PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Fhl2 Traf4 16184196 biogrid exp G G G G G G G G G G G G G G Traf4 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA 22649194 biogrid exp G G G G G G G G G G G G G G G G G G Map3k4 Traf4 16157600 biogrid exp, ortho G G G G G G G G G G G G G G G G G G Bahd1 Traf4 ortho Psmc3 Traf4 ortho G G G G G G G G G G G G G G G G G G Pxdn Traf4 ortho Traf4 Spdl1 ortho G G G G G G G G G G Ncf2 Traf4 ortho G G G G G G G G G G G G G G G G Ube2i Traf4 ortho G G G G G G G G G G G G G G G G G G Traf4 Tyk2 ortho G G G G G G G G G G G G G G G G G G Traf4 Prmt5 ortho G G G G G G G G G G G G G G G G G G Traf4 Krt40 ortho Tnfrsf4 Traf4 ortho G G G G G G G G G G G G G G G G Traf4 Cchcr1 ortho Traf4 Gorasp2 ortho G G G G G G G G G G G G G G G G G G Traf4 Hip1r ortho G G G G G G G G G G G G G G G G G G Traf4 Traf4 ortho G G G G G G G G G G G G G G G G G G Traf4 Ubl4b ortho Traf4 Homez ortho Traf4 Wwp2 ortho G G G G G G G G G G G G G G G G G G Traf4 Kansl1 ortho G G G G G G G G G G G G G G G G G G Traf4 Nod1 ortho Traf4 Smurf1 ortho Gp1bb Traf4 ortho G G G G G G G Ncf1 Traf4 ortho G G G G G G G G Traf4 Mrpl28 ortho G G G G G G G G G G G G G G G G G G Bmi1 Traf4 ortho G G G G G G G G G G G G G G G G G G Sorbs2 Traf4 ortho Fth1 Traf4 ortho G G G G G G G G G G G G G G G G G G Smurf2 Traf4 ortho Gprasp1 Traf4 ortho G G G G G G G G G G G G G G G G G G Cd40 Traf4 ortho G G G G G Ripk2 Traf4 ortho G G G G G G G G G G G G G G G Traf4 Tgfbr1 ortho G G G G G G G G G G G G G G G G G G Traf4 Rps6kb1 ortho G G G G G G G G G G G G G G G G G G Traf4 Ube2o ortho G G G G G G G G G G G G Traf4 Ngfrap1 ortho G G G G G G G G G G G G G G G G G G Traf4 Cenpe ortho G G G G G Traf4 Tgfbr2 ortho G G G G G G G G G G G G G G G G G G Traf4 Dtx3 ortho G G G G G G G G G G G G G G Traf4 Rhot1 ortho G G G G G G G G G G G G G G G G G G Traf4 Kif11 ortho G G G G G G G G G Bcl6b Traf4 ortho G G G Traf4 Ngfr ortho G G G G G Exoc7 Traf4 ortho G G G G G G G G G G G G G G G G G G Arnt2 Traf4 ortho Traf4 Tbc1d7 ortho Traf4 Tgfb1i1 ortho G G G G G G G G G G G G G G G G G Traf4 Trim37 ortho G G G G G G G G G G G G G G G G G G Traf4 Ripk4 ortho G G G G G G G G G G G G G G Traf4 Tbc1d8 ortho G G G G G G G G G G G G G G G G G Bysl Traf4 ortho G G G G G G G G G G G G G G G G G G Protein Fbxl18 Traf4 ortho Traf4 Ptk2b ortho G G G G G G G G G G G G G G G G G Traf4 Maged1 ortho G G G G G G G G G G G G G G G G G Traf4 Plscr1 ortho G G G G G G G G G G G G G G G G G G Traf4 Fam214b ortho G G G G G G G G G G G G G G G G G G Bckdk Traf4 ortho G G G G G G G G G G G G G G G G G G Traf4 Isyna1 ortho G G G G G G G G G G G G G G G G G Traf4 Sqstm1 ortho G G G G G G G G G G G G G G G G G G Zfp113 Traf4 ortho G G G G G Traf4 Rpl14 ortho G G G G G G G G G G G G G G G G G G Traf4 Suz12 ortho G G G G G G G G G G G G G G G G G G Traf4 Wbp11 ortho G G G G G G G G G G G G G G G G G G Traf4 Cblc ortho G G G G G G G G G G G Traf4 Usp15 ortho G G G G G G G G G G G G G G G G G G Traf4 Usp7 ortho G G G G G G G G G G G G G G G G G G Ltbr Traf4 ortho G G G G G G G G G G G G G G G G G G Npas2 Traf4 ortho G G G G G G G G Traf4 Alkbh4 ortho G G G G G G G G G G G G G G G Traf4 Nod2 ortho Traf4 Kdm1a ortho G G G G G G G G G G G G G G G G G G Traf2 Traf4 ortho G G G G G G G G G G G G G G G G G G Traf4 Irak1 ortho G G G G G G G G G G G G G G G G G G Traf6 Traf4 ortho G G G G G G G G G G G G G G G G Sumo1 Traf4 ortho G G G G G G G G G G G G G G G G G G Traf4 Myh9 ortho G G G G G G G G G G G G G G G G G G Tarbp2 Traf4 ortho G G G G G G G G G G G G G G G G G G Traf4 Banp ortho G G G G G G G G G G G G G G G G G G Traf4 Znf512b ortho Chuk Traf4 ortho G G G G G G G G G G G G G G G G G G Traf4 Lipt1 ortho G G G G G G G G Traf4 Catsper4 ortho Tnfrsf9 Traf4 ortho G G G G G G G G G Cbl Traf4 ortho G G G G G G G G G G G G G G G G G G Traf4 Pde4dip ortho G G G G G G G G G G G G G G G G Traf4 Tp53bp2 ortho Traf4 Actn1 ortho G G G G G G G G G G G G G G G G G G Gp6 Traf4 ortho Traf4 Spop ortho G G G G G G G G G G G G G G G G G G Traf4 Wwp1 ortho G G G G G G G G G G G G G G G G G G Traf4 Rnf114 ortho G G G G G G G G G G G G G G G G G G Traf4 Ticam1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q61382 O08648 affinity chromatography technology 16157600 physical association X 2 Q61382 Q8N7N6 affinity chromatography technology 22649194 physical association X 2 Q61382 Q8N7N6 affinity chromatography technology 22649194 physical association X 2 Q61382 O70433 affinity chromatography technology 16184196 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Traf4 Traf3ip2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22649194 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_327525|BIOGRID_327530 prey|bait bait|prey Fhl2 Traf4 MI:0004(affinity chromatography technology) 16184196 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322592 prey bait Map3k4 Traf4 MI:0004(affinity chromatography technology) 16157600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322468 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MAP3K4 TRAF4 16157600 0004 LC FHL2 TRAF4 16184196 0004 LC TRAF4 TRAF3IP2 22649194 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q61382 O70433 TRAF4 FHL2 0.21 16184196 Q61382 O08648 TRAF4 MAP3K4 0.21 16157600