PTM - CPLM Gene Name UniProt ID Type Position Code IBTK; BTKI; KIAA1417 Q9P2D0 Ubiquitination 11 K IBTK; BTKI; KIAA1417 Q9P2D0 Ubiquitination 1213 K IBTK; BTKI; KIAA1417 Q9P2D0 Ubiquitination 655 K IBTK; BTKI; KIAA1417 Q9P2D0 Ubiquitination 687 K IBTK; BTKI; KIAA1417 Q9P2D0 Ubiquitination 1350 K

PTM - dbPAF Gene Name UniProt ID Position Type Species IBTK; BTKI; KIAA1417 Q9P2D0 1004 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1006 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1008 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1016 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1018 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1021 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1027 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1028 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1030 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1033 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1039 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 104 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1045 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1049 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1054 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1064 Y Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1068 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1069 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1072 Y Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1073 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1083 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1096 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1113 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1116 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 113 Y Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1138 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1141 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1181 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1195 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1198 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1200 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 1203 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 2 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 285 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 296 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 3 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 300 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 599 T Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 630 Y Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 660 Y Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 695 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 949 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 950 Y Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 96 Y Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 990 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 992 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 993 S Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 996 Y Homo sapiens(Human) IBTK; BTKI; KIAA1417 Q9P2D0 999 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9P2D0 K981-ac Acetylation MFKKAKTkAKkKPRK Q9P2D0 K984-ac Acetylation KAKTkAKkKPRKRsD Q9P2D0 K687-m1 Methylation KSAFEVYkSNQAQTV Q9P2D0 K1140-m1 Methylation QKCGAtPksHLGkTV Q9P2D0 K1145-m1 Methylation tPksHLGkTVSHGVK Q9P2D0 K1230-m1 Methylation HVKKVSFkGIENSQA Q9P2D0 Y96-p Phosphorylation ALHRSIFyGHIDCVW Q9P2D0 Y113-p Phosphorylation LKHGVSLyIQDKEGL Q9P2D0 T285-p Phosphorylation AKYLKGRtIIGVAAG Q9P2D0 T296-p Phosphorylation VAAGRFHtVLWtREA Q9P2D0 T300-p Phosphorylation RFHtVLWtREAVYTM Q9P2D0 T599-p Phosphorylation LFLSDGNtSEFTDIY Q9P2D0 Y630-p Phosphorylation VHPDMFEyLLQFIYT Q9P2D0 S949-p Phosphorylation YQDGPDIsyLEVEDG Q9P2D0 Y950-p Phosphorylation QDGPDIsyLEVEDGD Q9P2D0 S990-p Phosphorylation KkKPRKRsDssGGyN Q9P2D0 S992-p Phosphorylation KPRKRsDssGGyNLs Q9P2D0 S993-p Phosphorylation PRKRsDssGGyNLsD Q9P2D0 Y996-p Phosphorylation RsDssGGyNLsDIIQ Q9P2D0 S999-p Phosphorylation ssGGyNLsDIIQsPs Q9P2D0 S1004-p Phosphorylation NLsDIIQsPsStGLL Q9P2D0 S1006-p Phosphorylation sDIIQsPsStGLLKS Q9P2D0 T1008-p Phosphorylation IIQsPsStGLLKSGK Q9P2D0 T1016-p Phosphorylation GLLKSGKtNsVEsLP Q9P2D0 S1018-p Phosphorylation LKSGKtNsVEsLPEL Q9P2D0 S1021-p Phosphorylation GKtNsVEsLPELLTS Q9P2D0 S1030-p Phosphorylation PELLTSDsEGsYAGV Q9P2D0 S1033-p Phosphorylation LTSDsEGsYAGVGsP Q9P2D0 S1039-p Phosphorylation GsYAGVGsPRDLQsP Q9P2D0 S1045-p Phosphorylation GsPRDLQsPDFtTGF Q9P2D0 T1049-p Phosphorylation DLQsPDFtTGFHsDK Q9P2D0 S1054-p Phosphorylation DFtTGFHsDKIEAKV Q9P2D0 Y1064-p Phosphorylation IEAKVKPyVNGtsPV Q9P2D0 T1068-p Phosphorylation VKPyVNGtsPVysRE Q9P2D0 S1069-p Phosphorylation KPyVNGtsPVysRED Q9P2D0 Y1072-p Phosphorylation VNGtsPVysREDLKP Q9P2D0 S1073-p Phosphorylation NGtsPVysREDLKPW Q9P2D0 S1083-p Phosphorylation DLKPWEKsPILKISA Q9P2D0 S1096-p Phosphorylation SAPQPIPsNRIDTTS Q9P2D0 S1113-p Phosphorylation SWVAGSFsPVsPPVV Q9P2D0 S1116-p Phosphorylation AGSFsPVsPPVVDLR Q9P2D0 T1138-p Phosphorylation SRQKCGAtPksHLGk Q9P2D0 S1141-p Phosphorylation KCGAtPksHLGkTVS Q9P2D0 T1181-p Phosphorylation SMETVLFtPSKAPKP Q9P2D0 S1198-p Phosphorylation AWASSLHsVsSksFR Q9P2D0 S1200-p Phosphorylation ASSLHsVsSksFRDF Q9P2D0 S1203-p Phosphorylation LHsVsSksFRDFLLE Q9P2D0 K687-ub Ubiquitination KSAFEVYkSNQAQTV Q9P2D0 K1202-ub Ubiquitination SLHsVsSksFRDFLL

PTM - dbPTM UniProt ID Position Code Type Resources References Q9P2D0 630 Y Phosphorylation Swiss-Prot 1010711 17053785 Q9P2D0 990 S Phosphorylation Swiss-Prot 1010711 18669648 Q9P2D0 992 S Phosphorylation Swiss-Prot 1010711 18669648 Q9P2D0 993 S Phosphorylation Swiss-Prot 1010711 18669648 Q9P2D0 1004 S Phosphorylation Swiss-Prot 1010711 18669648 Q9P2D0 1045 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 Q9P2D0 1054 S Phosphorylation Swiss-Prot 1010711 18669648 Q9P2D0 990 S Phosphorylation PhosphoELM.10011 18669648 Q9P2D0 992 S Phosphorylation PhosphoELM.10011 18669648 Q9P2D0 993 S Phosphorylation PhosphoELM.10011 18669648 Q9P2D0 1004 S Phosphorylation PhosphoELM.10011 18669648 Q9P2D0 1045 S Phosphorylation PhosphoELM.10011 18669648;17081983 Q9P2D0 1054 S Phosphorylation PhosphoELM.10011 18669648 Q9P2D0 1049 T Phosphorylation PhosphoELM.10011 18669648 Q9P2D0 996 Y Phosphorylation PhosphoELM.10011 18669648 Q9P2D0 687 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9P2D0 1004 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;21659604;22115753 Q9P2D0 1006 S Phosphorylation Phosphositeplus.1010730 19276368 Q9P2D0 104 S Phosphorylation Phosphositeplus.1010730 18187866 Q9P2D0 1045 S Phosphorylation Phosphositeplus.1010730 18669648;18707149;19276368;20068231;20363803;21406692;22115753 Q9P2D0 1054 S Phosphorylation Phosphositeplus.1010730 18669648;19276368 Q9P2D0 1069 S Phosphorylation Phosphositeplus.1010730 19276368 Q9P2D0 1083 S Phosphorylation Phosphositeplus.1010730 19276368 Q9P2D0 1113 S Phosphorylation Phosphositeplus.1010730 20068231 Q9P2D0 1116 S Phosphorylation Phosphositeplus.1010730 20068231 Q9P2D0 1200 S Phosphorylation Phosphositeplus.1010730 21482705 Q9P2D0 1203 S Phosphorylation Phosphositeplus.1010730 21482705 Q9P2D0 990 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;21406692;21659604 Q9P2D0 992 S Phosphorylation Phosphositeplus.1010730 19276368 Q9P2D0 993 S Phosphorylation Phosphositeplus.1010730 19276368;21659604 Q9P2D0 999 S Phosphorylation Phosphositeplus.1010730 19276368 Q9P2D0 1008 T Phosphorylation Phosphositeplus.1010730 19276368;21659604 Q9P2D0 1068 T Phosphorylation Phosphositeplus.1010730 19276368 Q9P2D0 630 Y Phosphorylation Phosphositeplus.1010730 17053785 Q9P2D0 996 Y Phosphorylation Phosphositeplus.1010730 19276368;21659604 Q9P2D0 990 S Phosphorylation HPRD 9.0 18669648 Q9P2D0 992 S Phosphorylation HPRD 9.0 18669648,18452278 Q9P2D0 993 S Phosphorylation HPRD 9.0 18669648 Q9P2D0 1004 S Phosphorylation HPRD 9.0 18669648 Q9P2D0 1045 S Phosphorylation HPRD 9.0 18669648,19651622,18707149,18452278,20068231 Q9P2D0 1054 S Phosphorylation HPRD 9.0 18669648 Q9P2D0 1113 S Phosphorylation HPRD 9.0 20068231 Q9P2D0 1116 S Phosphorylation HPRD 9.0 20068231 Q9P2D0 1049 T Phosphorylation HPRD 9.0 18669648,20068231 Q9P2D0 1068 T Phosphorylation HPRD 9.0 20068231 Q9P2D0 996 Y Phosphorylation HPRD 9.0 18669648,18452278 Q9P2D0 990 S Phosphorylation SysPTM 1.1 18669648 Q9P2D0 992 S Phosphorylation SysPTM 1.1 18669648 Q9P2D0 993 S Phosphorylation SysPTM 1.1 18669648 Q9P2D0 1004 S Phosphorylation SysPTM 1.1 18669648 Q9P2D0 1045 S Phosphorylation SysPTM 1.1 18669648;17081983;18707149 Q9P2D0 1054 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References IBTK 1004 S Phosphorylation 18669648 IBTK 1045 S Phosphorylation 18669648,19651622,18707149,18452278,20068231 IBTK 1049 T Phosphorylation 18669648,20068231 IBTK 1054 S Phosphorylation 18669648 IBTK 1068 T Phosphorylation 20068231 IBTK 1113 S Phosphorylation 20068231 IBTK 1116 S Phosphorylation 20068231 IBTK 990 S Phosphorylation 18669648 IBTK 992 S Phosphorylation 18669648,18452278 IBTK 993 S Phosphorylation 18669648 IBTK 996 Y Phosphorylation 18669648,18452278

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9P2D0 993 S 18669648 HTP Phosphorylation Q9P2D0 992 S 18669648 HTP Phosphorylation Q9P2D0 1004 S 18669648 HTP Phosphorylation Q9P2D0 990 S 18669648 HTP Phosphorylation Q9P2D0 996 Y 18669648 HTP Phosphorylation Q9P2D0 1045 S 18669648 HTP Phosphorylation Q9P2D0 1045 S 17081983 HTP Phosphorylation Q9P2D0 1054 S 18669648 HTP Phosphorylation Q9P2D0 1049 T 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9P2D0 990 Phosphoserine 18669648 Q9P2D0 1004 Phosphoserine 18669648 Q9P2D0 1030 Phosphoserine 24275569 Q9P2D0 1033 Phosphoserine 24275569 Q9P2D0 1039 Phosphoserine 24275569 Q9P2D0 1045 Phosphoserine 18669648;20068231;21406692;23186163;24275569 Q9P2D0 1054 Phosphoserine 18669648 Q9P2D0 1083 Phosphoserine 23186163 Q9P2D0 1113 Phosphoserine 20068231 Q9P2D0 1116 Phosphoserine 20068231

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type IBTK IPI00165979 S 1041 SPRDLQpSPDFTTG phosphorylation IBTK IPI00165979 S 1109 WVAGSFpSPVSPPV phosphorylation IBTK IPI00165979 S 1112 GSFSPVpSPPVVDL phosphorylation IBTK IPI00165979 T 1045 LQSPDFpTTGFHSD phosphorylation IBTK IPI00165979 T 1064 KPYVNGpTSPVYSR phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID IBTK Homo sapiens (Human) 687 "687,SAFEVYKSNQAQT" 687:21906983 IBTK Homo sapiens (Human) 687 "687,SAFEVYKSNQAQT" 687:21906983