PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ccnb1 Ube2a i2d exp G Hist2h2bb Ube2a 11929833 biogrid exp P G Rfpl4a Ube2a 12525704 biogrid,i2d exp G Rad18 Ube2a 12509447 biogrid exp, ortho G G G G G G G Cd59b Ube2a ortho Prdx5 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cmtm2b Ube2a ortho Ubr3 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc73 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf170 Ube2a ortho P Med31 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zpr1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uchl3 Ube2a ortho P Psmb2 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2a Unc119 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf20 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zwilch Ube2a ortho G G G G G G G G G G G G G G G Znf512b Ube2a ortho Ankrd32 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbn Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Calr Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myo7b Ube2a ortho P G G G G G G G Ubr5 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sars2 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Cdk2 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Ubqln2 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Unk Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n Ube2a ortho P Ubr2 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Cdkn2a Ube2a ortho Hat1 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hltf Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2v1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uba1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zmym2 Ube2a ortho P Abhd10 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpa3 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpa2 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Atxn10 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wac Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pin1 Ube2a ortho P Crmp1 Ube2a ortho P G G G G G G G G G G Nipsnap1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Leo1 Ube2a ortho P Fam134c Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xiap Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk1 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G Rtf1 Ube2a ortho P Sdcbp Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx5 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2a Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kcmf1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pomp Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nipsnap3b Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2b Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Etnk2 Ube2a ortho Pex2 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zfyve19 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ssbp1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cse1l Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Twf1 Ube2a ortho P Cdk9 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf40 Ube2a ortho P Tax1bp1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcna Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxl6 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prpf19 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kif2c Ube2a ortho G G G G G G G G G G G G Trim27 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tyms Ube2a ortho G G Wdr61 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctr9 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp1 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bsg Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr4 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccnt1 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ttll12 Ube2a ortho P Shprh Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xrn2 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2l3 Ube2a ortho P Hdlbp Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Z255 P24860 - 12525704 - X 2 Q8VH31 Q9Z255 - 12525704 - X 2 Q9Z255 affinity chromatography technology 12509447 physical association X 2 Q9Z255 affinity chromatography technology 12509447 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Z255 Q64525 UBE2A HIST2H2BB 0.309 11929833 Q9Z255 Q8VH31 UBE2A RFPL4A 0.21 12525704 Q9Z255 Q9QXK2 UBE2A RAD18 0.376 12509447