PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ube2n Tax1bp1 20185725 innatedb,biogrid exp P Traf2 Tax1bp1 21765415,20185725 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Tax1bp1 20185725 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Shc1 Tax1bp1 15102471 mint,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Chuk 21765415 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Ripk1 18239685 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Ubc Tax1bp1 18239685 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf6 Tax1bp1 18239685,21765415,20185725 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G Tax1bp1 Tnfaip3 20185725,21765415 innatedb,biogrid,intact exp, ortho G G G G G Tax1bp1 Rnf11 19131965,21765415 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Itch 18246070,21765415 innatedb,biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Tsg101 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Rad54l2 ortho G G G G G G G G G G G G G G Tax1bp1 Myo6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Tax1bp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Tbc1d17 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Rnf126 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Ldlrad4 ortho G Tax1bp1 Fam189a2 ortho 9030611K07Rik Tax1bp1 ortho Tax1bp1 Gabarap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Tshz3 ortho Tax1bp1 Mrpl53 ortho P Tax1bp1 Tcea2 ortho G G G G G G G G G G G G G G G Tax1bp1 Rad18 ortho G G G G G G G Tax1bp1 Dstn ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Kif5b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Tbk1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Fam58b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Tax1bp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Hnrnpd ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Foxc2 ortho G G Tax1bp1 Map1lc3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Cog7 ortho Tax1bp1 Traf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Cxxc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Fam168a ortho Ntrk1 Tax1bp1 ortho Tax1bp1 Fhl5 ortho G Ikbkg Tax1bp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Sh3glb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab18 Tax1bp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Mrpl11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Reep4 ortho Tax1bp1 Med4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Plekhn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Lgals8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Cwf19l2 ortho Hsd17b3 Tax1bp1 ortho G Tax1bp1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Optn ortho Tax1bp1 Park2 ortho G G G G Tax1bp1 Ikbke ortho G G G G G G G G G G G G G Ube2i Tax1bp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Arhgap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Ralbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Nmrk1 ortho G G G G G G G G G G Tax1bp1 Orc5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Emilin1 ortho G G G G G G G G G G G G G G G G G G G G G Jun Tax1bp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tax1bp1 Stard13 ortho G G G G G G G G G G G G G G G G G G G Tax1bp1 Dazap2 ortho Gabrr1 Tax1bp1 ortho G Tax1bp1 Tnip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P39429 Q3UKC1 affinity chromatography technology 20185725 physical association X 2 P39429 Q3UKC1 affinity chromatography technology 21765415 physical association X 2 P61079 Q3UKC1 affinity chromatography technology 20185725 physical association X 2 Q3UKC1 P0CG50 affinity chromatography technology 18239685 physical association X 2 Q3UKC1 Q3TBB9 affinity chromatography technology 20185725 physical association X 2 Q3UKC1 Q3TBB9 affinity chromatography technology 20185725 physical association X 2 Q3UKC1 Q3TBB9 affinity chromatography technology 21765415 physical association X 2 Q9QYK7 Q3UKC1 affinity chromatography technology 21765415 physical association X 2 Q60855 Q3UKC1 affinity chromatography technology 18239685 physical association X 2 Q60855 Q3UKC1 affinity chromatography technology 18239685 physical association X 2 Q3UKC1 P70196 affinity chromatography technology 18239685 physical association X 2 Q3UKC1 P70196 affinity chromatography technology 18239685 physical association X 2 Q3UKC1 P70196 affinity chromatography technology 20185725 physical association X 2 Q3UKC1 Q3TPN9 enzymatic study 21765415 direct interaction X 2 Q3UKC1 Q3TPN9 affinity chromatography technology 21765415 physical association X 2 Q3UKC1 P70196 affinity chromatography technology 21765415 physical association X 2 Q8C863 Q3UKC1 affinity chromatography technology 21765415 physical association X 2 P61089 Q3UKC1 affinity chromatography technology 20185725 physical association X 2 Q3UKC1 anti bait coimmunoprecipitation 19131965 association C 4 P98083 Q3UKC1 two hybrid 15102471 physical association X 2 P98083 Q3UKC1 two hybrid 15102471 physical association X 2 Q60769 Q3UKC1 anti bait coimmunoprecipitation 21765415 physical association X 2 Q60680 Q3UKC1 anti bait coimmunoprecipitation 21765415 physical association X 2 Q8C863 Q3UKC1 anti bait coimmunoprecipitation 21765415 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Traf2 Tax1bp1 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 20185725,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_319666|BIOGRID_318881 bait|bait prey|prey Tax1bp1 Itch MI:0415(enzymatic study)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_319674|UniProt_113521|UniProt_171883 bait|bait|bait prey|prey|prey Ube2n Tax1bp1 MI:0004(affinity chromatography technology) 20185725 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318882 prey bait Tax1bp1 Ripk1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18239685 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_326010|BIOGRID_326011 bait|prey prey|bait Tax1bp1 Ube2d3 MI:0004(affinity chromatography technology) 20185725 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318883 bait prey Tax1bp1 Chuk MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_113524|UniProt_171886 bait|bait prey|prey Tax1bp1 Tnfaip3 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 20185725,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_319676|BIOGRID_318891|BIOGRID_318889|UniProt_113522|UniProt_171884 prey|bait|prey|prey|prey bait|prey|bait|bait|bait Tax1bp1 Rnf11 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0415(enzymatic study) 19131965,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid) UniProt_169598|MINT_70539|BIOGRID_319671 prey|prey|prey bait|bait|bait Shc1 Tax1bp1 MI:0018(two hybrid)|MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_164717|UniProt_164716 bait|bait prey|prey Traf6 Tax1bp1 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18239685,20185725,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_319656|BIOGRID_326006|BIOGRID_326007|BIOGRID_318875 bait|prey|bait|bait prey|bait|prey|prey Ubc Tax1bp1 MI:0004(affinity chromatography technology) 18239685 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_326005 bait prey

PPI - HINT Gene A Gene B PMID Method Quality SHC1 TAX1BP1 15102471 0018 LC TAX1BP1 CHUK 21765415,21765415,21765415 0006,0004,0415 LC UBC TAX1BP1 18239685 0096 LC TRAF2 TAX1BP1 20185725,21765415,20185725 0007,0004,0004 LC UBE2D3 TAX1BP1 20185725 0004 LC UBE2N TAX1BP1 20185725,20185725 0007,0004 LC TRAF6 TAX1BP1 20185725,18239685,21765415,20185725 0007,0004,0004,0004 LC TAX1BP1 CHUK 21765415,21765415,21765415 0006,0004,0415 LC TAX1BP1 TNFAIP3 20185725,21765415,21765415,20185725 0007,0006,0004,0004 LC TAX1BP1 RIPK1 18239685 0004 LC TAX1BP1 ITCH 21765415,21765415 0006,0004 LC TAX1BP1 RNF11 21765415,19131965 0004,0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q3UKC1 P0CG50 TAX1BP1 UBC 0.309 18239685 Q3UKC1 P39429 TAX1BP1 TRAF2 0.376 20185725,21765415 Q3UKC1 P61079 TAX1BP1 UBE2D3 0.21 20185725 Q3UKC1 P61089 TAX1BP1 UBE2N 0.21 20185725 Q3UKC1 P70196 TAX1BP1 TRAF6 0.61 18239685,20185725,21765415 Q3UKC1 P98083 TAX1BP1 SHC1 0.183 15102471 Q60769 Q3UKC1 TNFAIP3 TAX1BP1 0.507 20185725,21765415 Q60855 Q3UKC1 RIPK1 TAX1BP1 0.376 18239685 Q8C863 Q3UKC1 ITCH TAX1BP1 0.21 21765415 Q9QYK7 Q3UKC1 RNF11 TAX1BP1 0.507 19131965,21765415