PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Map3k7 Tab2 24270572,17158449,17384642,19026643,19955178,19843958 innatedb,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfrsf1a Tab2 19150425 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Tmem115 19955178 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trim30a Tab2 18345001 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G Uba52 Tab2 19927120 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Ppp6c 19955178 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf2 Tab2 17384642 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Tab2 19136968 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncor1 Tab2 12150997 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr2c2 Tab2 21811235,doi:21811235 mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sptan1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Hdac5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k8 Tab2 ortho G G G G G G G G Tank Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdlim7 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnf Tab2 ortho App Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr34 Tab2 ortho Traf3ip1 Tab2 ortho Cltc Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac3 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Npm1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tirap Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Dnaja1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Ruvbl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bag2 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd40 Tab2 ortho G G G G G Irak1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfrsf11a Tab2 ortho G G G G G G G G Tab3 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa8 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eif2ak2 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G Tab1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Xpo1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Tubb4a ortho G G G G G G G G G G G G G G G G G G G Tab2 Timm50 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lgals3bp Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xiap Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tubb5 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac2 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 Tab2 ortho G G G G G G G G G G G G G G G G G G Tab2 Tlr3 ortho G G G G G G G G G G G G G G G G G G G G G G G Smad7 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G UPF0586 protein C9orf41 homolog Tab2 ortho Hspa5 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Gtf2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Actg1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Tbl1x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Tab2 ortho G G G G G Protein Trim38 Tab2 ortho Hspa9 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Erbb4 Tab2 ortho Fosl1 Tab2 ortho G Ttn Tab2 ortho G G G G G G G G G G G G G G G G G G G G G Ruvbl1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl23 Tab2 ortho Ripk2 Tab2 ortho G G G G G G G G G G G G G G G G G G G G Ube2i Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf6 Tab2 ortho G G G G G G G G G G G G G G G G G G G G Tab2 Dbn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccar2 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Cst9 ortho G Tab2 Sec13 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Edaradd Tab2 ortho G G G G G Ar Tab2 ortho G G G G G G G G G G G G G G G G Nfkb1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhaz Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G C1qbp Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Cs ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nlk Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Numbl Tab2 ortho G G G G G G G G G G G G G G G G G G G G G Sin3a Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cad Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Malt1 Tab2 ortho Atg13 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fn1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Mbd3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cntrob Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfbr1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2cb Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ripk1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Flna Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnik Tab2 ortho Tbl1xr1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Becn1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eef1a2 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Slc19a3 ortho G G Hnrnph1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pfkl Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgm2 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkb Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa2 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Sik3 Tab2 ortho Vim Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chuk Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99K90 affinity chromatography technology 17384642 physical association X 2 Q99K90 affinity chromatography technology 19955178 physical association X 2 Q8CF89 Q99K90 affinity chromatography technology 25260751 physical association X 2 Q9WUH1 Q99K90 affinity chromatography technology 19955178 physical association X 2 Q99K90 P0CG50 pull down 19136968 direct interaction X 2 P49117 Q99K90 anti bait coimmunoprecipitation 21811235 association X 2 Q99K90 anti bait coimmunoprecipitation 24270572 association C 3 Q99K90 anti bait coimmunoprecipitation 24270572 association C 3 Q99K90 anti bait coimmunoprecipitation 19026643 association C 5 Q543B5 Q99K90 pull down 17158449 physical association X 2 Q543B5 Q99K90 anti bait coimmunoprecipitation 17158449 physical association X 2 Q543B5 Q99K90 anti tag coimmunoprecipitation 17158449 physical association X 2 Q543B5 Q99K90 anti bait coimmunoprecipitation 17158449 physical association X 2 Q543B5 Q99K90 pull down 17158449 physical association X 2 Q99K90 P62984 pull down 19927120 direct interaction X 2 Q99K90 P62984 pull down 19927120 direct interaction X 2 Q99K90 P62984 pull down 19927120 direct interaction X 2 Q99K90 P62984 pull down 19927120 direct interaction X 2 Q99K90 P62984 pull down 19927120 direct interaction X 2 Q99K90 P62984 x-ray crystallography 19927120 direct interaction X 2 Q99K90 P62984 pull down 19927120 direct interaction X 2 Q99K90 P62984 pull down 19927120 direct interaction X 2 Q99K90 P62984 pull down 19927120 direct interaction X 2

PPI - HINT Gene A Gene B PMID Method Quality UBC TAB2 19927120,19927120 0114,0096 LC LMO2 TAB2 26764384 0018 LC UBA52 TAB2 19927120,19927120 0114,0096 LC NCOR1 TAB2 12150997 0018 LC UBC TAB2 19136968,19927120,19927120 0096,0114,0096 LC TNFRSF1A TAB2 19150425 0007 LC TRAF2 TAB2 17384642 0007 LC NR2C2 TAB2 21811235 0006 LC UBA52 TAB2 19927120,19927120 0114,0096 LC TRAF6 TAB2 26474655,25828701 0004,0004 LC MAP3K7 TAB2 17158449,17384642,17158449,19955178,19843958,19955178,19026643,24270572,17158449 0007,0004,0096,0007,0004,0004,0006,0006,0006 LC TAB2 TLR3 25828701 0004 LC TAB2 PPP6C 19955178 0007 LC TAB2 TMEM115 19955178 0004 LC TAB2 GSK3B 25828701 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WUH1 Q99K90 TMEM115 TAB2 0.21 19955178 Q9WV60 Q99K90 GSK3B TAB2 0.21 25828701 Q99K90 P70196 TAB2 TRAF6 0.376 26474655,25828701 Q99K90 Q62073 TAB2 MAP3K7 0.905 17384642,19955178,24270572,19026643,17158449,19843958 Q99K90 P25801 TAB2 LMO2 0.183 26764384 Q99K90 O14920 TAB2 IKBKB 0.21 24270572 Q99K90 P0CG50 TAB2 UBC 0.309 19136968 Q99K90 P62991 TAB2 UBA52 0.671 19927120 Q99MB1 Q99K90 TLR3 TAB2 0.21 25828701 Q99K90 P49117 TAB2 NR2C2 0.21 21811235