PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Faf1 Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Faf1 24619421 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Vcp 24619421 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fas Faf1 8524870 mint,intact exp, ortho G G G G G G G G G G G G G G G G G Faf1 Vapb 24885147 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Fam114a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Pja2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Sec23a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Ascc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Hirip3 ortho Faf1 Sirt6 ortho Faf1 Klhl22 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 NACHT, Protein Nlrp2 ortho Cbx3 Faf1 ortho P G G G G Faf1 Taf1d ortho G G G G G G G G G G G G G G G G G G G G G G G G G Anxa1 Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Asna1 Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Rap1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Skp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Prmt3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdkn1a Faf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Bag6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Xpo7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Rcc1 ortho P G G G G G G G G G G G G G G G G Casp8 Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Tln1 Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Ntrk1 ortho Ikbkb Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Vapa ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Swap70 ortho GP G G G G G G G G G G G G G G G G G G G G Faf1 Rpn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Ubr2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Snip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Cul2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Carm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Cars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Prpsap2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Hif1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Nr1h2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Anxa7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Gart ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Magix ortho G G G G Faf1 Faf2 ortho P Faf1 Ranbp3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ilk Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Hsph1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr4 Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Set ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Farsb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Csnk2a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23a Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Cul3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Tceal1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Ugp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Samhd1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 ortho P G G G G G G G G G G G G G G Faf1 Plod2 ortho G G G G G G G G G G G G G G G G G G G G G Tk1 Faf1 ortho G G G G G G G G G G G G G Faf1 Nlrp10 ortho Faf1 Puf60 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Urod ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Iap Faf1 ortho G G Faf1 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Csnk2b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Ctnnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Cul1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Rpl24 ortho Igf2 Faf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Itgb1bp1 Faf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Chm ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsd17b10 Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trove2 Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Nlrp12 Faf1 ortho Tnnt1 Faf1 ortho G G G G G G G G G Faf1 Nudt21 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Plaa Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Hspa8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Cdc5l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Dnajb11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd40 Faf1 ortho G G G G G Faf1 Trpv1 ortho Faf1 Vcpip1 ortho Ubc Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Tsc22d1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Ngly1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Get4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Fbxw11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Rap1b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Amfr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Nlrp3 ortho G G G Faf1 Rela ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 G3bp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Dnaja1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Ppm1g ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddost Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Schip1 ortho MCG9018, Protein Kbtbd7 Faf1 ortho Faf1 Hspa4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Cdc73 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Wdr26 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Skil ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Rae1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr4a1 Faf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Fadd ortho GP G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q921E6 P54731 affinity chromatography technology 24457600 physical association X 2 P54731 P54731 pull down 24619421 direct interaction X 2 Q8BH80 P54731 affinity chromatography technology 24885147 physical association X 2 Q01853 P54731 pull down 24619421 direct interaction X 2 Q01853 P54731 x-ray crystallography 24619421 association X 2 P25446 P54731 two hybrid 8524870 physical association X 2 P25446 P54731 coimmunoprecipitation 8524870 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Faf1 Vcp MI:0096(pull down)|MI:0096(pull down) 24619421 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_333020|BIOGRID_333018 bait|bait prey|prey Faf1 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332701 prey bait Fas Faf1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 8524870 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0471(mint)|MI:0471(mint) UniProt_177439|UniProt_177438|MINT_80725|MINT_80726 prey|prey|prey|prey bait|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality FAS FAF1 8524870,8524870 0018,0019 LC FAF1 VCP 24619421,24619421 0114,0096 LC FAF1 FAF1 24619421 0096 LC FAF1 VCP 24619421,24619421 0114,0096 LC FAF1 EED 24457600 0004 LC FAF1 VAPB 24885147 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q01853 P54731 VCP FAF1 0.523 24619421 P54731 P25446 FAF1 FAS 0.454 8524870 Q921E6 P54731 EED FAF1 0.126 24457600 P54731 P54731 FAF1 FAF1 0.332 24619421