PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Pklr Pard6a 19379695 biogrid exp G G G G G G Nes Pard6a 20603020 intact exp G G G G G G G G G Mtss1 Pard6a 23446420 dip exp G G G G G G G G G G G G G G G G G G G G G G G Srsf1 Pard6a 19379695 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G Map2k5 Pard6a 12813044 innatedb,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pard6a 17101696 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G Llgl1 Pard6a 12629547 innatedb,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Tgfbr1 Pard6a i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Prkci Pard6a 12813044 innatedb,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Dvl2 Pard6a 19379695 biogrid exp, ortho G G G G G G G G G G G Pard3 Pard6a 19379695,16510873 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G Prkcz Pard6a 10873802,14685273,16510873,12629547 innatedb,biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G Smurf1 Pard6a 19379695 biogrid,i2d exp, ortho Smurf2 Pard6a 19379695 biogrid,intact exp, ortho Ect2 Pard6a ortho G G G G G G G G G G Arid5b Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Prkcg Pard6a ortho G G G G Orc2 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Sirt6 Pard6a ortho Ywhaz Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Axin2 Pard6a ortho G G G G G G G G G G G G G G G G G Mark2 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Gls Pard6a ortho Glud1 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Fbxo31 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G Elp3 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Rictor Pard6a ortho Pnma1 Pard6a ortho Tubg1 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Arhgap17 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Smad1 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Ttc3 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Nkd1 Pard6a ortho G G G G G G Pik3r3 Pard6a ortho Dpp9 Pard6a ortho Tp53bp2 Pard6a ortho Csnk1e Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G Rassf8 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G Cdh5 Pard6a ortho G G G G G G G G G G G G G G G G G G Rhoq Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G Plxna3 Pard6a ortho G G G G G G G G G G G G G G G G G G G G Lrch3 Pard6a ortho Apc Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Dvl3 Pard6a ortho Inadl Pard6a ortho G G G G G G G G G G G G G G G G G G G Tmem126a Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Pms2 Pard6a ortho G G G G G G G G G G G G G G G G G G G G Nol8 Pard6a ortho Ywhah Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Pih1d1 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Pard6b Pard6a ortho G G G G G G Ephb4 Pard6a ortho G G G G G G G G G G Mpp5 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Tjp1 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Sugt1 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Mark4 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Llgl2 Pard6a ortho G G G G G G G G G G G G G G G G G Pdrg1 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Zak Pard6a ortho G G G G App Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Smarca4 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Kif1b Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G Plcb3 Pard6a ortho G G G G G G G G G G G G G G G G Prkd1 Pard6a ortho G G G G G G G G G G G G G G G G G Prkch Pard6a ortho G G G G G G G G G G G G G G G Ash1l Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Pard6a Plcb1 ortho G G G G G G G G G G G Prdx3 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Rpap3 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Grb2 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Rac1 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Dvl1 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Dgkz Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Wdr92 Pard6a ortho Protein Arhgef11, Rho guanine nucleotide exchange factor (GEF) 11 Pard6a ortho Cdc42bpa Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Wdr83 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Z101 pull down 10934474 association C 4 Q9Z101 coimmunoprecipitation 11532031 association C 4 Q9Z101 coimmunoprecipitation 11257119 association C 4 Q9Z101 pull down 14653998 association C 7 Q9Z101 anti bait coimmunoprecipitation 12629547 association C 3 Q9Z101 coimmunoprecipitation 11532031 association C 6 Q9CUN6 Q9Z101 anti tag coimmunoprecipitation 15761148 association X 2 Q9Z101 anti bait coimmunoprecipitation 12629547 association C 3 Q9Z101 anti bait coimmunoprecipitation 23446420 - C 4 Q8R1S4 Q9Z101 anti bait coimmunoprecipitation 23446420 physical association X 2 Q9Z101 anti tag coimmunoprecipitation 19379695 association C 3 Q9Z101 anti tag coimmunoprecipitation 19379695 association C 3 Q9Z101 anti tag coimmunoprecipitation 19379695 physical association C 3 Q9Z101 tandem affinity purification 19379695 association C 3 Q9Z101 A0A024RAE4 two hybrid 10934474 physical association X 2 Q9Z101 P36897 anti tag coimmunoprecipitation 15761153 physical association X 2 A4D2P1 Q9Z101 two hybrid 10934474 physical association X 2 A0A024R0W7 Q9Z101 anti tag coimmunoprecipitation 19379695 physical association X 2 Q9Z101 confocal microscopy 20603020 colocalization C 3 O14641 Q9Z101 luminescence based mammalian interactome mapping 19379695 physical association X 2 O14641 Q9Z101 anti tag coimmunoprecipitation 19379695 physical association X 2 O14641 Q9Z101 anti tag coimmunoprecipitation 19379695 physical association X 2 O00254 Q9Z101 anti bait coimmunoprecipitation 19379695 physical association X 2 Q12799 Q9Z101 two hybrid 10934474 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Pard6a Smurf2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0729(luminescence based mammalian interactome mapping)|MI:0729(luminescence based mammalian interactome mapping)|MI:0729(luminescence based mammalian interactome mapping)|MI:0729(luminescence based mammalian interactome mapping)|MI:0729(luminescence based mammalian interactome mapping)|MI:0729(luminescence based mammalian interactome mapping)|MI:0729(luminescence based mammalian interactome mapping)|MI:0729(luminescence based mammalian interactome mapping) 19379695 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_327226|BIOGRID_327221|UniProt_98600|UniProt_98590|UniProt_168074|UniProt_168082|UniProt_98587|UniProt_98586|UniProt_168071|UniProt_168070 bait|prey|prey|bait|bait|prey|prey|prey|prey|prey prey|bait|prey|prey|prey|prey|prey|bait|prey|bait Pard3 Pard6a MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16510873,19379695 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_327234|BIOGRID_325363|BIOGRID_325361 prey|prey|bait bait|bait|prey Smurf1 Pard6a MI:0004(affinity chromatography technology) 19379695 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327232 bait prey Vhl Pard6a MI:0004(affinity chromatography technology) 17101696 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322684 bait prey Srsf1 Pard6a MI:0004(affinity chromatography technology) 19379695 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327225 bait prey Dvl2 Pard6a MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19379695 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_327224|BIOGRID_327222 prey|bait bait|prey Pklr Pard6a MI:0004(affinity chromatography technology) 19379695 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327229 prey bait Prkcz Pard6a MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 14685273,16510873 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323892|BIOGRID_325362 bait|bait prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Z101 Q60838 PARD6A DVL2 0.236 19379695 Q9Z101 O00254 PARD6A F2RL2 0.126 19379695 Q9Z101 O14641 PARD6A DVL2 0.61 19379695 Q9Z101 P60953 PARD6A CDC42 0.309 10934474 Q9Z101 P63000 PARD6A RAC1 0.309 10934474 Q9Z101 Q12799 PARD6A TCP10 0.309 10934474 Q9Z101 Q6P5H2 PARD6A NES 0.126 20603020 Q9Z101 Q6PDM2 PARD6A SRSF1 0.126 19379695 Q9Z101 A2A5Z6 PARD6A SMURF2 0.49 19379695 Q9Z101 Q02956 PARD6A PRKCZ 0.376 16510873,14685273 Q9Z101 P36897 PARD6A TGFBR1 0.236 15761153 Q9Z101 Q99NH2 PARD6A PARD3 0.454 19379695,16510873 Q9Z101 Q96MT3 PARD6A PRICKLE1 0.126 19379695 Q9Z101 Q9CUN6 PARD6A SMURF1 0.126 19379695 Q9Z101 P40338 PARD6A VHL 0.21 17101696