PTM - CPLM Gene Name UniProt ID Type Position Code IKBKG; FIP3; NEMO Q9Y6K9 Sumoylation 277 K IKBKG; FIP3; NEMO Q9Y6K9 Sumoylation 309 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 399 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 309 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 111 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 139 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 143 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 226 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 246 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 264 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 277 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 283 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 285 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 292 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 302 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 321 K IKBKG; FIP3; NEMO Q9Y6K9 Ubiquitination 344 K

PTM - dbPAF Gene Name UniProt ID Position Type Species IKBKG; FIP3; NEMO Q9Y6K9 178 S Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 186 S Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 297 T Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 308 Y Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 31 S Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 374 Y Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 376 S Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 377 S Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 383 S Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 387 S Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 43 S Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 68 S Homo sapiens(Human) IKBKG; FIP3; NEMO Q9Y6K9 85 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9Y6K9 K255-ac Acetylation SVVGsERkRGMQLED Q9Y6K9 S8-p Phosphorylation MNRHLWKsQLCEMVQ Q9Y6K9 S17-p Phosphorylation LCEMVQPsGGPAADQ Q9Y6K9 S31-p Phosphorylation QDVLGEEsPLGKPAM Q9Y6K9 S43-p Phosphorylation PAMLHLPsEQGAPET Q9Y6K9 S68-p Phosphorylation LRDAIRQsNQILRER Q9Y6K9 S85-p Phosphorylation ELLHFQAsQREEKEF Q9Y6K9 S178-p Phosphorylation EGRARAAsEQARQLE Q9Y6K9 S196-p Phosphorylation EALQQQHsVQVDQLR Q9Y6K9 S252-p Phosphorylation IKSSVVGsERkRGMQ Q9Y6K9 T297-p Phosphorylation QHkIVMEtVPVLKAQ Q9Y6K9 Y308-p Phosphorylation LKAQADIykADFQAE Q9Y6K9 Y374-p Phosphorylation PLPPAPAyLssPLAL Q9Y6K9 S376-p Phosphorylation PPAPAyLssPLALPs Q9Y6K9 S377-p Phosphorylation PAPAyLssPLALPsQ Q9Y6K9 S383-p Phosphorylation ssPLALPsQRRsPPE Q9Y6K9 S387-p Phosphorylation ALPsQRRsPPEEPPD Q9Y6K9 K277-sm Sumoylation AEEALVAkQEVIDkL Q9Y6K9 K309-sm Sumoylation KAQADIykADFQAER Q9Y6K9 K111-ub Ubiquitination VERLGLEkLDLKRQK Q9Y6K9 K143-ub Ubiquitination AEDKASVkAQVTSLL Q9Y6K9 K277-ub Ubiquitination AEEALVAkQEVIDkL Q9Y6K9 K283-ub Ubiquitination AkQEVIDkLkEEAEQ Q9Y6K9 K285-ub Ubiquitination QEVIDkLkEEAEQHk Q9Y6K9 K292-ub Ubiquitination kEEAEQHkIVMEtVP Q9Y6K9 K309-ub Ubiquitination KAQADIykADFQAER Q9Y6K9 K321-ub Ubiquitination AERQAREkLAEkkEL Q9Y6K9 K325-ub Ubiquitination AREkLAEkkELLQEQ Q9Y6K9 K326-ub Ubiquitination REkLAEkkELLQEQL Q9Y6K9 K344-ub Ubiquitination QREYSKLkASCQESA Q9Y6K9 K399-ub Ubiquitination PPDFCCPkCQYQAPD

PTM - dbPTM UniProt ID Position Code Type Resources References Q9Y6K9 31 S Phosphorylation Swiss-Prot 1010711 12657630 Q9Y6K9 43 S Phosphorylation Swiss-Prot 1010711 12657630 Q9Y6K9 68 S Phosphorylation Swiss-Prot 1010711 17977820 Q9Y6K9 85 S Phosphorylation Swiss-Prot 1010711 16497931 Q9Y6K9 111 K Ubiquitylation Swiss-Prot 1010711 21455181 Q9Y6K9 139 K Ubiquitylation Swiss-Prot 1010711 21455181 Q9Y6K9 143 K Ubiquitylation Swiss-Prot 1010711 21455181 Q9Y6K9 226 K Ubiquitylation Swiss-Prot 1010711 21455181 Q9Y6K9 246 K Ubiquitylation Swiss-Prot 1010711 21455181 Q9Y6K9 264 K Ubiquitylation Swiss-Prot 1010711 21455181 Q9Y6K9 277 K Sumoylation Swiss-Prot 1010711 14651848;21455181 Q9Y6K9 283 K Ubiquitylation Swiss-Prot 1010711 21455181 Q9Y6K9 285 K Ubiquitylation Swiss-Prot 1010711 15620648;19136968;21455181 Q9Y6K9 292 K Ubiquitylation Swiss-Prot 1010711 21455181 Q9Y6K9 302 K Ubiquitylation Swiss-Prot 1010711 21455181 Q9Y6K9 309 K Sumoylation Swiss-Prot 1010711 14651848;19136968;20010814;21455181 Q9Y6K9 321 K Ubiquitylation Swiss-Prot 1010711 20010814 Q9Y6K9 374 Y Phosphorylation Swiss-Prot 1010711 19369195 Q9Y6K9 376 S Phosphorylation Swiss-Prot 1010711 12657630 Q9Y6K9 377 S Phosphorylation Swiss-Prot 1010711 18669648 Q9Y6K9 387 S Phosphorylation Swiss-Prot 1010711 18669648;19369195 Q9Y6K9 399 K Ubiquitylation Swiss-Prot 1010711 14695475 Q9Y6K9 277 K Ubiquitylation Swiss-Prot 1010711 - Q9Y6K9 309 K Ubiquitylation Swiss-Prot 1010711 - Q9Y6K9 377 S Phosphorylation PhosphoELM.10011 18669648 Q9Y6K9 387 S Phosphorylation PhosphoELM.10011 18669648 Q9Y6K9 85 S Phosphorylation PhosphoELM.10011 16497931 Q9Y6K9 31 S Phosphorylation PhosphoELM.10011 12657630 Q9Y6K9 43 S Phosphorylation PhosphoELM.10011 12657630 Q9Y6K9 376 S Phosphorylation PhosphoELM.10011 12657630 Q9Y6K9 277 K Sumoylation Phosphositeplus.1010730 14651848;16906147;20065354 Q9Y6K9 309 K Sumoylation Phosphositeplus.1010730 14651848;16906147;20065354 Q9Y6K9 277 K Ubiquitylation Phosphositeplus.1010730 14651848 Q9Y6K9 285 K Ubiquitylation Phosphositeplus.1010730 15620648;17728323;19136968;20932475;21811235;21906983 Q9Y6K9 309 K Ubiquitylation Phosphositeplus.1010730 14651848;19136968;21811235;21890473 Q9Y6K9 321 K Ubiquitylation Phosphositeplus.1010730 17728323 Q9Y6K9 325 K Ubiquitylation Phosphositeplus.1010730 17728323 Q9Y6K9 326 K Ubiquitylation Phosphositeplus.1010730 17728323 Q9Y6K9 344 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9Y6K9 399 K Ubiquitylation Phosphositeplus.1010730 14695475;15125833;17728323 Q9Y6K9 31 S Phosphorylation Phosphositeplus.1010730 12657630 Q9Y6K9 376 S Phosphorylation Phosphositeplus.1010730 12657630;18922932 Q9Y6K9 377 S Phosphorylation Phosphositeplus.1010730 18669648 Q9Y6K9 383 S Phosphorylation Phosphositeplus.1010730 20068231 Q9Y6K9 387 S Phosphorylation Phosphositeplus.1010730 18669648;19369195 Q9Y6K9 43 S Phosphorylation Phosphositeplus.1010730 12657630;17977820 Q9Y6K9 68 S Phosphorylation Phosphositeplus.1010730 17977820 Q9Y6K9 85 S Phosphorylation Phosphositeplus.1010730 16497931;17977820;20932476;21811235 Q9Y6K9 297 T Phosphorylation Phosphositeplus.1010730 20068231 Q9Y6K9 377 S Phosphorylation HPRD 9.0 18669648,18691976,20068231 Q9Y6K9 383 S Phosphorylation HPRD 9.0 20068231 Q9Y6K9 387 S Phosphorylation HPRD 9.0 18669648 Q9Y6K9 297 T Phosphorylation HPRD 9.0 20068231 Q9Y6K9 31 S Phosphorylation (IKBKB) HPRD 9.0 12657630 Q9Y6K9 43 S Phosphorylation (IKBKB) HPRD 9.0 12657630 Q9Y6K9 376 S Phosphorylation (IKBKB) HPRD 9.0 12657630,18691976 Q9Y6K9 399 K Ubiquitylation HPRD 9.0 17363905 Q9Y6K9 377 S Phosphorylation SysPTM 1.1 18669648 Q9Y6K9 387 S Phosphorylation SysPTM 1.1 18669648 Q9Y6K9 399 K Ubiquitylation UbiProtDB 1.0 14695475

PTM - HPRD Symbol Position Code Type References IKBKG 297 T Phosphorylation 20068231 IKBKG 31 S Phosphorylation 12657630 IKBKG 376 S Phosphorylation 12657630,18691976 IKBKG 377 S Phosphorylation 18669648,18691976,20068231 IKBKG 383 S Phosphorylation 20068231 IKBKG 387 S Phosphorylation 18669648 IKBKG 399 K Ubiquitination 17363905 IKBKG 43 S Phosphorylation 12657630

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9Y6K9 85 S 16497931 ATM LTP Phosphorylation Q9Y6K9 387 S 18669648 HTP Phosphorylation Q9Y6K9 43 S 12657630 IKK_beta LTP Phosphorylation Q9Y6K9 376 S 12657630 IKK_beta LTP Phosphorylation Q9Y6K9 377 S 18669648 HTP Phosphorylation Q9Y6K9 31 S 12657630 IKK_beta LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9Y6K9 31 Phosphoserine; by IKKB 12657630 Q9Y6K9 43 Phosphoserine; by IKKB 12657630 Q9Y6K9 68 Phosphoserine 17977820 Q9Y6K9 85 Phosphoserine; by ATM 16497931 Q9Y6K9 376 Phosphoserine; by IKKB 12657630 Q9Y6K9 387 Phosphoserine 24275569;24012789

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type IKBKG IPI00002411 S 387 LPSQRRpSPPEEPP phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 8517 114089 - K Ubiquitination 17135271 8517 114089 - K Sumoylation 16360037 8517 114089 - K Ubiquitination 16360037 8517 114089 - K Ubiquitination 14748687 8517 114089 - K Sumoylation 14651848 8517 114089 - K Ubiquitination 14651848 8517 114089 - K Ubiquitination 12867425 8517 114089 - K Ubiquitination 19897484 8517 114089 - K Ubiquitination 17314283 8517 114089 - K Ubiquitination 19820708 8517 114089 - K Ubiquitination 20010814 8517 114089 - K Ubiquitination 21896478 8517 114089 - K Ubiquitination 21184742 8517 114089 - K Ubiquitination 21220427 8517 114089 - K Ubiquitination 19365808 8517 114089 - K Ubiquitination 20932475 8517 114089 - K Sumoylation 20932475 8517 114089 - K Ubiquitination 20164171 8517 114089 - K Neddylation 21474709 8517 114089 - K Ubiquitination 20837477 8517 114089 - K Ubiquitination 22118674 8517 114089 - K Ubiquitination 18952891 8517 114089 - K Ubiquitination 15620648 8517 114089 - K Ubiquitination 21513986 8517 114089 - K Ubiquitination 21139048 8517 114089 - K Ubiquitination 21890473 8517 114089 - K Ubiquitination 21906983 8517 114089 - K Ubiquitination 19854204 8517 114089 - K Ubiquitination 18212736 8517 114089 - K Ubiquitination 16497931 8517 114089 - K Ubiquitination 20724660 8517 114089 - K Sumoylation 21777808 8517 114089 - K Ubiquitination 21862596 8517 114089 - K Ubiquitination 18620544 8517 114089 - K Ubiquitination 17728323 8517 114089 - K Ubiquitination 21097508 8517 114089 - K Ubiquitination 23032187 8517 114089 - K Ubiquitination 21458669 8517 114089 - K Ubiquitination 22505724 8517 114089 - K Ubiquitination 19880420 8517 114089 - K Ubiquitination 22732732 8517 114089 - K Ubiquitination 16874300 8517 114089 - K Ubiquitination 17363905 8517 114089 - K Ubiquitination 21811235 8517 114089 - K Ubiquitination 14695475 8517 114089 - K Sumoylation 18583959 8517 114089 - K Ubiquitination 21963094 8517 114089 - K Ubiquitination 23000965 8517 114089 - K Ubiquitination 23575687 8517 114089 - K Ubiquitination 23746843 8517 114089 - K Ubiquitination 23102662 8517 114089 - K Ubiquitination 23732909 8517 114089 - K Ubiquitination 24100029 8517 114089 - K Ubiquitination 24270572 8517 114089 - K Ubiquitination 24456201 8517 114089 - K Ubiquitination 24270048 8517 114089 - K Ubiquitination 24586659 8517 114089 - K Ubiquitination 24469399 8517 114089 - K Ubiquitination 24491438 8517 114089 - K Ubiquitination 24832601 8517 114089 - K Ubiquitination 24816145 8517 114089 - K Ubiquitination 23131831 8517 114089 - K Ubiquitination 24957606 8517 114089 - K Ubiquitination 25152375 8517 114089 - K Ubiquitination 24457965 8517 114089 - K Sumoylation 24457965 8517 114089 - K Ubiquitination 24020126 8517 114089 - K Ubiquitination 21115689 8517 114089 - K Ubiquitination 19675569 8517 114089 - K Ubiquitination 20959607 8517 114089 - K Sumoylation 20959607 8517 114089 - K Sumoylation 16906147 8517 114089 - K Ubiquitination 18362144 8517 114089 - K Ubiquitination 18931663

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID IKBKG Homo sapiens (Human) 258 "258,AQADIYKADFQAE" 258:21890473 IKBKG Homo sapiens (Human) 100 "100,EVIDKLKEEAEQH" 100:21906983 IKBKG Homo sapiens (Human) 210 "210,REYSKLKASCQES" 210:21906983 IKBKG Homo sapiens (Human) 308; 277; 336 "308,AQADIYKADFQAE; 277,EVIDKLKEEAEQH; 336,REYSKLKASCQES" 308:21890473; 277:21906983; 336:21906983 IKBKG Homo sapiens (Human) 278; 337 "278,EVIDKLKEEAEQH; 337,REYSKLKASCQES" 278:21906983; 337:21906983 IKBKG Homo sapiens (Human) 377 "377,AQADIYKADFQAE" 377:21890473 IKBKG Homo sapiens (Human) 168 "168,AQADIYKADFQAE" 168:21890473; 285:21906983; 344:21906983 IKBKG Homo sapiens (Human) 309 "309,AQADIYKADFQAE" 309:21890473 IKBKG Homo sapiens (Human) 308 "308,AQADIYKADFQAE" 234:21906983; 293:21906983; 308:21890473