PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Ubqln4 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tfcp2l1 Ubqln4 20362541 biogrid,intact exp G G G G G G G G G G G G G G Ttc9c Ubqln4 ortho Map1lc3a Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pick1 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdia5 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23a Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdlim7 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Gja1 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mief2 Ubqln4 ortho Zg16 Ubqln4 ortho GP G G G G G G G G Prl Ubqln4 ortho G G G G G Ppib Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Ube2c ortho G G G G G G G G G G G G G G G G G G Ubqln4 Gkap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabrd Ubqln4 ortho G G G Pip4k2b Ubqln4 ortho P Qsox1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Erp29 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Ccdc107 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ric8a Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Immt Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Scmh1 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Nme3 ortho P Ccdc33 Ubqln4 ortho Psmd4 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Agr2 Ubqln4 ortho GP G G G G G G G G Hspa5 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Cd2bp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nae1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cstf2t Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rxra Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Lat2 ortho G G G G G G Oat Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nxf1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fzd7 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Pin1 ortho P Serpine1 Ubqln4 ortho G G G G G G G Protein Tnfrsf14, Tumor necrosis factor receptor superfamily member 14 Ubqln4 ortho Adam33 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G Srsf2 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Unc119 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Pnma1 Ubqln4 ortho Nppa Ubqln4 ortho G G G G Ubqln4 Efemp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Mllt6 Ubqln4 ortho G G G G G G G Ubqln4 Nphp1 ortho G G G G G G G G G G G G G G G G G G G Stam Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trim32 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Zfpm2 Ubqln4 ortho G G G G G G G G G G G G G Ctsb Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Herpud1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf2 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G UPF0705 protein C11orf49 homolog Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tff1 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppic Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Ccdc136 Ubqln4 ortho G G G G G G G G G G G G G G G G Ubqln4 Bag6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gpx7 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G Protein Pcdh17 Ubqln4 ortho Vip Ubqln4 ortho G G G G G G G G G G G Ptn Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G Ankrd13d Ubqln4 ortho P Ubqln1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dtx2 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G Peli2 Ubqln4 ortho G G G G Tnrc6b Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Robo2 Ubqln4 ortho Rpn1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Smarcb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cpsf6 Ubqln4 ortho P Ptprn2 Ubqln4 ortho P Hk2 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Wac Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad3 Ubqln4 ortho G G G G G G G G G G G G G G G Fa2h Ubqln4 ortho G G G G G G G G G G G G G G G G G G Ubqln4 Cyb5r1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Areg Ubqln4 ortho G G G G G Tgfb1i1 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adpgk Ubqln4 ortho G G G G G G G G G G Uros Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Col8a1 Ubqln4 ortho G G G G G G Ccdc14 Ubqln4 ortho Scg5 Ubqln4 ortho P G G G G G G G G G G G G Dnajb11 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Igfbp6 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Moap1 ortho P Usmg5 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Rai2 ortho G G G G G G G G G G G Ubqln4 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tyms Ubqln4 ortho G G Pla2g16 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fkbp7 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc134 Ubqln4 ortho P G G Zpr1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps26a Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bpifa1 Ubqln4 ortho G G G Edn1 Ubqln4 ortho G G G G G G G G G G G G Ubqln4 Zbtb22 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Runx1t1 Ubqln4 ortho G G G G G G G G G G G G Usp34 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stmn1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Prpf40a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cstf2 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Pmepa1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 C1qtnf1 ortho G G G G G G G G G G G Ubqln4 Zfyve19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ahcyl1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Smad9 ortho Serpinh1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein CK137956 Ubqln4 ortho Zfp13 Ubqln4 ortho Eapp Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23b Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Ubqln2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Cacna1g Ubqln4 ortho G G G G G G G G Ubqln4 Dazap2 ortho Rnps1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps4b Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eef1a1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Cend1 ortho G G G G G Ubqln4 Mydgf ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pbxip1 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Shfm1 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Spag8 Ubqln4 ortho Ube2b Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Klhl42 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Serpini2 ortho P G Ptprn Ubqln4 ortho P G G G G G G G G G G G Itpripl1 Ubqln4 ortho Spp1 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G Atxn1 Ubqln4 ortho Hspa13 Ubqln4 ortho P Cript Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atpif1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fkbp2 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdk Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Copb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Txn Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd2 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx3 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcdh8 Ubqln4 ortho G G G G G G Dmpk Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G Rbm10 Ubqln4 ortho Trib2 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mif4gd Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf185 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zdhhc3 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fgfbp1 Ubqln4 ortho G G G G G G G G G Gdi1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Ube2v1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr7 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Scg2 Ubqln4 ortho P G G G G G G G G G G G G G Ubqln4 Erp27 ortho P Arl4c Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G Klhl26 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hgs Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Dkk3 ortho G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Orc5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epdr1 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Spint1 ortho G G G G G G G G G G G G G G G G G G G G Asns Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99NB8 Q3UNW5 affinity chromatography technology 20362541 physical association X 2 Q99NB8 enzymatic study 25260751 direct interaction X 2 Q99NB8 anti tag coimmunoprecipitation 20362541 association C 93 Q99NB8 P0CG53 nuclear magnetic resonance 20127391 direct interaction X 2 Q99NB8 P08050 nuclear magnetic resonance 20127391 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Tfcp2l1 Ubqln4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 20362541 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact) BIOGRID_314100|UniProt_170696|UniProt_107197 bait|bait|bait prey|prey|prey Ubqln4 Ubqln4 MI:0077(nuclear magnetic resonance)|MI:0077(nuclear magnetic resonance) 20127391 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact) UniProt_184443|UniProt_169865 neutral component|neutral component neutral component|neutral component

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q99NB8 P62259 UBQLN4 YWHAE 0.081 16615898 Q99NB8 Q3UNW5 UBQLN4 TFCP2L1 0.236 20362541