PTM - CPLM Gene Name UniProt ID Type Position Code Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 490 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 532 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 544 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 600 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 602 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 630 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 692 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 699 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 827 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 836 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 846 K Eps15l1; Eps15-rs; Eps15R Q60902 Ubiquitination 849 K

PTM - dbPAF Gene Name UniProt ID Position Type Species Eps15l1; Eps15-rs; Eps15R Q60902 107 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 108 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 115 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 229 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 235 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 238 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 239 T Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 241 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 244 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 246 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 247 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 250 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 251 T Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 253 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 255 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 291 Y Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 30 Y Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 304 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 31 T Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 353 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 360 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 364 T Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 371 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 372 T Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 375 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 432 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 462 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 480 T Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 484 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 487 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 49 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 546 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 558 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 562 Y Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 570 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 573 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 607 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 610 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 646 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 650 T Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 664 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 669 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 670 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 671 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 672 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 687 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 695 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 706 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 713 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 715 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 74 Y Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 794 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 798 S Mus musculus(Mouse) Eps15l1; Eps15-rs; Eps15R Q60902 9 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q60902 Y30-p Phosphorylation YKQVDPAyTGRVGAS Q60902 S49-p Phosphorylation FLKKSGLsDIILGKI Q60902 Y74-p Phosphorylation FLDKQGFyVALRLVA Q60902 S107-p Phosphorylation PPKFHDTssPLMATQ Q60902 S108-p Phosphorylation PKFHDTssPLMATQS Q60902 S229-p Phosphorylation AVPVLPAsPPPKDsL Q60902 S235-p Phosphorylation AsPPPKDsLRsTPsH Q60902 S238-p Phosphorylation PPKDsLRsTPsHGsV Q60902 S241-p Phosphorylation DsLRsTPsHGsVSSL Q60902 S244-p Phosphorylation RsTPsHGsVSSLNst Q60902 S250-p Phosphorylation GsVSSLNstGsLsPK Q60902 T251-p Phosphorylation sVSSLNstGsLsPKH Q60902 S253-p Phosphorylation SSLNstGsLsPKHSV Q60902 S255-p Phosphorylation LNstGsLsPKHSVKQ Q60902 S304-p Phosphorylation VKEIFMHsGLTQNLL Q60902 S353-p Phosphorylation IDPPQVLsPDMVPPs Q60902 S360-p Phosphorylation sPDMVPPsERGtPIP Q60902 T364-p Phosphorylation VPPsERGtPIPDSSs Q60902 S371-p Phosphorylation tPIPDSSstLAsGEF Q60902 T372-p Phosphorylation PIPDSSstLAsGEFT Q60902 S375-p Phosphorylation DSSstLAsGEFTGVK Q60902 S400-p Phosphorylation QLQREKYsLEQDIRE Q60902 T480-p Phosphorylation QTISSLKtQIQsQEs Q60902 S484-p Phosphorylation SLKtQIQsQEsDLkS Q60902 S487-p Phosphorylation tQIQsQEsDLkSQED Q60902 S558-p Phosphorylation SHLEAHRsLEQyDQV Q60902 Y562-p Phosphorylation AHRsLEQyDQVPDGV Q60902 S573-p Phosphorylation PDGVSGTsLPDLATL Q60902 S610-p Phosphorylation ALLFSNNsQELHPDP Q60902 S646-p Phosphorylation PFQSDPFsEQQtAAT Q60902 T650-p Phosphorylation DPFsEQQtAATDPFG Q60902 S669-p Phosphorylation KESDPFHsSSSDDFF Q60902 S687-p Phosphorylation TkNDPFTsDPFTkNP Q60902 S695-p Phosphorylation DPFTkNPsLPSkLDP Q60902 S808-p Phosphorylation GSSDFPEsPDPFQPL Q60902 K490-ub Ubiquitination QsQEsDLkSQEDDLN Q60902 K532-ub Ubiquitination ETILRSLkCTQDDIN Q60902 K544-ub Ubiquitination DINQARSkLSQLQES Q60902 K600-ub Ubiquitination GAMDDPFkNkALLFS Q60902 K602-ub Ubiquitination MDDPFkNkALLFSNN Q60902 K625-ub Ubiquitination FQAEDPFkSDPFkGA Q60902 K630-ub Ubiquitination PFkSDPFkGADPFkG Q60902 K636-ub Ubiquitination FkGADPFkGDPFQSD Q60902 K677-ub Ubiquitination SSSDDFFkkQTkNDP Q60902 K678-ub Ubiquitination SSDDFFkkQTkNDPF Q60902 K681-ub Ubiquitination DFFkkQTkNDPFTsD Q60902 K692-ub Ubiquitination FTsDPFTkNPsLPSk Q60902 K699-ub Ubiquitination kNPsLPSkLDPFESS Q60902 K827-ub Ubiquitination GDPFQNKkGFGDPFS Q60902 K836-ub Ubiquitination FGDPFSGkDPFAPSS Q60902 K846-ub Ubiquitination FAPSSSAkPPKTSSS

PTM - dbPTM UniProt ID Position Code Type Resources References Q60902 9 S Phosphorylation Swiss-Prot 1010711 19144319 Q60902 30 Y Phosphorylation Swiss-Prot 1010711 19144319 Q60902 31 T Phosphorylation Swiss-Prot 1010711 19144319 Q60902 74 Y Phosphorylation Swiss-Prot 1010711 16452087 Q60902 229 S Phosphorylation Swiss-Prot 1010711 17114649 Q60902 238 S Phosphorylation Swiss-Prot 1010711 19144319 Q60902 244 S Phosphorylation Swiss-Prot 1010711 17242355 Q60902 250 S Phosphorylation Swiss-Prot 1010711 17242355 Q60902 255 S Phosphorylation Swiss-Prot 1010711 17242355;19144319;19367708 Q60902 353 S Phosphorylation Swiss-Prot 1010711 17114649 Q60902 364 T Phosphorylation Swiss-Prot 1010711 17114649 Q60902 108 S Phosphorylation PhosphoELM.10011 19144319 Q60902 229 S Phosphorylation PhosphoELM.10011 17114649 Q60902 244 S Phosphorylation PhosphoELM.10011 17242355 Q60902 250 S Phosphorylation PhosphoELM.10011 17242355 Q60902 255 S Phosphorylation PhosphoELM.10011 17242355 Q60902 353 S Phosphorylation PhosphoELM.10011 17114649 Q60902 364 T Phosphorylation PhosphoELM.10011 17114649 Q60902 74 Y Phosphorylation PhosphoELM.10011 16452087 Q60902 562 Y Phosphorylation PhosphoELM.10011 15592455 Q60902 107 S Phosphorylation Phosphositeplus.1010730 21183079;21659605 Q60902 108 S Phosphorylation Phosphositeplus.1010730 21183079 Q60902 229 S Phosphorylation Phosphositeplus.1010730 17114649;18056256;19737024;19854140;20415495;21659604;21659605 Q60902 235 S Phosphorylation Phosphositeplus.1010730 20415495;21183079 Q60902 238 S Phosphorylation Phosphositeplus.1010730 19144319;21659604 Q60902 241 S Phosphorylation Phosphositeplus.1010730 17242355;19367708;21183079 Q60902 244 S Phosphorylation Phosphositeplus.1010730 17242355;21183079 Q60902 246 S Phosphorylation Phosphositeplus.1010730 21183079 Q60902 250 S Phosphorylation Phosphositeplus.1010730 21183079 Q60902 253 S Phosphorylation Phosphositeplus.1010730 17242355;21183079 Q60902 255 S Phosphorylation Phosphositeplus.1010730 17242355;18846507;19144319;19367708;19854140;20531401;21183079;21659604;21659605 Q60902 304 S Phosphorylation Phosphositeplus.1010730 20495213 Q60902 353 S Phosphorylation Phosphositeplus.1010730 17114649;18056256;19737024;20415495 Q60902 360 S Phosphorylation Phosphositeplus.1010730 21183079 Q60902 484 S Phosphorylation Phosphositeplus.1010730 18779572 Q60902 487 S Phosphorylation Phosphositeplus.1010730 18779572 Q60902 610 S Phosphorylation Phosphositeplus.1010730 19144319;19367708;20415495;21183079 Q60902 687 S Phosphorylation Phosphositeplus.1010730 18779572 Q60902 251 T Phosphorylation Phosphositeplus.1010730 21183079 Q60902 364 T Phosphorylation Phosphositeplus.1010730 17114649;20415495;21183079 Q60902 480 T Phosphorylation Phosphositeplus.1010730 18779572 Q60902 562 Y Phosphorylation Phosphositeplus.1010730 15592455;18515860 Q60902 74 Y Phosphorylation Phosphositeplus.1010730 16452087 Q60902 229 S Phosphorylation SysPTM 1.1 17114649;18056256 Q60902 238 S Phosphorylation SysPTM 1.1 17242355 Q60902 241 S Phosphorylation SysPTM 1.1 17242355 Q60902 244 S Phosphorylation SysPTM 1.1 17242355 Q60902 250 S Phosphorylation SysPTM 1.1 17242355 Q60902 253 S Phosphorylation SysPTM 1.1 17242355 Q60902 255 S Phosphorylation SysPTM 1.1 17242355 Q60902 353 S Phosphorylation SysPTM 1.1 17114649;18056256 Q60902 484 S Phosphorylation SysPTM 1.1 18779572 Q60902 487 S Phosphorylation SysPTM 1.1 18779572 Q60902 687 S Phosphorylation SysPTM 1.1 18779572 Q60902 239 T Phosphorylation SysPTM 1.1 17242355 Q60902 480 T Phosphorylation SysPTM 1.1 18779572 Q60902 562 Y Phosphorylation SysPTM 1.1 18515860

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q60902 74 Y 16452087 HTP Phosphorylation Q60902 244 S 17242355 HTP Phosphorylation Q60902 353 S 17114649 HTP Phosphorylation Q60902 108 S 19144319 HTP Phosphorylation Q60902 562 Y 15592455 HTP Phosphorylation Q60902 364 T 17114649 HTP Phosphorylation Q60902 229 S 17114649 HTP Phosphorylation Q60902 255 S 17242355 HTP Phosphorylation Q60902 250 S 17242355 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q60902 74 Phosphotyrosine 16452087 Q60902 107 Phosphoserine 21183079 Q60902 108 Phosphoserine 19144319;21183079 Q60902 244 Phosphoserine 17242355;21183079 Q60902 253 Phosphoserine 21183079 Q60902 255 Phosphoserine 17242355;21183079 Q60902 360 Phosphoserine 21183079 Q60902 364 Phosphothreonine 21183079 Q60902 562 Phosphotyrosine 15592455 Q60902 610 Phosphoserine 21183079

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type Eps15l1 IPI00420185 S 107 PKFHDTpSSPLMAT phosphorylation Eps15l1 IPI00420185 S 229 VPVLPApSPPPKDS phosphorylation Eps15l1 IPI00420185 S 235 SPPPKDpSLRSTPS phosphorylation Eps15l1 IPI00420185 S 255 NSTGSLpSPKHSVK phosphorylation Eps15l1 IPI00420185 S 353 DPPQVLpSPDMVPP phosphorylation Eps15l1 IPI00420185 S 610 LLFSNNpSQELHPD phosphorylation Eps15l1 IPI00420185 S 695 PFTKNPpSLPSKLD phosphorylation Eps15l1 IPI00420185 T 364 PPSERGpTPIPDSS phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID Eps15l1 Mus musculus (Mouse) 600; 849; 827; 846; 836; 602; 692; 699; 630; 544; 532; 490 "600,AMDDPFKNKALLF; 849,SSAKPPKTSSSGF; 827,DPFQNKKGFGDPF; 846,APSSSAKPPKTSS; 836,GDPFSGKDPFAPS; 602,DDPFKNKALLFSN; 692,TSDPFTKNPSLPS; 699,NPSLPSKLDPFES; 630,FKSDPFKGADPFK; 544,INQARSKLSQLQE; 532,TILRSLKCTQDDI; 490,SQESDLKSQEDDL" 600:22790023; 849:22790023; 827:22790023; 846:22790023; 836:22790023; 602:22790023; 692:22790023; 699:22790023; 630:22790023; 544:22790023; 532:22790023; 490:22790023