Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 1 145682086 145682086 + Silent SNP T T C TCGA-DK-A2I4-01A-11D-A21A-08 TCGA-DK-A2I4-10A-01D-A21A-08 g.chr1:145682086T>C c.492T>C c.(490-492)ccT>ccC p.P164P BLCA 1 145687020 145687020 + Missense_Mutation SNP G G A TCGA-DK-A2I4-01A-11D-A21A-08 TCGA-DK-A2I4-10A-01D-A21A-08 g.chr1:145687020G>A c.712G>A c.(712-714)Gaa>Aaa p.E238K BLCA 1 145687023 145687023 + Missense_Mutation SNP G G A TCGA-DK-A2I4-01A-11D-A21A-08 TCGA-DK-A2I4-10A-01D-A21A-08 g.chr1:145687023G>A c.715G>A c.(715-717)Gag>Aag p.E239K BLCA 1 145688151 145688151 + Silent SNP G G A TCGA-DK-A1AC-01A-11D-A13W-08 TCGA-DK-A1AC-10A-01D-A13W-08 g.chr1:145688151G>A c.846G>A c.(844-846)caG>caA p.Q282Q BRCA 1 145663210 145663210 + Missense_Mutation SNP C C G TCGA-EW-A1J5-01A-11D-A13L-09 TCGA-EW-A1J5-10A-01D-A13O-09 g.chr1:145663210C>G c.271C>G c.(271-273)Cta>Gta p.L91V BRCA 1 145688197 145688197 + Missense_Mutation SNP C C G TCGA-AC-A3W6-01A-12D-A228-09 TCGA-AC-A3W6-10A-01D-A22A-09 g.chr1:145688197C>G c.892C>G c.(892-894)Cta>Gta p.L298V CESC 1 145650536 145650536 + Missense_Mutation SNP C C T TCGA-C5-A1BK-01B-11D-A13W-08 TCGA-C5-A1BK-10A-01D-A13W-08 g.chr1:145650536C>T c.215C>T c.(214-216)gCa>gTa p.A72V COAD 1 145663167 145663167 + Silent SNP C C T TCGA-A6-6782-01A-11D-1835-10 TCGA-A6-6782-10A-01D-1835-10 g.chr1:145663167C>T c.228C>T c.(226-228)ggC>ggT p.G76G COAD 1 145682046 145682046 + Missense_Mutation SNP G G T TCGA-D5-6532-01A-11D-1719-10 TCGA-D5-6532-10A-01D-1719-10 g.chr1:145682046G>T c.452G>T c.(451-453)gGa>gTa p.G151V COAD 1 145684643 145684643 + Missense_Mutation SNP C C A TCGA-AA-3977-01A-01W-0995-10 TCGA-AA-3977-10A-01W-0999-10 g.chr1:145684643C>A c.632C>A c.(631-633)tCt>tAt p.S211Y COAD 1 145688206 145688206 + Nonsense_Mutation SNP C C T TCGA-AA-3977-01A-01W-0995-10 TCGA-AA-3977-10A-01W-0999-10 g.chr1:145688206C>T c.901C>T c.(901-903)Cga>Tga p.R301* COADREAD 1 145663167 145663167 + Silent SNP C C T TCGA-A6-6782-01A-11D-1835-10 TCGA-A6-6782-10A-01D-1835-10 g.chr1:145663167C>T c.228C>T c.(226-228)ggC>ggT p.G76G COADREAD 1 145682046 145682046 + Missense_Mutation SNP G G T TCGA-D5-6532-01A-11D-1719-10 TCGA-D5-6532-10A-01D-1719-10 g.chr1:145682046G>T c.452G>T c.(451-453)gGa>gTa p.G151V COADREAD 1 145684643 145684643 + Missense_Mutation SNP C C A TCGA-AA-3977-01A-01W-0995-10 TCGA-AA-3977-10A-01W-0999-10 g.chr1:145684643C>A c.632C>A c.(631-633)tCt>tAt p.S211Y COADREAD 1 145688206 145688206 + Nonsense_Mutation SNP C C T TCGA-AA-3977-01A-01W-0995-10 TCGA-AA-3977-10A-01W-0999-10 g.chr1:145688206C>T c.901C>T c.(901-903)Cga>Tga p.R301* ESCA 1 145682022 145682022 + Splice_Site SNP G G A TCGA-Q9-A6FU-01A-11D-A31U-09 TCGA-Q9-A6FU-10A-01D-A31U-09 g.chr1:145682022G>A c.e5-1 HNSC 1 145650515 145650515 + Missense_Mutation SNP A A G TCGA-QK-A8Z9-01B-11D-A391-08 TCGA-QK-A8Z9-10A-01D-A394-08 g.chr1:145650515A>G c.194A>G c.(193-195)aAt>aGt p.N65S HNSC 1 145682086 145682086 + Silent SNP T T C TCGA-QK-AA3J-01A-11D-A391-08 TCGA-QK-AA3J-10A-01D-A394-08 g.chr1:145682086T>C c.492T>C c.(490-492)ccT>ccC p.P164P KICH 1 145687066 145687066 + Missense_Mutation SNP G G A TCGA-KL-8342-01A-11D-2310-10 TCGA-KL-8342-11A-01D-2310-10 g.chr1:145687066G>A c.758G>A c.(757-759)aGt>aAt p.S253N KIPAN 1 145684607 145684607 + Missense_Mutation SNP C C G TCGA-CZ-5982-01A-11D-1669-08 TCGA-CZ-5982-11A-01D-1669-08 g.chr1:145684607C>G c.596C>G c.(595-597)aCa>aGa p.T199R KIPAN 1 145687066 145687066 + Missense_Mutation SNP G G A TCGA-KL-8342-01A-11D-2310-10 TCGA-KL-8342-11A-01D-2310-10 g.chr1:145687066G>A c.758G>A c.(757-759)aGt>aAt p.S253N KIPAN 1 145688091 145688091 + Missense_Mutation SNP T T A TCGA-EV-5901-01A-11D-1589-08 TCGA-EV-5901-10A-01D-1589-08 g.chr1:145688091T>A c.786T>A c.(784-786)caT>caA p.H262Q KIRC 1 145684607 145684607 + Missense_Mutation SNP C C G TCGA-CZ-5982-01A-11D-1669-08 TCGA-CZ-5982-11A-01D-1669-08 g.chr1:145684607C>G c.596C>G c.(595-597)aCa>aGa p.T199R KIRP 1 145688091 145688091 + Missense_Mutation SNP T T A TCGA-EV-5901-01A-11D-1589-08 TCGA-EV-5901-10A-01D-1589-08 g.chr1:145688091T>A c.786T>A c.(784-786)caT>caA p.H262Q LIHC 1 145663367 145663367 + Splice_Site SNP G G C TCGA-UB-A7MB-01A-11D-A33Q-10 TCGA-UB-A7MB-10A-01D-A33Q-10 g.chr1:145663367G>C c.428G>C c.(427-429)gGa>gCa p.G143A LIHC 1 145688137 145688137 + Missense_Mutation SNP A A T TCGA-CC-A5UD-01A-11D-A28X-10 TCGA-CC-A5UD-10A-01D-A28X-10 g.chr1:145688137A>T c.832A>T c.(832-834)Act>Tct p.T278S LUAD 1 145611284 145611284 + 5'Flank SNP A A T TCGA-44-8120-01A-11D-2238-08 TCGA-44-8120-10A-01D-2238-08 g.chr1:145611284A>T LUAD 1 145611303 145611303 + 5'Flank SNP T T C TCGA-17-Z004-01A-01W-0746-08 TCGA-17-Z004-11A-01W-0746-08 g.chr1:145611303T>C LUAD 1 145663206 145663206 + Silent SNP C C G TCGA-49-4514-01A-21D-1855-08 TCGA-49-4514-11A-01D-1855-08 g.chr1:145663206C>G c.267C>G c.(265-267)ccC>ccG p.P89P LUAD 1 145663350 145663350 + Missense_Mutation SNP A A T TCGA-MP-A4TE-01A-22D-A25L-08 TCGA-MP-A4TE-10A-01D-A25L-08 g.chr1:145663350A>T c.411A>T c.(409-411)agA>agT p.R137S LUSC 1 145650499 145650499 + Missense_Mutation SNP G G A TCGA-60-2698-01A-01D-1522-08 TCGA-60-2698-11A-01D-1522-08 g.chr1:145650499G>A c.178G>A c.(178-180)Ggc>Agc p.G60S OV 1 145682024 145682024 + Splice_Site SNP A A G TCGA-61-1899-01A-01W-0639-09 TCGA-61-1899-11A-01W-0639-09 g.chr1:145682024A>G c.430A>G c.(430-432)Ata>Gta p.I144V OV 1 145682046 145682046 + Missense_Mutation SNP G G A TCGA-13-0904-01A-02W-0420-08 TCGA-13-0904-10A-01D-0399-08 g.chr1:145682046G>A c.452G>A c.(451-453)gGa>gAa p.G151E PAAD 1 145663313 145663313 + Missense_Mutation SNP G G A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr1:145663313G>A c.374G>A c.(373-375)cGg>cAg p.R125Q PAAD 1 145682086 145682086 + Frame_Shift_Del DEL T T - TCGA-2J-AABU-01A-11D-A40W-08 TCGA-2J-AABU-10A-01D-A40W-08 g.chr1:145682086delT c.492delT c.(490-492)cctfs p.P164fs

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-EI-6917-01 COSM3418005 c.243G>A p.T81T Substitution - coding silent 1:145771896-145771896 - PD23567a COSM5800597 c.606C>A p.P202P Substitution - coding silent 1:145750468-145750468 + HN_62825 COSM125888 c.139G>A p.E47K Substitution - Missense 1:145788930-145788930 - TCGA-BP-4167-01 COSM1134687 c.668A>G p.D223G Substitution - Missense 1:145748110-145748110 - TCGA-BR-6452-01 COSM4021797 c.119G>A p.R40K Substitution - Missense 1:145788950-145788950 - TCGA-B0-5088-01 COSM462860 c.632C>G p.S211C Substitution - Missense 1:145750442-145750442 - 2_RESISTANT COSM1723273 c.492delT p.S166fs*24 Deletion - Frameshift 1:145752986-145752986 - TCGA-BS-A0UV-01 COSM895241 c.256G>T p.D86Y Substitution - Missense 1:145771883-145771883 - TCGA-61-1899-01 COSM1320029 c.430A>G p.I144V Substitution - Missense 1:145753048-145753048 - 2881_T COSM3976050 c.161G>T p.S54I Substitution - Missense 1:145788908-145788908 - CSCC-49-T COSM1688470 c.497C>T p.S166F Substitution - Missense 1:145752981-145752981 - NPC15F COSM4995260 c.599G>A p.G200D Substitution - Missense 1:145750475-145750475 - TCGA-DK-A2I4-01 COSM3788603 c.492T>C p.P164P Substitution - coding silent 1:145752986-145752986 - PTC_449 COSM5960078 c.529G>A p.D177N Substitution - Missense 1:145751482-145751482 - DLBCL-PatientD COSM221286 c.296A>G p.D99G Substitution - Missense 1:145771843-145771843 - S02234 COSM5675881 c.556G>T p.D186Y Substitution - Missense 1:145751455-145751455 + BD173T COSM5505691 c.219+3A>C p.? Unknown 1:145784536-145784536 - TCGA-C5-A1BK-01 COSM4826207 c.215C>T p.A72V Substitution - Missense 1:145784543-145784543 - TCGA-DK-A1AC-01 COSM1294940 c.846G>A p.Q282Q Substitution - coding silent 1:145746935-145746935 - YUDAB COSM1688470 c.497C>T p.S166F Substitution - Missense 1:145752981-145752981 - TCGA-AP-A051-01 COSM895243 c.684T>A p.C228* Substitution - Nonsense 1:145748094-145748094 - ESO-0015 COSM1264340 c.862G>A p.A288T Substitution - Missense 1:145746919-145746919 - HCC82T COSM1600719 c.724C>T p.R242W Substitution - Missense 1:145748054-145748054 - 0058_CRUK_PC_0058_T1_DNA COSM5420610 c.93C>A p.P31P Substitution - coding silent 1:145823781-145823781 - YUWAND COSM1688469 c.238C>T p.H80Y Substitution - Missense 1:145771901-145771901 - TCGA-EV-5901-01 COSM3984176 c.786T>A p.H262Q Substitution - Missense 1:145746995-145746995 - TCGA-CZ-5982-01 COSM462859 c.596C>G p.T199R Substitution - Missense 1:145750478-145750478 - CSCC-31-T COSM4507488 c.747C>T p.F249F Substitution - coding silent 1:145748031-145748031 - Au4 COSM5604712 c.664G>C p.V222L Substitution - Missense 1:145750410-145750410 - BD217T COSM5495343 c.424G>C p.E142Q Substitution - Missense 1:145771715-145771715 - TCGA-AX-A060-01 COSM895240 c.185G>A p.R62Q Substitution - Missense 1:145784573-145784573 - 9227_T COSM5040256 c.755G>A p.S252N Substitution - Missense 1:145748023-145748023 - KM12 COSM2121209 c.174T>C p.G58G Substitution - coding silent 1:145784584-145784584 - TCGA-UB-A7MB-01 COSM4932301 c.428G>C p.G143A Substitution - Missense 1:145771711-145771711 - BCM723T COSM5347983 c.608delC p.P203fs*13 Deletion - Frameshift 1:145750466-145750466 - EGC3 COSM5052506 c.725G>A p.R242Q Substitution - Missense 1:145748053-145748053 - C0089T COSM4140815 c.81C>T p.G27G Substitution - coding silent 1:145823793-145823793 - 587222 COSM1223887 c.260T>G p.F87C Substitution - Missense 1:145771879-145771879 - PT52 COSM1600719 c.724C>T p.R242W Substitution - Missense 1:145748054-145748054 - 990515 COSM1582192 c.220C>G p.L74V Substitution - Missense 1:145771919-145771919 - T3091 COSM4721958 c.49G>A p.A17T Substitution - Missense 1:145823825-145823825 - EGC20 COSM4507488 c.747C>T p.F249F Substitution - coding silent 1:145748031-145748031 - PD4123a COSM164035 c.604C>T p.P202S Substitution - Missense 1:145750470-145750470 - TCGA-60-2698-01 COSM674778 c.178G>A p.G60S Substitution - Missense 1:145784580-145784580 - CH-109-T2 COSM5650546 c.180C>T p.G60G Substitution - coding silent 1:145784578-145784578 + TCGA-DK-A2I4-01 COSM3788604 c.712G>A p.E238K Substitution - Missense 1:145748066-145748066 - TCGA-AC-A3W6-01 COSM3801665 c.892C>G p.L298V Substitution - Missense 1:145746889-145746889 - CSCC-6-T COSM4503330 c.637C>T p.P213S Substitution - Missense 1:145750437-145750437 - T3091 COSM4721959 c.358C>T p.R120W Substitution - Missense 1:145771781-145771781 - 343 COSM1742159 c.271C>T p.L91L Substitution - coding silent 1:145771868-145771868 - 6948_PT COSM5754167 c.578T>G p.L193* Substitution - Nonsense 1:145750496-145750496 + T3080 COSM4721960 c.822T>C p.G274G Substitution - coding silent 1:145746959-145746959 - TCGA-A6-6782-01 COSM1333622 c.228C>T p.G76G Substitution - coding silent 1:145771911-145771911 - TCGA-BS-A0UV-01 COSM895242 c.624G>T p.K208N Substitution - Missense 1:145750450-145750450 - BD217T COSM5495344 c.428+10T>C p.? Unknown 1:145771701-145771701 - RK178_C01 COSM3740611 c.740A>G p.N247S Substitution - Missense 1:145748038-145748038 - TCGA-EW-A1J5-01 COSM1472537 c.271C>G p.L91V Substitution - Missense 1:145771868-145771868 - 6948_CLM COSM5754167 c.578T>G p.L193* Substitution - Nonsense 1:145750496-145750496 + PD6047a COSM1600719 c.724C>T p.R242W Substitution - Missense 1:145748054-145748054 - 4537_T COSM3976051 c.783+1G>A p.? Unknown 1:145747994-145747994 - HCC82 COSM1600719 c.724C>T p.R242W Substitution - Missense 1:145748054-145748054 - TCGA-DK-A2I4-01 COSM3788605 c.715G>A p.E239K Substitution - Missense 1:145748063-145748063 - TCGA-13-0904-01 COSM72452 c.452G>A p.G151E Substitution - Missense 1:145753026-145753026 - 2318491 COSM3788604 c.712G>A p.E238K Substitution - Missense 1:145748066-145748066 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.523530;Hs.523550 1q21.1

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer C G Missense p.T199R c.596C>G 1 145684607 RCCC C G Synonymous p.P89P c.267C>G 1 145663206 LUAD C T Missense p.H77Y c.229C>T 1 145663168 CM C T Missense p.P202S c.604C>T 1 145684615 BRCA G A Missense p.A288T c.862G>A 1 145688167 ESCA G A Missense p.E238K c.712G>A 1 145687020 BLCA G A Missense p.E239K c.715G>A 1 145687023 BLCA G A Missense p.E47K c.139G>A 1 145646151 HNSC G A Missense p.G151E c.452G>A 1 145682046 OV G A Missense p.R62Q c.185G>A 1 145650506 UCEC G T IntronicSNV . c.103-16786G>T 1 145629329 CLL T C 3-UTRSNV . c.912+39T>C 1 145688256 CM T C Missense p.C22R c.64T>C 1 145611303 LUAD T G Missense p.F165L c.495T>G 1 145682089 CM