PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Nanog Fbxw5 24793005 biogrid exp Fbxw5 Skp1 23314863 i2d,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxr1 Fbxw5 ortho Csnk1e Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sass6 Fbxw5 ortho G G G G G G G G G G G G G Smad1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfaip8l1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G Nlk Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adamtsl4 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G Cul4a Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Plk4 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G Fam168a Fbxw5 ortho Ddb1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Odf3l2 Fbxw5 ortho S100b Fbxw5 ortho G G G G G G G G G G G Xpo1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt40 Fbxw5 ortho Ube2r2 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trim27 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfbr1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmpr1b Fbxw5 ortho G G G Cdc20 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G Hspb9 Fbxw5 ortho Eps8 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw5 Dlc1 ortho G G Hsp90aa1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG14935, isoform CRA_a, WD repeat-containing protein 20 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rest Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myb Fbxw5 ortho G G G G G G G G G G G G G G G Tsc1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Srfbp1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tsc2 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdfi Fbxw5 ortho G G G Znrf1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul3 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw5 Cul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk1a1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gps1 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw5 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops4 Fbxw5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9QXW2 - 10531037 - X 2 O00238 Q9QXW2 affinity chromatography technology 15761153 physical association X 2 P63208 Q9QXW2 pull down 10531037 direct interaction X 2 Q9QXW2 P36897 affinity chromatography technology 15761153 physical association X 2 Q9QXW2 Q9WTX5 molecular sieving 23314863 direct interaction X 2 Q9QXW2 Q9WTX5 pull down 23314863 direct interaction X 2

PPI - HINT Gene A Gene B PMID Method Quality FBXW5 SKP1 23314863,23314863 0071,0096 LC NANOG FBXW5 24793005 0004 LC FBXW5 SKP1 23314863,10531037,23314863 0071,0004,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9QXW2 Q80Z64 FBXW5 NANOG 0.21 24793005 Q9QXW2 P36897 FBXW5 TGFBR1 0.126 15761153 Q9QXW2 P63208 FBXW5 SKP1 0.309 10531037 Q9QXW2 O00238 FBXW5 BMPR1B 0.126 15761153