PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rel Peli1 21874024 intact exp G G G G Smad7 Peli1 20171181 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Peli1 22007846 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad6 Peli1 20171181,16951688 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G Irak1 Peli1 16951688 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Peli1 Irak4 ortho G G G G G G G G G G G G G G G G G G G G Ube2d2 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uba1 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Peli1 Deaf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Peli1 Irak2 ortho Il1r1 Peli1 ortho G G G G G G G G G G G G G G G G G G G Srpk2 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2i Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkb Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n Peli1 ortho Ripk1 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Traf6 Peli1 ortho G G G G G G G G G G G G G G G G G G G G Ube2d1 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irs1 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Peli1 Ube2v1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trip13 Peli1 ortho G G G G G G G G G G G G G G Peli1 Tbk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tfap2a Peli1 ortho G G G G G G Srpk1 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Peli1 Uba2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vac14 Peli1 ortho G G G G G G G G G G G G G G G G Nr2c2 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myd88 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8C669 P0CG50 enzymatic study 22007846 direct interaction X 2 Q8C669 P47985 affinity chromatography technology 25027698 physical association X 2 Q8C669 P51617-3 affinity chromatography technology 25027698 physical association X 2 Q8C669 P51617 pull down 19081057 physical association X 2 Q8C669 P15307 anti bait coimmunoprecipitation 21874024 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8C669 P0CG50 PELI1 UBC 0.309 22007846 Q8C669 P47985 PELI1 UQCRFS1 0.21 25027698 Q8C669 P51617 PELI1 IRAK1 0.376 25027698,19081057