PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Pwp1 Ssbp3 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpgrip1l Pwp1 21565611 intact exp Ewsr1 Pwp1 20211142 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Pwp1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuba1c Pwp1 ortho P Actg1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capza2 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct8 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Noc2l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct3 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct7 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lsg1 Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx10 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk1a1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct4 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap1m1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Smc1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cnbp Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Cul3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Ddx24 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Npm1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx18 Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Dda1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lyar Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct5 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarca5 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Nop56 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capzb Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul4a Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Coro1c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc4 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lin28a Pwp1 ortho G G Blm Pwp1 ortho G G G G G G Fech Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kiaa0020 Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Dkc1 ortho P Myh7 Pwp1 ortho GP G G G G G G G G G G Fbl Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Top1 Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Gtpbp4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx55 Pwp1 ortho Pwp1 Ssbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Rpf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddb1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Otc Pwp1 ortho P G G G G G G Myo5a Pwp1 ortho GP G G G G G G G G G G G G G G G G G G Nfya Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mus81 Pwp1 ortho G G G G G G G G G G G G G G G G G G G G Jun Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sox2 Pwp1 ortho G G G G G G G G G G G Pwp1 Rnf2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ipo4 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nop58 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cltc Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tyw1 Pwp1 ortho G G G G G G G G G G G G G G G G G Polr1b Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rplp0 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Ftsj3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Utp20 Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Snw1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarapl2 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbm34 Pwp1 ortho Cct6a Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr2 Pwp1 ortho G Cad Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops5 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa5 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Pes1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops6 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Cul1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Idh3g Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tcp1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xpo1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl5 Pwp1 ortho P Hoxa3 Pwp1 ortho G G G Pwp1 Smurf1 ortho Atp6v1b2 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Supt16h Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx5 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pwp1 Gabarap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r3 Pwp1 ortho P Cand1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp5b Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31, Protein Ddx31 Pwp1 ortho Hspa9 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk2a2 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarapl1 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prr11 Pwp1 ortho Bmpr1b Pwp1 ortho G G G Tns2 Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G Pwp1 Brix1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sirt7 Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rrp12 Pwp1 ortho P G G G G G G Protein Dnajc21 Pwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct2 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99LL5 affinity chromatography technology 15761153 physical association X 2 Q99LL5 Q61545 two hybrid 20211142 direct interaction X 2 Q99LL5 two hybrid 20211142 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ewsr1 Pwp1 MI:0027(cosedimentation)|MI:0018(two hybrid) 16615898,20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_167137|BIOGRID_313083 neutral component|bait neutral component|prey Pwp1 Ssbp3 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313771 prey bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAE PWP1 16615898 0027 LC EWSR1 PWP1 20211142 0018 HT PWP1 SSBP3 20211142 0018 HT RPGRIP1L PWP1 21565611 0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q99LL5 Q61545 PWP1 EWSR1 0.183 20211142 Q99LL5 Q8CG73 PWP1 RPGRIP1L 0.126 21565611 Q99LL5 P62259 PWP1 YWHAE 0.081 16615898 Q9HCE7 Q99LL5 SMURF1 PWP1 0.126 15761153 Q9D032 Q99LL5 SSBP3 PWP1 0.183 20211142