PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Epha4 Vav2 i2d exp Smn1 Vav2 15102471 mint,intact exp G Cblb Vav2 15102471 intact exp, ortho Grb2 Vav2 15102471 mint,intact exp, ortho G Ephb2 Vav2 i2d exp, ortho Vav2 Snw1 ortho G Tarbp2 Vav2 ortho G Vav2 Arhgef1 ortho G Vav2 Nek3 ortho G Vav2 Ube4b ortho G Protein Akap13 Vav2 ortho Vav2 Itsn1 ortho G Vav2 Dnmbp ortho G Vav2 Med21 ortho G Fyn Vav2 ortho G Vav2 Cep170 ortho Prlr Vav2 ortho Elavl1 Vav2 ortho G Vav2 Thop1 ortho Crcp Vav2 ortho G Rhog Vav2 ortho G Vav2 Erbb3 ortho G Vav2 Bcr ortho G Prkar2b Vav2 ortho Vav2 Gapvd1 ortho Vav2 Hnrnpf ortho G Protein Dnajc21 Vav2 ortho G Cd44 Vav2 ortho G Vav2 Arhgef18 ortho G Cav1 Vav2 ortho G Vav2 Phf10 ortho G Vav2 Pnma1 ortho Erbb2 Vav2 ortho Rasgrf1 Vav2 ortho Ar Vav2 ortho Trio Vav2 ortho G Cct2 Vav2 ortho G Vav2 Smad3 ortho G Cbl Vav2 ortho G Vav2 Brdt ortho Vav2 Arhgef6 ortho Vav2 Rhoa ortho G Vav2 Protein Arhgef11, Rho guanine nucleotide exchange factor (GEF) 11 ortho Vav2 Bzw1 ortho G Protein Bod1l Vav2 ortho G Vav2 Abi1 ortho G Vav2 Crk ortho G Vav2 March7 ortho G Tiam1 Vav2 ortho G Cct3 Vav2 ortho G Rac1 Vav2 ortho G Vav2 Mrgbp ortho Vav2 Dcun1d4 ortho Vav2 Pogz ortho Arhgef16 Vav2 ortho Vav2 Tom1l1 ortho Abr Vav2 ortho G Rad23a Vav2 ortho G Rbbp6 Vav2 ortho G Vav2 Vav2 ortho G Ntrk1 Vav2 ortho Vav2 Serbp1 ortho G Met Vav2 ortho G Vav1 Vav2 ortho G Rtel1 Vav2 ortho Vav2 Farp2 ortho Tcp11 Vav2 ortho Birc6 Vav2 ortho G Vav2 Arih1 ortho G Vav2 Fuca1 ortho G Egfr Vav2 ortho Vav2 Usp38 ortho G Vav2 St13 ortho G Cd19 Vav2 ortho G Vav2 Sos1 ortho Vav2 Srrt ortho G Vav2 Sf3a3 ortho G Vav2 Arhgef7 ortho G Vav2 Stk24 ortho G Vav2 Gab1 ortho G Socs1 Vav2 ortho Vav2 Hsph1 ortho G Vav2 Fnta ortho G Lcp2 Vav2 ortho G Vav2 Chmp3 ortho G Vav2 Ipo4 ortho G Syk Vav2 ortho G Farp1 Vav2 ortho G Sh3bp2 Vav2 ortho G Vav2 Tpd52l2 ortho G Ppm1b Vav2 ortho G Pdgfrb Vav2 ortho G Vav2 Mcf2l ortho Srpk2 Vav2 ortho G Protein Arhgef5 Vav2 ortho G Vav2 Vcpip1 ortho Ctnnd1 Vav2 ortho G Vav2 Eif4g3 ortho G Protein Nckap5 Vav2 ortho Ccno Vav2 ortho Ttn Vav2 ortho G Vav2 Itsn2 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q60992 - 15848800 - X 2 Q60992 Q03137 - 15848800 - X 2 B9EKI5 Q60992 two hybrid 15102471 physical association X 2 Q60992 P97801 two hybrid 15102471 physical association X 2 Q60631 Q60992 two hybrid 15102471 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Vav2 Cblb MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164800 bait prey Smn1 Vav2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164798 prey bait Grb2 Vav2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_162838 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q60992 Q60631 VAV2 GRB2 0.183 15102471 Q60992 Q15637 VAV2 SF1 0.126 26420826 Q60992 B9EKI5 VAV2 CBLB 0.183 15102471 Q60992 P97801 VAV2 SMN1 0.183 15102471