PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Tnfaip3 Sqstm1 25609235 innatedb exp G G G G G Tnfaip3 Ssbp2 20211142 biogrid exp G G G G G Tnfaip3 Rhbdd3 24859449 biogrid exp G G G G G Ripk2 Tnfaip3 18342009 innatedb exp G G G Tnfaip3 Ssbp3 20211142 biogrid exp G G G G G Tnfaip3 Med16 20211142 biogrid exp G G G G G Ube2d3 Tnfaip3 20185725 innatedb,biogrid exp G G G G G Tnfaip3 Ripk1 23602765,18239685,18246070,21765415 innatedb,biogrid,intact exp, ortho G G G G G Tnfaip3 Rnf11 19131965,22975135,21765415 biogrid,intact exp, ortho G G G G G Traf6 Tnfaip3 17703191,15334086,20185725,21765415 innatedb,biogrid,intact exp, ortho G G G G G Tnfaip3 Tnip2 11389905 innatedb,i2d exp, ortho G G Ubc Tnfaip3 23602765 biogrid exp, ortho G G G G G Tax1bp1 Tnfaip3 20185725,21765415 innatedb,biogrid,intact exp, ortho G G G G G Traf2 Tnfaip3 20185725,21765415,15102471 innatedb,biogrid,intact exp, ortho G G G G G 9030611K07Rik Tnfaip3 22173278 biogrid exp, ortho Tnfaip3 Tnip1 10385526,19060883,11389905,12586352 innatedb,intact,dip exp, ortho G G G G G Tnfrsf1a Tnfaip3 23602765 biogrid exp, ortho G G G G G Ikbkg Tnfaip3 24859449,20211142 biogrid exp, ortho G G G G G Tnfaip3 Tnfaip3 10385526,23602765 biogrid,intact exp, ortho G G G G G Ube2n Tnfaip3 20185725 innatedb,biogrid exp, ortho Rnf5 Tnfaip3 ortho G G G G G Wnk1 Tnfaip3 ortho G G G G G Ube2d1 Tnfaip3 ortho G G G G G Tnfaip3 Arrdc3 ortho Tnfaip3 Ocln ortho G G G Axin1 Tnfaip3 ortho G G G G G Ywhaz Tnfaip3 ortho G G G G G Tnfaip3 Kif11 ortho G G G G G Tnfaip3 Sharpin ortho G G G G G Ywhae Tnfaip3 ortho G G G G G Tnfaip3 Git2 ortho G G G G G Becn1 Tnfaip3 ortho G G G G G Tnf Tnfaip3 ortho Ikbkb Tnfaip3 ortho G G G G G Tnfaip3 Birc2 ortho G G G G G Tp53 Tnfaip3 ortho G G G G G Chuk Tnfaip3 ortho G G G G G Tnfaip3 Irak1 ortho G G G G G Lrrc47 Tnfaip3 ortho Tnfaip3 Rnf31 ortho Tnfaip3 Trim8 ortho G G G G G Lamp1 Tnfaip3 ortho G G G G G Rela Tnfaip3 ortho G G G G G Tnfaip3 Nxf1 ortho G G G G G Irf7 Tnfaip3 ortho G G G G G Tnfaip3 Krr1 ortho G G G G G Tnfsf10 Tnfaip3 ortho G G G Tnfaip3 Rbck1 ortho G G G G G Tnfaip3 Ticam1 ortho Tnfaip3 Laptm5 ortho G G G G G Tnfaip3 Rnf114 ortho G G G G G Tnfaip3 Rnf14 ortho G G G G G Tnfaip3 Trim23 ortho G G G G Tnfaip3 Ppp6r3 ortho G G G G G Tnfaip3 Trim3 ortho G G G G Tnfaip3 Ndufs1 ortho G G G G G Malt1 Tnfaip3 ortho Hsp90ab1 Tnfaip3 ortho G G G G G Tradd Tnfaip3 ortho G G G G G Tnfaip3 Rnh1 ortho G G G G G Birc3 Tnfaip3 ortho G G G G G Tnfaip3 Ddx58 ortho Traf1 Tnfaip3 ortho G G Map3k5 Tnfaip3 ortho G G G Tnfaip3 Aldh9a1 ortho G G G G G Ywhah Tnfaip3 ortho G G G G G Elavl1 Tnfaip3 ortho G G G G G Tnfaip3 Irak2 ortho Tnfaip3 Ppp2r1b ortho G G G G G Mcm6 Tnfaip3 ortho G G G G G Tnfaip3 Trim2 ortho G G G G G Tnfaip3 Fbxo3 ortho G G G G G Tnfaip3 Gldc ortho Tnfaip3 Kcnip3 ortho Hsp90aa1 Tnfaip3 ortho G G G G G Tnfaip3 Rlim ortho G G G G G Tnfaip3 Cnksr2 ortho Ywhag Tnfaip3 ortho G G G G G Zfand5 Tnfaip3 ortho G G G G G Tnfaip3 Tbk1 ortho G G G G G Tnfaip3 Ikbke ortho G G G G G Tnfaip3 Nfkb2 ortho G G G G G Tnfaip3 Fadd ortho G G G G G Tnfaip3 Usf1 ortho G G G G G Tnfaip3 Ywhab ortho G G G G G Tnfaip3 Apc ortho G G G G G Casp8 Tnfaip3 ortho G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants E9QM75 Q60769 anti tag coimmunoprecipitation 19060883 physical association X 2 Q60769 anti bait coimmunoprecipitation 21765415 association C 5 Q60769 anti bait coimmunoprecipitation 21765415 association C 7 Q60769 anti bait coimmunoprecipitation 21765415 association C 7 Q60769 anti bait coimmunoprecipitation 19131965 association C 4 Q60855 Q60769 anti bait coimmunoprecipitation 21765415 physical association X 2 Q60769 Q60769 two hybrid 10385526 physical association X 2 Q60769 Q3UKC1 anti bait coimmunoprecipitation 21765415 physical association X 2 Q60769 anti bait coimmunoprecipitation 21765415 association C 5 Q9WUU8-2 Q60769 two hybrid 10385526 physical association X 2 Q9WUU8 Q60769 two hybrid 10385526 physical association X 2 Q9WUU8 Q60769 two hybrid 10385526 physical association X 2 Q9WUU8 Q60769 anti tag coimmunoprecipitation 10385526 physical association X 2 Q9WUU8 Q60769 anti tag coimmunoprecipitation 12586352 physical association X 2 P39429 Q60769 two hybrid 15102471 physical association X 2 P39429 Q60769 two hybrid 15102471 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ubc Tnfaip3 MI:0004(affinity chromatography technology) 23602765 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328880 prey bait Tax1bp1 Tnfaip3 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 20185725,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_319676|BIOGRID_318891|BIOGRID_318889|UniProt_113522|UniProt_171884 prey|bait|prey|prey|prey bait|prey|bait|bait|bait Ube2d3 Tnfaip3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20185725 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_318890|BIOGRID_318888 prey|bait bait|prey Traf6 Tnfaip3 MI:0424(protein kinase assay)|MI:0424(protein kinase assay)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 17703191,20185725,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_113517|UniProt_171879|BIOGRID_318871|BIOGRID_314631|BIOGRID_319661 bait|bait|bait|prey|bait prey|prey|prey|bait|prey Traf2 Tnfaip3 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 15102471,20185725,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|(biogrid)|(intact)|(intact)|(intact) UniProt_164733|BIOGRID_318877|BIOGRID_319664|UniProt_164732|UniProt_171878|UniProt_113516 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey Ikbkg Tnfaip3 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313254 bait prey Tnfaip3 Ripk1 MI:0004(affinity chromatography technology)|MI:0424(protein kinase assay)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0424(protein kinase assay) 18239685,18246070,21765415,23602765 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_321312|UniProt_171882|BIOGRID_319675|BIOGRID_319673|BIOGRID_326012|BIOGRID_328881|UniProt_113520 prey|prey|bait|prey|prey|bait|prey bait|bait|prey|bait|bait|prey|bait Tnfaip3 Ssbp2 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313622 bait prey Tnip3 Tnfaip3 MI:0004(affinity chromatography technology) 22173278 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321290 bait prey Tnfaip3 Tnip1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 10385526,12586352 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact) UniProt_159995|UniProt_159996|UniProt_161883|UniProt_159993|UniProt_159994 bait|bait|prey|bait|bait null|prey|bait|prey|null Ube2n Tnfaip3 MI:0004(affinity chromatography technology) 20185725 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318887 bait prey Tnfaip3 Rnf11 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 19131965,21765415,22975135 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_169598|MINT_70539|UniProt_171880|UniProt_113518|UniProt_171881|UniProt_113519|BIOGRID_323988|BIOGRID_319669 prey|prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait|bait Tnfaip3 Ssbp3 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313623 bait prey Tnfrsf1a Tnfaip3 MI:0004(affinity chromatography technology) 23602765 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328879 bait prey

PPI - HINT Gene A Gene B PMID Method Quality IKBKG TNFAIP3 20211142,24859449,24859449,24859449 0018,0004,0415,0096 HT,LC TRAF2 TNFAIP3 15102471 0018 LC RIPK2 TNFAIP3 18342009 0204 LC TRAF6 TNFAIP3 15334086 0204 LC TNFAIP3 TNFAIP3 PDB_5DQ6,10385526 0114,0018 LC TNFAIP3 MED16 20211142 0018 HT TNFAIP3 SSBP2 20211142 0018 HT TNFAIP3 SSBP3 20211142 0018 HT TNFAIP3 TNIP1 10385526,10385526 0018,0007 LC IKBKG TNFAIP3 24859449,24859449,24859449 0004,0415,0096 LC UBC TNFAIP3 23602765 0096 LC IL1B TNFAIP3 25607459 0004 LC TNFRSF1A TNFAIP3 23602765 0004 LC CASP1 TNFAIP3 25607459 0004 LC TRAF2 TNFAIP3 20185725,21765415,21765415,20185725 0007,0006,0004,0004 LC UBE2D3 TNFAIP3 20185725,20185725 0007,0004 LC UBE2N TNFAIP3 20185725,20185725 0007,0004 LC YWHAG TNFAIP3 16931600 0007 LC TRAF6 TNFAIP3 17703191,21765415,20185725,20185725,21765415 0004,0006,0004,0007,0004 LC RELA TNFAIP3 21343618,16931600 0007,0007 LC TNIP3 TNFAIP3 22173278 0004 LC TAX1BP1 TNFAIP3 20185725,21765415,21765415,20185725 0007,0006,0004,0004 LC TNFAIP3 TNFAIP3 23602765,23602765 0096,0004 LC TNFAIP3 RIPK1 18246070,21765415,18239685,23602765,21765415,18246070 0007,0006,0004,0096,0004,0004 LC TNFAIP3 RHBDD3 24859449 0004 LC TNFAIP3 YWHAB 16931600 0007 LC TNFAIP3 RNF11 21765415,22975135,21765415,19131965 0006,0004,0004,0006 LC TNFAIP3 TNIP1 11389905,12586352,10385526,10385526,19060883 0007,0007,0018,0007,0007 LC TNFAIP3 NFKBIA 16931600 0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q60769 P61079 TNFAIP3 UBE2D3 0.376 20185725 Q60769 P61089 TNFAIP3 UBE2N 0.21 20185725 Q60769 O88522 TNFAIP3 IKBKG 0.692 20211142,24859449 Q60769 P0CG50 TNFAIP3 UBC 0.309 23602765 Q60769 P39429 TNFAIP3 TRAF2 0.49 15102471,20185725,21765415 Q60769 P70196 TNFAIP3 TRAF6 0.507 17703191,20185725,21765415 Q9CYZ8 Q60769 SSBP2 TNFAIP3 0.183 20211142 Q9D032 Q60769 SSBP3 TNFAIP3 0.183 20211142 Q9QYK7 Q60769 RNF11 TNFAIP3 0.61 22975135,21765415,19131965 Q60769 P25118 TNFAIP3 TNFRSF1A 0.21 23602765 Q8BP97 Q60769 RHBDD3 TNFAIP3 0.21 24859449 Q60769 P10749 TNFAIP3 IL1B 0.21 25607459 Q60855 Q60769 RIPK1 TNFAIP3 0.731 18239685,18246070,21765415,23602765 Q60769 Q60769 TNFAIP3 TNFAIP3 0.49 23602765 Q60769 P29452 TNFAIP3 CASP1 0.21 25607459 Q60769 Q3UKC1 TNFAIP3 TAX1BP1 0.507 20185725,21765415