0362 inference MI:0461 interaction database HSPA4L USP51 MI:0362 inference MI:0461 interaction database TUBB4A USP51 MI:0362 inference MI:0461 interaction database GAPDH USP51 MI:0362 inference MI:0461 interaction database HIST1H2AB USP51 MI:0362 inference MI:0461 interaction database ALDH2 USP51 MI:0362 inference MI:0461 interaction database RPLP1 USP51 MI:0362 inference MI:0461 interaction database RPLP2 USP51 MI:0362 inference MI:0461 interaction database RPLP0 USP51 MI:0362 inference MI:0461 interaction database ATP5B USP51 MI:0362 inference MI:0461 interaction database HIST1H2BJ USP51 MI:0362 inference MI:0461 interaction database TUBB USP51 MI:0362 inference MI:0461 interaction database HSP90AA1 USP51 MI:0362 inference MI:0461 interaction database PFKM USP51 MI:0362 inference MI:0461 interaction database HSP90AB1 USP51 MI:0362 inference MI:0461 interaction database HIST1H2AG USP51 MI:0362 inference MI:0461 interaction database H2AFB1 USP51 MI:0362 inference MI:0461 interaction database H2AFB2 USP51 MI:0362 inference MI:0461 interaction database UBC USP51 MI:0362 inference MI:0461 interaction database HSPA1A USP51 MI:0362 inference MI:0461 interaction database HSPA1B USP51 MI:0362 inference MI:0461 interaction database HSPD1 USP51 MI:0362 inference MI:0461 interaction database HSPA5 USP51 MI:0362 inference MI:0461 interaction database MYH3 USP51 MI:0362 inference MI:0461 interaction database HSPA8 USP51 MI:0362 inference MI:0461 interaction database MYH1 USP51 MI:0362 inference MI:0461 interaction database MYH7 USP51 MI:0362 inference MI:0461 interaction database MYH8 USP51 MI:0362 inference MI:0461 interaction database EEF2 USP51 MI:0362 inference MI:0461 interaction database GSPT1 USP51 MI:0362 inference MI:0461 interaction database H2AFX USP51 MI:0362 inference MI:0461 interaction database PPP3CB USP51 MI:0362 inference MI:0461 interaction database HSPA6 USP51 MI:0362 inference MI:0461 interaction database PRKACA USP51 MI:0362 inference MI:0461 interaction database CTPS1 USP51 MI:0362 inference MI:0461 interaction database DDX5 USP51 MI:0362 inference MI:0461 interaction database PFKL USP51 MI:0362 inference MI:0461 interaction database PSMC3 USP51 MI:0362 inference MI:0461 interaction database RCC1 USP51 MI:0362 inference MI:0461 interaction database POLR2E USP51 MI:0362 inference MI:0461 interaction database PSMB1 USP51 MI:0362 inference MI:0461 interaction database HIST1H2AD USP51 MI:0362 inference MI:0461 interaction database TAF1 USP51 MI:0362 inference MI:0461 interaction database VDAC1 USP51 MI:0362 inference MI:0461 interaction database PRKACG USP51 MI:0362 inference MI:0461 interaction database PRKACB USP51 MI:0362 inference MI:0461 interaction database ME2 USP51 MI:0362 inference MI:0461 interaction database HIST1H2BO USP51 MI:0362 inference MI:0461 interaction database POLR2A USP51 MI:0362 inference MI:0461 interaction database DNAJB1 USP51 MI:0362 inference MI:0461 interaction database VARS USP51 MI:0362 inference MI:0461 interaction database EEF1G USP51 MI:0362 inference MI:0461 interaction database CALML3 USP51 MI:0362 inference MI:0461 interaction database RPL12 USP51 MI:0362 inference MI:0461 interaction database ALDH1B1 USP51 MI:0362 inference MI:0461 interaction database POLR2B USP51 MI:0362 inference MI:0461 interaction database MAT2A USP51 MI:0362 inference MI:0461 interaction database PRDX2 USP51 MI:0362 inference MI:0461 interaction database HIST1H2BB USP51 MI:0362 inference MI:0461 interaction database HSPA1L USP51 MI:0362 inference MI:0461 interaction database HSPA4 USP51 MI:0362 inference MI:0461 interaction database MYH9 USP51 MI:0362 inference MI:0461 interaction database MYH10 USP51 MI:0362 inference MI:0461 interaction database COPB2 USP51 MI:0362 inference MI:0461 interaction database MYH11 USP51 MI:0362 inference MI:0461 interaction database CPOX USP51 MI:0362 inference MI:0461 interaction database NUP62 USP51 MI:0362 inference MI:0461 interaction database ATP6V1A USP51 MI:0362 inference MI:0461 interaction database HSPA9 USP51 MI:0362 inference MI:0461 interaction database CCT6A USP51 MI:0362 inference MI:0461 interaction database EIF2S3 USP51 MI:0362 inference MI:0461 interaction database GARS USP51 MI:0362 inference MI:0461 interaction database VDAC2 USP51 MI:0362 inference MI:0461 interaction database CAPZA2 USP51 MI:0362 inference MI:0461 interaction database PPP3CC USP51 MI:0362 inference MI:0461 interaction database CCT5 USP51 MI:0362 inference MI:0461 interaction database CCT3 USP51 MI:0362 inference MI:0461 interaction database TAF6 USP51 MI:0362 inference MI:0461 interaction database CCT8 USP51 MI:0362 inference MI:0461 interaction database USP11 USP51 MI:0362 inference MI:0461 interaction database KPNA1 USP51 MI:0362 inference MI:0461 interaction database CAPZA1 USP51 MI:0362 inference MI:0461 interaction database COPA USP51 MI:0362 inference MI:0461 interaction database CLTCL1 USP51 MI:0362 inference MI:0461 interaction database PRKAA2 USP51 MI:0362 inference MI:0461 interaction database HSPA2 USP51 MI:0362 inference MI:0461 interaction database VCP USP51 MI:0362 inference MI:0461 interaction database MARS USP51 MI:0362 inference MI:0461 interaction database HIST1H2BD USP51 MI:0362 inference MI:0461 interaction database DNAJB13 USP51 MI:0362 inference MI:0461 interaction database EIF4A1 USP51 MI:0362 inference MI:0461 interaction database SRP54 USP51 MI:0362 inference MI:0461 interaction database CALM1 USP51 MI:0362 inference MI:0461 interaction database PSMC1 USP51 MI:0362 inference MI:0461 interaction database ETF1 USP51 MI:0362 inference MI:0461 interaction database HIST1H2BC USP51 MI:0362 inference MI:0461 interaction database RPL30 USP51 MI:0362 inference MI:0461 interaction database RPL10A USP51 MI:0362 inference MI:0461 interaction database RPL8 USP51 MI:0362 inference MI:0461 interaction database RPS27A USP51 MI:0362 inference MI:0461 interaction database UBA52 USP51 MI:0362 inference MI:0461 interaction database TUBB4B USP51 MI:0362 inference MI:0461 interaction database HIST1H3A USP51 MI:0362 inference MI:0461 interaction database H3F3A USP51 MI:0362 inference MI:0461 interaction database MAT1A USP51 MI:0362 inference MI:0461 interaction database CLTC USP51 MI:0362 inference MI:0461 interaction database PFKP USP51 MI:0362 inference MI:0461 interaction database RPL18A USP51 MI:0362 inference MI:0461 interaction database GFPT1 USP51 MI:0362 inference MI:0461 interaction database PPP3CA USP51 MI:0362 inference MI:0461 interaction database ACACA USP51 MI:0362 inference MI:0461 interaction database USP4 USP51 MI:0362 inference MI:0461 interaction database EIF2B5 USP51 MI:0362 inference MI:0461 interaction database PRDX4 USP51 MI:0362 inference MI:0461 interaction database PSMD2 USP51 MI:0362 inference MI:0461 interaction database EIF3I USP51 MI:0362 inference MI:0461 interaction database TUBB3 USP51 MI:0362 inference MI:0461 interaction database HDAC1 USP51 MI:0362 inference MI:0461 interaction database DDX39B USP51 MI:0362 inference MI:0461 interaction database TUBB2A USP51 MI:0362 inference MI:0461 interaction database EIF4A2 USP51 MI:0362 inference MI:0461 interaction database TAF5 USP51 MI:0362 inference MI:0461 interaction database TAF7 USP51 MI:0362 inference MI:0461 interaction database TAF9 USP51 MI:0362 inference MI:0461 interaction database HIST3H3 USP51 MI:0362 inference MI:0461 interaction database HIST2H2AC USP51 MI:0362 inference MI:0461 interaction database HIST2H2BE USP51 MI:0362 inference MI:0461 interaction database TUBB8 USP51 MI:0362 inference MI:0461 interaction database TAF7L USP51 MI:0362 inference MI:0461 interaction database HIST2H2BF USP51 MI:0362 inference MI:0461 interaction database HIST2H2AA3 USP51 MI:0362 inference MI:0461 interaction database H3F3C USP51 MI:0362 inference MI:0461 interaction database USP51 HIST2H3A MI:0362 inference MI:0461 interaction database USP51 HIST3H2A MI:0362 inference MI:0461 interaction database USP51 H2BFWT MI:0362 inference MI:0461 interaction database USP51 MYH14 MI:0362 inference MI:0461 interaction database USP51 TADA2B MI:0362 inference MI:0461 interaction database USP51 HIST2H2AB MI:0362 inference MI:0461 interaction database USP51 GSPT2 MI:0362 inference MI:0461 interaction database USP51 TAF1L MI:0362 inference MI:0461 interaction database USP51 HIST3H2BB MI:0362 inference MI:0461 interaction database USP51 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database USP51 CALML6 MI:0362 inference MI:0461 interaction database USP51 BRIX1 MI:0362 inference MI:0461 interaction database USP51 CCT6B MI:0362 inference MI:0461 interaction database USP51 HSPH1 MI:0362 inference MI:0461 interaction database USP51 HDAC2 MI:0362 inference MI:0461 interaction database USP51 KAT2A MI:0362 inference MI:0461 interaction database USP51 KAT2B MI:0362 inference MI:0461 interaction database USP51 HIST1H2AC MI:0362 inference MI:0461 interaction database USP51 HIST1H2BH MI:0362 inference MI:0461 interaction database USP51 HIST1H2BA MI:0362 inference MI:0461 interaction database USP51 DNAJA3 MI:0362 inference MI:0461 interaction database USP51 HIST1H2AH MI:0362 inference MI:0461 interaction database USP51 CAPZA3 MI:0362 inference MI:0461 interaction database USP51 HIST1H2AA MI:0362 inference MI:0461 interaction database USP51 USP28 MI:0045 experimental interaction detection MI:0461 interaction database USP51 SIN3A MI:0362 inference MI:0461 interaction database USP51 PSMD1 MI:0362 inference MI:0461 interaction database USP51 EIF3C MI:0362 inference MI:0461 interaction database USP51 CCT7 MI:0362 inference MI:0461 interaction database USP51 HIST1H2BN MI:0362 inference MI:0461 interaction database USP51 HIST1H2AJ MI:0362 inference MI:0461 interaction database USP51 HIST1H2BM MI:0362 inference MI:0461 interaction database USP51 HIST1H2BL MI:0362 inference MI:0461 interaction database USP51 RIOK1 MI:0362 inference MI:0461 interaction database USP51 H2AFJ MI:0362 inference MI:0461 interaction database USP51 TUBB6 MI:0362 inference MI:0461 interaction database USP51 TUBB2B MI:0362 inference MI:0461 interaction database USP51 NAT10 MI:0362 inference MI:0461 interaction database USP51 TUBB1 MI:0362 inference MI:0461 interaction database USP51 TAF9B MI:0362 inference MI:0461 interaction database USP51 MYO5C MI:0362 inference MI:0461 interaction database USP51 ACSS2 MI:0362 inference MI:0461 interaction database USP51 CTPS2 MI:0362 inference MI:0461 interaction database USP51 ACSS1 MI:0362 inference MI:0461 interaction database USP51 TRMT1 MI:0362 inference MI:0461 interaction database USP51 GAR1 MI:0362 inference MI:0461 interaction database USP51 CALML5 MI:0362 inference MI:0461 interaction database USP51 DNAJB4 MI:0362 inference MI:0461 interaction database USP51 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP51 MYH2 MI:0362 inference MI:0461 interaction database USP51 MYH13 MI:0362 inference MI:0461 interaction database USP51 MYO5B MI:0362 inference MI:0461 interaction database USP51 RUVBL2 MI:0362 inference MI:0461 interaction database USP51 RUVBL1 MI:0362 inference MI:0461 interaction database USP51 VDAC3 MI:0362 inference MI:0461 interaction database USP51 FARSA MI:0362 inference MI:0461 interaction database USP51 MYH15 MI:0362 inference MI:0461 interaction database USP51 NOP58 MI:0362 inference MI:0461 interaction database USP51 TRRAP MI:0362 inference MI:0461 interaction database USP51 USP15 MI:0045 experimental interaction detection MI:0461 interaction database USP51 MYO5A MI:0362 inference MI:0461 interaction database USP51 SUPT16H MI:0362 inference MI:0461 interaction database USP51 MYH4 MI:0362 inference MI:0461 interaction database