PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Xpot Aire 20085707 intact exp Hist2h2bb Aire 20085707 intact exp Gcn1l1 Aire 20085707 intact exp Cand1 Aire 20085707 intact exp Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2ag, Hist1h2ai, Hist1h2an, Hist1h2ao Aire 20085707 intact exp C1qbp Aire 20085707 intact exp Ranbp2 Aire 20085707 intact exp Supt16h Aire 20085707 intact exp Hist1h3a, Hist1h3g, Hist1h3h, Hist1h3i Aire 20085707 intact exp, ortho Msh2 Aire 20085707 intact exp, ortho Prkdc Aire 20085707 intact exp, ortho Snrpd3 Aire 20085707 intact exp, ortho Mcm2 Aire 20085707 intact exp, ortho Pcna Aire 20085707 intact exp, ortho Parp1 Aire 20085707 intact exp, ortho Pabpc1 Aire 20085707 intact exp, ortho Gemin5 Aire 20085707 intact exp, ortho Ipo7 Aire 20085707 intact exp, ortho Srsf3 Aire 20085707 intact exp, ortho Smc1a Aire 20085707 intact exp, ortho Snrpb Aire 20085707 intact exp, ortho Polr2b Aire 20085707 intact exp, ortho Top2a Aire 20085707 intact exp, ortho Srsf1 Aire 20085707 intact exp, ortho Mybbp1a Aire 20085707 intact exp, ortho Chd6 Aire 20085707 intact exp, ortho Aire Aire 11533054 intact exp, ortho Xpo1 Aire 20085707 intact exp, ortho Mcm6 Aire 20085707 intact exp, ortho Ruvbl2 Aire 20085707 intact exp, ortho Rad21 Aire 20085707 intact exp, ortho Srsf2 Aire 20085707 intact exp, ortho Ranbp9 Aire 20085707 intact exp, ortho Mcm5 Aire 20085707 intact exp, ortho Nasp Aire 20085707 intact exp, ortho Kpnb1 Aire 20085707 intact exp, ortho Ddx5 Aire 20085707 intact exp, ortho Smc3 Aire 20085707 intact exp, ortho Nup93 Aire 20085707 intact exp, ortho Nop56 Aire 20085707 intact exp, ortho Trim28 Aire 20085707 intact exp, ortho Ddx17 Aire 20085707 intact exp, ortho Msh6 Aire 20085707 intact exp, ortho Lmnb1 Aire 20085707 intact exp, ortho Polr2a Aire 20085707 intact exp, ortho Eftud2 Aire 20085707 intact exp, ortho Tubb5 Aire ortho Hspa8 Aire ortho Crk Aire ortho Fyn Aire ortho Tmprss13 Aire ortho Daxx Aire ortho Protein Fat1 Aire ortho Pik3r1 Aire ortho H2afx Aire ortho Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Aire ortho Nck1 Aire ortho Hdac1 Aire ortho Gigyf2 Aire ortho Plcg1 Aire ortho Hist1h2bp Aire ortho Hspa5 Aire ortho Raver1 Aire ortho Src Aire ortho Hspa4 Aire ortho Hspa1l Aire ortho Xrcc5 Aire ortho Hist1h2bb Aire ortho Tubb4b Aire ortho Eif4ebp3 Aire ortho Ssrp1 Aire ortho Atp4a Aire ortho Ccdc87 Aire ortho Hsp90ab1 Aire ortho Ubac1 Aire ortho Grb2 Aire ortho Abl1 Aire ortho Hdac2 Aire ortho Tuba1c Aire ortho Crebbp Aire ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Z0E3 anti tag coimmunoprecipitation 20085707 association C 46 Q9Z0E3 anti tag coimmunoprecipitation 20085707 association C 46 Q9Z0E3 Q9Z0E3 molecular sieving 11533054 physical association Y 1 Q9Z0E3 Q9Z0E3 molecular sieving 11533054 physical association Y 1 Q9Z0E3 Q9Z0E3 biochemical 11533054 physical association Y 1 Q9Z0E3 Q9Z0E3 biochemical 11533054 physical association Y 1

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Aire Aire MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0065(isothermal titration calorimetry)|MI:0071(molecular sieving)|MI:0071(molecular sieving) 11533054,18840680 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0465(dip)|(intact)|(intact) UniProt_160513|UniProt_160510|DIP_788|UniProt_160512|UniProt_160511 neutral component|neutral component|-|neutral component|neutral component neutral component|neutral component|-|neutral component|neutral component

PPI - HINT Gene A Gene B PMID Method Quality AIRE AIRE 11533054,11533054 0071,0401 LC CHD6 AIRE 20085707 0007 LC GCN1 AIRE 20085707 0007 LC EFTUD2 AIRE 20085707 0007 LC C1QBP AIRE 20085707 0007 LC POLR2A AIRE 20085707 0007 LC PARP1 AIRE 20085707 0007 LC LMNB1 AIRE 20085707 0007 LC PCNA AIRE 20085707 0007 LC HIST1H2AB|HIST1H2AC|HIST1H2AD|HIST1H2AE|HIST1H2AG|HIST1H2AI|HIST1H2AN|HIST1H2AO AIRE 20085707 0007 LC SNRPB AIRE 20085707 0007 LC PABPC1 AIRE 20085707 0007 LC MSH2 AIRE 20085707 0007 LC MCM5 AIRE 20085707 0007 LC MSH6 AIRE 20085707 0007 LC TLR8 AIRE 21628060 0007 LC SNRPD3 AIRE 20085707 0007 LC HIST1H3A|HIST1H3G|HIST1H3H|HIST1H3I AIRE 20085707 0007 LC RANBP9 AIRE 20085707 0007 LC KPNB1 AIRE 20085707 0007 LC SRSF3 AIRE 20085707 0007 LC MCM2 AIRE 20085707 0007 LC MCM6 AIRE 20085707 0007 LC PRKDC AIRE 20085707 0007 LC TOP2A AIRE 20085707 0007 LC DDX17 AIRE 20085707 0007 LC RAD21 AIRE 20085707 0007 LC DDX5 AIRE 20085707 0007 LC SRSF2 AIRE 20085707 0007 LC TRIM28 AIRE 20085707 0007 LC HIST2H2BB AIRE 20085707 0007 LC XPO1 AIRE 20085707 0007 LC SRSF1 AIRE 20085707 0007 LC CAND1 AIRE 20085707 0007 LC MYBBP1A AIRE 20085707 0007 LC NUP93 AIRE 20085707 0007 LC GEMIN5 AIRE 20085707 0007 LC POLR2B AIRE 20085707 0007 LC SUPT16H AIRE 20085707 0007 LC TLR3 AIRE 21628060 0007 LC NASP AIRE 20085707 0007 LC XPOT AIRE 20085707 0007 LC SMC1A AIRE 20085707 0007 LC SMC3 AIRE 20085707 0007 LC NOP56 AIRE 20085707 0007 LC IPO7 AIRE 20085707 0007 LC TLR1 AIRE 21628060 0007 LC RANBP2 AIRE 20085707 0007 LC RUVBL2 AIRE 20085707 0007 LC AIRE AIRE 11533054,11533054 0071,0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Z0E3 O14980 AIRE XPO1 0.236 20085707 Q9Z0E3 P23527 AIRE HIST1H2BO 0.236 20085707 Q9Z0E3 O43592 AIRE XPOT 0.236 20085707 Q9Z0E3 Q62093 AIRE SRSF2 0.236 20085707 Q9Z0E3 Q8CFI7 AIRE POLR2B 0.236 20085707 Q9Z0E3 P24928 AIRE POLR2A 0.236 20085707 Q9Z0E3 P62318 AIRE SNRPD3 0.236 20085707 Q9Z0E3 P62320 AIRE SNRPD3 0.236 20085707 Q9Z0E3 Q8N1F7 AIRE NUP93 0.236 20085707 Q9Z0E3 Q8TD26 AIRE CHD6 0.236 20085707 Q9Z0E3 Q9WTM5 AIRE RUVBL2 0.236 20085707 Q9Z0E3 Q9Y5B9 AIRE SUPT16H 0.236 20085707 Q9Z0E3 O35658 AIRE C1QBP 0.236 20085707 Q9Z0E3 P08775 AIRE POLR2A 0.236 20085707 Q9Z0E3 P11388 AIRE TOP2A 0.236 20085707 Q9Z0E3 P12004 AIRE PCNA 0.236 20085707 Q9Z0E3 Q62318 AIRE TRIM28 0.236 20085707 Q9Z0E3 Q64525 AIRE HIST2H2BB 0.236 20085707 Q9Z0E3 Q6P5F9 AIRE XPO1 0.236 20085707 Q9Z0E3 Q6PDM2 AIRE SRSF1 0.236 20085707 Q9Z0E3 Q6ZQ38 AIRE CAND1 0.236 20085707 Q9Z0E3 Q8BJ71 AIRE NUP93 0.236 20085707 Q9Z0E3 Q8BX17 AIRE GEMIN5 0.236 20085707 Q9Z0E3 O95373 AIRE IPO7 0.236 20085707 Q9Z0E3 Q9Z0E3 AIRE AIRE 0.416 11533054 Q9Z0E3 Q9CU62 AIRE SMC1A 0.236 20085707 Q9Z0E3 Q7TPV4 AIRE MYBBP1A 0.236 20085707 Q9Z0E3 Q16695 AIRE HIST3H3 0.236 20085707 Q9Z0E3 P97311 AIRE MCM6 0.236 20085707 Q9Z0E3 P54276 AIRE MSH6 0.236 20085707 Q9Z0E3 P43246 AIRE MSH2 0.236 20085707 Q9Z0E3 P17918 AIRE PCNA 0.236 20085707 Q9Z0E3 P09874 AIRE PARP1 0.236 20085707 Q9Z0E3 O08810 AIRE EFTUD2 0.236 20085707 Q9Z0E3 P52701 AIRE MSH6 0.236 20085707 Q9Z0E3 P49792 AIRE RANBP2 0.236 20085707 Q9Z0E3 P49736 AIRE MCM2 0.236 20085707 Q9Z0E3 P11103 AIRE PARP1 0.236 20085707 Q9Z0E3 P49321 AIRE NASP 0.236 20085707 Q9Z0E3 Q8TEQ6 AIRE GEMIN5 0.236 20085707 Q9Z0E3 P97313 AIRE PRKDC 0.236 20085707 Q9Z0E3 P84103 AIRE SRSF3 0.236 20085707 Q9Z0E3 Q86VP6 AIRE CAND1 0.236 20085707 Q9Z0E3 Q01130 AIRE SRSF2 0.236 20085707 Q9Z0E3 Q61656 AIRE DDX5 0.236 20085707 Q9Z0E3 Q9Y230 AIRE RUVBL2 0.236 20085707 Q9Z0E3 P11940 AIRE PABPC1 0.236 20085707 Q9Z0E3 P14678 AIRE SNRPB 0.236 20085707 Q9Z0E3 Q9CRT8 AIRE XPOT 0.236 20085707 Q9Z0E3 P20700 AIRE LMNB1 0.236 20085707 Q9Z0E3 P22752 AIRE HIST1H2AO 0.236 20085707 Q9Z0E3 P97310 AIRE MCM2 0.236 20085707 Q9Z0E3 Q9EPL8 AIRE IPO7 0.236 20085707 Q9Z0E3 P78527 AIRE PRKDC 0.236 20085707 Q9Z0E3 P84104 AIRE SRSF3 0.236 20085707 Q9Z0E3 O60216 AIRE RAD21 0.236 20085707 Q9Z0E3 A3KFM7 AIRE CHD6 0.236 20085707 Q9Z0E3 Q99MD9 AIRE NASP 0.236 20085707 Q9Z0E3 Q14566 AIRE MCM6 0.236 20085707 Q9Z0E3 Q61550 AIRE RAD21 0.236 20085707 Q9Z0E3 P29341 AIRE PABPC1 0.236 20085707 Q9Z0E3 Q92841 AIRE DDX17 0.236 20085707 Q9Z0E3 Q93077 AIRE HIST1H2AC 0.236 20085707 Q9Z0E3 Q92616 AIRE GCN1L1 0.236 20085707 Q9Z0E3 P30876 AIRE POLR2B 0.236 20085707 Q9Z0E3 Q920B9 AIRE SUPT16H 0.236 20085707 Q9Z0E3 Q9BQG0 AIRE MYBBP1A 0.236 20085707 Q9Z0E3 P27048 AIRE SNRPB 0.236 20085707 Q9Z0E3 Q96S59 AIRE RANBP9 0.236 20085707 Q9Z0E3 Q9CW03 AIRE SMC3 0.236 20085707 Q9Z0E3 Q9D6Z1 AIRE NOP56 0.236 20085707 Q9Z0E3 Q9ERU9 AIRE RANBP2 0.236 20085707 Q9Z0E3 P33992 AIRE MCM5 0.236 20085707 Q9Z0E3 Q9UQE7 AIRE SMC3 0.236 20085707 Q9Z0E3 P17844 AIRE DDX5 0.236 20085707 Q9Z0E3 P14733 AIRE LMNB1 0.236 20085707 Q9Z0E3 P49718 AIRE MCM5 0.236 20085707 Q9Z0E3 Q14683 AIRE SMC1A 0.236 20085707 Q9Z0E3 Q14974 AIRE KPNB1 0.236 20085707 Q9Z0E3 P43247 AIRE MSH2 0.236 20085707 Q9Z0E3 Q13263 AIRE TRIM28 0.236 20085707 Q9Z0E3 Q15029 AIRE EFTUD2 0.236 20085707 Q9Z0E3 Q01320 AIRE TOP2A 0.236 20085707 Q9Z0E3 P70168 AIRE KPNB1 0.236 20085707 Q9Z0E3 P68433 AIRE HIST1H3I 0.236 20085707 Q9Z0E3 P69566 AIRE RANBP9 0.236 20085707 Q9Z0E3 Q07021 AIRE C1QBP 0.236 20085707 Q9Z0E3 O00567 AIRE NOP56 0.236 20085707 Q9Z0E3 Q07955 AIRE SRSF1 0.236 20085707 Q9Z0E3 Q3UHQ5 AIRE GCN1L1 0.236 20085707 Q9Z0E3 Q501J6 AIRE DDX17 0.236 20085707