PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus plagl2 Pias4 15208321 biogrid exp G G G G G G G G G G G G G G G G G Axin1 Pias4 12223491 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Pias4 16816390 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lef1 Pias4 11731474,20211142 innatedb,biogrid,i2d exp, ortho G G G Tp53 Pias4 16816390 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rela Pias4 17606919,20054338 biogrid,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trim32 Pias4 16816390 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zw10 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kntc1 Pias4 ortho Kpnb1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53bp1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Herc2 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hif1a Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias2 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Immt Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brca1 Pias4 ortho G G G G G G G G G G G G G Gfi1 Pias4 ortho G G G G G G Rif1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Oaz1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt18 Pias4 ortho G G G G G G G G G G G G G G G G G G G G Pias4 Gadd45g ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad2 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnrnpul1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Parp1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Satb1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G Erbb4 Pias4 ortho Coil Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tcerg1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pde4dip Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad4 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad7 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irf7 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lamp2 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias4 Hic1 ortho G G G G G G G G G G G G G G G G G G G G G G Ticam1 Pias4 ortho Phgdh Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Btaf1 Pias4 ortho Tcf4 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Top2a Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G Serpina5 Pias4 ortho G G Sh3gl3 Pias4 ortho G G G G G G G G G G G G Xrcc5 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Smad1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Optn Pias4 ortho Ss18 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ets1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Serbp1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ca10 Pias4 ortho G G G G G G G G Prkcz Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G Smad6 Pias4 ortho G G G G G G G G G G G G G G G G G G G G Pias4 Sumo3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo2 Pias4 ortho Pde4a Pias4 ortho G G G G G G G G G G G G G G Xrcc6 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bard1 Pias4 ortho Lrif1 Pias4 ortho Trim27 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snip1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nkd1 Pias4 ortho G G G G G G Tgm2 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Znf512b Pias4 ortho Tada3 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prmt5 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nefl Pias4 ortho G G G G G G G G G Setdb1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vim Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aldoa Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Skil Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2i Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdc1 Pias4 ortho Eif5b Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zmiz2 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Chd3 Pias4 ortho Pias4 Plag1 ortho Htt Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Il15ra Pias4 ortho G G G G G G G G G G G G G G G G G Clk1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad3 Pias4 ortho G G G G G G G G G G G G G G G Pias4 Mecom ortho G Ptn Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G Vhl Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mprip Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map1lc3a Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zhx1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cebpd Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Men1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac2 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias4 Prpf40a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fth1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irf3 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr4a2 Pias4 ortho G G G G G G G G G G G G G G G G Actn1 Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ar Pias4 ortho G G G G G G G G G G G G G G G G Hnf4a Pias4 ortho G G G G G G G G G G G Pias4 Mageh1 ortho G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JM05 P0CG50 affinity chromatography technology 16816390 physical association X 2 Q9JM05 Q04207 affinity chromatography technology 20054338 physical association X 2 Q9JM05 two hybrid 15208321 direct interaction X 2 Q9JM05 pull down 15208321 direct interaction X 2 Q9JM05 P27782 two hybrid 20211142 direct interaction X 2 Q9JM05 Q3TLR3 two hybrid 16816390 direct interaction X 2 Q9JM05 Q549C9 two hybrid 16816390 direct interaction X 2 Q9JM05 Q3TLR3 affinity chromatography technology 16816390 physical association X 2 Q9JM05 Q3TLR3 imaging technique 16816390 colocalization X 2 Q9JM05 Q8UN00 anti tag coimmunoprecipitation 22685230 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JM05 Q04207 PIAS4 RELA 0.21 20054338 Q9JM05 O35625 PIAS4 AXIN1 0.309 12223491 Q9JM05 P0CG50 PIAS4 UBC 0.21 16816390 Q9JM05 P02340 PIAS4 TP53 0.309 16816390 Q9JM05 Q8CH72 PIAS4 TRIM32 0.523 16816390 Q9JM05 P27782 PIAS4 LEF1 0.183 20211142