PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Arnt Esrrg 18509053 dip exp G G Foxa2 Arnt 20609350 intact exp G G G G G G G G G Arnt Npas1 i2d exp Arnt Grin2b 16635246 intact exp G G G Grin1 Arnt 16635246 intact exp G G G G G Arnt Esrrb 18509053 dip exp G G Arnt Calcoco1 15383530 biogrid exp Arnt Hes6 20609350 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Ahrr 19251700 biogrid exp, ortho Arnt Sim1 9020169 i2d,intact exp, ortho G G G G G Arnt Hif1a 10873592,20609350 i2d,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Sim2 9020169 i2d,intact exp, ortho G G Ahr Arnt 7488247,9020169 i2d,intact,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Foxr2 ortho Arnt Gtf2f2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Ube2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Egln2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Diablo ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfaip1 Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Pias2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Gmnn Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Herc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Arnt ortho G G G G G Arnt Csnk2a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Strbp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ldha Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Cul2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Senp6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Hey2 ortho G G Arnt Gtf2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Foxn1 ortho G Arnt Ncor2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Gtf2f1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Epas1 ortho G G G G G G G G G G G G G G G G G G G Arnt Hey1 ortho G G G G G G G G G G G G Arnt Pml ortho G G G G G G G G G G G G G G G G G G G G G Arnt Ncoa7 ortho Arnt Npas4 ortho Arnt C1qtnf2 ortho Arnt Egln3 ortho G G G G G G G G G G G G G G G G Arnt Ncoa1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Rb1 Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Smad9 ortho Adh5 Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Bcat1 Arnt ortho G G G G G G G G Myc Arnt ortho G G G G G G G G G G G G G G G G G G G G Aip Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Mta3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Trip11 Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Lsm8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Hif1an ortho Arnt Elavl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Arnt2 ortho G G G Arnt Egln1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Ncoa2 ortho G G G G Setd2 Arnt ortho Arnt Creb1 ortho G G G G G G G G G G G G G G G G G G G G Sp1 Arnt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Arnt Irak4 ortho G G G G G G G G G G G G G G G G G G G Arnt Hif3a ortho G G G G G G G G G G G G Arnt Dcaf15 ortho G G G G G G G G G G G G G G G G G G Ep300 Arnt ortho Brca1 Arnt ortho G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q61079 P53762 coimmunoprecipitation 11782478 association X 2 P53762 Q61045 coimmunoprecipitation 11782478 association X 2 P30561 P53762 coimmunoprecipitation 1317062 association X 2 P53762 pull down 18509053 - C 3 P53762 pull down 18509053 - C 3 P53762 pull down 18509053 - C 3 P53762 pull down 18509053 - C 3 P53762 pull down 18509053 - C 3 P53762 pull down 18509053 - C 3 P62509 P53762 pull down 18509053 physical association X 2 P62509 P53762 pull down 18509053 physical association X 2 P53762 Q61539 pull down 18509053 physical association X 2 P53762 Q61539 pull down 18509053 physical association X 2 P30561 P53762 two hybrid 7488247 physical association X 2 P11474 P53762 pull down 18509053 physical association X 2 P11474 P53762 pull down 18509053 physical association X 2 P53762 affinity chromatography technology 16635246 association C 94 P53762 anti bait coimmunoprecipitation 16635246 association C 96 Q61079 P53762 two hybrid 9020169 physical association X 2 P53762 Q61045 two hybrid 9020169 physical association X 2 P53762 Q61045 coimmunoprecipitation 9020169 physical association X 2 P53762 pull down 20609350 physical association C 3 P53762 anti bait coimmunoprecipitation 20609350 association C 3 P53762 anti bait coimmunoprecipitation 20609350 association C 3 P53762 anti bait coimmunoprecipitation 20609350 association C 3 P30561 P53762 two hybrid 9020169 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ahr Arnt MI:0018(two hybrid)|MI:0018(two hybrid) 7488247,9020169 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0465(dip) UniProt_176895|DIP_49 prey|- bait|- Arnt Calcoco1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15383530 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_327886|BIOGRID_327884 bait|prey prey|bait Arnt Esrrg MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18509053 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|-|-|- MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip) DIP_563|DIP_508|DIP_505|DIP_54269 -|-|-|- -|-|-|- Arnt Esrrb MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18509053 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|-|-|- MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip) DIP_561|DIP_507|DIP_504|DIP_54268 -|-|-|- -|-|-|- Arnt Sim2 MI:0018(two hybrid) 9020169 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_176897 bait prey Arnt Sim1 MI:0018(two hybrid)|MI:0018(two hybrid) 9020169 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_176898|UniProt_176896 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality AHR ARNT 9083006,9020169,7488247,1317062 0018,0018,0018,0019 LC ARNT NPAS1 15635607 0019 LC ARNT EPAS1 26245371 0114 LC ARNT SIM1 9020169,11782478,9020169 0019,0019,0018 LC ARNT SIM2 9704006,11782478,9020169 0018,0019,0018 LC ARNT HIF1A 26245371 0114 LC ARNT NPAS3 27782878 0114 LC GRIN1 ARNT 16635246 0006 HT FOXA2 ARNT 20609350 0006 LC ARNT ESRRG 18509053 0096 LC ARNT GRIN2B 16635246 0004 HT ARNT HIF1A 20609350,20609350 0096,0006 LC ARNT ESRRB 18509053 0096 LC ARNT AHRR 19251700 0004 LC ARNT CALCOCO1 15383530 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53762 P11474 ARNT ESRRA 0.21 18509053 Q61221 P53762 HIF1A ARNT 0.61 20609350,10873592 Q61045 P53762 SIM1 ARNT 0.454 9020169 P53762 P30561 ARNT AHR 0.332 9020169,7488247 P53762 P35438 ARNT GRIN1 0.126 16635246 Q99814 P53762 EPAS1 ARNT 0.21 9000051 P62509 P53762 ESRRG ARNT 0.21 18509053 Q01097 P53762 GRIN2B ARNT 0.126 16635246 Q3U1U7 P53762 AHRR ARNT 0.376 19251700 P53762 P35583 ARNT FOXA2 0.21 20609350 Q8CGU1 P53762 CALCOCO1 ARNT 0.376 15383530 Q61539 P53762 ESRRB ARNT 0.21 18509053 Q61079 P53762 SIM2 ARNT 0.309 9020169