PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Esr1 Tcf7l1 18202148 biogrid exp G G G G Esr1 Kdm4c 21445275 biogrid exp G G G G G Esr1 Lef1 18202148 biogrid exp Esr1 Sox9 20005806 intact exp G G G Esr1 Ncoa6 10681503 biogrid exp G G G G G Esr1 Protein Scand1, SCAN domain-containing 1, Scand1 10393183 biogrid exp G G G G G Foxl2 Esr1 20005806 intact exp Esr1 Kdm4a 21445275 biogrid exp Esr1 Afmid 25453901 intact exp Esr1 Cdc42bpa 12374744 innatedb,biogrid exp G G G G G Esr1 Ppp1cc 17274640 biogrid,intact exp G G G G G Esr1 Tdo2 25453901 intact exp Esr1 Pou4f2 20211142 biogrid,i2d exp, ortho Src Esr1 17921256 biogrid exp, ortho G G G Esr1 Brca1 16807234 biogrid exp, ortho G G Jun Esr1 19605792 biogrid exp, ortho G G G G G Esr1 Nos3 17921256 biogrid exp, ortho G G G G G Esr1 Grip1 8643509 biogrid exp, ortho G G Esr1 Kdm4b 21445275 biogrid exp, ortho G G G G G Esr1 Ctnnb1 18202148 biogrid exp, ortho G G G G G Smarce1 Esr1 12145209 biogrid exp, ortho G G G G G Esr1 Stat5a 15304355 biogrid exp, ortho G G G G G Esr1 Trim24 8978696 intact exp, ortho G G G G G Esr1 Pgr 22396492 biogrid exp, ortho G Esr1 Psmd1 16857966 intact exp, ortho G G G G G Pou4f1 Esr1 20211142 biogrid,i2d exp, ortho Esr1 Ncoa2 20211142 biogrid,i2d exp, ortho G Esr1 Nr0b2 25720568 intact exp, ortho Esr1 Ptpn6 ortho G G G G G Hax1 Esr1 ortho G G G G G Esr1 Rbfox2 ortho G G G G G Krt13 Esr1 ortho G Esr1 Rps23 ortho Protein Chd3 Esr1 ortho Esr1 Rps20 ortho G G G G G Hsp90ab1 Esr1 ortho G G G G G Esr1 Phgdh ortho G G G G G Safb Esr1 ortho G G G G G Esr1 Rps14 ortho G G G G G Esr1 Hyou1 ortho G G G G G Men1 Esr1 ortho G G G G G Nccrp1 Esr1 ortho Esr1 Cebpb ortho G G G G G Esr1 Jup ortho G G G G G Rpl27a Esr1 ortho G G G G G Esr1 St13 ortho G G G G G Esr1 Rpl18 ortho G G G G G Fasn Esr1 ortho G G G G G Esr1 S100a8 ortho G G G Esr1 Pgam5 ortho G G G G G Ubc Esr1 ortho G G G G G Pias3 Esr1 ortho G G G G G Esr1 Rbm14 ortho G G G G G Esr1 Blcap ortho G G G G G Esr1 Psmc1 ortho G G G G G Esr1 Snx6 ortho G G G G G Esr1 Bcl3 ortho G G G G Esr1 Caprin1 ortho G G G G G Esr1 Skp2 ortho G G Rps6ka1 Esr1 ortho G G G G G Esr1 Ski ortho G G G G G Esr1 Glyr1 ortho G G G G G Esr1 Egfr ortho G G G G G Esr1 Dars ortho G G G G G Esr1 Rps26 ortho G G G G G Esr1 Eif5a ortho G G G G G Esr1 Rtcb ortho G G G G G Esr1 Rabgef1 ortho G G G G G Esr1 Exosc10 ortho G G G G G Esr1 Psmc5 ortho G G G G G Esr1 Dyx1c1 ortho Esr1 Mrps9 ortho G G G G G Esr1 Psmb9 ortho G G G G G Esr1 Nudt21 ortho G G G G G Esr1 Ppib ortho G G G G G Esr1 Rpl18a ortho Esr1 Asxl1 ortho G G G G G Esr1 Prkdc ortho G G G G G Esr1 Lcor ortho G Esr1 Ncor1 ortho G G G G G Esr1 Srebf1 ortho G G G G G Esr1 Rpn1 ortho G G G G G Esr1 Heterogeneous nuclear ribonucleoprotein R, Protein Hnrnpr ortho G G G G G Esr1 Ppp1ca ortho G G G G G Esr1 Rpl19 ortho G G G G G Esr1 Gadd45g ortho G G G G G Pik3r2 Esr1 ortho G G G G G Esr1 Prpf6 ortho G G G G G Esr1 Rps5 ortho G G G G G Gnai1 Esr1 ortho G G G G G Esr1 Lactb ortho G G G G G Esr1 Serpinb5 ortho Esr1 E2f1 ortho Esr1 Nsf ortho G G G G G Esr1 Snd1 ortho G G G G G Esr1 Decr1 ortho G G G G G Esr1 Gtf2h1 ortho G G G G G Esr1 Hexim1 ortho G G G G G Esr1 Rgs3 ortho G G G G G Esr1 Irs2 ortho G G G Esr1 Foxk2 ortho G G G G G Esr1 Hnrnpf ortho G G G G G Esr1 Grb2 ortho G G G G G Esr1 Igf1r ortho G G G G G Esr1 Msh2 ortho G G G G G Esr1 Mtch2 ortho G G G G G Esr1 Rpl24 ortho Esr1 Rbbp7 ortho G G G G G Strn Esr1 ortho G G G G G Esr1 Chd9 ortho Esr1 Cdk8 ortho G G G G G Esr1 Spop ortho G G G G G Esr1 Mrps17 ortho G G G G G Esr1 Ran ortho G G G G G Esr1 Smyd3 ortho Esr1 Mbd2 ortho G G G G G Esr1 Flnb ortho G G G G G Esr1 Snw1 ortho G G G G G Esr1 Mms19 ortho G G G G G Esr1 Ddx21 ortho G G G G G Esr1 Eif4a3 ortho Esr1 U2af2 ortho G G G G G Esr1 Srsf7 ortho G G G G G Esr1 Syncrip ortho G G G G G Krt4 Esr1 ortho Esr1 Irs1 ortho G G G G G Esr1 Tecr ortho G G G G G Esr1 Epb41l5 ortho G G G Rps6ka3 Esr1 ortho G G G G G Esr1 Actn4 ortho G G G G G Esr1 Tsc1 ortho G G G G G Esr1 Rbbp6 ortho G G G G G Esr1 Prpf4b ortho G G G G G Esr2 Esr1 ortho G Esr1 Cbr1 ortho G G G G G Esr1 Rps6 ortho G G G G G Junb Esr1 ortho G G G G G Esr1 Kdm6b ortho Protein Krt78 Esr1 ortho Prkcsh Esr1 ortho G G G G G Esr1 Supt6h ortho G G G G G Esr1 Med16 ortho G G G G G Esr1 Safb2 ortho G G G G G Esr1 Grwd1 ortho G G G G G Phb2 Esr1 ortho G G G G G Esr1 Srsf1 ortho G G G G G Esr1 Abcc5 ortho G G G G G Sec22b Esr1 ortho G G G G G Esr1 Hnrnpu ortho G G G G G Esr1 Rbbp4 ortho G G G G G Esr1 Gata3 ortho Esr1 Rpl36a ortho Esr1 Scyl2 ortho Esr1 Rpl28 ortho Esr1 Rfx4 ortho Esr1 Phb ortho Esr1 Rrp1b ortho G G G G G Esr1 Nop58 ortho G G G G G Esr1 Fmr1 ortho G G G G G Esr1 Arnt ortho G G G G G Esr1 Mknk2 ortho G G G G G Hnrnpa2b1 Esr1 ortho G G G G G Anxa2 Esr1 ortho G G G G G Esr1 Pagr1a ortho G G G G G Esr1 Rbbp5 ortho Esr1 Numa1 ortho G G G G G Esr1 Ddx54 ortho G G G G G Esr1 Ezh2 ortho G G G G G Esr1 Med10 ortho G G G G G Esr1 Whsc1l1 ortho Esr1 Polr2d ortho G G G G G Esr1 Chd4 ortho G G G G G Esr1 Rpl8 ortho G G G G G Esr1 Ncor2 ortho G G G G G Esr1 Hnrnpk ortho G G G G G Myod1 Esr1 ortho G Esr1 Arhgef15 ortho Protein Akap13 Esr1 ortho Esr1 Xpo1 ortho G G G G G Esr1 Ftsj3 ortho G G G G G Esr1 Hnrnpab ortho G G G G G Esr1 Rps18 ortho G G G G G Esr1 Tuba1a ortho G G G G G Esr1 Ppp5c ortho G G G G G Esr1 Ilf3 ortho G G G G G Esr1 Serine hydroxymethyltransferase ortho G G G G G Tp53 Esr1 ortho G G G G G Esr1 Rps13 ortho G G Esr1 Whsc1 ortho Esr1 Rbm39 ortho G G G G G Esr1 Nr0b1 ortho G G Esr1 Med24 ortho G G G G G Esr1 Yars ortho G G G G G Esr1 Rpl11 ortho G G G G G Esr1 Ccnd1 ortho G G G G G Esr1 Csnk2b ortho G G G G G Esr1 Trrap ortho G G G G G Esr1 Angptl4 ortho G G G G G Esr1 Hspa8 ortho G G G G G Dnmt3b Esr1 ortho G G Esr1 Med20 ortho G G G G G Esr1 Foxc1 ortho G Esr1 Dek ortho G G G G G Esr1 Rpl15 ortho Esr1 Pdia6 ortho G G G G G Esr1 Kat5 ortho Esr1 U2surp ortho G G G G G Esr1 Csrp1 ortho G G G G G Esr1 Edf1 ortho Esr1 Polr2h ortho G G G G G Esr1 Luc7l3 ortho G G G G G Esr1 Prdx3 ortho G G G G G Esr1 Pfn1 ortho G G G G G Cops5 Esr1 ortho G G G G G Esr1 Svil ortho G G G G G Gnai2 Esr1 ortho G G G G G Esr1 Tbl2 ortho G G G G Serpinh1 Esr1 ortho G G G G G Esr1 Ddx17 ortho G G G G G Esr1 Pnrc2 ortho G G G G G Esr1 Rac3 ortho G G G Esr1 Ep400 ortho G G G G G Esr1 Mapkapk2 ortho G G G G G Esr1 Alkbh7 ortho Esr1 Polr2b ortho G G G G G Ppia Esr1 ortho Protein Nup153 Esr1 ortho G G G G G Esr1 Pik3ca ortho G G G G G Esr1 Dnm1l ortho G G G G G Esr1 Pik3r1 ortho G G G G G Esr1 Ahrr ortho Esr1 Tff1 ortho G G G G G Sfn Esr1 ortho G Esr1 Ddx3y ortho G G G Esr1 Bcas2 ortho G G G G G Esr1 Sin3b ortho G G G G G Esr1 Prmt2 ortho G G G G G Esr1 Mrps35 ortho G G G G G Esr1 Rps3 ortho G G G G G Esr1 Polr1b ortho G G G G G Myc Esr1 ortho G G G G Esr1 Dctn2 ortho G G G G G Esr1 Smarca4 ortho G G G G G Esr1 Unc45a ortho G G G G G Esr1 Ahr ortho G G G G Esr1 Pgc ortho Esr1 Top2a ortho G G G G Esr1 Myh14 ortho G G G G G Esr1 Rrp12 ortho G Esr1 Med27 ortho G G G G G Protein Prdm2 Esr1 ortho Esr1 Srsf3 ortho G G G G G Esr1 Gstm5 ortho G G G G G Esr1 Ptcd3 ortho G G G G G Esr1 Tcf20 ortho G G G G G Esr1 Hnrnpc ortho G G G G G Esr1 Polyadenylate-binding protein, PABP ortho G G G G G Esr1 Map3k1 ortho G G G G G Esr1 Sra1 ortho G G G G G Esr1 Nr1h4 ortho Esr1 Ttc5 ortho G G G G G Rpl7a Esr1 ortho G G G G G Esr1 Myo6 ortho G G G G G Esr1 Sos1 ortho G G Esr1 Pla2g7 ortho G G G G G Esr1 Fubp1 ortho G G G G G Esr1 Ywhaz ortho G G G G G Esr1 Med4 ortho G G G G G Esr1 Esr1 ortho G G G G G Hdac1 Esr1 ortho G G G G G Esr1 Arsb ortho Esr1 Med23 ortho G G G G G Esr1 Xrcc6 ortho G G G G G Esr1 Galk1 ortho G G G G Esr1 Wdr5b ortho Esr1 Eif4g3 ortho G G G G G Esr1 Akap8 ortho G G G G G Esr1 Ilf2 ortho G G G G G Esr1 Hnf4a ortho G G Med14 Esr1 ortho Esr1 Cebpa ortho G G G G Ep300 Esr1 ortho Esr1 Cacul1 ortho G G G G G Esr1 Myl6b ortho Esr1 Vcp ortho G G G G G Esr1 Taf10 ortho G G G G G Esr1 Med30 ortho G G G G G Esr1 Cav1 ortho G G G G G Esr1 Gnl2 ortho G G G G G Esr1 Ddx27 ortho G G G G Esr1 Bri3bp ortho Esr1 Tap1 ortho Esr1 Rlim ortho G G G G G Esr1 Eppk1 ortho G G G G Rpl7 Esr1 ortho G G G G G C130039O16Rik Esr1 ortho Esr1 Kallikrein 1-related peptidase b5, Kallikrein related-peptidase 5 ortho Esr1 Topbp1 ortho G G G G G Esr1 Protein Wdr36 ortho G G G G G Nppa Esr1 ortho Esr1 Ints1 ortho G G G G G Esr1 Rpl5 ortho Jund Esr1 ortho G G G G G Esr1 Tf ortho Pias1 Esr1 ortho G G G G G Polr2j Esr1 ortho G G G G G Esr1 Top2b ortho G G G G G Esr1 Bdnf ortho G Ncoa3 Esr1 ortho G G G G G Hspb1 Esr1 ortho G G G G G Esr1 Tcerg1 ortho G G G G G Esr1 Med17 ortho G G G G G Esr1 Isl1 ortho G Esr1 Mthfd1 ortho G G G G G Esr1 Krt35 ortho Esr1 Arg1 ortho G G Esr1 Foxa1 ortho Esr1 Hnrnpm ortho G G G G G Esr1 Bap1 ortho G G G G G Esr1 Hdac5 ortho G G G G G Esr1 Smurf1 ortho Esr1 Rela ortho G G G G G Esr1 Hbp1 ortho G G G G G Psmc3ip Esr1 ortho G G G Esr1 Rpl4 ortho G G G G G Esr1 Gadd45a ortho G G G G G Protein Vps13d Esr1 ortho Esr1 Rxra ortho G G G G G Esr1 Huwe1 ortho G G G G G Esr1 Hspa5 ortho G G G G G Esr1 Nop2 ortho G G G G G Esr1 Polr2g ortho G G G G G Esr1 Golga2 ortho G G G G G Esr1 Trip4 ortho G G G G G Esr1 Med25 ortho G G G G G Krt8 Esr1 ortho G G G G G Esr1 Rps8 ortho Sp3 Esr1 ortho G G G G G Esr1 Katnal2 ortho Esr1 Uba3 ortho G G G G G Esr1 Capzb ortho G G G G G Esr1 Dync1h1 ortho G G G G G Esr1 Polr2i ortho G G G G G Esr1 Ppargc1b ortho G G G G G Esr1 Trim28 ortho G G G G G Esr1 Btf3 ortho G G G G G Esr1 Ncoa7 ortho Esr1 Plod3 ortho G G G G G Esr1 Ube2i ortho G G G G G Esr1 Ptpn1 ortho G G G G G Esr1 Hdac2 ortho G G G G G Esr1 Cltc ortho G G G G G Esr1 Kmt2d ortho G G G G G Esr1 Actr3 ortho G G G G G Esr1 Mylk2 ortho G G Esr1 Ccnc ortho G G G G G Foxm1 Esr1 ortho Esr1 Sp2 ortho G G G G Esr1 Ube4b ortho G G G G G Esr1 Polr2k ortho Esr1 Txnrd1 ortho G G G G G Esr1 Eif3i ortho G G G G G Esr1 Dnaja1 ortho G G G G G Esr1 Gadd45b ortho G G G G G Rara Esr1 ortho Esr1 Eef2 ortho G G G G G Esr1 Gnai3 ortho G G G G G Ncl Esr1 ortho G G G G G Esr1 Mapk14 ortho G G G G G Esr1 Hist1h2bc, Hist1h2be, Hist1h2bg ortho Esr1 Tab2 ortho G G G G G Esr1 Epsti1 ortho G G G G Esr1 Cdk2 ortho G G G G G Esr1 Smarcd3 ortho G G G G G Esr1 Nfkb1 ortho G G G G G Esr1 Actc1 ortho G G G Esr1 Foxo1 ortho G G G G G Esr1 Iqgap1 ortho G G G G G Krt18 Esr1 ortho G G G G G Sp1 Esr1 ortho G G G G G Esr1 Rdx ortho G G G G G Esr1 Kallikrein 1-related peptidase b9, Kallikrein 9, Klk9 protein ortho Esr1 Ppid ortho Esr1 Usf1 ortho G G G G G Esr1 Pou2f1 ortho G G G G G Srpk1 Esr1 ortho G G G G G Krt1 Esr1 ortho G G Esr1 Lmo4 ortho G G G G G Esr1 Slc25a20 ortho G G G G G Esr1 Smc1a ortho G G G G G Esr1 Rpn2 ortho G G G G G Esr1 Prpf19 ortho G G G G G Esr1 Trim25 ortho G G G G G Dnah2 Esr1 ortho Esr1 Bclaf1 ortho G G G G G Esr1 Flna ortho G G G G G Esr1 Mrps2 ortho G G G G G Esr1 Nme2 ortho G G G G G Esr1 Polr2c ortho G G G G G Esr1 Psip1 ortho G G G G G Esr1 Znhit3 ortho G G G G G Esr1 Actn1 ortho G G G G G Esr1 Prkcz ortho G G G Ppargc1a Esr1 ortho G G Esr1 Prmt1 ortho G G G G G Esr1 Ddx50 ortho G G G G G Esr1 Cep290 ortho G Esr1 Rnf40 ortho Esr1 Tram1 ortho G G G G G Esr1 Mapk3 ortho G G G G G Esr1 Actr2 ortho G G G G G Esr1 Skp1 ortho G G G G G Esr1 Senp5 ortho Esr1 Pias2 ortho G G G G G Esr1 Znf131 ortho G G G G G Esr1 Rpl22 ortho G G G G G Esr1 Plec ortho G G G G G Esr1 Smad4 ortho G G G G G Esr1 Ddx18 ortho G G G G G Esr1 Foxo4 ortho Esr1 Cuedc2 ortho G G G G G Esr1 Thra ortho G G G G G Esr1 Il17e ortho Pdlim1 Esr1 ortho G G G G G Rpsa Esr1 ortho G G G G G Esr1 Foxo3 ortho G G G G G Esr1 Exosc4 ortho G G G G G Esr1 Bag1 ortho G G G G G Esr1 Actb ortho G G G G G Esr1 Pa2g4 ortho G G G G G Esr1 Chuk ortho G G G G G Esr1 Smc3 ortho G G G G G Esr1 Nr2c2 ortho G G G G G Esr1 Sos2 ortho G G G G G Esr1 Ybx3 ortho G G G G G Esr1 Nelfb ortho G G G G G Esr1 Sept2 ortho G G G G G Fhl2 Esr1 ortho G G G G Esr1 Pou2f2 ortho Esr1 Myh9 ortho G G G G G Esr1 Gnb1 ortho G G G G G Rplp0 Esr1 ortho G G G G G Esr1 Hpcal1 ortho G G G G G Esr1 Serbp1 ortho G G G G G Esr1 Mrps6 ortho G G G G G Esr1 Top1 ortho G G G G G Esr1 Nr2c1 ortho G G G G G Esr1 Smarcd1 ortho G G G Esr1 Tubb3 ortho G Protein Sec16a Esr1 ortho G G G G G Esr1 Hnrnpd ortho G G G G G Esr1 Kars ortho G G G G G Esr1 Med1 ortho G G G G G Tubb1 Esr1 ortho Esr1 Mdm2 ortho G G G G G Esr1 Pabpc1 ortho G G G G G Esr1 Protein Zfp398 ortho Esr1 Pik3r3 ortho Polr2a Esr1 ortho G G G G G Esr1 Ddx1 ortho G G G G G Esr1 Gnb4 ortho G G G G G Esr1 Smad3 ortho G G G G Esr1 Psmd2 ortho G G G G G Srpk2 Esr1 ortho G G G G G Esr1 Cct2 ortho G G G G G Shoc2 Esr1 ortho G G G G G Esr1 Gnb2l1 ortho G G G G G Esr1 Sin3a ortho G G G G G Esr1 Bcar1 ortho G G G G G Esr1 Krt79 ortho G G Esr1 Smarcb1 ortho G G G G G Esr1 Pdia3 ortho G G G G G Esr1 Ndrg2 ortho G G G G G Esr1 Cdkn1a ortho G G G G G Esr1 Bud13 ortho G G G G G Trip12 Esr1 ortho G G G G G Esr1 Med7 ortho G G G G G Esr1 Sfpq ortho G G G G G Axin2 Esr1 ortho G G G G Esr1 G3bp1 ortho G G G G G Esr1 Rpl9 ortho Esr1 Skil ortho G G G G G Esr1 Zc3hav1 ortho Esr1 Hnrnpul1 ortho G G G G G Esr1 Setd7 ortho Esr1 Rnf4 ortho G G G G G Esr1 Srsf2 ortho G G G G G Esr1 Cirbp ortho G G G G G Esr1 Rps24 ortho G G G G G Med12 Esr1 ortho G G G G G Esr1 Cited1 ortho G G Esr1 Mars ortho Esr1 Apod ortho G G G G Esr1 Suv420h1 ortho G G G G G Emd Esr1 ortho G G G G G Esr1 Sept8 ortho G G G G G Esr1 Dnttip2 ortho G G G G G Esr1 Myo1c ortho G G G G G Esr1 Aifm1 ortho G G G G G Atp9a Esr1 ortho G G G G G Esr1 Stub1 ortho G G G G G Esr1 Smarca2 ortho G G G G G Esr1 Tubal3 ortho Esr1 Rexo4 ortho G G G G G Esr1 Myo1b ortho G G G G G Esr1 Gnb2 ortho G G G G G Esr1 Ppp6r1 ortho Esr1 Nat10 ortho Esr1 Rarb ortho G G G G Esr1 Dap3 ortho G G G G G Dhx15 Esr1 ortho G G G G G Bloc1s1 Esr1 ortho Esr1 Dbn1 ortho G G G G G Esr1 Ap2m1 ortho G G G G G Esr1 Lpcat1 ortho G G G G G Esr1 Larp4 ortho Esr1 Ash2l ortho G G G G G Esr1 Upf1 ortho G G G G G Esr1 Ruvbl1 ortho G G G G G Protein Ahnak Esr1 ortho G G G G G Esr1 Protein Tnfrsf14, Tumor necrosis factor receptor superfamily member 14 ortho Esr1 Nop56 ortho G G G G G Krt19 Esr1 ortho G G G G Esr1 Cdc25b ortho G G G Esr1 Krt15 ortho G Esr1 Hspa4 ortho G G G G G Esr1 Ybx1 ortho G G G G G Esr1 Rpl10 ortho Esr1 Wdr5 ortho G G G G G Xbp1 Esr1 ortho G G G G G Esr1 Tfap2c ortho Esr1 Tada3 ortho G G G G G Esr1 Rsl1d1 ortho G G G G G Esr1 Pqbp1 ortho G G G G G Esr1 Polr2e ortho G G G G G Esr1 Pelp1 ortho G G G G G Esr1 Hif1a ortho G G G G G Esr1 Rbmx ortho G G G G G Esr1 Protein Zfp366, Zinc finger protein 366 ortho Esr1 Ubtf ortho G G G G G Esr1 Ythdf2 ortho G G G G G Esr1 Zbtb17 ortho G G G G G Esr1 Med6 ortho G G G G G Esr1 Zdhhc7 ortho G G G G G Ar Esr1 ortho G G G G G Esr1 Atad2 ortho Esr1 Akt2 ortho G G G G G Esr1 Fhl1 ortho G G G G G Esr1 Hspd1 ortho G G G G G Esr1 Mrps31 ortho G G G G G Esr1 Traf6 ortho G G G Esr1 Pspc1 ortho G G G G G Ube3a Esr1 ortho G G G G G Esr1 Zdhhc21 ortho Esr1 Mgmt ortho Esr1 Set ortho G G G G G Esr1 Arhgdia ortho G G G G G Esr1 Znf512b ortho Ccdc6 Esr1 ortho G G G G G Esr1 Sec61b ortho G G G G G Esr1 Mvp ortho G G G G G Esr1 Taf2 ortho Esr1 Crebbp ortho G G G G G Esr1 Supt16h ortho G G G G G Cad Esr1 ortho G G G G G Esr1 Poly A binding protein, cytoplasmic 5, Poly(A) binding protein, cytoplasmic 5, Protein Pabpc5 ortho Esr1 Ccnt1 ortho G G G G G Esr1 Dkc1 ortho Esr1 Sarnp ortho G G G G G Esr1 Tfap2a ortho G Cfl1 Esr1 ortho G G G G G Esr1 Snrpd1 ortho Esr1 Them6 ortho Esr1 Lars ortho G G G G G Esr1 Mta2 ortho G G G G G Esr1 Mnat1 ortho G G G G G Esr1 Cdk7 ortho G G G G G Esr1 Lyar ortho G G G G G Esr1 Glce ortho G G G G G Esr1 Slc30a9 ortho G G G G G Esr1 Med21 ortho G G G G G Ttn Esr1 ortho G G G Esr1 Hacd3 ortho G G G G G Esr1 Tubb5 ortho G G G G G Esr1 Lrrfip1 ortho G G G G G Esr1 Pak6 ortho Esr1 Hspa9 ortho G G G G G Esr1 Fbxo18 ortho G G G G G Esr1 Mrps27 ortho Esr1 Npm1 ortho G G G G G Esr1 Wdr26 ortho G G G G G Esr1 Wdr18 ortho Esr1 Rbm28 ortho G G G G G Esr1 Cct7 ortho G G G G G Esr1 Hist2h2ac ortho Esr1 Nr2f1 ortho G G G Lck Esr1 ortho G G G Esr1 Taf1a ortho G G G G G Esr1 Ruvbl2 ortho G G G G G Cul4b Esr1 ortho G G G G G Esr1 Atp5b ortho G G G G G Rarg Esr1 ortho G G G G G Esr1 Dhx30 ortho G G G G G Esr1 Trim59 ortho G G Esr1 Tbl1xr1 ortho G G G G G Tcof1 Esr1 ortho G G G G G Esr1 Lrif1 ortho Hdac3 Esr1 ortho G G G G G Esr1 Cct3 ortho G G G G G Esr1 Utp14a ortho Prkaca Esr1 ortho G G G G G Fgfr1 Esr1 ortho G G G G G Esr1 Itgb3bp ortho G G G G Esr1 Tuba1c ortho Esr1 Nrip1 ortho G G G G G Esr1 Ppp2r1a ortho G G G G G Fkbpl Esr1 ortho G G G G G Esr1 Rbck1 ortho G G G G G Esr1 Cbll1 ortho G G G G G Esr1 Stat3 ortho G G G G G Esr1 Kat6a ortho G G G G G Esr1 G3bp2 ortho G G G G G Esr1 Mtdh ortho G G G G G Esr1 Polr2f ortho G G G G G Esr1 Sars2 ortho G G G G Esr1 Atad3 ortho G G G G G Rps16 Esr1 ortho Esr1 Vav3 ortho G G G Esr1 Dnajb11 ortho G G G G G Tuba1b Esr1 ortho G G G G G Esr1 Myl6 ortho G G G G G Esr1 Smad2 ortho G G G G G Esr1 Ing1 ortho G G G G G Esr1 Rnf31 ortho Esr1 Hdac7 ortho G G G G G Rpl13a Esr1 ortho G G G G G Esr1 Fkbp4 ortho G G G G G Esr1 Eprs ortho G G G G G Esr1 Rpl14 ortho G G G G G Fos Esr1 ortho G G G G G Esr1 Fkbp5 ortho G G G G G Esr1 Rps2 ortho G G G G G Esr1 Ncoa5 ortho G G G G G Eftud2 Esr1 ortho G G G G G Esr1 Ascc1 ortho G G G G G Esr1 Mpg ortho G G G G G Esr1 Rpl12 ortho G G G G G Arid1a Esr1 ortho G G G G G Parp1 Esr1 ortho G G G G G Esr1 Uimc1 ortho G G G G G Esr1 Ehmt2 ortho G G G G G Esr1 Luzp2 ortho Esr1 Thrb ortho G Esr1 Kifc1 ortho G Esr1 Utp3 ortho G G G G G Esr1 Sptbn1 ortho G G G G G Hsp90b1 Esr1 ortho G G G G G Esr1 Hdac4 ortho Esr1 Polr2l ortho Esr1 Arid5a ortho G G G G Esr1 Dutp ortho G G G G G Esr1 Rps11 ortho G G G G G Esr1 Mapk1 ortho G G G G G Esr1 Rps15a ortho Esr1 Kdm5a ortho G G G G G Esr1 Nono ortho G G G G G Esr1 Smyd2 ortho G G G G G Esr1 Ddx3x ortho G G G G G Esr1 Ywhah ortho G G G G G Esr1 Mta1 ortho G G G G G Lancl1 Esr1 ortho G G G G G Esr1 Shc1 ortho G G G G G Esr1 Tbp ortho G G G G G Esr1 Gnl3 ortho G G G G G Esr1 Hnrnpa0 ortho Esr1 Tfrc ortho G G G G G Esr1 Prdx2 ortho G G G G G Esr1 Mrps22 ortho G G G G G MCG129038, Protein Serpinb3a Esr1 ortho Esr1 Hdac9 ortho Esr1 Twist1 ortho G G G Esr1 Psmc2 ortho G G G G G Esr1 Gtf2b ortho G G G G G Esr1 Rps12 ortho Esr1 Psmc4 ortho G G G G G Gsn Esr1 ortho G G G G G Hspa1l Esr1 ortho G Esr1 Ddx5 ortho G G G G G Esr1 Srsf6 ortho G G G G G P4hb Esr1 ortho G G G G G Esr1 Cul3 ortho G G G G G Esr1 Ranbp9 ortho G G G G G Esr1 MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 ortho G G G G G Esr1 Iars ortho G G G G G Esr1 Nedd8 ortho G G G G G Esr1 Tbr1 ortho Esr1 Arfgap2 ortho G G G G G Dhx9 Esr1 ortho G G G G G Esr1 Mrps15 ortho G G G G G Esr1 Blood vessel epicardial substance, Processing of 1, ribonuclease P/MRP family, (S. cerevisiae) ortho Esr1 Copg2 ortho G G G G G Esr1 Ccnh ortho G G G G G Esr1 Sirt1 ortho G G G G G Esr1 Thrap3 ortho G G G G G Sptan1 Esr1 ortho G G G G G Esr1 Rpl10a ortho G G G G G Esr1 Med13 ortho Esr1 Akt1 ortho G G G G G Esr1 Rps9 ortho G G G G G Esr1 Stat1 ortho G G G G G Esr1 Smarcc2 ortho Esr1 Wipi1 ortho G G G G G Esr1 Tnip1 ortho G G G G G Esr1 Pbxip1 ortho G G G G G Hsp90aa1 Esr1 ortho G G G G G Esr1 Rpl3 ortho Esr1 Khdrbs1 ortho G G G G G Esr1 Cul1 ortho G G G G G Esr1 Tubb6 ortho G G G G G Esr1 Nfkb2 ortho G G Bard1 Esr1 ortho Esr1 Rpl37a ortho G G G G G Esr1 Nr2f6 ortho G G G G G Esr1 H2afx ortho G G G G G Esr1 Larp1 ortho G G G G G Esr1 Slc25a5 ortho G G G G G Esr1 Mta3 ortho G G G G G Pten Esr1 ortho G G G G G Esr1 Rnf14 ortho G G G G G Esr1 Gtpbp4 ortho G G G G G Esr1 Asf1a ortho G G G G G Esr1 Greb1 ortho G G G G Esr1 Klf5 ortho G G G G Esr1 Eif4a1 ortho G G G G G Esr1 Nuclear receptor coactivator 4, Protein Ncoa4 ortho G G G G G Esr1 Mcm2 ortho G G G G G Esr1 Mybbp1a ortho G G G G G Esr1 Flii ortho G G G G G Esr1 Macrod1 ortho G G G G G Esr1 Nap1l4 ortho G G G G G Esr1 Pof1b ortho G Rpl21 Esr1 ortho Esr1 Eif4g1 ortho G G G G G Esr1 Taf1b ortho G G G G G Esr1 Xrcc5 ortho G G G G G Esr1 Stau1 ortho G G G G G Suv39h1 Esr1 ortho G G G G Esr1 Kdm1a ortho G G G G G Esr1 Erbb2 ortho G G Esr1 Ncoa1 ortho G G G G G Esr1 Breast carcinoma-amplified sequence 3 homolog ortho G G G G G Esr1 Ldb1 ortho G G G G G Esr1 Bag4 ortho G G G G Esr1 Tsc2 ortho G G G G G Protein Mki67 Esr1 ortho G G G G Esr1 Sf3b1 ortho G G G G G Esr1 Hdlbp ortho G G G G G Esr1 Farsa ortho G G G G G Esr1 Eif2s2 ortho G G G G G Esr1 Wrnip1 ortho G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P19785 - 9448000 - X 2 P19785 O88846 - 9710597 - X 2 P19785 - 9448000 - X 2 P19785 - 9448000 - X 2 P19785 - 8643509 - X 2 P19785 Q63934 - 9448000 - X 2 P19785 affinity chromatography technology 10393183 physical association X 2 P48754 P19785 affinity chromatography technology 16807234 physical association X 2 A6H6A5 P19785 imaging technique 22396492 colocalization X 2 A6H6A5 P19785 affinity chromatography technology 22396492 physical association X 2 A6H6A5 P19785 affinity chromatography technology 22396492 physical association X 2 P00523 P19785 enzymatic study 17921256 direct interaction X 2 P27782 P19785 affinity chromatography technology 18202148 physical association X 2 P0CG48 P19785 affinity chromatography technology 16055746 physical association X 2 P63087 P19785 affinity chromatography technology 17274640 physical association X 2 P19785 affinity chromatography technology 21445275 physical association X 2 P19785 Q02248 affinity chromatography technology 18202148 physical association X 2 P19785 A1A549 affinity chromatography technology 18202148 physical association X 2 P19785 Q02248 affinity chromatography technology 18202148 physical association X 2 P17208 P19785 two hybrid 20211142 direct interaction X 2 O54941 P19785 pull down 12145209 direct interaction X 2 P05480 P19785 affinity chromatography technology 17921256 physical association X 2 O88643 P19785 affinity chromatography technology 12374744 physical association X 2 Q91VY5 P19785 affinity chromatography technology 21445275 physical association X 2 Q91VY5 P19785 affinity chromatography technology 21445275 physical association X 2 Q3UZ79 P19785 affinity chromatography technology 15304355 physical association X 2 Q3UZ79 P19785 affinity chromatography technology 15304355 physical association X 2 A5YKK6 P19785 two hybrid 16778766 direct interaction X 2 P70313 P19785 affinity chromatography technology 17921256 physical association X 2 Q8C961 P19785 two hybrid 20211142 direct interaction X 2 P19785 Q5XJV5 pull down 10681503 direct interaction X 2 P19785 A0A024R1S7 pull down 12145209 direct interaction X 2 P19785 P05627 affinity chromatography technology 19605792 physical association X 2 P19785 P05627 affinity chromatography technology 19605792 physical association X 2 P19785 Q63934 two hybrid 20211142 direct interaction X 2 P19785 A0A024R1S7 pull down 16769725 direct interaction X 2 P19785 affinity chromatography technology 21445275 physical association X 2 Q15788 P19785 pull down 10207113 physical association X 2 Q15788 P19785 two hybrid 10207113 physical association X 2 Q15788-2 P19785 pull down 10207113 physical association X 2 O88470 P19785 anti tag coimmunoprecipitation 20005806 physical association X 2 Q64127 P19785 two hybrid 8978696 physical association X 2 P63087 P19785 antibody array 17274640 physical association X 2 A5YKK6 P19785 two hybrid 16778766 physical association X 2 P19785 Q3TXS7 fluorescence microscopy 16857966 colocalization X 2 P19785 O88846 two hybrid 9710597 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Esr1 Ncoa2 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313043 bait prey Esr1 Pou4f2 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313045 bait prey Esr1 Lef1 MI:0004(affinity chromatography technology) 18202148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320201 bait prey Esr1 Stat5a MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15304355 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_328147|BIOGRID_328146 bait|prey prey|bait Esr1 Brca1 MI:0004(affinity chromatography technology) 16807234 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325916 prey bait Esr1 Psmd1 MI:0091(chromatography technology) 16857966 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (intact) UniProt_166811 neutral component neutral component Esr1 Pgr MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22396492 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid) BIOGRID_320613|BIOGRID_320612|BIOGRID_320611 prey|bait|bait bait|prey|prey Smarce1 Esr1 MI:0018(two hybrid) 12145209 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_311180 bait prey Foxl2 Esr1 MI:0402(chromatin immunoprecipitation assay) 20005806 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_170667 prey bait Esr1 Tcf7l1 MI:0004(affinity chromatography technology) 18202148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320202 bait prey Jun Esr1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19605792 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_312832|BIOGRID_312831 prey|bait bait|prey Esr1 Nos3 MI:0004(affinity chromatography technology) 17921256 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328826 bait prey Esr1 Kdm4a MI:0004(affinity chromatography technology) 21445275 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315575 prey bait Pou4f1 Esr1 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313044 prey bait Esr1 Ctnnb1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18202148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_320200|BIOGRID_320203 prey|bait bait|prey Esr1 Ppp1cc MI:0004(affinity chromatography technology)|MI:0678(antibody array) 17274640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_321961|UniProt_166741 prey|bait bait|null Src Esr1 MI:0004(affinity chromatography technology) 17921256 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328825 prey bait Esr1 Kdm4c MI:0004(affinity chromatography technology) 21445275 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315582 prey bait Esr1 Scand1 MI:0004(affinity chromatography technology) 10393183 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329189 prey bait Esr1 Kdm4b MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21445275 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_315574|BIOGRID_315573 prey|bait bait|prey Esr1 Trim24 MI:0018(two hybrid) 8978696 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_176908 prey bait

PPI - HINT Gene A Gene B PMID Method Quality POU4F1 ESR1 20211142 0018 HT ESR1 PPP1CC 17274640,17274640 0004,0678 LC ESR1 PSMD1 16857966 0416 LC ESR1 NCOA2 20211142,8643509,8643509 0018,0018,0004 HT,LC ESR1 POU4F2 20211142,9448000,9448000,9448000 0018,0004,0019,0018 HT,LC ESR1 TRIM24 8978696 0018 LC ESR1 GRIP1 8643509,8643509 0018,0004 LC SMARCE1 ESR1 12145209 0096 LC FOXL2 ESR1 20005806 0007 LC PAK1 ESR1 12374744,12374744 0007,0004 LC SRC ESR1 17921256 0004 LC JUN ESR1 19605792 0004 LC ESR1 LEF1 18202148 0004 LC ESR1 STAT5A 15304355 0004 LC ESR1 BRCA1 16807234 0004 LC ESR1 PPP1CC 17274640,17274640 0004,0678 LC ESR1 NOS3 17921256 0004 LC ESR1 PGR 22396492,22396492 0428,0004 LC ESR1 CTNNB1 18202148 0004 LC ESR1 SCAND1 10393183 0004 LC ESR1 NCOA2 8643509,8643509 0018,0004 LC ESR1 POU4F2 9448000,9448000,9448000 0004,0019,0018 LC ESR1 Q6ZWM8 17274640 0004 LC ESR1 KDM4A 21445275 0004 LC ESR1 KDM4C 21445275 0004 LC ESR1 KDM4B 21445275 0004 LC ESR1 GRIP1 8643509,8643509 0018,0004 LC ESR1 NCOA6 10681503 0096 LC ESR1 TCF7L1 18202148 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P19785 O54941 ESR1 SMARCE1 0.309 12145209 Q8VCD7 P19785 KDM4C ESR1 0.21 21445275 Q64127 P19785 TRIM24 ESR1 0.309 8978696 P19785 P0CG48 ESR1 UBC 0.21 16055746 Q8BW72 P19785 KDM4A ESR1 0.21 21445275 P19785 P00523 ESR1 SRC 0.309 17921256 Q925T6 P19785 GRIP1 ESR1 0.454 8643509 Q00175 P19785 PGR ESR1 0.309 22396492 Q969G3 P19785 SMARCE1 ESR1 0.523 12145209,16769725 P19785 A5YKK6 ESR1 CNOT1 0.523 16778766 Q91VY5 P19785 KDM4B ESR1 0.376 21445275 P48754 P19785 BRCA1 ESR1 0.21 16807234 P63087 P19785 PPP1CC ESR1 0.236 17274640 P42230 P19785 STAT5A ESR1 0.376 15304355 P19785 O88470 ESR1 FOXL2 0.376 20005806 P19785 O94763 ESR1 URI1 0.376 25453901 P19785 P05480 ESR1 SRC 0.21 17921256 P19785 P05627 ESR1 JUN 0.376 19605792 P19785 P17208 ESR1 POU4F1 0.183 20211142 P27782 P19785 LEF1 ESR1 0.21 18202148 P70313 P19785 NOS3 ESR1 0.21 17921256 Q02248 P19785 CTNNB1 ESR1 0.376 18202148 Q61026 P19785 NCOA2 ESR1 0.183 20211142 Q63934 P19785 POU4F2 ESR1 0.183 20211142 Q9Z1J1 P19785 TCF7L1 ESR1 0.21 18202148 P19785 A6H6A5 ESR1 PGR 0.454 Q3TXS7 P19785 PSMD1 ESR1 0.126 16857966