PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 Keap1 23086144 biogrid exp G G G G G G G G G G G G G G G G G G Ptma Keap1 19279002 biogrid exp Ywhae Keap1 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbx1 Keap1 19279002 biogrid exp Abcf1 Keap1 23263557 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkb Keap1 15102471 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Keap1 17420218 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Keap1 24011591,20173742 innatedb,biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Neil2 Keap1 24366543 biogrid exp, ortho Keap1 Keap1 12145307,20133743 biogrid,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul3 Keap1 19279002 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfe2l2 Keap1 12145307,16785233,17591699,17420218,18358244,16581765,19279002,15143058,18512965,19560419,22688683,17903176,24366543,17785452,16507366,24011591,20173742 innatedb,biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gbas Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ipo11 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cacybp Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Enc1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Get4 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rela Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sesn1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Etf1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map1lc3a Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myo7a Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarap Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG11933, Protein Fam46a Keap1 ortho Mcmbp Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map1lc3b Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slx4 Keap1 ortho Med4 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbm45 Keap1 ortho Mad2l1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Klhl3 Keap1 ortho Cdk13 Keap1 ortho Protein Tsc22d2 Keap1 ortho Cep135 Keap1 ortho Myh7 Keap1 ortho G G G G G G G G G G G Ctr9 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cat Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nkd1 Keap1 ortho G G G G G G Wdr1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkce Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Amer1 Keap1 ortho Mthfd1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Neu2 Keap1 ortho G G G G G G G Bad Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irf1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syne4 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G Fbxw11 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddit3 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapkbp1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mlst8 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Copg1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dll1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Maz Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Npm1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Reck Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr83 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Glrx5 Keap1 ortho Fermt3 Keap1 ortho G G G G G G G G G G G Atg5 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa8 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Bbs1 Keap1 ortho Osbpl6 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slk Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabpa Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sugt1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul2 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tsc22d4 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tubg1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clu Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chuk Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fkbpl Keap1 ortho G G G G G G G G G G G G G G G G G G G Aarsd1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tmem160 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdcd6ip Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zranb1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfe2l1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Oxr1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl2 Keap1 ortho G G G G G G G G G G G G G G G Arcn1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sesn2 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G Nudcd3 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mcm3 Keap1 ortho G G G G G G G G G G G G G G G G G G G Xpo1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Polr3e Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccnb1ip1 Keap1 ortho G Pidd1 Keap1 ortho G G G G G Lsm3 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ttyh3 Keap1 ortho Pfas Keap1 ortho Bag3 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fam117b Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kpna6 Keap1 ortho G G G G G G G G G G G G G Klhl2 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Naf1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Terf1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Sass6 Keap1 ortho G G G G G G G G G G G G G Fam129b Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Polr2f Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkag1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin2 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G Protein Bod1l Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snrpn Keap1 ortho G G G G G Nudt4 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarapl1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pgam5 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dpp3 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Bptf Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vwa8 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp11 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G Ikbkg Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarapl2 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ak4 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Z2X8 Q60795 affinity chromatography technology 17903176 physical association X 2 Q9Z2X8 Q60795 x-ray crystallography 16581765 association X 2 Q9Z2X8 Q60795 pull down 16581765 direct interaction X 2 Q9Z2X8 Q60795 unspecified method 22688683 direct interaction X 2 Q9Z2X8 Q60795 x-ray crystallography 16507366 association X 2 Q9Z2X8 Q60795 affinity chromatography technology 16507366 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 20173742 physical association X 2 Q9Z2X8 affinity chromatography technology 23086144 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 12145307 physical association X 2 Q9Z2X8 Q60795 unspecified method 17785452 direct interaction X 2 Q9Z2X8 pull down 24366543 direct interaction X 2 Q9Z2X8 Q60795 pull down 24366543 direct interaction X 2 Q9Z2X8 Q60795 unspecified method 24366543 direct interaction X 2 Q9Z2X8 Q60795 x-ray crystallography 24366543 association X 2 Q9Z2X8 Q60795 affinity chromatography technology 18358244 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 18512965 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 17591699 physical association X 2 Q9Z2X8 P0CG50 affinity chromatography technology 17420218 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 17420218 physical association X 2 Q9Z2X8 Q9JLV5 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 P62878 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 P62878 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 Q9JLV5 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 19560419 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 16785233 physical association X 2 Q9Z2X8 Q60795 affinity chromatography technology 15143058 physical association X 2 Q64337 Q9Z2X8 affinity chromatography technology 20173742 physical association X 2 Q64337 Q9Z2X8 pull down 20173742 direct interaction X 2 Q64337 Q9Z2X8 affinity chromatography technology 20173742 physical association X 2 Q64337 Q9Z2X8 x-ray crystallography 20173742 association X 2 Q64337 Q9Z2X8 imaging technique 20173742 colocalization X 2 Q64337 Q9Z2X8 pull down 20173742 direct interaction X 2 Q9Z2X8 Q9Z2X8 x-ray crystallography 20133743 association X 2 Q9Z2X8 Q9Z2X8 affinity chromatography technology 12145307 physical association X 2 Q9Z2X8 Q16236-3 two hybrid 9887101 direct interaction X 2 Q9Z2X8 Q16236-3 pull down 9887101 direct interaction X 2 Q9Z2X8 P06454 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 P06454 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 P26350 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 P26350 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 cosedimentation through density gradient 17903176 association C 3 Q9Z2X8 Q60795 anti bait coimmunoprecipitation 17903176 association X 2 Q9Z2X8 Q9Z2X8 transmission electron microscopy 20133743 direct interaction Y 1 Q9Z2X8 Q9Z2X8 comigration in sds page 20133743 direct interaction Y 1 Q9Z2X8 Q9Z2X8 molecular sieving 20133743 direct interaction Y 1 Q9Z2X8 Q13501 anti tag coimmunoprecipitation 20173742 physical association X 2 Q64337 Q9Z2X8 pull down 20173742 direct interaction X 2 Q64337 Q9Z2X8 pull down 20173742 direct interaction X 2 Q64337 Q9Z2X8 anti tag coimmunoprecipitation 20173742 physical association X 2 Q64337 Q9Z2X8 x-ray crystallography 20173742 direct interaction X 2 Q64337 Q9Z2X8 isothermal titration calorimetry 20173742 direct interaction X 2 Q9Z2X8 anti tag coimmunoprecipitation 20173742 physical association C 3 Q9Z2X8 O88351 two hybrid 15102471 physical association X 2 Q16236 Q9Z2X8 anti tag coimmunoprecipitation 20173742 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality IKBKB KEAP1 15102471 0018 LC PTMA KEAP1 18391415 0114 LC YWHAE KEAP1 16615898 0027 LC NFE2L2 KEAP1 24366543,24366543,16507366,16507366,24366543,16581765,16581765,24366543,24366543,17785452 0114,1235,0114,0004,0107,0114,0096,0096,0065,0114 LC SQSTM1 KEAP1 20173742,20173742,20173742,20173742,24011591,20173742,20173742 0004,0007,0428,0114,0114,0065,0096 LC KEAP1 KEAP1 20133743,27345495,24366543,20133743,20133743,20133743 0020,0114,0114,0071,0114,0808 LC UBC KEAP1 17420218 0004 LC PTMA KEAP1 19279002 0004 LC RBX1 KEAP1 19279002 0004 LC ZBTB16 KEAP1 23086144 0004 LC NFE2L2 KEAP1 17903176,24366543,24366543,16507366,12145307,17591699,16507366,20173742,19560419,24366543,17903176,18512965,16785233,19279002,16581765,16581765,17420218,18358244,15143058,24366543,24366543 0004,0114,1235,0114,0004,0004,0004,0004,0004,0107,0006,0004,0004,0004,0114,0096,0004,0004,0004,0096,0065 LC SQSTM1 KEAP1 20173742,20173742,20173742,20173742,20173742,20173742 0004,0007,0428,0114,0065,0096 LC ABCF1 KEAP1 23263557 0006 LC NEIL2 KEAP1 24366543 0096 LC CUL3 KEAP1 19279002 0004 LC KEAP1 KEAP1 12145307 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Z2X8 P62259 KEAP1 YWHAE 0.081 16615898 Q9Z2X8 Q9JLV5 KEAP1 CUL3 0.376 19279002 Q9Z2X8 O88351 KEAP1 IKBKB 0.183 15102471 Q9Z2X8 P06454 KEAP1 PTMA 0.376 19279002 Q9Z2X8 P0CG50 KEAP1 UBC 0.21 17420218 Q9Z2X8 Q13501 KEAP1 SQSTM1 0.21 20173742 Q9Z2X8 Q6R2P8 KEAP1 NEIL2 0.309 24366543 Q9Z2X8 Q9Z2X8 KEAP1 KEAP1 0.49 20133743,12145307 Q9Z2X8 Q64337 KEAP1 SQSTM1 0.932 20173742 Q9Z2X8 Q60795 KEAP1 NFE2L2 0.999 24366543,16581765,16785233,12145307,15143058,19279002,17420218,17785452,20173742,17903176,18358244,16507366,22688683,19560419,17591699,18512965 Q9Z2X8 P26350 KEAP1 PTMA 0.376 19279002 Q9Z2X8 P62878 KEAP1 RBX1 0.376 19279002 Q9Z2X8 Q12830 KEAP1 BPTF 0.376 19279002 Q9Z2X8 Q16236 KEAP1 NFE2L2 0.623 20173742,9887101