PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Wdr1 Ywhaz 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Wdr61 19345177 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Pgls 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ilk Wdr1 23612611 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ruvbl2 19345177 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Leo1 19345177 biogrid exp P Wdr1 Ywhae 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Sf3b4 19345177 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ruvbl1 19345177 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cdc73 19345177 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Gmppb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Txndc17 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Got1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Adss ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Card11 ortho Wdr1 Scly ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Myo18a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ntrk1 ortho Wdr1 Ldhb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cth ortho GP G G G G G G G G G G G G G G G G G G G Wdr1 Synpo ortho P G G G G G G G G G G G G G G G G G G G G G Wdr1 Msn ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ifi30 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 L-lactate dehydrogenase ortho Wdr1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Usp7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Tkt ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Hspb2 ortho G G G G G G G G G G G G G G Wdr1 Txn ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Myo19 ortho G G G G G G G G G G G G G G G Wdr1 Eno2 ortho P G G G G G G G G G G Prdx6 Wdr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Uap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Mapk14 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ambra1 Wdr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cul3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Grb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Dis3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cct2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Sumo3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Actg1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Csnk2b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ppme1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Atp6ap2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Hspe1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Gsto2 ortho P Wdr1 Mapre1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd14 Wdr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Tyms ortho G G Wdr1 Ldha ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Iqgap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Nagk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Rbbp7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Lima1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Hsph1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Isg15 ortho P Wdr1 Mov10 ortho G G G G G G G G G G G G G G G G G G G G Wdr1 Gale ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Prpf40b ortho G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Dbn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cndp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Nup107 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Itpa ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Psmg4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ctbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Nme1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Dnajb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Myo1c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cbx3 ortho P G G G G Srpk1 Wdr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Calr ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Dstn ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Flna ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ggct ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ldhc ortho P G G G G G Wdr1 Mvd ortho GP G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Hspa4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Taldo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Lactb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Capza2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Gpi ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Protein Skiv2l, Superkiller viralicidic activity 2-like (S. cerevisiae) ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Anln ortho G G G G G G G G G G G G G G G G G G G G G G Wdr1 Eif5a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ppp1cb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Isyna1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Msi2 ortho P G G G G G G G G G G G G G G G Wdr1 Pcbd1 ortho GP G G G G G G G G G G G G G G G G G G G G G Fructose-bisphosphate aldolase Wdr1 ortho P G Wdr1 Ester hydrolase C11orf54 homolog ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ezr ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Rgn ortho GP G G G G G G Wdr1 Ubc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Oxct1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc3 Wdr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Polyadenylate-binding protein, PABP ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Nme2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Myh9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Znhit3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cfl2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Bag3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Smap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Thop1 ortho G G G G G G G G G G G G G G G G G G G G G Wdr1 Nedd4l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Uap1l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cfl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Cdk2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Wdr1 Ppih ortho P Wdr1 Abce1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5XJE5 O88342 affinity chromatography technology 19345177 physical association X 2 O88342 Q921E6 affinity chromatography technology 24457600 physical association X 2 O88342 Q3TXT7 affinity chromatography technology 19345177 physical association X 2 O88342 A0MNP4 affinity chromatography technology 19345177 physical association X 2 O88342 Q8JZM7 affinity chromatography technology 19345177 physical association X 2 O88342 Q8QZY9 affinity chromatography technology 19345177 physical association X 2 O88342 P60122 affinity chromatography technology 19345177 physical association X 2 O88342 anti tag coimmunoprecipitation 23612611 association C 41

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Wdr1 Ruvbl2 MI:0004(affinity chromatography technology) 19345177 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316197 bait prey Wdr1 Cdc73 MI:0004(affinity chromatography technology) 19345177 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316194 bait prey Wdr1 Sf3b4 MI:0004(affinity chromatography technology) 19345177 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316196 bait prey Wdr1 Leo1 MI:0004(affinity chromatography technology) 19345177 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316195 bait prey Wdr1 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332893 prey bait Wdr1 Wdr61 MI:0004(affinity chromatography technology) 19345177 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316193 bait prey Wdr1 Ruvbl1 MI:0004(affinity chromatography technology) 19345177 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316198 bait prey

PPI - HINT Gene A Gene B PMID Method Quality WDR1 YWHAE 16615898 0027 LC WDR1 YWHAZ 16615898 0027 LC WDR1 PGLS 16615898 0027 LC RAB33B WDR1 26885862 0676 LC ILK WDR1 23612611 0007 LC WDR1 RAB5C 26885862 0676 LC WDR1 RAB21 26885862 0676 LC WDR1 RAB19 26885862 0676 LC WDR1 RAB4A 26885862 0676 LC WDR1 RUVBL1 19345177 0004 LC WDR1 RAB1A 26885862 0676 LC WDR1 LEO1 19345177 0004 LC WDR1 RAB35 26885862 0676 LC WDR1 CDC73 19345177 0004 LC WDR1 SF3B4 19345177 0004 LC WDR1 RAB4B 26885862 0676 LC WDR1 EED 24457600 0004 LC WDR1 RAB27B 26885862 0676 LC WDR1 WDR61 19345177 0004 LC WDR1 RUVBL2 19345177 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O88342 O55222 WDR1 ILK 0.126 23612611 Q6PHN9 O88342 RAB35 WDR1 0.126 26885862 P60122 O88342 RUVBL1 WDR1 0.21 19345177 Q5XJE5 O88342 LEO1 WDR1 0.21 19345177 Q8JZM7 O88342 CDC73 WDR1 0.21 19345177 Q8QZY9 O88342 SF3B4 WDR1 0.21 19345177 Q9ERF3 O88342 WDR61 WDR1 0.21 19345177 Q9WTM5 O88342 RUVBL2 WDR1 0.21 19345177 O88342 O35963 WDR1 RAB33B 0.126 26885862 Q91ZR1 O88342 RAB4B WDR1 0.126 26885862 Q921E6 O88342 EED WDR1 0.126 24457600 Q99P58 O88342 RAB27B WDR1 0.126 26885862 P35278 O88342 RAB5C WDR1 0.126 26885862 P35282 O88342 RAB21 WDR1 0.126 26885862 P35294 O88342 RAB19 WDR1 0.126 26885862 P62821 O88342 RAB1A WDR1 0.126 26885862 P56371 O88342 RAB4A WDR1 0.126 26885862