Disease associated variation - ClinVar Allele ID Type Name RS#dbSNP Phenotype IDs Chromosome Start Stop Reference Alternate 16169 single nucleotide variant NM_030803.6(ATG16L1):c.898A>G (p.Thr300Ala) 2241880 MedGen:CN169374 2 234183368 234183368 A G 16169 single nucleotide variant NM_030803.6(ATG16L1):c.898A>G (p.Thr300Ala) 2241880 MedGen:CN169374 2 233274722 233274722 A G 193644 single nucleotide variant NM_030803.6(ATG16L1):c.220G>A (p.Asp74Asn) 794727513 MedGen:CN169374 2 234171786 234171786 G A 193644 single nucleotide variant NM_030803.6(ATG16L1):c.220G>A (p.Asp74Asn) 794727513 MedGen:CN169374 2 233263140 233263140 G A

Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 2 234158839 rs10210302 C T rs10210302 5.00E-14 Crohn's disease HPOID:0100280 DOID:8778 T nearGene-5 GWASdb_trait 2 234161448 rs6752107 G A rs6752107 3.80E-05 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 234161769 rs6431654 C T rs6431654 1.39E-16 Multiple complex diseases HPOID:0000118 NA C intron GWASdb_trait 2 234170397 rs6737398 G A rs6737398 1.23E-06 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 2 234173503 rs12994997 G A rs12994997 4.00E-70 Crohn's disease HPOID:0100280 DOID:8778 G intron GWASdb_trait 2 234180410 rs3828309 A G rs3828309 7.98E-05 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 2 234180410 rs3828309 A G rs3828309 2.00E-32 Crohn's disease HPOID:0100280 DOID:8778 T intron GWASdb_trait 2 234180410 rs3828309 A G rs3828309 2.00E-32 Asthma HPOID:0002099 DOID:2841 T intron GWASdb_trait 2 234180410 rs3828309 A G rs3828309 2.36E-32 Multiple sclerosis HPOID:0000096|HPOID:0001967|HPOID:0009741|HPOID:0008664|HPOID:0001150|HPOID:0005450|HPOID:0005652|HPOID:0005686|HPOID:0005789|HPOID:0100923|HPOID:0100925|HPOID:0006623|HPOID:0100861|HPOID:0002694|HPOID:0004979|HPOID:0003881|HPOID:0003991|HPOID:0003854|HPOID:0003933|HPOID:0004030|HPOID:0100899|HPOID:0002634 DOID:2377 T intron GWASdb_trait 2 234182025 rs2289473 C A,G,T rs2289473 1.20E-07 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234183368 rs2241880 A G rs2241880 1.00E-13 Crohn's disease HPOID:0100280 DOID:8778 T missense GWASdb_trait 2 234183368 rs2241880 A G rs2241880 8.68E-07 Crohn's disease HPOID:0100280 DOID:8778 T missense GWASdb_trait 2 234183368 rs2241880 A G rs2241880 4.61E-25 Crohn's disease HPOID:0100280 DOID:8778 T missense GWASdb_trait 2 234183368 rs2241880 A G rs2241880 3.00E-06 Crohn's disease HPOID:0100280 DOID:8778 T missense GWASdb_trait 2 234183368 rs2241880 A G rs2241880 1.00E-12 Crohn's disease HPOID:0100280 DOID:8778 T missense GWASdb_trait 2 234184417 rs3792109 G A rs3792109 7.00E-41 Crohn's disease HPOID:0100280 DOID:8778 T intron GWASdb_trait 2 234184417 rs3792109 G A rs3792109 5.00E-09 Crohn's disease HPOID:0100280 DOID:8778 T intron GWASdb_trait 2 234190740 rs3792106 T C rs3792106 2.60E-13 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 234192251 rs4663396 C T rs4663396 7.58E-08 Multiple complex diseases HPOID:0000118 NA C intron GWASdb_trait 2 234194755 rs7587051 G C rs7587051 3.60E-10 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234199401 rs11890449 C T rs11890449 6.13E-04 Multiple complex diseases HPOID:0000118 NA C intron GWASdb_trait 2 234199537 rs6431262 G T rs6431262 6.28E-05 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 2 234201700 rs4663421 G C rs4663421 1.30E-04 Multiple complex diseases HPOID:0000118 NA C intron GWASdb_trait

Disease associated variation - GWAS Central Study Name Source Marker Accession Chromosome Marker Start Marker Stop Alleles Gene Section P-value -log(p-value) GWAS of prostate cancer rs6861 2 234204113 234204113 UTR3 0.710369 0.14851599911951102 GWAS of prostate cancer rs11890449 2 234199401 234199401 intronic 0.611048 0.213924673036757