PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ube2g2 Skp1 22306998 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rbx1 22020328,22024926,21343341,23871831 biogrid exp P Ube2g2 Ube2g2 17310145,24366945 biogrid,intact,dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rnf111 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 DEAH (Asp-Glu-Ala-His) box polypeptide 38, Protein Dhx38 ortho P G G G G G G Ube2g2 Prdx2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Pigl ortho Ube2g2 Arfrp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Vbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rffl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Smpx ortho GP G G G G G G G G G G G G G G Rnf5 Ube2g2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Chmp3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Malt1 ortho Ube2g2 Erlec1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Shfm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Coq5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Xaa-Pro aminopeptidase 1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Mars ortho P Arfgef1 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap1g2 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Plcd4 ortho Ube2g2 Coq3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Dtd1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Msh5 ortho G G Aurkb Ube2g2 ortho G G G G G G G G G G G G G Ube2g2 Tmem216 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Ube2h ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Cbwd1 ortho GP G G G G G G G G G G G G G G G G G G Ube2g2 Aup1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctsd Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsd17b7 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G Ube2g2 Pdcl3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppia Ube2g2 ortho P Msh2 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Egfr ortho GP G G G G G G G G G G G G G G G G G Kdm2a Ube2g2 ortho Ube2g2 Slc25a26 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Cdc23 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Vps37b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Otub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Hbs1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Abcb7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Upf2, UPF2 regulator of nonsense transcripts homolog (Yeast) Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Etfa ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Ndufs4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Uba2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Luc7l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gosr1 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Park2 ortho G G G G Ube2g2 Ikbkap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Fdx1l ortho P Ube2g2 Stxbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rnf139 ortho Ube2g2 Polr3f ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Mul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Dnaja3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Pin1 ortho P Ube2g2 Zpr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Eif4a3 ortho P Ube2g2 Slc47a1 ortho G G G G G G G G G G G G G G Ube2g2 Trmt13 ortho Ube2g2 Trim3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Csnk1d ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Exoc5 ortho P Ube2g2 Ecm29 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkar2a Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G Vamp8 Ube2g2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Phf5a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Psmd9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Alg2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Vars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cnbp Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rae1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Cdipt ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Wdr59 ortho P Ube2g2 Taco1 ortho P Ube2g2 Rhoa ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Smc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Mpv17 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Ddx11 ortho Ube2g2 Rfc5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Cpsf3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Noc4l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Zc3h15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Hnrnpd ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb8 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Stk16 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rnf146 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Fbxw11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Tmem45b ortho G G G G G G G G G G G G G G G G G Ube2g2 Rnf168 ortho Por Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Gnl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Nhp2l1 ortho P Ube2g2 Nln ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Alg11 ortho P Ube2g2 Dhrs11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ascc3 Ube2g2 ortho P Ube2g2 Mgrn1 ortho Ube2g2 Wipi2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Taf9 ortho Ube2g2 Uba1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Trim9 ortho Ube2g2 Trit1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Ipo7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Slc35e1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Sdhb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Dusp12 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rps13 ortho P G G G G G G G G G G G G Ube2g2 Sgpl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Nop56 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Protein Znrf4, Zinc and ring finger 4 ortho G G Ube2g2 Alg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Coro1a Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Ddx19a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Dnajb14 ortho Ube2g2 Ddx39b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Prps2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Trmt61a ortho P Ube2g2 Bag3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Alg9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Slc9a9 ortho Ube2g2 Prune ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Hspd1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fkbp8 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31, Protein Ddx31 ortho Polr2a Ube2g2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbl Ube2g2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Mllt6 Ube2g2 ortho G G G G G G G Ube2g2 Hnrnpdl ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Nedd4l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Arl14 ortho Ube2g2 Naa20 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc2 Ube2g2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ranbp1 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Actg1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Xpr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Polr1a Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Sbds ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sptlc1 Ube2g2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rps27a ortho P Ube2g2 Pfkp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Npepps ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Pank4 ortho P Ube2g2 Ube2j2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap1m1 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Pdss1 ortho G G G G G G G G G G G G G G G G G G Ube2g2 Rpa1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Ube2r2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Hao2 ortho P G G G G G G G Ube2g2 Sars2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Yif1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2g2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Ube2v2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Mecr ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Fa2h ortho G G G G G G G G G G G G G G G G G G Ube2g2 Dars2 ortho P Ube2g2 Samm50 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkaca Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Amfr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Cnnm3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rnf157 ortho G G G G G G G G G G G G G Ube2g2 Rab1A ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Uba6 ortho P Ube2g2 Eftud1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Abhd13 ortho P Pola1 Ube2g2 ortho P G G G G G G G G G G G G G G Cpox Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Rnf26 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Cul9 ortho P G G G G G G G G G G G Pex10 Ube2g2 ortho Ube2g2 Cct6a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Cse1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Hnrnpab ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cad Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Atp5c1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Sco1 ortho P Hspa9 Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Pus7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Farp2 ortho G G G G G G G G Ube2g2 Usp15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q08109 P60605 pull down 11724934 direct interaction X 2 P60605 P62878 pull down 22024926 direct interaction X 2 P60605 P62878 pull down 21343341 direct interaction X 2 P60605 P62878 pull down 23871831 direct interaction X 2 P60605 O60337 pull down 19103148 direct interaction X 2 P60605 Q9NZS9 affinity chromatography technology 21068390 physical association X 2 Q9UKV5 P60605 pull down 17310145 direct interaction X 2 Q9UKV5 P60605 pull down 19103148 direct interaction X 2 Q9UKV5 P60605 imaging technique 11724934 colocalization X 2 Q9UKV5 P60605 affinity chromatography technology 11724934 physical association X 2 Q9UKV5 P60605 affinity chromatography technology 11724934 physical association X 2 Q9UKV5 P60605 pull down 11724934 direct interaction X 2 P60605 Q9WTX5 pull down 22306998 direct interaction X 2 P60605 Q86TM6-3 pull down 19103148 direct interaction X 2 P60605 Q86TM6-3 pull down 11724934 direct interaction X 2 P60605 P62987 comigration in sds page 17310145 covalent binding X 2 P60605 P62987 pull down 19223579 covalent binding X 2 P60605 P62987 comigration in sds page 19223579 covalent binding X 2 P60605 P62987 comigration in sds page 17310145 covalent binding X 2 Q9UKV5 P60605 anti tag coimmunoprecipitation 16407162 direct interaction X 2 Q9UKV5 P60605 x-ray crystallography 19223579 direct interaction X 2 Q9UKV5 P60605 molecular sieving 19223579 direct interaction X 2 Q9UKV5 P60605 pull down 16407162 direct interaction X 2 Q9UKV5 P60605 anti tag coimmunoprecipitation 16407162 direct interaction X 2 Q9UKV5 P60605 anti tag coimmunoprecipitation 19223579 direct interaction X 2 Q9UKV5 P60605 anti tag coimmunoprecipitation 19223579 direct interaction X 2 Q9UKV5 P60605 surface plasmon resonance 19223579 direct interaction X 2 Q9UKV5 P60605 pull down 16407162 direct interaction X 2 Q9UKV5 P60605 pull down 19223579 direct interaction X 2 Q9UKV5 P60605 pull down 16462746 direct interaction X 2 P60605 P60605 molecular sieving 17310145 direct interaction Y 1 P60605 P60605 cross-linking study 24366945 direct interaction Y 1 P60605 P60605 cross-linking study 24366945 direct interaction Y 1 P60605 P60605 atomic force microscopy 24366945 direct interaction Y 1 P60605 P60605 bio-layer interferometry 24366945 direct interaction Y 1 P60605 P60605 bio-layer interferometry 24366945 direct interaction Y 1 P60605 P60605 cross-linking study 24366945 direct interaction X 2 P60605 P60605 cross-linking study 24366945 direct interaction X 2 P60605 P60605 cross-linking study 24366945 direct interaction Y 1 P60605 P60605 cross-linking study 24366945 direct interaction Y 1 P60605 P60605 atomic force microscopy 24366945 direct interaction Y 1 P60605 P60605 atomic force microscopy 24366945 direct interaction Y 1

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ube2g2 Rbx1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 21343341,22024926,23871831 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_331186|BIOGRID_325654|BIOGRID_323632 prey|prey|prey bait|bait|bait Ube2g2 Skp1 MI:0096(pull down) 22306998 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_328992 prey bait

PPI - HINT Gene A Gene B PMID Method Quality UBE2G2 UBE2G2 17310145,24366945,24366945,24366945,17310145,19223579 0071,0872,0030,0969,0415,0114 LC UBE2G2 RBX1 22020328,22024926,21343341,23871831 0096,0096,0096,0096 LC UBE2G2 SKP1 22306998 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q08109 P60605 HRD1 UBE2G2 0.309 11724934 Q9UKV5 P60605 AMFR UBE2G2 0.82 19103148,16462746,11724934 P60605 O60337 UBE2G2 MARCH6 0.309 19103148 Q9NZS9 P60605 BFAR UBE2G2 0.21 21068390 Q9WTX5 P60605 SKP1 UBE2G2 0.309 22306998 Q86TM6 P60605 SYVN1 UBE2G2 0.523 19103148,11724934 P62878 P60605 RBX1 UBE2G2 0.772 22024926,23871831,21343341,22020328 P60605 P60605 UBE2G2 UBE2G2 0.801 24366945,17310145