PTM - CPLM Gene Name UniProt ID Type Position Code LYN; JTK8 P07948 Ubiquitination 101 K LYN; JTK8 P07948 Ubiquitination 477 K LYN; JTK8 P07948 Ubiquitination 20 K LYN; JTK8 P07948 Ubiquitination 9 K LYN; JTK8 P07948 Ubiquitination 213 K

PTM - dbPAF Gene Name UniProt ID Position Type Species LYN; JTK8 P07948 11 S Homo sapiens(Human) LYN; JTK8 P07948 115 S Homo sapiens(Human) LYN; JTK8 P07948 117 Y Homo sapiens(Human) LYN; JTK8 P07948 13 S Homo sapiens(Human) LYN; JTK8 P07948 135 T Homo sapiens(Human) LYN; JTK8 P07948 149 S Homo sapiens(Human) LYN; JTK8 P07948 158 S Homo sapiens(Human) LYN; JTK8 P07948 164 S Homo sapiens(Human) LYN; JTK8 P07948 166 S Homo sapiens(Human) LYN; JTK8 P07948 193 Y Homo sapiens(Human) LYN; JTK8 P07948 194 Y Homo sapiens(Human) LYN; JTK8 P07948 228 S Homo sapiens(Human) LYN; JTK8 P07948 246 S Homo sapiens(Human) LYN; JTK8 P07948 265 Y Homo sapiens(Human) LYN; JTK8 P07948 266 Y Homo sapiens(Human) LYN; JTK8 P07948 269 S Homo sapiens(Human) LYN; JTK8 P07948 276 T Homo sapiens(Human) LYN; JTK8 P07948 281 T Homo sapiens(Human) LYN; JTK8 P07948 283 S Homo sapiens(Human) LYN; JTK8 P07948 296 T Homo sapiens(Human) LYN; JTK8 P07948 30 T Homo sapiens(Human) LYN; JTK8 P07948 306 Y Homo sapiens(Human) LYN; JTK8 P07948 310 T Homo sapiens(Human) LYN; JTK8 P07948 316 Y Homo sapiens(Human) LYN; JTK8 P07948 319 T Homo sapiens(Human) LYN; JTK8 P07948 32 Y Homo sapiens(Human) LYN; JTK8 P07948 321 Y Homo sapiens(Human) LYN; JTK8 P07948 326 S Homo sapiens(Human) LYN; JTK8 P07948 37 T Homo sapiens(Human) LYN; JTK8 P07948 38 S Homo sapiens(Human) LYN; JTK8 P07948 397 Y Homo sapiens(Human) LYN; JTK8 P07948 398 T Homo sapiens(Human) LYN; JTK8 P07948 438 T Homo sapiens(Human) LYN; JTK8 P07948 439 Y Homo sapiens(Human) LYN; JTK8 P07948 448 T Homo sapiens(Human) LYN; JTK8 P07948 460 Y Homo sapiens(Human) LYN; JTK8 P07948 473 Y Homo sapiens(Human) LYN; JTK8 P07948 489 T Homo sapiens(Human) LYN; JTK8 P07948 492 Y Homo sapiens(Human) LYN; JTK8 P07948 501 Y Homo sapiens(Human) LYN; JTK8 P07948 502 T Homo sapiens(Human) LYN; JTK8 P07948 504 T Homo sapiens(Human) LYN; JTK8 P07948 508 Y Homo sapiens(Human) LYN; JTK8 P07948 58 T Homo sapiens(Human) LYN; JTK8 P07948 6 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P07948 S11-p Phosphorylation IKSKGkDsLsDDGVD P07948 S13-p Phosphorylation SKGkDsLsDDGVDLk P07948 Y32-p Phosphorylation RNTERTIyVRDPTSN P07948 T58-p Phosphorylation LPGQRFQtkDPEEQG P07948 S115-p Phosphorylation KKEGFIPsNyVAKLN P07948 Y117-p Phosphorylation EGFIPsNyVAKLNTL P07948 T135-p Phosphorylation EWFFKDItRKDAERQ P07948 S149-p Phosphorylation QLLAPGNsAGAFLIR P07948 S158-p Phosphorylation GAFLIREsETLKGsF P07948 S164-p Phosphorylation EsETLKGsFsLSVRD P07948 S166-p Phosphorylation ETLKGsFsLSVRDFD P07948 S187-p Phosphorylation IKHYKIRsLDNGGyy P07948 Y193-p Phosphorylation RsLDNGGyyISPRIT P07948 Y194-p Phosphorylation sLDNGGyyISPRITF P07948 S228-p Phosphorylation RLEKACIsPKPQKPW P07948 S246-p Phosphorylation AWEIPREsIKLVKRL P07948 Y265-p Phosphorylation FGEVWMGyyNNsTKV P07948 Y266-p Phosphorylation GEVWMGyyNNsTKVA P07948 S269-p Phosphorylation WMGyyNNsTKVAVKt P07948 T276-p Phosphorylation sTKVAVKtLKPGtMs P07948 T281-p Phosphorylation VKtLKPGtMsVQAFL P07948 S283-p Phosphorylation tLKPGtMsVQAFLEE P07948 T296-p Phosphorylation EEANLMKtLQHDKLV P07948 Y306-p Phosphorylation HDKLVRLyAVVTREE P07948 Y316-p Phosphorylation VTREEPIyIItEyMA P07948 T319-p Phosphorylation EEPIyIItEyMAKGs P07948 Y321-p Phosphorylation PIyIItEyMAKGsLL P07948 S326-p Phosphorylation tEyMAKGsLLDFLKS P07948 Y397-p Phosphorylation RVIEDNEytAREGAk P07948 T398-p Phosphorylation VIEDNEytAREGAkF P07948 T438-p Phosphorylation ILLYEIVtyGKIPYP P07948 Y439-p Phosphorylation LLYEIVtyGKIPYPG P07948 T448-p Phosphorylation KIPYPGRtNADVMTA P07948 Y460-p Phosphorylation MTALSQGyRMPRVEN P07948 Y473-p Phosphorylation ENCPDELyDIMkMCW P07948 Y501-p Phosphorylation QSVLDDFytAtEGQy P07948 T502-p Phosphorylation SVLDDFytAtEGQyQ P07948 T504-p Phosphorylation LDDFytAtEGQyQQQ P07948 Y508-p Phosphorylation ytAtEGQyQQQP___ P07948 K9-ub Ubiquitination GCIKSKGkDsLsDDG P07948 K20-ub Ubiquitination sDDGVDLkTQPVRNT P07948 K59-ub Ubiquitination PGQRFQtkDPEEQGD P07948 K101-ub Ubiquitination EEHGEWWkAKSLLTK P07948 K404-ub Ubiquitination ytAREGAkFPIKWTA P07948 K477-ub Ubiquitination DELyDIMkMCWKEKA

PTM - dbPTM UniProt ID Position Code Type Resources References P07948 6 S Phosphorylation Swiss-Prot 1010711 19369195 P07948 11 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;18691976;19369195 P07948 13 S Phosphorylation Swiss-Prot 1010711 17192257;18088087;18669648;18691976;19007248;19369195 P07948 30 T Phosphorylation Swiss-Prot 1010711 19369195 P07948 32 Y Phosphorylation Swiss-Prot 1010711 18691976;19369195 P07948 37 T Phosphorylation Swiss-Prot 1010711 19369195 P07948 193 Y Phosphorylation Swiss-Prot 1010711 18083107;19369195;19534553 P07948 194 Y Phosphorylation Swiss-Prot 1010711 18083107;18691976;19369195 P07948 228 S Phosphorylation Swiss-Prot 1010711 18691976;19369195 P07948 265 Y Phosphorylation Swiss-Prot 1010711 19369195 P07948 306 Y Phosphorylation Swiss-Prot 1010711 18083107;19369195 P07948 316 Y Phosphorylation Swiss-Prot 1010711 17389395;19369195 P07948 397 Y Phosphorylation Swiss-Prot 1010711 7935444;18070987;18083107;18088087;18691976;19534553 P07948 473 Y Phosphorylation Swiss-Prot 1010711 18083107;18691976;19369195 P07948 489 T Phosphorylation Swiss-Prot 1010711 19369195 P07948 502 T Phosphorylation Swiss-Prot 1010711 19369195 P07948 508 Y Phosphorylation Swiss-Prot 1010711 7935444;9171348;15592455;17081983;18070987;18083107;18691976;19369195;19534553 P07948 13 S Phosphorylation PhosphoELM.10011 18088087;17192257 P07948 193 Y Phosphorylation PhosphoELM.10011 18083107;16497976 P07948 194 Y Phosphorylation PhosphoELM.10011 18083107 P07948 306 Y Phosphorylation PhosphoELM.10011 18083107 P07948 473 Y Phosphorylation PhosphoELM.10011 18083107 P07948 508 Y Phosphorylation PhosphoELM.10011 18083107;9171348 P07948 397 Y Phosphorylation PhosphoELM.10011 18083107;18088087;17081983;8530369 P07948 20 K Ubiquitylation Phosphositeplus.1010730 21906983 P07948 9 K Ubiquitylation Phosphositeplus.1010730 21906983 P07948 11 S Phosphorylation Phosphositeplus.1010730 18669648;18691976;19369195;21406692;22115753 P07948 13 S Phosphorylation Phosphositeplus.1010730 17192257;18088087;18669648;18691976;19369195;19415658;19664994;19691289;20068231;20166139;20363803;20562096;20815410;21406692;21659604;22115753 P07948 228 S Phosphorylation Phosphositeplus.1010730 18691976;19369195 P07948 246 S Phosphorylation Phosphositeplus.1010730 20068231;21406692;22115753 P07948 398 T Phosphorylation Phosphositeplus.1010730 22115753 P07948 502 T Phosphorylation Phosphositeplus.1010730 21659604 P07948 504 T Phosphorylation Phosphositeplus.1010730 21659604 P07948 58 T Phosphorylation Phosphositeplus.1010730 22115753 P07948 117 Y Phosphorylation Phosphositeplus.1010730 18083107 P07948 193 Y Phosphorylation Phosphositeplus.1010730 16497976;18083107;18180459;19534553;20007894;20090780;21253578 P07948 194 Y Phosphorylation Phosphositeplus.1010730 17016520;17360941;18083107;18180459;18691976;19369195;19658100;20007894;20205385;21253578;21403953;21447384 P07948 265 Y Phosphorylation Phosphositeplus.1010730 19369195 P07948 306 Y Phosphorylation Phosphositeplus.1010730 17360941;18083107;19369195;20007894 P07948 316 Y Phosphorylation Phosphositeplus.1010730 17389395;18083107;18180459;19369195;20007894;20736484;21394647 P07948 32 Y Phosphorylation Phosphositeplus.1010730 18083107;18691976;19369195;21253578;22115753;22322096 P07948 397 Y Phosphorylation Phosphositeplus.1010730 15489898;15626731;17360941;18070987;18083107;18088087;18180459;18587398;18691976;19369195;19534553;19658100;19664994;19901323;20007894;20068231;20090780;20190765;20205385;20564182;20736484;21253578;21394647;21403953;21447384;22115753;22322096;9171348 P07948 460 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459 P07948 473 Y Phosphorylation Phosphositeplus.1010730 16464493;17360941;18083107;18180459;18691976;19369195;20090780;21253578;21394647;21403953;21447384 P07948 501 Y Phosphorylation Phosphositeplus.1010730 18083107 P07948 508 Y Phosphorylation Phosphositeplus.1010730 15592455;15626731;16464493;16497976;17575268;18070987;18083107;18180459;18691976;19369195;19534553;19658100;19901323;20068231;20090780;20564182;20736484;21253578;21394647;9171348 P07948 397 Y Dephosphorylation HPRD 9.0 11042209 P07948 397 Y Dephosphorylation HPRD 9.0 10415030 P07948 508 Y Dephosphorylation HPRD 9.0 10415030 P07948 11 S Phosphorylation HPRD 9.0 17081983,18669648,18691976,19651622,18767875,20068231 P07948 13 S Phosphorylation HPRD 9.0 17322306,18669648,19415658,18691976,19007248,18088087,19651622,19691289,19664994,18767875,20166139,20068231 P07948 228 S Phosphorylation HPRD 9.0 18691976 P07948 246 S Phosphorylation HPRD 9.0 20068231 P07948 489 T Phosphorylation HPRD 9.0 18691976 P07948 504 T Phosphorylation HPRD 9.0 18691976 P07948 32 Y Phosphorylation HPRD 9.0 18691976 P07948 193 Y Phosphorylation HPRD 9.0 18083107,16497976 P07948 194 Y Phosphorylation HPRD 9.0 18083107,18691976,16497976,17016520 P07948 306 Y Phosphorylation HPRD 9.0 20068231 P07948 316 Y Phosphorylation HPRD 9.0 17389395 P07948 473 Y Phosphorylation HPRD 9.0 18083107,18691976 P07948 492 Y Phosphorylation HPRD 9.0 16497976 P07948 501 Y Phosphorylation HPRD 9.0 17081983,16497976 P07948 508 Y Phosphorylation (CSK) HPRD 9.0 8612628,18669648,18691976,19651622,16497976,18452278,19901323,20068231 P07948 397 Y Phosphorylation (LYN) HPRD 9.0 9171348,18691976,18088087,19901323,20068231 P07948 508 Y Phosphorylation (MATK) HPRD 9.0 8612628,18669648,18691976,19651622,16497976,18452278,19901323,20068231 P07948 18 D Proteolytic Cleavage HPRD 9.0 11526478 P07948 11 S Phosphorylation SysPTM 1.1 18669648;18691976;17081983 P07948 13 S Phosphorylation SysPTM 1.1 18669648;18691976;18088087 P07948 228 S Phosphorylation SysPTM 1.1 18691976 P07948 32 Y Phosphorylation SysPTM 1.1 18691976 P07948 194 Y Phosphorylation SysPTM 1.1 18691976 P07948 397 Y Phosphorylation SysPTM 1.1 18691976;18088087 P07948 473 Y Phosphorylation SysPTM 1.1 18691976 P07948 501 Y Phosphorylation SysPTM 1.1 17081983 P07948 508 Y Phosphorylation SysPTM 1.1 17081983;18691976

PTM - HPRD Symbol Position Code Type References LYN 11 S Phosphorylation 17081983,18669648,18691976,19651622,18767875,20068231 LYN 13 S Phosphorylation 17322306,18669648,19415658,18691976,19007248,18088087,19651622,19691289,19664994,18767875,20166139,20068231 LYN 18 D Proteolytic Cleavage 11526478 LYN 193 Y Phosphorylation 18083107,16497976 LYN 194 Y Phosphorylation 18083107,18691976,16497976,17016520 LYN 228 S Phosphorylation 18691976 LYN 246 S Phosphorylation 20068231 LYN 306 Y Phosphorylation 20068231 LYN 316 Y Phosphorylation 17389395 LYN 32 Y Phosphorylation 18691976 LYN 397 Y Dephosphorylation 10415030 LYN 397 Y Dephosphorylation 11042209 LYN 397 Y Phosphorylation 9171348,18691976,18088087,19901323,20068231 LYN 473 Y Phosphorylation 18083107,18691976 LYN 489 T Phosphorylation 18691976 LYN 492 Y Phosphorylation 16497976 LYN 501 Y Phosphorylation 17081983,16497976 LYN 504 T Phosphorylation 18691976 LYN 508 Y Dephosphorylation 10415030 LYN 508 Y Phosphorylation 8612628,18669648,18691976,19651622,16497976,18452278,19901323,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P07948 13 S 18088087 HTP Phosphorylation P07948 13 S 17192257 HTP Phosphorylation P07948 306 Y 18083107 HTP Phosphorylation P07948 508 Y 18083107 HTP Phosphorylation P07948 508 Y 9171348 Csk LTP Phosphorylation P07948 397 Y 18083107 HTP Phosphorylation P07948 397 Y 18088087 HTP Phosphorylation P07948 397 Y 17081983 HTP Phosphorylation P07948 397 Y 8530369 Lyn LTP Phosphorylation P07948 194 Y 18083107 HTP Phosphorylation P07948 193 Y 18083107 HTP Phosphorylation P07948 193 Y 16497976 HTP Phosphorylation P07948 473 Y 18083107 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P07948 11 Phosphoserine 18691976;19369195;21406692;23186163;24275569 P07948 13 Phosphoserine 18691976;19369195;20068231;21406692;23186163;24275569 P07948 193 Phosphotyrosine 18577747 P07948 228 Phosphoserine 19369195 P07948 306 Phosphotyrosine 19369195 P07948 316 Phosphotyrosine 19369195 P07948 397 Phosphotyrosine; by autocatalysis 18070987;7935444 P07948 460 Phosphotyrosine 18577747 P07948 473 Phosphotyrosine 18691976;19369195

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type LYN IPI00298625 S 11 KSKGKDpSLSDDGV phosphorylation LYN IPI00298625 S 13 KGKDSLpSDDGVDL phosphorylation LYN IPI00298625 S 228 LEKACIpSPKPQKP phosphorylation LYN IPI00298625 Y 194 LDNGGYpYISPRIT phosphorylation LYN IPI00298625 Y 265 GEVWMGpYYNNSTK phosphorylation LYN IPI00298625 Y 306 DKLVRLpYAVVTRE phosphorylation LYN IPI00298625 Y 316 TREEPIpYIITEYM phosphorylation LYN IPI00298625 Y 32 NTERTIpYVRDPTS phosphorylation LYN IPI00298625 Y 397 VIEDNEpYTAREGA phosphorylation LYN IPI00298625 Y 473 NCPDELpYDIMKMC phosphorylation LYN IPI00298625 Y 508 TATEGQpYQQQP__ phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 4067 110245 - K Ubiquitination 19930468 4067 110245 - K Ubiquitination 20534535 4067 110245 - K Ubiquitination 21139048 4067 110245 - K Ubiquitination 21890473 4067 110245 - K Ubiquitination 21906983 4067 110245 - K Ubiquitination 15190072 4067 110245 - K Ubiquitination 21963094 4067 110245 - K Ubiquitination 25015289 4067 110245 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID LYN Homo sapiens (Human) 80; 456 "80,EHGEWWKAKSLLT; 456,ELYDIMKMCWKEK" 80:21890473; 456:21890473 LYN Homo sapiens (Human) 101; 477 "101,EHGEWWKAKSLLT; 477,ELYDIMKMCWKEK" 101:21890473; 477:21890473 LYN Homo sapiens (Human) 101; 477; 20; 9 "101,EHGEWWKAKSLLT; 477,ELYDIMKMCWKEK; 20,DDGVDLKTQPVRN; 9,CIKSKGKDSLSDD" 101:21890473; 477:21890473; 20:21906983; 9:21906983 LYN Homo sapiens (Human) 20; 80; 456; 9 "20,DDGVDLKTQPVPE; 80,EHGEWWKAKSLLT; 456,ELYDIMKMCWKEK; 9,CIKSKGKDSLSDD" 20:21906983; 80:21890473; 456:21890473; 9:21906983 LYN Homo sapiens (Human) 171; 547 "171,EHGEWWKAKSLLT; 547,ELYDIMKMCWKEK" 171:21890473; 547:21890473