PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Diaph1 Yes1 18194650 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G Dab1 Yes1 15062102 biogrid exp G G G G G Ywhae Yes1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G Yes1 Ednra 11546805 biogrid,i2d exp G G G G G G G Hmga2 Yes1 26045162 intact exp G G G G Yes1 Yes1 i2d exp, ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Jak2 8702385 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Khdrbs1 10844001 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Arrb1 11546805 biogrid,i2d exp, ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Adam12 i2d exp, ortho G G G G G G G G Yes1 Slc25a11 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Nono ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Ogt ortho GP G G G G G G G G G G G G G G G G G G G G G Erh Yes1 ortho P Yes1 Cyp51a1 ortho GP G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Cdh1 Yes1 ortho G G G G G G G G G G G G G G G G G G Yes1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G Fyn Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Thap1 ortho Yes1 Tp53bp2 ortho P Yes1 Prpf8 ortho GP G G G G G G G G G G G G G G G G G G G G G Yap1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Dbn1 ortho GP G G G G G G G G G G G G G G G G G G G Yes1 Pdcd6ip ortho GP G G G G G G G G G G G G G G G G G G G G G Ctnnd1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G Xrcc6 Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Ddx39b ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Prpf19 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Cse1l ortho GP G G G G G G G G G G G G G G G G G G G G G Tnk2 Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Myh9 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Nfkbia ortho GP G G G G G G G G G G G G G G G G G G G G G Hoxb5 Yes1 ortho G G G G G G G Yes1 Fxr2 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Ssbp3 ortho G G G G G G G G G G G G G G G G G G G G G G Rps10 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Cct6a Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Cbl Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Protein CK137956 Yes1 ortho Eef1d Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Rps13 Yes1 ortho P G G G G G G G G G Kpnb1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Trim28 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Znf512b ortho Yes1 Kars ortho GP G G G G G G G G G G G G G G G G G G G G G Eef2 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Pdia6 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Snrnp200 ortho P Snap23 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Faf2 ortho P Traf2 Yes1 ortho G G G G G G G G G G G G G G G G G G G G Traf6 Yes1 ortho G G G G G G G G G G G G G G G G G G Yes1 Cdc37 ortho GP G G G G G G G G G G G G G G G G G G G G G Eftud2 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Eif3c ortho GP G G G G G G G G G G G G G G G G G G G G G Cct7 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 E2f7 ortho Yes1 Eif4g1 ortho GP G G G G G G G G G G G G G G G G G G G G G Dnaja1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Elavl1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Cd46 Yes1 ortho G G G Yes1 Tmem17 ortho Hsp90ab1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Txndc12 ortho GP G G G G G G G G G G G G G G G G G G G G G Fas Yes1 ortho G G G G G G G G G G G G G Yes1 Pecam1 ortho GP G G G G G G G G G G G G G G G G G G G Tuba1b Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Limch1 ortho GP G G G G G G G G G G G G G G G G G Ptpre Yes1 ortho G G G G G G G G G G G G G G G Eif5a Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 H1 histone family, member X, Protein H1fx ortho G G G G G G G G G G Yes1 Nphs1 ortho G G G G Ar Yes1 ortho G G G G G G G G G G G G Yes1 Dvl2 ortho G G G G G G G G G Aimp1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Iars ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Eif2s1 ortho GP G G G G G G G G G G G G G G G G G G G G G Itgb3 Yes1 ortho G Snrpd3 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Adam15 Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G Slc9a3r1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Cd36 ortho GP G G G G G G G G G G G G G G G G G G Yes1 Lima1 ortho GP G G G G G G G G G G G G G G G G G G G G G Ckap5 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Fn1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Gpr35 ortho G G G G G Yes1 Rpl10 ortho P Yes1 Trpv4 ortho G G G Yes1 Srsf1 ortho GP G G G G G G G G G G G G G G G G G G G G G Rps11 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Rpl18a Yes1 ortho P Socs3 Yes1 ortho G G G G G G G G G G G G G G G G G G G G Yes1 Pifo ortho Yes1 Atp1a1 ortho GP G G G G G G G G G G G G G G G G G G G G G Nme2 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Mapre1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Pdlim7 ortho GP G G G G G G G G G G G G G G G G G G G Yes1 Fyttd1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Pan2 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Dars ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Eif3l ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Ipo8 ortho GP G G G G G G G G G G G G G G G G G G G G G Psmc5 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Pak2 ortho GP G G G G G G G G G G G G G G G G G G G G G Cct2 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Atp6v1e1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Ankyrin repeat domain 12, isoform CRA_a, Protein Ankrd12 Yes1 ortho Atp5b Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G G3bp2 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Mst1r ortho G G G G G G G G Yes1 Olig1 ortho G G G Yes1 Acsl3 ortho Yes1 Rps21 ortho P Ppp1cb Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Sumo3 ortho GP G G G G G G G G G G G G G G G G G G G G G Itgb4 Yes1 ortho P G G G G G G G G G Tyro3 Yes1 ortho G G G G G G G G G Yes1 Matr3 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Gab1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Abi1 ortho GP G G G G G G G G G G G G G G G G G G G G G Psmc4 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Eef1b Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Nap1l1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Ctnnb1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Protein Rasa1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Fundc1 ortho GP G G G G G G G G G G G G G G G G G G G G G Slc30a4 Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Slc16a14 ortho Becn1 Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Jsrp1 ortho Psmc3 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Gcn1l1 ortho P Yes1 Nsun2 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Sf3b1 ortho GP G G G G G G G G G G G G G G G G G G G G G Igf2bp1 Yes1 ortho G Csf1r Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Tecr ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Ccnl2 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Cul7 ortho GP G G G G G G G G G G G G G G G G G G G Vcam1 Yes1 ortho GP G G G G G G G G G G G G G G G G G Prdx6 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Ccr1 Yes1 ortho G G G G G G G G Yes1 Nif3l1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Slc25a3 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Anln ortho G G G G G G G G G G G G G G G Yes1 Ilf2 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Med28 ortho GP G G G G G G G G G G G G G G G G G G G G G Csk Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Psmc6 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Flot1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Khsrp ortho P Hist1h1c Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Srsf3 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Cdcp1 ortho GP G G G G G G G G G G G G G G G G Ttn Yes1 ortho GP G G G G G G G G G G G G G G Yes1 Tsr1 ortho GP G G G G G G G G G G G G G G G G G G G G G Pdgfrb Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Eif2s3x ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Coro1c ortho GP G G G G G G G G G G G G G G G G G G G G G Cct5 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Cherp ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Coprs ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Slc25a41 ortho Yes1 Stip1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Zbtb8a ortho G G G G G G G G G G G G G G Hnrnph1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Ephb2 Yes1 ortho G G G G G G G G G G Yes1 Eef1g ortho P Pten Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Rcn2 ortho GP G G G G G G G G G G G G G G G G G G G G G Prkdc Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Slc16a1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Prpsap1 ortho GP G G G G G G G G G G G G G G G G G G G G G Met Yes1 ortho G G G G G G G G G G G G G G G G G G G G G Tmem185a Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Kit Yes1 ortho G G G G G G G G G G G G G G G G G G G Yes1 Polyadenylate-binding protein, PABP ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Ocln ortho G G G G G G G G G G G G G G G G G G Xrcc5 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G Yes1 Dlg4 ortho P G G G G G G G Yes1 Mrpl12 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Prps2 ortho GP G G G G G G G G G G G G G G G G G G G Ptk2 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Egfr Yes1 ortho GP G G G G G G G G G G G G G G G G Yes1 Eif2s2 ortho GP G G G G G G G G G G G G G G G G G G G G G Flt1 Yes1 ortho G G G G G G G G G G G G G Protein Ahnak Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Cdkn1b Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Alox5 Yes1 ortho Rps24 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Snrpd1 Yes1 ortho P Rpl35a Yes1 ortho P Gp6 Yes1 ortho Yes1 Psmd2 ortho GP G G G G G G G G G G G G G G G G G G G G G Cct8 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Rps7 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Hnrnpa0 ortho P Yes1 Heterogeneous nuclear ribonucleoprotein R, Protein Hnrnpr ortho GP G G G G G G G G G G G G G G G G G G G G G Dhx9 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Atp5a1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Eif4a1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Rars ortho GP G G G G G G G G G G G G G G G G G G G G G Yes1 Kctd5 ortho G G G G G G G G G G G G G G G G G G G G G G Dok1 Yes1 ortho G G G G G G G G G G G G G G G G Phb Yes1 ortho P Sec61a1 Yes1 ortho GP G G G G G G G G G G G G G G G G G G G G G Faslg Yes1 ortho G Yes1 Prpf31 ortho GP G G G G G G G G G G G G G G G G G G G G G Grpel2 Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Yes1 Mars ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q04736 Q04736 - 11546805 - X 2 Q04736 Q8BWG8-2 - 11546805 - X 2 Q04736 - 11127814 - X 2 Q61614 Q04736 - 11546805 - X 2 Q04736 O08808 affinity chromatography technology 18194650 physical association X 2 Q04736 affinity chromatography technology 11546805 physical association X 2 Q61614 Q04736 affinity chromatography technology 11546805 physical association X 2 Q04736 Q60749 enzymatic study 10844001 direct interaction X 2 Q04736 P97318-3 affinity chromatography technology 15062102 physical association X 2 Q04736 P23469 anti tag coimmunoprecipitation 14980517 physical association X 2 P49446 Q04736 genetic interference 14980517 genetic interaction X 2 Q04736 P07333 coimmunoprecipitation 7730365 association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Yes1 Khdrbs1 MI:0415(enzymatic study) 10844001 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322111 bait prey Ptpre Yes1 MI:0007(anti tag coimmunoprecipitation) 14980517 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0208(genetic interaction) (intact) UniProt_163699 neutral component neutral component Dab1 Yes1 MI:0004(affinity chromatography technology) 15062102 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325791 bait prey Yes1 Ednra MI:0004(affinity chromatography technology) 11546805 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325168 prey bait Diaph1 Yes1 MI:0004(affinity chromatography technology) 18194650 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323150 prey bait Yes1 Arrb1 MI:0004(affinity chromatography technology) 11546805 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325169 prey bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAE YES1 16615898 0027 LC YES1 KHDRBS1 10844001 0415 LC DIAPH1 YES1 18194650 0004 LC HMGA2 YES1 26045162 0096 LC DAB1 YES1 15062102 0004 LC YES1 EDNRA 11546805 0004 LC YES1 JAK2 8702385 0004 LC YES1 ARRB1 11546805 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q61614 Q04736 EDNRA YES1 0.21 11546805 Q04736 P07333 YES1 CSF1R 0.21 7730365 Q04736 O08808 YES1 DIAPH1 0.21 18194650 Q62120 Q04736 JAK2 YES1 0.376 8702385 Q04736 P23469 YES1 PTPRE 0.21 14980517 Q60749 Q04736 KHDRBS1 YES1 0.309 10844001 Q8BWG8 Q04736 ARRB1 YES1 0.21 11546805 Q04736 P97318 YES1 DAB1 0.21 15062102 Q04736 P52927 YES1 HMGA2 0.126 26045162