PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Uba52 Nbr1 19250911 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Tmed10 19427866 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map1b Nbr1 22654911 biogrid exp GP G G G G G G G G G G G G G G G G G G Nbr1 Plcg2 15102471 mint,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G Ubb Nbr1 19427866 biogrid exp P Mapk14 Nbr1 20616007 innatedb,biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Ube2o 19427866 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G Nbr1 Lamtor2 19427866 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Nbr1 19427866 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Sqstm1 20616007,19250911 innatedb,biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Spred2 19822672 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Gtse1 ortho G G G G G Nbr1 Vta1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Jun Nbr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syt4 Nbr1 ortho G G G G G G G G G Nbr1 Nbr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Scgn ortho GP G G G G G G G G G G G G G G Nbr1 Gsk3a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG19772, Protein Trim55 Nbr1 ortho Sod1 Nbr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Gsk3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Trim63 ortho Nbr1 Gabarapl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atxn1l Nbr1 ortho Nbr1 Usp8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Gabarap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map2k4 Nbr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Map3k3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Map1lc3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Vapb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Fez1 ortho G G G G G G G G G G G G G G G G G Nbr1 Itsn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Cib1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Nbr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Map1lc3a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarapl2 Nbr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Htt Nbr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ttn Nbr1 ortho GP G G G G G G G G G G G G G G G G G G G G Ltbr Nbr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Cep55 ortho G G G G G G G G G G G G G Nbr1 Cep135 ortho P

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ubb Nbr1 MI:0018(two hybrid) 19427866 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321725 prey bait Mapk14 Nbr1 MI:0004(affinity chromatography technology) 20616007 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319827 prey bait Nbr1 Sqstm1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 19250911,20616007 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_168867|UniProt_168866|BIOGRID_319828 neutral component|neutral component|bait neutral component|neutral component|prey Nbr1 Ube2o MI:0018(two hybrid) 19427866 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321726 bait prey Nbr1 Tmed10 MI:0018(two hybrid) 19427866 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321728 bait prey Nbr1 Lamtor2 MI:0018(two hybrid) 19427866 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321727 bait prey Map1b Nbr1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 22654911 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_320624|BIOGRID_320623|BIOGRID_320622 prey|bait|prey bait|prey|bait Ubc Nbr1 MI:0018(two hybrid) 19427866 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321729 prey bait Nbr1 Plcg2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_162745 prey bait Ubb Nbr1 MI:0018(two hybrid) 19250911 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (intact) UniProt_168868 neutral component neutral component

PPI - HINT Gene A Gene B PMID Method Quality UBB NBR1 19427866 0018 LC MAP1B NBR1 22654911,22654911,22654911 0096,0018,0004 LC NBR1 UBE2O 19427866 0018 LC NBR1 PLCG2 15102471 0018 LC NBR1 TMED10 19427866 0018 LC NBR1 LAMTOR2 19427866 0018 LC UBC NBR1 19250911,19427866 0663,0096 LC MAP1B NBR1 22654911,22654911,22654911 0096,0018,0004 LC GJA1 NBR1 25605500 0004 LC MAPK14 NBR1 20616007,20616007 0007,0004 LC UBA52 NBR1 19250911 0663 LC NBR1 SQSTM1 19250911,20616007 0663,0096 LC NBR1 SPRED2 19822672 0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P97432 P23242 NBR1 GJA1 0.21 25605500 Q64337 P97432 SQSTM1 NBR1 0.416 19250911,20616007 P97432 P0CG48 NBR1 UBC 0.309 19427866 P97432 P0CG49 NBR1 UBB 0.309 19427866 P97432 P0CG50 NBR1 UBC 0.309 19427866 P97432 P47811 NBR1 MAPK14 0.21 20616007 P97432 P49840 NBR1 GSK3A 0.454 20368287 P97432 P49841 NBR1 GSK3B 0.454 20368287 P97432 P60520 NBR1 GABARAPL2 0.126 19250911 P97432 P62991 NBR1 UBA52 0.081 19250911 Q6ZPJ3 P97432 UBE2O NBR1 0.309 19427866 Q8CIH5 P97432 PLCG2 NBR1 0.183 15102471 Q9D1D4 P97432 TMED10 NBR1 0.309 19427866 Q9GZQ8 P97432 MAP1LC3B NBR1 0.126 19250911 Q9JHS3 P97432 LAMTOR2 NBR1 0.309 19427866 P97432 P14873 NBR1 MAP1B 0.623 22654911