Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 11 8009015 8009015 + Missense_Mutation SNP C C T TCGA-OR-A5L4-01A-11D-A29I-10 TCGA-OR-A5L4-10A-01D-A29L-10 g.chr11:8009015C>T c.116C>T c.(115-117)cCc>cTc p.P39L BLCA 11 8009014 8009014 + Missense_Mutation SNP C C T TCGA-DK-AA75-01A-11D-A391-08 TCGA-DK-AA75-10A-01D-A394-08 g.chr11:8009014C>T c.115C>T c.(115-117)Ccc>Tcc p.P39S BLCA 11 8013370 8013370 + Nonsense_Mutation SNP C C A TCGA-K4-A54R-01A-11D-A26M-08 TCGA-K4-A54R-10A-01D-A26K-08 g.chr11:8013370C>A c.407C>A c.(406-408)tCa>tAa p.S136* BLCA 11 8014480 8014480 + Missense_Mutation SNP G G A TCGA-DK-A1AC-01A-11D-A13W-08 TCGA-DK-A1AC-10A-01D-A13W-08 g.chr11:8014480G>A c.562G>A c.(562-564)Gag>Aag p.E188K BLCA 11 8016018 8016018 + Silent SNP G G A TCGA-DK-A6AW-01A-11D-A30E-08 TCGA-DK-A6AW-10A-01D-A30H-08 g.chr11:8016018G>A c.699G>A c.(697-699)acG>acA p.T233T BRCA 11 8013646 8013646 + Nonsense_Mutation SNP G G T TCGA-AC-A5XS-01A-11D-A29N-09 TCGA-AC-A5XS-11A-13D-A29N-09 g.chr11:8013646G>T c.451G>T c.(451-453)Gaa>Taa p.E151* BRCA 11 8016560 8016560 + Silent SNP C C T TCGA-D8-A13Z-01A-11D-A10Y-09 TCGA-D8-A13Z-10A-01D-A110-09 g.chr11:8016560C>T c.777C>T c.(775-777)ccC>ccT p.P259P COAD 11 8013337 8013337 + Missense_Mutation SNP A A T TCGA-AA-3715-01A-01W-0900-09 TCGA-AA-3715-10A-01W-0900-09 g.chr11:8013337A>T c.374A>T c.(373-375)gAc>gTc p.D125V COAD 11 8016557 8016557 + Silent SNP C C T TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr11:8016557C>T c.774C>T c.(772-774)agC>agT p.S258S COAD 11 8016616 8016616 + Missense_Mutation SNP G G A TCGA-D5-6924-01A-11D-1924-10 TCGA-D5-6924-10A-01D-1924-10 g.chr11:8016616G>A c.833G>A c.(832-834)cGc>cAc p.R278H COAD 11 8016859 8016859 + Missense_Mutation SNP A A G TCGA-AA-3845-01A-01W-0995-10 TCGA-AA-3845-10A-01W-0995-10 g.chr11:8016859A>G c.941A>G c.(940-942)cAa>cGa p.Q314R COADREAD 11 8009135 8009135 + Missense_Mutation SNP G G A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr11:8009135G>A c.236G>A c.(235-237)gGt>gAt p.G79D COADREAD 11 8013337 8013337 + Missense_Mutation SNP A A T TCGA-AA-3715-01A-01W-0900-09 TCGA-AA-3715-10A-01W-0900-09 g.chr11:8013337A>T c.374A>T c.(373-375)gAc>gTc p.D125V COADREAD 11 8013365 8013365 + Nonsense_Mutation SNP C C A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr11:8013365C>A c.402C>A c.(400-402)tgC>tgA p.C134* COADREAD 11 8013380 8013380 + Silent SNP C C T TCGA-AG-3581-01A-01W-0831-10 TCGA-AG-3581-10A-01W-0831-10 g.chr11:8013380C>T c.417C>T c.(415-417)caC>caT p.H139H COADREAD 11 8016557 8016557 + Silent SNP C C T TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr11:8016557C>T c.774C>T c.(772-774)agC>agT p.S258S COADREAD 11 8016616 8016616 + Missense_Mutation SNP G G A TCGA-D5-6924-01A-11D-1924-10 TCGA-D5-6924-10A-01D-1924-10 g.chr11:8016616G>A c.833G>A c.(832-834)cGc>cAc p.R278H COADREAD 11 8016859 8016859 + Missense_Mutation SNP A A G TCGA-AA-3845-01A-01W-0995-10 TCGA-AA-3845-10A-01W-0995-10 g.chr11:8016859A>G c.941A>G c.(940-942)cAa>cGa p.Q314R DLBC 11 8016899 8016899 + Silent SNP C C G TCGA-GS-A9TZ-01A-11D-A38X-10 TCGA-GS-A9TZ-10A-01D-A38X-10 g.chr11:8016899C>G c.981C>G c.(979-981)ctC>ctG p.L327L ESCA 11 8015982 8015982 + Missense_Mutation SNP G G T TCGA-L5-A4OJ-01A-11D-A27G-09 TCGA-L5-A4OJ-11A-12D-A27G-09 g.chr11:8015982G>T c.663G>T c.(661-663)atG>atT p.M221I LIHC 11 8017529 8017529 + Missense_Mutation SNP A A T TCGA-CC-A5UD-01A-11D-A28X-10 TCGA-CC-A5UD-10A-01D-A28X-10 g.chr11:8017529A>T c.1034A>T c.(1033-1035)cAg>cTg p.Q345L LUAD 11 8008911 8008911 + Silent SNP G G T TCGA-86-8585-01A-11D-2393-08 TCGA-86-8585-10A-01D-2393-08 g.chr11:8008911G>T c.12G>T c.(10-12)ccG>ccT p.P4P LUAD 11 8008914 8008914 + Silent SNP G G C TCGA-17-Z022-01A-01W-0746-08 TCGA-17-Z022-11A-01W-0746-08 g.chr11:8008914G>C c.15G>C c.(13-15)gcG>gcC p.A5A LUAD 11 8008941 8008941 + Silent SNP G G A TCGA-17-Z053-01A-01W-0747-08 TCGA-17-Z053-11A-01W-0747-08 g.chr11:8008941G>A c.42G>A c.(40-42)acG>acA p.T14T LUAD 11 8009161 8009161 + Missense_Mutation SNP G G A TCGA-44-5644-01A-21D-2036-08 TCGA-44-5644-10A-01D-2036-08 g.chr11:8009161G>A c.262G>A c.(262-264)Ggc>Agc p.G88S LUAD 11 8013694 8013694 + Nonsense_Mutation SNP G G T TCGA-55-7995-01A-11D-2184-08 TCGA-55-7995-10A-01D-2184-08 g.chr11:8013694G>T c.499G>T c.(499-501)Gag>Tag p.E167* LUSC 11 8016065 8016065 + Splice_Site SNP G G T TCGA-66-2766-01A-01D-1522-08 TCGA-66-2766-11A-01D-1522-08 g.chr11:8016065G>T c.e7+1 LUSC 11 8016879 8016879 + Missense_Mutation SNP G G C TCGA-39-5030-01A-01D-1441-08 TCGA-39-5030-11A-01D-1441-08 g.chr11:8016879G>C c.961G>C c.(961-963)Gat>Cat p.D321H PAAD 11 8014505 8014505 + Missense_Mutation SNP A A C TCGA-FB-AAPU-01A-31D-A40W-08 TCGA-FB-AAPU-11A-12D-A40W-08 g.chr11:8014505A>C c.587A>C c.(586-588)aAc>aCc p.N196T PRAD 11 8013378 8013378 + Missense_Mutation SNP C C T TCGA-XK-AAIW-01A-11D-A41K-08 TCGA-XK-AAIW-10A-01D-A41N-08 g.chr11:8013378C>T c.415C>T c.(415-417)Cac>Tac p.H139Y PRAD 11 8017564 8017564 + Missense_Mutation SNP C C A TCGA-XK-AAIW-01A-11D-A41K-08 TCGA-XK-AAIW-10A-01D-A41N-08 g.chr11:8017564C>A c.1069C>A c.(1069-1071)Ctg>Atg p.L357M READ 11 8009135 8009135 + Missense_Mutation SNP G G A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr11:8009135G>A c.236G>A c.(235-237)gGt>gAt p.G79D READ 11 8013365 8013365 + Nonsense_Mutation SNP C C A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr11:8013365C>A c.402C>A c.(400-402)tgC>tgA p.C134* READ 11 8013380 8013380 + Silent SNP C C T TCGA-AG-3581-01A-01W-0831-10 TCGA-AG-3581-10A-01W-0831-10 g.chr11:8013380C>T c.417C>T c.(415-417)caC>caT p.H139H SKCM 11 8013684 8013684 + Silent SNP T T A TCGA-EE-A2M5-06A-12D-A197-08 TCGA-EE-A2M5-10A-01D-A199-08 g.chr11:8013684T>A c.489T>A c.(487-489)gtT>gtA p.V163V SKCM 11 8014441 8014441 + Missense_Mutation SNP A A C TCGA-D3-A3CB-06A-11D-A196-08 TCGA-D3-A3CB-10A-01D-A198-08 g.chr11:8014441A>C c.523A>C c.(523-525)Acg>Ccg p.T175P SKCM 11 8014500 8014500 + Silent SNP C C T TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr11:8014500C>T c.582C>T c.(580-582)gcC>gcT p.A194A SKCM 11 8016539 8016539 + Silent SNP C C T TCGA-GN-A266-06A-11D-A197-08 TCGA-GN-A266-10A-01D-A199-08 g.chr11:8016539C>T c.756C>T c.(754-756)atC>atT p.I252I SKCM 11 8016890 8016890 + Silent SNP G G A TCGA-EE-A2A2-06A-11D-A196-08 TCGA-EE-A2A2-10A-01D-A198-08 g.chr11:8016890G>A c.972G>A c.(970-972)gaG>gaA p.E324E

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-39-5030-01 COSM690490 c.961G>C p.D321H Substitution - Missense 11:7995332-7995332 + TCGA-AP-A051-01 COSM932462 c.773G>T p.S258I Substitution - Missense 11:7995009-7995009 + TCGA-AG-3581-01 COSM287856 c.417C>T p.H139H Substitution - coding silent 11:7991833-7991833 + S02274 COSM5682384 c.280C>T p.L94L Substitution - coding silent 11:7987632-7987632 + sysucc-880T COSM1492728 c.923T>C p.L308P Substitution - Missense 11:7995294-7995294 + LC_C9 COSM1188161 c.1008G>T p.M336I Substitution - Missense 11:7995956-7995956 + TCGA-A6-5667-01 COSM3687677 c.116C>T p.P39L Substitution - Missense 11:7987468-7987468 + TCGA-A3-3363-01 COSM1492728 c.923T>C p.L308P Substitution - Missense 11:7995294-7995294 + PD18730a COSM5787164 c.703C>T p.L235L Substitution - coding silent 11:7994475-7994475 + TCGA-BR-8679-01 COSM4037030 c.117C>T p.P39P Substitution - coding silent 11:7987469-7987469 + T3064 COSM4680611 c.16G>A p.V6I Substitution - Missense 11:7987368-7987368 + BD72T COSM5512755 c.726C>T p.Y242Y Substitution - coding silent 11:7994498-7994498 + S00050 COSM5657045 c.142G>T p.D48Y Substitution - Missense 11:7987494-7987494 + TCGA-D1-A16N-01 COSM932461 c.524C>T p.T175M Substitution - Missense 11:7992895-7992895 + TCGA-66-2766-01 COSM690491 c.745+1G>T p.? Unknown 11:7994518-7994518 + Gp5D COSM2220200 c.718G>T p.A240S Substitution - Missense 11:7994490-7994490 + 7 COSM327354 c.549_550delTG p.V184fs*61 Deletion - Frameshift 11:7992920-7992921 + TCGA-AC-A5XS-01 COSM4390962 c.451G>T p.E151* Substitution - Nonsense 11:7992099-7992099 + T368 COSM4680613 c.100G>A p.A34T Substitution - Missense 11:7987452-7987452 + TCGA-D7-A4YT-01 COSM4037032 c.336T>G p.G112G Substitution - coding silent 11:7987688-7987688 + T16 COSM5617915 c.887G>C p.G296A Substitution - Missense 11:7995258-7995258 + S02255 COSM5680442 c.636C>G p.S212R Substitution - Missense 11:7993007-7993007 + TCGA-D5-6924-01 COSM1357315 c.833G>A p.R278H Substitution - Missense 11:7995069-7995069 + TCGA-D8-A13Z-01 COSM429953 c.777C>T p.P259P Substitution - coding silent 11:7995013-7995013 + PTC-7C COSM4146366 c.561C>T p.H187H Substitution - coding silent 11:7992932-7992932 + ME045T COSM229537 c.684G>A p.M228I Substitution - Missense 11:7994456-7994456 + STC246 COSM5051164 c.898G>A p.A300T Substitution - Missense 11:7995269-7995269 + HCC127T COSM5822925 c.976A>G p.M326V Substitution - Missense 11:7995347-7995347 + TCGA-FW-A3R5-06 COSM3870300 c.582C>T p.A194A Substitution - coding silent 11:7992953-7992953 + TCGA-AA-3715-01 COSM269086 c.374A>T p.D125V Substitution - Missense 11:7991790-7991790 + T3225 COSM4680615 c.525G>A p.T175T Substitution - coding silent 11:7992896-7992896 + ESCC-249T COSM3935646 c.481A>T p.K161* Substitution - Nonsense 11:7992129-7992129 + TCGA-EE-A2M5-06 COSM3453843 c.489T>A p.V163V Substitution - coding silent 11:7992137-7992137 + TCGA-E3-A3E5-01 COSM3368581 c.654-2A>T p.? Unknown 11:7994424-7994424 + 86571 COSM94185 c.910G>C p.V304L Substitution - Missense 11:7995281-7995281 + TCGA-AZ-6601-01 COSM1357314 c.774C>T p.S258S Substitution - coding silent 11:7995010-7995010 + TCGA-CD-8527-01 COSM4037028 c.112G>C p.V38L Substitution - Missense 11:7987464-7987464 + LOVO COSM4645082 c.130G>A p.A44T Substitution - Missense 11:7987482-7987482 + 2492712 COSM5718960 c.789T>A p.I263I Substitution - coding silent 11:7995025-7995025 + BN31T COSM1605279 c.451_452insA p.F152fs*3 Insertion - Frameshift 11:7992099-7992100 + TCGA-EE-A2A2-06 COSM3453849 c.972G>A p.E324E Substitution - coding silent 11:7995343-7995343 + SJDOSTEOS002 COSM5759713 c.997_998insA p.D333fs*20 Insertion - Frameshift 11:7995945-7995946 + LUAD-F00170 COSM366785 c.664_665GG>TT p.G222>? Complex 11:7994436-7994437 + BCM783T COSM4799431 c.630C>T p.R210R Substitution - coding silent 11:7993001-7993001 + BCM783T COSM4799431 c.630C>T p.R210R Substitution - coding silent 11:7993001-7993001 + T1743 COSM4680617 c.1005G>C p.L335F Substitution - Missense 11:7995953-7995953 + J65_T COSM3953851 c.774C>A p.S258R Substitution - Missense 11:7995010-7995010 + TCGA-GN-A266-06 COSM3453847 c.756C>T p.I252I Substitution - coding silent 11:7994992-7994992 + TCGA-DK-A1AC-01 COSM1298681 c.562G>A p.E188K Substitution - Missense 11:7992933-7992933 + PCSI_0506_Pa_P_526 COSM4808891 c.138C>T p.S46S Substitution - coding silent 11:7987490-7987490 + I2L-P7-Tumor-Organoid COSM5361149 c.818G>A p.G273E Substitution - Missense 11:7995054-7995054 + OSCC-GB_00560111 COSM4883613 c.363G>T p.L121F Substitution - Missense 11:7987715-7987715 + TCGA-D3-A3CB-06 COSM3870298 c.523A>C p.T175P Substitution - Missense 11:7992894-7992894 + Gp2D COSM2220200 c.718G>T p.A240S Substitution - Missense 11:7994490-7994490 + SC_9047 COSM5573414 c.365-1G>T p.? Unknown 11:7991780-7991780 + PD11372a COSM5800716 c.247C>G p.P83A Substitution - Missense 11:7987599-7987599 + TCGA-AG-A002-01 COSM289682 c.236G>A p.G79D Substitution - Missense 11:7987588-7987588 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.515976;Hs.515985;Hs.516023 11p15.4 603914 2432519|CGAP|BC000490|C/T|coding|His187His|566|Validated; 2432520|CGAP|BC000490|C/T|coding|Ala114Ala|347|Candidate; 2432521|CGAP|BC000490|A/G|non-coding||1139|Candidate; 2453544|CGAP|BC000490|G/T|coding|Trp172Leu|520|Candidate; 2453548|CGAP|BC000490|C/T|coding|Ala114Ala|347|Candidate; 2453549|CGAP|BC000490|C/T|coding|His187His|566|Validated

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A C Missense p.T175P c.523A>C 11 8014441 CM A G 5-UTRSNV . c.1-45A>G 11 8008855 THCA A G 5-UTRSNV . c.1-94A>G 11 8008806 ESCA A T SpliceAcceptorSNV . c.654-2A>T 11 8015971 THCA C A 3-UTRSNV . c.1071+561C>A 11 8018127 MB C T 3-UTRSNV . c.1071+3590C>T 11 8021156 HC C T 5-UTRSNV . c.1-148C>T 11 8008752 CM C T 5-UTRSNV . c.1-46C>T 11 8008854 CM C T 5-UTRSNV . c.1-90C>T 11 8008810 CM C T IntronicSNV . c.996+128C>T 11 8017042 CM C T IntronicSNV . c.996+9C>T 11 8016923 CM C T Missense p.T175M c.524C>T 11 8014442 UCEC C T Synonymous p.H139H c.417C>T 11 8013380 COREAD C T Synonymous p.P259P c.777C>T 11 8016560 BRCA G A Missense p.D333N c.997G>A 11 8017492 LUAD G A Missense p.M228I c.684G>A 11 8016003 CM G A Missense p.R210H c.629G>A 11 8014547 THCA G A Synonymous p.E324E c.972G>A 11 8016890 CM G C Missense p.D321H c.961G>C 11 8016879 LUSC G C Synonymous p.A5A c.15G>C 11 8008914 LUAD G T 5-UTRSNV . c.1-144G>T 11 8008756 ESCA G T SpliceDonorSNV . c.745+1G>T 11 8016065 LUSC T A Synonymous p.V163V c.489T>A 11 8013684 CM T G Missense p.V312G c.935T>G 11 8016853 CM