PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Uhrf1 Supt16h 25451918 biogrid exp G G G G G G G G G G G G G H3f3a, H3f3b Uhrf1 14993289,23463006 biogrid exp Nanog Uhrf1 21589869 biogrid exp Atm Uhrf1 23754744 biogrid exp G G G G G G G G G G G G Uhrf1 Rcc1 25451918 biogrid exp G G G G G G G G G G G G Top2b Uhrf1 25451918 biogrid exp G G G G G G G G G G G G G Dnmt1 Uhrf1 24013172,24782312,23463006,23754744 biogrid exp, ortho G G G G G G G G G G G G G Parp1 Uhrf1 25451918,24782312 biogrid exp, ortho G G G G G G G G G G G G G Uhrf1 Mus81 18692478 biogrid exp, ortho G G G G G G G G Eme1 Uhrf1 18692478 biogrid exp, ortho G G G Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2ag, Hist1h2ai, Hist1h2an, Hist1h2ao Uhrf1 14993289 mint,intact exp, ortho Top2a Uhrf1 25451918 biogrid exp, ortho G G G G G G G G G G G G G Hist1h2bf, Hist1h2bj, Hist1h2bl, Hist1h2bn Uhrf1 14993289 mint,intact exp, ortho Uhrf1 Uhrf1 14993289 biogrid exp, ortho G G G G G G G G G G G G G Hdac1 Uhrf1 ortho G G G G G G G G G G G G G Suz12 Uhrf1 ortho G G G G G G G G G G G G G Dnmt3b Uhrf1 ortho G G G G G G G G Trpv5 Uhrf1 ortho Pcna Uhrf1 ortho G G G G G G G G G G G G G Ercc1 Uhrf1 ortho G G G G G G G G G G G G G Elavl1 Uhrf1 ortho G G G G G G G G G G G G G Btrc Uhrf1 ortho G G G G G G G G G G G G Zpr1 Uhrf1 ortho G G G G G G G G G G G G G Uhrf1 Uqcrb ortho G G G G G G G G G G G G G Mpg Uhrf1 ortho G G G G G G G G G G G G G Trim28 Uhrf1 ortho G G G G G G G G G G G G G Parp2 Uhrf1 ortho G G G G G G G G G G G G G Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Uhrf1 ortho G G Ntrk1 Uhrf1 ortho Uhrf1 Ehmt2 ortho G G G G G G G G G G G G G Uhrf1 Mbd4 ortho G G G G G G G Protein Uhrf1bp1 Uhrf1 ortho G G G G G G G G G G G G G Suv39h1 Uhrf1 ortho G G G G G G G G G G G G G Uhrf1 Rnf4 ortho G G G G G G G G G G G G G Uhrf1 Ercc4 ortho G G G G G G G G Uhrf1 Dbn1 ortho G G G G G G G G G G Ahsa1 Uhrf1 ortho G G G G G G G G G G G G G Ccndbp1 Uhrf1 ortho G G G G G G G G G G G G G Kat5 Uhrf1 ortho Uhrf1 Rnf2 ortho G G G G G G G G G G G G G Hist1h2bb Uhrf1 ortho Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 Uhrf1 ortho G G G G G G Prkaca Uhrf1 ortho G G G G G G G G G G G G G Dnmt3a Uhrf1 ortho G G G G G G G G G Usp7 Uhrf1 ortho G G G G G G G G G G G G G Hist1h2bc, Hist1h2be, Hist1h2bg Uhrf1 ortho Wipi1 Uhrf1 ortho G G G G G G G G G G G G G Uhrf1 Usp11 ortho G G G G G G G G Ezh2 Uhrf1 ortho G G G G G G G G G G G G G Uhrf1 Cul1 ortho G G G G G G G G G G G G G Uhrf1 Tceal1 ortho G G G G G G G G G Rpl10 Uhrf1 ortho Pml Uhrf1 ortho G G G G G G G G G G G G Uhrf1 Hnrnpu ortho G G G G G G G G G G G G G Uhrf2 Uhrf1 ortho Ccdc8 Uhrf1 ortho Rb1 Uhrf1 ortho G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q16777 Q8VDF2 affinity chromatography technology 14993289 physical association X 2 O95243 Q8VDF2 affinity chromatography technology 25358258 physical association X 2 Q8VDF2 Q3UHZ3 affinity chromatography technology 23754744 physical association X 2 Q8VDF2 Q3UHZ3 affinity chromatography technology 24013172 physical association X 2 Q8VDF2 Q3UHZ3 affinity chromatography technology 24782312 physical association X 2 Q8VDF2 Q3UHZ3 imaging technique 23463006 colocalization X 2 Q8VDF2 Q8BJW7 two hybrid 18692478 direct interaction X 2 Q8VDF2 Q8BJW7 pull down 18692478 direct interaction X 2 Q8VDF2 Q8BJW7 affinity chromatography technology 18692478 physical association X 2 Q8VDF2 Q8BJW7 affinity chromatography technology 18692478 physical association X 2 Q8VDF2 Q6GM86 enzymatic study 14993289 direct interaction X 2 Q62388 Q8VDF2 affinity chromatography technology 23754744 physical association X 2 Q5E9F8 Q8VDF2 far western blotting 14993289 direct interaction X 2 Q921K2 Q8VDF2 affinity chromatography technology 24782312 physical association X 2 Q921K2 Q8VDF2 affinity chromatography technology 24782312 physical association X 2 Q02539 Q8VDF2 far western blotting 14993289 direct interaction X 2 G3N131 Q8VDF2 far western blotting 14993289 direct interaction X 2 Q92133 Q8VDF2 enzymatic study 14993289 direct interaction X 2 Q8VDF2 A2RS90 affinity chromatography technology 21589869 physical association X 2 Q8VDF2 Q91ZJ0 pull down 18692478 direct interaction X 2 Q8VDF2 P68431 far western blotting 14993289 direct interaction X 2 Q8VDF2 Q16778 far western blotting 14993289 direct interaction X 2 Q8VDF2 Q8VDF2 enzymatic study 14993289 direct interaction X 2 Q8VDF2 P68431 affinity chromatography technology 14993289 physical association X 2 Q8VDF2 Q16778 affinity chromatography technology 14993289 physical association X 2 P84244 Q8VDF2 imaging technique 23463006 colocalization X 2 P84244 Q8VDF2 unspecified method 23463006 direct interaction X 2 P84244 Q8VDF2 affinity chromatography technology 14993289 physical association X 2 P62799 Q8VDF2 enzymatic study 14993289 direct interaction X 2 Q8VDF2 far western blotting 14993289 direct interaction X 2 P02281 Q8VDF2 enzymatic study 14993289 direct interaction X 2 P10853 Q8VDF2 experimental interaction detection 14993289 ubiquitination reaction X 2 P10853 Q8VDF2 far western blotting 14993289 direct interaction X 2 B2R4R0 Q8VDF2 experimental interaction detection 14993289 ubiquitination reaction X 2 Q8VDF2 P68431 anti bait coimmunoprecipitation 14993289 physical association X 2 Q8VDF2 P68431 experimental interaction detection 14993289 ubiquitination reaction X 2 Q8VDF2 P68431 far western blotting 14993289 direct interaction X 2 P22752 Q8VDF2 experimental interaction detection 14993289 ubiquitination reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Eme1 Uhrf1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692478 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_312259|BIOGRID_312258|BIOGRID_312257|BIOGRID_312254 bait|prey|prey|bait prey|bait|bait|prey Uhrf1 H3f3a MI:0047(far western blotting) 14993289 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316348 bait prey Atm Uhrf1 MI:0004(affinity chromatography technology) 23754744 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329814 bait prey Dnmt1 Uhrf1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23754744,24013172 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_329811|BIOGRID_331563 bait|bait prey|prey Hist1h2bf Uhrf1 MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0006(anti bait coimmunoprecipitation)|MI:0045(experimental interaction detection)|MI:0006(anti bait coimmunoprecipitation)|MI:0045(experimental interaction detection) 14993289 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0220(ubiquitination reaction)|MI:0407(direct interaction)|MI:0220(ubiquitination reaction)|MI:0220(ubiquitination reaction)|MI:0407(direct interaction) (intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact) UniProt_163342|UniProt_76171|MINT_57962|UniProt_163338|MINT_57964|UniProt_76175 prey|unspecified role|prey|unspecified role|unspecified role|prey bait|unspecified role|bait|unspecified role|unspecified role|bait Mus81 Uhrf1 MI:0018(two hybrid) 18692478 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312256 prey bait Nanog Uhrf1 MI:0428(imaging technique) 21589869 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321462 bait prey Hist1h2ab; Uhrf1 MI:0045(experimental interaction detection)|MI:0006(anti bait coimmunoprecipitation)|MI:0045(experimental interaction detection) 14993289 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0220(ubiquitination reaction)|MI:0220(ubiquitination reaction)|MI:0220(ubiquitination reaction) (intact)|MI:0471(mint)|(intact) UniProt_76172|MINT_57965|UniProt_163339 unspecified role|unspecified role|unspecified role unspecified role|unspecified role|unspecified role

PPI - HINT Gene A Gene B PMID Method Quality HIST1H2BF|HIST1H2BJ|HIST1H2BL|HIST1H2BN UHRF1 14993289,14993289 0045,0047 LC HIST1H2AB|HIST1H2AC|HIST1H2AD|HIST1H2AE|HIST1H2AG|HIST1H2AI|HIST1H2AN|HIST1H2AO UHRF1 14993289 0045 LC LMO2 UHRF1 26764384 0018 LC EME1 UHRF1 18692478,18692478,18692478 0004,0096,0018 LC UHRF1 UHRF1 19077538,18772891,14993289 0114,0114,0415 LC PARP1 UHRF1 24782312,25451918 0004,0004 LC DNMT1 UHRF1 24782312,23754744,23463006,24013172 0004,0004,0428,0004 LC H3F3A|H3F3B UHRF1 14993289,23463006 0004,0428 LC TOP2A UHRF1 25451918,25451918 0428,0004 LC ATM UHRF1 23754744 0004 LC TOP2B UHRF1 25451918 0004 LC NANOG UHRF1 21589869 0004 LC EME1 UHRF1 18692478,18692478,18692478 0004,0096,0018 LC UHRF1 RCC1 25451918 0004 LC UHRF1 MUS81 18692478 0096 LC UHRF1 SUPT16H 25451918 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8VDF2 Q5E9F8 UHRF1 H3F3B 0.309 14993289 Q8VDF2 P02281 UHRF1 P02281 0.309 14993289 Q8VDF2 P22752 UHRF1 HIST1H2AO 0.033 14993289 Q8VDF2 P62799 UHRF1 P62799 0.309 14993289 Q8VDF2 P62805 UHRF1 HIST4H4 0.033 14993289 Q8VDF2 P84244 UHRF1 H3F3B 0.523 14993289,23463006 Q8VDF2 Q16777 UHRF1 HIST2H2AC 0.21 14993289 Q8VDF2 Q64511 UHRF1 TOP2B 0.21 25451918 Q8VDF2 Q8VDF2 UHRF1 UHRF1 0.332 14993289 Q8VE37 Q8VDF2 RCC1 UHRF1 0.21 25451918 Q91ZJ0 Q8VDF2 MUS81 UHRF1 0.309 18692478 Q920B9 Q8VDF2 SUPT16H UHRF1 0.21 25451918 Q8VDF2 Q62388 UHRF1 ATM 0.21 23754744 Q8VDF2 Q80Z64 UHRF1 NANOG 0.126 21589869 Q8VDF2 O95243 UHRF1 MBD4 0.21 25358258 Q8VDF2 Q8BJW7 UHRF1 EME1 0.702 18692478 Q8VDF2 P10853 UHRF1 HIST1H2BN 0.332 14993289 Q8VDF2 Q01320 UHRF1 TOP2A 0.309 25451918 Q8VDF2 P13864 UHRF1 DNMT1 0.569 24782312,23463006,24013172,23754744 Q8VDF2 P25801 UHRF1 LMO2 0.183 26764384 Q8VDF2 G3N131 UHRF1 HIST1H1A 0.309 14993289 Q8VDF2 Q02539 UHRF1 HIST1H1A 0.309 14993289 Q8VDF2 P68431 UHRF1 HIST1H3J 0.712 14993289 Q8VDF2 Q16778 UHRF1 HIST2H2BE 0.454 14993289