PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Dnmt3b Zbtb17 i2d exp G G G G G G G G G G Myc Zbtb17 17471507 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G Irf8 Zbtb17 12904288,18045875 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Crebbp Zbtb17 15752756 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hk3 Zbtb17 ortho Zbtb17 Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr2 Zbtb17 ortho G Zbtb17 Hcfc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dnmt3a Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G Cdkn2b Zbtb17 ortho G G G G G G G G G G G G G G G G G G G Zbtb17 Gtf2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Msx2 Zbtb17 ortho G G Bcl6 Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhah Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Zbtb4 Zbtb17 ortho Gfi1 Zbtb17 ortho G G G G G G Itgb5 Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspb1 Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zbtb17 Dis3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zbtb17 Topbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zbtb17 Klf5 ortho G G G G G G G G G G G G G G G G G G G G G G G Ube2h Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hk2 Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tmprss11a Zbtb17 ortho Zbtb17 Zbtb49 ortho Tp53 Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Lep Zbtb17 ortho G G Esr1 Zbtb17 ortho G G G G G Mycn Zbtb17 ortho G G G G G G G Pgr Zbtb17 ortho G Ep300 Zbtb17 ortho Hsp90aa1 Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zbtb17 Cdkn2a ortho Zbtb17 Huwe1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Max Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants F8VPR5 Q60821 two hybrid 15752756 direct interaction X 2 F8VPR5 Q60821 pull down 15752756 direct interaction X 2 P23611 Q60821 two hybrid 12904288 direct interaction X 2 P23611 Q60821 protein complementation assay 18045875 direct interaction X 2 Q60821 anti tag coimmunoprecipitation 19164764 - C 3 Q60821 Q07120 anti bait coimmunoprecipitation 19164764 physical association X 2 Q60821 Q07120 anti tag coimmunoprecipitation 19164764 physical association X 2 Q60821 Q07120 anti tag coimmunoprecipitation 19164764 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality IRF8 ZBTB17 12904288,18045875 0018,0090 LC CREBBP ZBTB17 15752756,15752756,15752756 0096,0004,0018 LC MYC ZBTB17 17471507 0007 LC CREBBP ZBTB17 15752756,15752756,15752756 0096,0004,0018 LC CEBPG ZBTB17 17471507 0007 LC ZBTB17 DVL2 25558878 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q60821 P23611 ZBTB17 IRF8 0.523 18045875,12904288 Q60838 Q60821 DVL2 ZBTB17 0.21 25558878 Q60821 Q07120 ZBTB17 GFI1 0.376 19164764