PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Anapc1 Ywhae 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppargc1a Anapc1 i2d exp G G G G G G G G G G G G G G G G G G G G G Anapc1 Notch1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Phf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Magix ortho G G G G Mov10 Anapc1 ortho G G G G G G G G G G G G G G G G G G G G Foxq1 Anapc1 ortho G G G G G G G G G G G G Anapc1 Cdc26 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Anapc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Cep120 ortho Protein Taf4a Anapc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Nap1l4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Mdc1 ortho P Grap2 Anapc1 ortho Anapc1 Pifo ortho Anapc1 Ino80 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Mad2l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Ttll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Tenm2 ortho P G G G G G G Anapc1 Map1lc3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Anapc10 ortho Anapc1 Tcf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adam19 Anapc1 ortho G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Cdc5l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Cdc23 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Sirt7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Tp53bp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Cep19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Smarcad1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Rpap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Med19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Fbxo5 ortho Ncl Anapc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Bub3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc13 Anapc1 ortho Nek2 Anapc1 ortho G G G G G G G G Anapc1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Anapc13 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Ctnnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Cfap97 ortho G G G Ubc Anapc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Usp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Bub1b ortho G G G G G G G G G G G G Anapc1 Anapc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Snw1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Cdc20 ortho G G G G G G G G G G G G G G G G G G G G G G Anapc1 Sirt6 ortho Anapc1 Ppp5c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncam1 Anapc1 ortho G G G G G G G G G G G G G G G G G Anapc1 Anapc5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Liph ortho Sox2 Anapc1 ortho G G G G G G G G G G G Penk Anapc1 ortho G G G G G G G G G G G G G G G G G G G G G Anapc1 Ntrk1 ortho Anapc1 Hecw2 ortho Cdc27 Anapc1 ortho G G G G G G Anapc1 Lats2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Rpap3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntn1 Anapc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Trim33 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9P2B7 P53995 affinity chromatography technology 20360068 physical association X 2 Q9UJX6 P53995 affinity chromatography technology 20360068 physical association X 2 P53995 Q9UJX4-2 affinity chromatography technology 20360068 physical association X 2 P53995 A0A024R832 affinity chromatography technology 20360068 physical association X 2 P53995 Q9UJX5 affinity chromatography technology 20360068 physical association X 2 O60566 P53995 affinity chromatography technology 20360068 physical association X 2 Q12834 P53995 affinity chromatography technology 20360068 physical association X 2 P53995 affinity chromatography technology 20360068 physical association X 2 P53995 C5H3H2 affinity chromatography technology 20360068 physical association X 2 P53995 Q13042-2 affinity chromatography technology 20360068 physical association X 2 P53995 Q9UM13 affinity chromatography technology 20360068 physical association X 2 P53995 Q9UJX2 affinity chromatography technology 20360068 physical association X 2 P53995 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 P53995 affinity chromatography technology 20360068 physical association X 2 P53995 coimmunoprecipitation 10318877 association C 9 P53995 cosedimentation 16615898 colocalization C 1216

PPI - HINT Gene A Gene B PMID Method Quality ANAPC1 YWHAE 16615898 0027 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62259 P53995 YWHAE ANAPC1 0.081 16615898 P53995 O60566 ANAPC1 BUB1B 0.126 20360068 P53995 P30260 ANAPC1 CDC27 0.126 20360068 Q12834 P53995 CDC20 ANAPC1 0.126 20360068 Q13042 P53995 CDC16 ANAPC1 0.126 20360068 Q8NHZ8 P53995 CDC26 ANAPC1 0.126 20360068 Q96DE5 P53995 ANAPC16 ANAPC1 0.126 20360068 Q9H1A4 P53995 ANAPC1 ANAPC1 0.126 20360068 Q9P2B7 P53995 KIAA1430 ANAPC1 0.126 20360068 Q9UJX2 P53995 CDC23 ANAPC1 0.126 20360068 Q9UJX3 P53995 ANAPC7 ANAPC1 0.126 20360068 Q9UJX4 P53995 ANAPC5 ANAPC1 0.126 20360068 Q9UJX5 P53995 ANAPC4 ANAPC1 0.126 20360068 Q9UJX6 P53995 ANAPC2 ANAPC1 0.126 20360068 Q9UM13 P53995 ANAPC10 ANAPC1 0.126 20360068