PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Apaf1 Apaf1 i2d exp GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Ppp1ca 17274640 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Triap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Top1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Casp9 ortho G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Casp3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Casp4 ortho G G G G G G G G G G G G G Nalp1b Apaf1 ortho Apaf1 Xiap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Apip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Endov ortho Apaf1 Hsp90aa1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Fem1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Fas ortho G G G G G G G G G G G G G G Apaf1 Bcl2l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Hip1 ortho GP G G G G G G G G G G G G G G G G G G G G G Apaf1 Ywhae ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Hspa4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Serine hydroxymethyltransferase ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Aven ortho P Apaf1 Bcl2l10 ortho G Apaf1 Casp8 ortho GP G G G G G G G G G G G G G G G G G G G G Apaf1 Cycs ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Apaf1 Elavl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P62137 O88879 affinity chromatography technology 17274640 physical association X 2 O88879 O88879 molecular sieving 15907471 association Y 1 P62137 O88879 antibody array 17274640 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Apaf1 Ppp1ca MI:0678(antibody array)|MI:0004(affinity chromatography technology) 17274640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_166735|BIOGRID_321933 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality APAF1 APAF1 15907471 0071 LC APAF1 PPP1CA 17274640,17274640 0004,0678 LC APAF1 PPP1CA 17274640,17274640 0004,0678 LC