PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Ranbp2 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Top2a Ranbp2 18394993 intact exp G G G G G G G G G G G G G G G G G G G G G G Kcna2 Ranbp2 15102471 mint,intact exp G G G G G Sumo1 Ranbp2 15094046 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ranbp2 Park2 16332688 intact exp G G G G Plcg1 Ranbp2 15102471 intact exp P Foxp3 Ranbp2 22922362 biogrid exp Nanog Ranbp2 23892456 biogrid,intact exp Ranbp2 Aire 20085707 intact exp Eed Ranbp2 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkar1a Ranbp2 15102471 mint,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trpm7 Ranbp2 24855944 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P49792 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 P0DJD1 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 Q53Z59 Q9ERU9 affinity chromatography technology 22922362 physical association X 2 Q9ERU9 A2RS90 affinity chromatography technology 23892456 physical association X 2 Q9ERU9 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q9ERU9 A0A024R3Z2 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 Q96FU2 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 Q14980 affinity chromatography technology 20360068 physical association X 2 Q14974 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 P63279 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 P52292 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 P0DJD0 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 P63166 enzymatic study 15094046 direct interaction X 2 Q9ERU9 A0A024R1U0 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 A0A024RDV7 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 P62826 affinity chromatography technology 20360068 physical association X 2 P46061 Q9ERU9 affinity chromatography technology 8978815 physical association X 2 O00629 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 P43487 Q9ERU9 affinity chromatography technology 20360068 physical association X 2 Q9ERU9 anti tag coimmunoprecipitation 23892456 association C 143 Q9DBC7 Q9ERU9 two hybrid 15102471 physical association X 2 P63141 Q9ERU9 two hybrid 15102471 physical association X 2 Q62077 Q9ERU9 two hybrid 15102471 physical association X 2 Q9ERU9 tandem affinity purification 20360068 physical association C 20 Q9ERU9 anti tag coimmunoprecipitation 20085707 association C 46 Q01320 Q9ERU9 anti bait coimmunoprecipitation 18394993 physical association X 2 Q9WVS6 Q9ERU9 anti bait coimmunoprecipitation 16332688 physical association X 2 Q9WVS6 Q9ERU9 anti bait coimmunoprecipitation 16332688 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ranbp2 Park2 MI:0018(two hybrid)|MI:0018(two hybrid) 16332688 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_166713|UniProt_166714 prey|bait bait|prey Nanog Ranbp2 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 23892456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_177306|BIOGRID_331353 bait|bait prey|prey Sumo1 Ranbp2 MI:0415(enzymatic study) 15094046 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_325354 bait prey Plcg1 Ranbp2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164799 bait prey Rangap1 Ranbp2 MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 16615898,8978815 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(biogrid)|(intact)|(intact)|(intact) UniProt_167137|BIOGRID_325642|UniProt_167117|UniProt_167125|UniProt_167129 neutral component|bait|neutral component|neutral component|neutral component neutral component|prey|neutral component|neutral component|neutral component Eed Ranbp2 MI:0027(cosedimentation)|MI:0004(affinity chromatography technology) 16615898,24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid) UniProt_167137|BIOGRID_332229 neutral component|bait neutral component|prey Top2a Ranbp2 MI:0027(cosedimentation)|MI:0006(anti bait coimmunoprecipitation) 16615898,18394993 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact) UniProt_167137|UniProt_168270 neutral component|prey neutral component|bait Prkar1a Ranbp2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164863 bait prey Kcna2 Ranbp2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_163184 bait prey Foxp3 Ranbp2 MI:0004(affinity chromatography technology) 22922362 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324844 bait prey

PPI - HINT Gene A Gene B PMID Method Quality YWHAE RANBP2 16615898 0027 LC KCNA2 RANBP2 15102471 0018 LC PLCG1 RANBP2 15102471 0018 LC PRKAR1A RANBP2 15102471 0018 LC SUMO1 RANBP2 15094046 0004 LC TOP2A RANBP2 18394993 0006 LC NANOG RANBP2 23892456,23892456 0007,0004 LC EED RANBP2 24457600 0004 LC TRPM7 RANBP2 24855944 0007 LC FOXP3 RANBP2 22922362 0004 LC RANBP2 CHAF1A 26365490 0004 LC RANBP2 PARK2 16332688 0006 LC RANBP2 AIRE 20085707 0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9ERU9 P62259 RANBP2 YWHAE 0.081 16615898 Q9ERU9 P36873 RANBP2 PPP1CC 0.236 26496610 Q9ERU9 P35658 RANBP2 NUP214 0.236 26496610 Q9ERU9 P14373 RANBP2 TRIM27 0.236 26496610 Q9ERU9 O95373 RANBP2 IPO7 0.236 26496610 Q9ERU9 O14524 RANBP2 TMEM194A 0.236 26496610 Q9ERU9 O94905 RANBP2 ERLIN2 0.236 26496610 Q9ERU9 O15504 RANBP2 NUPL2 0.236 26496610 Q9ERU9 O14715 RANBP2 RGPD8 0.236 26496610 Q9ERU9 O75694 RANBP2 NUP155 0.236 26496610 Q9ERU9 O43633 RANBP2 CHMP2A 0.236 26496610 Q9ERU9 O60678 RANBP2 PRMT3 0.236 26496610 Q9ERU9 Q6NUQ4 RANBP2 TMEM214 0.236 26496610 Q9ERU9 P78406 RANBP2 RAE1 0.236 26496610 Q9ERU9 P52292 RANBP2 KPNA2 0.236 20360068 Q9ERU9 P43487 RANBP2 RANBP1 0.236 20360068 Q9ERU9 P37198 RANBP2 NUP62 0.236 26496610 Q9ERU9 P49792 RANBP2 RANBP2 0.236 20360068 Q9ERU9 P49790 RANBP2 NUP153 0.236 26496610 Q9ERU9 P57740 RANBP2 NUP107 0.236 26496610 Q9ERU9 P52948 RANBP2 NUP98 0.236 26496610 Q9ERU9 P55735 RANBP2 SEC13 0.236 26496610 Q9ERU9 P61956 RANBP2 SUMO2 0.236 26496610 Q9ERU9 Q69YH5 RANBP2 CDCA2 0.236 26496610 Q9ERU9 Q13751 RANBP2 LAMB3 0.236 26496610 Q9ERU9 P98170 RANBP2 XIAP 0.236 26496610 Q9ERU9 Q12769 RANBP2 NUP160 0.236 26496610 Q9ERU9 Q5T4S7 RANBP2 UBR4 0.236 26496610 Q9ERU9 Q14527 RANBP2 HLTF 0.236 26496610 Q9ERU9 Q5SRE5 RANBP2 NUP188 0.236 26496610 Q9ERU9 Q53GS7 RANBP2 GLE1 0.236 26496610 Q9P0U3 Q9ERU9 SENP1 RANBP2 0.236 26496610 Q9ERU9 Q96KM6 RANBP2 ZNF512B 0.236 26496610 Q9ERU9 Q8TB61 RANBP2 SLC35B2 0.236 26496610 Q9ERU9 Q8N1F7 RANBP2 NUP93 0.236 26496610 Q9ERU9 Q7Z4Q2 RANBP2 HEATR3 0.236 26496610 Q9ERU9 Q8NFH5 RANBP2 NUP35 0.236 26496610 Q9ERU9 Q8NFH3 RANBP2 NUP43 0.236 26496610 Q9ERU9 Q8NFH4 RANBP2 NUP37 0.236 26496610 Q9ERU9 Q96EE3 RANBP2 SEH1L 0.236 26496610 Q9ERU9 Q8WUM0 RANBP2 NUP133 0.236 26496610 Q9ERU9 Q8TD16 RANBP2 BICD2 0.236 20360068 Q9ERU9 Q96A33 RANBP2 CCDC47 0.236 26496610 Q9ERU9 Q8WUM4 RANBP2 PDCD6IP 0.236 26496610 Q9ERU9 Q92621 RANBP2 NUP205 0.236 26496610 Q9NRG9 Q9ERU9 AAAS RANBP2 0.236 26496610 Q9ERU9 Q9BXS6 RANBP2 NUSAP1 0.236 20360068 Q9ERU9 Q99567 RANBP2 NUP88 0.236 26496610 Q9ERU9 Q96SK2 RANBP2 TMEM209 0.236 26496610 Q9ERU9 Q9BW27 RANBP2 NUP85 0.236 26496610 Q9ERU9 Q9BTX1 RANBP2 NDC1 0.236 26496610 Q9NPJ8 Q9ERU9 NXT2 RANBP2 0.236 26496610 Q9H9B4 Q9ERU9 SFXN1 RANBP2 0.236 26496610 Q9H444 Q9ERU9 CHMP4B RANBP2 0.236 26496610 Q9H568 Q9ERU9 ACTL8 RANBP2 0.236 26496610 Q9HD47 Q9ERU9 RANGRF RANBP2 0.236 26496610 Q9HC62 Q9ERU9 SENP2 RANBP2 0.236 26496610 Q9HD42 Q9ERU9 CHMP1A RANBP2 0.236 26496610 Q9UKK6 Q9ERU9 NXT1 RANBP2 0.236 26496610 Q9UHQ1 Q9ERU9 NARF RANBP2 0.236 26496610 Q9UKX7 Q9ERU9 NUP50 RANBP2 0.236 26496610 Q9Y4R8 Q9ERU9 TELO2 RANBP2 0.236 26496610 Q9ERU9 Q80Z64 RANBP2 NANOG 0.236 23892456 Q9ERU9 P18754 RANBP2 RCC1 0.332 26496610,20360068 Q9ERU9 O00629 RANBP2 KPNA4 0.416 26496610,20360068 Q9ERU9 O00505 RANBP2 KPNA3 0.416 26496610,20360068 Q9UBU9 Q9ERU9 NXF1 RANBP2 0.416 26496610,20360068 Q9ERU9 P46060 RANBP2 RANGAP1 0.416 26496610,20360068 Q9ERU9 P63279 RANBP2 UBE2I 0.416 26496610,20360068 Q9ERU9 P63165 RANBP2 SUMO1 0.416 26496610,20360068 Q9ERU9 P62826 RANBP2 RAN 0.416 26496610,20360068 Q9ERU9 Q14974 RANBP2 KPNB1 0.416 26496610,20360068 Q9ERU9 Q99666 RANBP2 RGPD6 0.416 26496610,20360068 Q9ERU9 Q921E6 RANBP2 EED 0.126 24457600 Q9ERU9 Q923J1 RANBP2 TRPM7 0.126 24855944 Q9ERU9 Q99JB6 RANBP2 FOXP3 0.126 22922362 Q9ERU9 A8CG34 RANBP2 POM121C 0.126 26496610 Q9ERU9 A8K394 RANBP2 A8K394 0.126 20360068 Q9ERU9 A8K7Q2 RANBP2 HSPA8 {ECO:0000313|ENSEMBL:ENSP00000433316} 0.126 26496610 Q9ERU9 B4DQN6 RANBP2 B4DQN6 0.126 20360068 Q9ERU9 P0DJD0 RANBP2 RGPD1 0.126 20360068 Q9ERU9 P0DJD1 RANBP2 RGPD2 0.126 20360068 Q9ERU9 P11142 RANBP2 HSPA8 0.126 26496610 Q9ERU9 P55854 RANBP2 SUMO3 0.126 20360068 Q9ERU9 P63141 RANBP2 KCNA2 0.183 15102471 Q9ERU9 P63166 RANBP2 SUMO1 0.21 15094046 Q9ERU9 Q14980 RANBP2 NUMA1 0.126 20360068 Q9ERU9 Q62077 RANBP2 PLCG1 0.183 15102471 Q9ERU9 Q9BW19 RANBP2 KIFC1 0.126 20360068 Q9ERU9 Q9DBC7 RANBP2 PRKAR1A 0.183 15102471 Q9UF83 Q9ERU9 Q9UF83 RANBP2 0.126 26496610 Q9WVS6 Q9ERU9 PARK2 RANBP2 0.376 16332688 Q9Z0E3 Q9ERU9 AIRE RANBP2 0.236 20085707 Q9QWF0 Q9ERU9 CHAF1A RANBP2 0.126 26365490 Q9ERU9 Q01320 RANBP2 TOP2A 0.21 18394993