PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Sf3a1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ezh2 Sf3a1 23624931 intact exp G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Eed 24457600 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Tpbg ortho G G G G G G G Cand1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snrpd2 Sf3a1 ortho P Srsf7 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Skiv2l2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ralyl Sf3a1 ortho Huwe1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Hnrnpu ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad3 Sf3a1 ortho G G G G G G G G G G G G G G G Sf3a1 Gsk3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mcm5 Sf3a1 ortho P G G G G G G G G G G G G G G Sf3a1 Eif4a3 ortho P Sf3a1 Prpf40a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Prpf8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Xab2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx46 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Wbp4 Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epb41 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Sp1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zc3h18 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Sf3b4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Smurf1 ortho Cyp1a1 Sf3a1 ortho G G G G G G Sf3a1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Sart1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gas7 Sf3a1 ortho P G G G Smek1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Luc7l2 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sarm1 Sf3a1 ortho Usp39 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Hdac6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Rbm10 ortho Snrpd3 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vdac1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Sfpq ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tsks Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Psma6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Il7r Sf3a1 ortho G G G G G G G G G Tcerg1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Enthd2 Sf3a1 ortho G G Snrpd1 Sf3a1 ortho P Sf3a1 Prpf6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Actn3 Sf3a1 ortho GP G G G G G G G G G G G Sf3a1 Plrg1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sirt7 Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpa2 Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Rnf2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Zbtb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Actl6a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx42 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Sf3a1 ortho P G G G G Utp14a Sf3a1 ortho P Sf3a1 Vasn ortho G G G G G G G G G G G G G G G G G G G G G G G G G Jun Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Supt16h ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Thrap3 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ilk Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Snw1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Prkab1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Znf326 Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxq1 Sf3a1 ortho G G G G G G G G G G G G Patl1 Sf3a1 ortho P Sf3a1 Ikbke ortho G G G G G G G G G G G G G Nr3c1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eif4g1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG19772, Protein Trim55 Sf3a1 ortho Snrpa1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Psmb3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Qprt ortho G G G Vhl Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Psma5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Sf3a1 ortho Sf3a1 Sf3b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vtn Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G Ptbp3 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Rbm7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Smyd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc6 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tra2a Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk2a1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Actr1a Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snrnp200 Sf3a1 ortho P Sf3a1 Wdr77 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd7 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbfox2 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Snrpb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pabpc1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Emc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Heterogeneous nuclear ribonucleoprotein R, Protein Hnrnpr ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Znf830 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Acin1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Ssbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Hdac11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G U2surp Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnrnpk Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcc2 Sf3a1 ortho P Sf3a1 Hdac5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gapvd1 Sf3a1 ortho P Mcm4 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Prpf31 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gtf2f1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Prpf4 ortho P Mcm6 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp4r2 Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arf6 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Rpa3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncor1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Txnl4a Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zmat3 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Isy1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbm14 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fnbp1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp30 Sf3a1 ortho Tcea1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Dync1h1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Serpinb5 Sf3a1 ortho G G G G Smarcc1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Rbmx ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snrnp70 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Abce1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Trmt112 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx5 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Vav3 ortho G G G G G G G G G G G G G G G G G Rae1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Prpf19 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tox4 Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G Sf3a1 Cul7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Trip10 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Prpf3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Ddx41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Chm ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Srsf1 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Rpa1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Hnrnpm ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc5l Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Cul3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Sf3a3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Wwox ortho G G G G G G G G G G G G G G G G G G G G Zrsr2 Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdc1 Sf3a1 ortho P Sf3a1 Gabarap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a2 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Gabarapl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Hnrnpc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Magoh Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brcc3 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx17 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr2 Sf3a1 ortho G Suz12 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Xrcc3 ortho Sf3a1 Sf3b3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Map1lc3a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dhx15 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Apbb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mcm7 Sf3a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8K4Z5 Q32P28-2 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 affinity chromatography technology 15761153 physical association X 2 Q15427 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q921E6 Q8K4Z5 affinity chromatography technology 24457600 physical association X 2 P62318 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 P62306 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q5W009 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 P62304 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 P62308 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q96F63 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 O75718 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q15428 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q7Z497 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q15393 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 P08579 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 O43143 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 A0A024R1K8 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 P14678 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 P62316-2 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 P09661 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 E1P5S2 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 Q7L014 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 Q9BWJ5 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 Q9GZS3 affinity chromatography technology 20360068 physical association X 2 P62314 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 O15042 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 A0A024R1U2 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q6PID6 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 O75937 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q9Y3B4 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q8IWX8 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 O43719 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q13435 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q12874 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q86XP3 Q8K4Z5 affinity chromatography technology 20360068 physical association X 2 Q8K4Z5 pull down 23624931 association C 129 Q8K4Z5 tandem affinity purification 20360068 physical association C 36

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sf3a1 Eed MI:0004(affinity chromatography technology)|MI:0027(cosedimentation) 16615898,24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(intact) BIOGRID_332459|UniProt_167137 prey|neutral component bait|neutral component

PPI - HINT Gene A Gene B PMID Method Quality YWHAE SF3A1 16615898 0027 LC EZH2 SF3A1 23624931 0096 LC SF3A1 EED 24457600 0004 LC SF3A1 CHAF1A 26365490 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8K4Z5 P63162 SF3A1 SNRPN 0.126 20360068 Q8K4Z5 P62259 SF3A1 YWHAE 0.081 16615898 Q9HCE7 Q8K4Z5 SMURF1 SF3A1 0.126 15761153 Q8K4Z5 Q6AXH7 SF3A1 EZH2 0.126 23624931 Q8K4Z5 Q13435 SF3A1 SF3B2 0.236 20360068 Q8K4Z5 Q12874 SF3A1 SF3A3 0.236 20360068 Q8K4Z5 O43143 SF3A1 DHX15 0.236 20360068 Q8K4Z5 O15042 SF3A1 U2SURP 0.236 20360068 Q8K4Z5 P62318 SF3A1 SNRPD3 0.236 20360068 Q8K4Z5 P08579 SF3A1 SNRPB2 0.236 20360068 Q8K4Z5 O75533 SF3A1 SF3B1 0.236 20360068 Q8K4Z5 O43719 SF3A1 HTATSF1 0.236 20360068 Q8K4Z5 O75937 SF3A1 DNAJC8 0.236 20360068 Q8K4Z5 O75718 SF3A1 CRTAP 0.236 20360068 Q8K4Z5 P62316 SF3A1 SNRPD2 0.236 20360068 Q8K4Z5 P62304 SF3A1 SNRPE 0.236 20360068 Q8K4Z5 P09661 SF3A1 SNRPA1 0.236 20360068 Q8K4Z5 P14678 SF3A1 SNRPB 0.236 20360068 Q8K4Z5 P62314 SF3A1 SNRPD1 0.236 20360068 Q8K4Z5 P62306 SF3A1 SNRPF 0.236 20360068 Q8K4Z5 P62308 SF3A1 SNRPG 0.236 20360068 Q8K4Z5 Q8IWX8 SF3A1 CHERP 0.236 20360068 Q8K4Z5 Q15459 SF3A1 SF3A1 0.236 20360068 Q8K4Z5 Q14498 SF3A1 RBM39 0.236 20360068 Q8K4Z5 Q15428 SF3A1 SF3A2 0.236 20360068 Q8K4Z5 Q15393 SF3A1 SF3B3 0.236 20360068 Q8K4Z5 Q15427 SF3A1 SF3B4 0.236 20360068 Q8K4Z5 Q86XP3 SF3A1 DDX42 0.236 20360068 Q8K4Z5 Q32P28 SF3A1 LEPRE1 0.236 20360068 Q8K4Z5 Q7RTV0 SF3A1 PHF5A 0.236 20360068 Q8K4Z5 Q6PID6 SF3A1 TTC33 0.236 20360068 Q8K4Z5 Q7L014 SF3A1 DDX46 0.236 20360068 Q9Y3B4 Q8K4Z5 SF3B6 SF3A1 0.236 20360068 Q96F63 Q8K4Z5 CCDC97 SF3A1 0.236 20360068 Q8N954 Q8K4Z5 GPATCH11 SF3A1 0.236 20360068 Q9GZS3 Q8K4Z5 WDR61 SF3A1 0.236 20360068 Q96I25 Q8K4Z5 RBM17 SF3A1 0.236 20360068 Q9BWJ5 Q8K4Z5 SF3B5 SF3A1 0.236 20360068 Q921E6 Q8K4Z5 EED SF3A1 0.126 24457600 Q9QWF0 Q8K4Z5 CHAF1A SF3A1 0.126 26365490 Q8K4Z5 Q15637 SF3A1 SF1 0.236 26420826