PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Smarcc1 Nacc1 17093407 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G L3mbtl2 Nacc1 22770845 biogrid exp Arid3a Nacc1 17093407 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Sall1 17093407 biogrid,i2d exp G G Sox2 Nacc1 21532573 intact exp G G G G G G G G G G G Rif1 Nacc1 17093407 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hmga2 Nacc1 26045162 intact exp G G G G Nacc1 Nacc2 17093407 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Znf281 17093407 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Pou5f1 Nacc1 22083510,20362541,17093407 biogrid,i2d,intact exp Nacc1 Gatad2b 17093407 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Sall4 20362541,17093407 biogrid,i2d,intact exp Wdr18 Nacc1 17093407 biogrid,i2d exp Zfp42 Nacc1 17093407 biogrid,i2d exp G G Nacc1 Nanog 23892456,17093407,18436640,23395962,21589869 biogrid,i2d,intact,dip exp Nacc1 Arid3b 17093407 biogrid,i2d exp G G G G G G G G Mybbp1a Nacc1 17093407 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Foxp3 22922362 biogrid exp, ortho Nacc1 Tardbp 23022214 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac3 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul4a Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Bcor ortho Zbtb14 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Strn3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin1 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Csnk1e ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Xpo1 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl1 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Klhl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Cul3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd7 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxa1 Nacc1 ortho G G G G G G G G G Nacc1 Park2 ortho G G G G Kpna3 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbpj Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Sumo3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kpna4 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Zbtb6 ortho Nacc1 Csnk1a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Mrpl43 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac4 Nacc1 ortho Nacc1 Foxj2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Itln1 Nacc1 ortho Enc1 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin2 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G Nacc1 Snw1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Nacc1 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxa2 Nacc1 ortho G G G G G G G G Cdc5l Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6P5E3 Q7TSZ8 affinity chromatography technology 17093407 physical association X 2 Q4VBE8 Q7TSZ8 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 affinity chromatography technology 22083510 physical association X 2 Q7TSZ8 affinity chromatography technology 20362541 physical association X 2 Q7TSZ8 affinity chromatography technology 17093407 physical association X 2 Q53Z59 Q7TSZ8 affinity chromatography technology 22922362 physical association X 2 P59178 Q7TSZ8 affinity chromatography technology 22770845 physical association X 2 Q7TSZ8 Q8R0B4 affinity chromatography technology 23022214 physical association X 2 Q7TSZ8 Q8R0B4 affinity chromatography technology 23022214 physical association X 2 Q7TSZ8 affinity chromatography technology 20362541 physical association X 2 Q7TSZ8 affinity chromatography technology 20362541 physical association X 2 Q7TSZ8 affinity chromatography technology 20362541 physical association X 2 Q7TSZ8 Q99LI5 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 Q9DCM7 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 P97496 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 affinity chromatography technology 17093407 physical association X 2 P56720 Q7TSZ8 affinity chromatography technology 24425205 physical association X 2 Q62431 Q7TSZ8 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 A2RS90 affinity chromatography technology 21589869 physical association X 2 Q7TSZ8 A2RS90 affinity chromatography technology 23892456 physical association X 2 Q7TSZ8 A2RS90 affinity chromatography technology 23892456 physical association X 2 Q7TSZ8 A2RS90 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 Q9Z1N7 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 Q8VHR5 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 Q7TPV4 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 A2RS90 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 A2RS90 affinity chromatography technology 17093407 physical association X 2 Q7TSZ8 A2RS90 anti tag coimmunoprecipitation 18436640 physical association X 2 Q7TSZ8 anti tag coimmunoprecipitation 23892456 association C 143 Q7TSZ8 anti tag coimmunoprecipitation 21532573 association C 50 Q7TSZ8 anti tag coimmunoprecipitation 20362541 association C 42 Q7TSZ8 anti tag coimmunoprecipitation 20362541 association C 45 Q8BX22 Q7TSZ8 anti tag coimmunoprecipitation 20362541 physical association X 2 Q8BX22 Q7TSZ8 anti bait coimmunoprecipitation 20362541 physical association X 2 Q8BX22 Q7TSZ8 anti tag coimmunoprecipitation 20362541 physical association X 2 Q7TSZ8 A2RS90 anti tag coimmunoprecipitation 23892456 association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Nacc1 Foxp3 MI:0004(affinity chromatography technology) 22922362 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324792 prey bait Smarcc1 Nacc1 MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314243 prey bait Rif1 Nacc1 MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314245 prey bait Nanog Nacc1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 17093407,18436640,21589869,23892456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0465(dip) UniProt_177306|BIOGRID_314281|BIOGRID_314216|BIOGRID_321431|BIOGRID_331210|BIOGRID_314276|BIOGRID_331266|UniProt_177305|DIP_448 bait|prey|bait|bait|bait|bait|bait|bait|- prey|bait|prey|prey|prey|prey|prey|prey|- Arid3a Nacc1 MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314238 prey bait Nacc1 Nacc2 MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314240 bait prey Pou5f1 Nacc1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 17093407,20362541,22083510 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_170695|UniProt_107196|BIOGRID_314235|BIOGRID_320965|BIOGRID_313935|UniProt_107195|UniProt_170681 bait|bait|prey|bait|bait|bait|bait prey|prey|bait|prey|prey|prey|prey Wdr18 Nacc1 MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314242 prey bait Nacc1 Tardbp MI:0096(pull down)|MI:0096(pull down) 23022214 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323117|BIOGRID_323116 bait|prey prey|bait Mybbp1a Nacc1 MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314246 prey bait L3mbtl2 Nacc1 MI:0004(affinity chromatography technology) 22770845 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328058 bait prey Zfp42 Nacc1 MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314264 bait prey Nacc1 Znf281 MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314237 bait prey Nacc1 Sall1 MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314236 bait prey Nacc1 Sall4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 17093407,20362541 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_313981|UniProt_170729|UniProt_170679|BIOGRID_314244|UniProt_170675|BIOGRID_314199|BIOGRID_314209|UniProt_107198|UniProt_170697 prey|prey|bait|bait|bait|bait|prey|prey|prey bait|bait|prey|prey|prey|prey|bait|bait|bait Nacc1 Gatad2b MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314241 bait prey Nacc1 Arid3b MI:0004(affinity chromatography technology) 17093407 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314239 bait prey

PPI - HINT Gene A Gene B PMID Method Quality POU5F1 NACC1 17093407,20362541,22083510,20362541 0004,0004,0004,0007 LC ZFP42 NACC1 17093407 0004 LC SOX2 NACC1 21532573 0007 LC HMGA2 NACC1 26045162 0096 LC L3MBTL2 NACC1 22770845 0004 LC SMARCC1 NACC1 17093407 0004 LC WDR18 NACC1 17093407 0004 LC ARID3A NACC1 17093407 0004 LC RIF1 NACC1 17093407 0004 LC MYBBP1A NACC1 17093407 0004 LC NACC1 NANOG 23892456,18436640,23892456,17093407,23395962,21589869 0007,0007,0004,0004,0004,0004 LC NACC1 SALL4 17093407,20362541,20362541,20362541 0004,0004,0006,0007 LC NACC1 GATAD2B 17093407 0004 LC NACC1 TARDBP 23022214 0004 LC NACC1 FOXP3 22922362 0004 LC NACC1 ZNF281 17093407 0004 LC NACC1 NACC2 17093407 0004 LC NACC1 SALL1 17093407 0004 LC NACC1 ARID3B 17093407 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7TSZ8 P56720 NACC1 SREBF1 0.21 24425205 Q7TSZ8 P59178 NACC1 L3MBTL2 0.21 22770845 Q7TSZ8 Q60I23 NACC1 SOX2 0.126 21532573 Q7TSZ8 P20263 NACC1 POU5F1 0.416 17093407,22083510,20362541 Q7TSZ8 P97496 NACC1 SMARCC1 0.126 17093407 Q7TSZ8 Q4VBE8 NACC1 WDR18 0.126 17093407 Q7TSZ8 Q62431 NACC1 ARID3A 0.126 17093407 Q7TSZ8 Q6PR54 NACC1 RIF1 0.126 17093407 Q7TSZ8 Q7TPV4 NACC1 MYBBP1A 0.126 17093407 Q8VHR5 Q7TSZ8 GATAD2B NACC1 0.126 17093407 Q99LI5 Q7TSZ8 ZNF281 NACC1 0.126 17093407 Q9DCM7 Q7TSZ8 NACC2 NACC1 0.126 17093407 Q9Z1N7 Q7TSZ8 ARID3B NACC1 0.126 17093407 Q80Z64 Q7TSZ8 NANOG NACC1 0.722 17093407,21589869,23395962,23892456,18436640 Q8BX22 Q7TSZ8 SALL4 NACC1 0.554 17093407,20362541 Q921F2 Q7TSZ8 TARDBP NACC1 0.376 23022214 Q99JB6 Q7TSZ8 FOXP3 NACC1 0.126 22922362 Q7TSZ8 P52927 NACC1 HMGA2 0.126 26045162 Q7TSZ8 P22227 NACC1 ZFP42 0.126 17093407