PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mdm2 Sumo2 15897463 biogrid exp Mdm2 Dhcr24 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Senp2 21183956 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pax3 22216266 biogrid exp G G G G Mdm2 Ndn 22905258 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ywhaq 20086099 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccng2 Mdm2 12167164 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Uba52 21730132,17936560 intact,dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Usp15 24777531 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Elavl1 22095636 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Sumo3 15897463 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG1048453, Protein AF366264 Mdm2 17086174 biogrid exp Mdm2 Cdkn2a 12167164,11715018,23580573,9529248,20832751,10713175,15485902 innatedb,biogrid,i2d,intact,dip exp, ortho Eef1a1 Mdm2 23260144 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rps6kb1 20657550 mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rassf1 18566590 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Sumo1 19090619,17086174,15897463,21183956 biogrid,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mre11a 15734743 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Akt1 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Dlg4 21849563,23260144 biogrid,intact exp, ortho G G G G G G G G G G Daxx Mdm2 15364927,18566590 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mdm2 18566590,17086174,17157790 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Arrb2 11588219 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2d1 21183956 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Mdm2 17086174,21730132 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pole 10982879 biogrid exp, ortho G G G G G G G G G Mdm2 Usp7 18566590,20697359 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hipk1 Mdm2 22173032 biogrid,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Mdm2 17616658,22666487,19573810,21730132,20697359,25117711 biogrid,intact,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ar Mdm2 i2d exp, ortho G G G G G G G G G G G G G G G G Mdm2 Ccng1 12167164,11983168 biogrid,i2d,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Mdm2 10706102,18566590,11715018,21738215,9732264,22216266,17086174,10205143,22666487,20697359,25117711,18309296,22805162,20818388,23580573,9653180,20832751,8058315,10982879,11953423,17936560,21183956 innatedb,biogrid,i2d,intact,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Tbp 9388200 dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Adrbk1 21081496 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rpl5 22789538,20832751,17936560 intact exp, ortho Ep300 Mdm2 11715018 innatedb exp, ortho Mdm2 Ccar1 22905258 biogrid exp, ortho Mdm2 Nbn 15734743 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rassf5 22173032 mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rad50 15734743 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Igf1r 15878855 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Gsk3b 21738215 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Foxo3 22094330 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Tp73 20921405 dip exp, ortho G Mdm2 Arrb1 15102471 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2i 21183956 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rpl23 20832751 biogrid,intact exp, ortho Mdm2 Rpl11 22789538,15989966,20832751,17936560 biogrid,i2d,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Eid1 24167073 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2d3 22216266 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mtbp i2d exp, ortho G G G G G Sfn Mdm2 ortho G G G G G G G G Mdm2 Krt14 ortho G G G G G G G Mdm2 G3bp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Atf3 ortho G G G G G G G G G G G G G G G G G Mdm2 Cdk5rap3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ezr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nr2f6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Srp19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hexim1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Crebbp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rps25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rhoa ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ddx39b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Tbca ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Znf318 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Suv39h1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Psmd10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myd88 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Edc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ranbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gsn Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zbtb7a Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Cmss1 ortho Terf2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Tbrg1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Sf3b3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 E2f1 ortho G G G G G Mdm2 Rnf126 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2e3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dhx9 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wt1 Mdm2 ortho G G G G G Mdm2 Nfia ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Arid2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Cdkn1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rassf6 ortho C130039O16Rik Mdm2 ortho Mdm2 Sdhc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pja1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Psmb6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hmha1 ortho G G G G G G G G Mdm2 Rcn2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rps6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Psmc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Phf7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Set ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rps23 ortho Mdm2 Rbbp6 ortho G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ehmt2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Elf4 ortho G G G G G G Mdm2 Trim13 ortho G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pml ortho G G G G G G G G G G G G G G G G G G G G G Mdm2 Foxo4 ortho Mdm2 Snai1 ortho G G G Mdm2 Snai2 ortho G G G G G G G G Mdm2 Ogdh ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ipo7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Xiap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eftud2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rasgrf1 ortho G G G G G G G G G G G G G G G G Mdm2 Agps ortho Mdm2 Tfcp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nfatc2 ortho G G G G G G G G G G G Mdm2 Acaca ortho G G G G G Mdm2 Sf3b1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ppp6r3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ctcf ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Fbxw11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Eef2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrb2 Mdm2 ortho G G G G G G G G G Usp42 Mdm2 ortho Mdm2 Smarcb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Znf668 ortho S100a6 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Zbtb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Soga3 ortho Mdm2 Bub1b ortho G G G G G G G G G G G G Mdm2 Casp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Clu ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2n ortho Mdm2 Dcaf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Coiled-coil domain containing 95, isoform CRA_g, INO80 complex subunit E, Protein Ino80e ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2d2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Sox4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ngef ortho G G G G G G G G G G G G G G G G G G Mdm2 Psma8 ortho G Hsp90aa1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G S100a4 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G Protein Srsf11 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hck Mdm2 ortho G G G G G G G G G G G G G G G G G G G G Mdm2 Usf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Abl1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mta3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tubb1 Mdm2 ortho Mdm2 Psma6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wiz Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Per2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rbbp8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ppib ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Gtf2e2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptbp1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ccar2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Csnk1e ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rps20 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Lmo7 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mbd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Gapdhs ortho G G G G G G G G Mdm2 Rps27l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hnrnpd ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Atm ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Psmc6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Fubp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Sec63 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hmgb2 ortho G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hnrnpk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Uhrf2 ortho Mdm2 Znhit6 ortho Mdm2 Recql ortho G G G G G G G G G G G G G G G G G G G G G Arid1a Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Plk1 ortho G G G G G G G G G G G G G G Sp1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mta1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Smurf1 ortho Mdm2 Rela ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rabl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Cul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ptgs2 ortho G G G G G G G G Mdm2 Ube2k ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Foxo1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Tfrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hrsp12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fhit Mdm2 ortho G G G G G G G G G G G G G G G G G G G Mdm2 Cdk9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Casp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Sesn2 ortho G G G G G G G G G G G G G G G G G G G G G G Mdm2 Psmc5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rab8a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops5 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Egr1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nav3 ortho Mdm2 Pim3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdm16 Mdm2 ortho Mdm2 Vrk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Banp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Uso1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rars ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nap1l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Gorab ortho Pknox1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Det1 ortho Mdm2 Ube2z ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Csnk1a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rpl37 ortho Mdm2 UPF0609 protein C4orf27 homolog ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pim1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ckap5 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Xpo1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Dnajb4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ruvbl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Chrac1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mea1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Snd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ctbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hipk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hnrnpm ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Chek2 ortho G G G G G G G G G G G G G G G G G G G G Mdm2 Igf2bp3 ortho G G G G Mdm2 Dtl ortho G G G G G G G G G G G Mdm2 Psmd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Erbb3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ubtf ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ubp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dhfr Mdm2 ortho G G G G G G G G G G G G G G G G G Mdm2 Rad54b ortho Mdm2 Dnajb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Eef1g ortho Smarce1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sp3 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Bcl2l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Baiap2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pbx1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Tsnax ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pgam2 Mdm2 ortho G G G G G G G G G G G G G Mdm2 Atf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Trim9 ortho Mdm2 Senp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Lats2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Eps15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nr0b2 ortho G G G G G G G G Hsp90b1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Tmem87a ortho G Mdm2 Ttf2 ortho Mdm2 Rffl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Kif5a ortho G G G G G G G G G Mdm2 Tubb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Med1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Eif2ak1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Trim28 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rps14 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pdlim7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pa2g4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mkrn3 ortho Mdm2 Pkm ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rps15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rfwd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rps3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Numb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pim2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Psma7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Yy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Src Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2e2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Baiap2l1 ortho G G G G G G G G G G G G G G G G G G Mdm2 Tubb2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pak1ip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hdac2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Sap130 ortho Mdm2 Rps27a ortho Mdm2 Xpc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ndufa12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Canx ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Brinp1 ortho G G G G G G G Mdm2 Gnl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nucks1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xrcc6 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 S100a8 ortho G G G G G G G G G G G G G G G G Mdm2 Sirt6 ortho Mdm2 Whsc1 ortho Mdm2 Rfwd3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Vcp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Aurka ortho G G G G G G G G G G G G G G Mdm2 Nr2f1 ortho G G G G G G G G G G G G G G G G Mdm2 Rrm2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tert Mdm2 ortho Mdm2 Mrps33 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Irs1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Activator protein 4, Protein Tfap4, Transcription factor AP4 ortho G G G G G G G Mdm2 Rps7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Taf1 ortho Mdm2 Zhx3 ortho Brd7 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Gtf2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Lats1 ortho G G G G G G G G G G G Mdm2 Iyd ortho G G G G G G G G G Mdm2 Ankrd17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Topbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2u Mdm2 ortho Mdm2 Dlat ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hif1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clock Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Btaf1 Mdm2 ortho Mdm2 Aldh16a1 ortho G G G G G G G G G G G G G G G G G G G G Esr1 Mdm2 ortho G G G G G Siva1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ran ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Smarca2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mgea5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irf1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Kat5 ortho Mdm2 S100a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pak6 ortho Mdm2 Rad23a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Zbtb7b ortho G G G G G G G G G G G G G G G G G G G G G G G G Protein Zfp462 Mdm2 ortho Mdm2 Fkbp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nfic ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Notch4 ortho G G G G G G G G G G G G G G G Mdm2 Wwox ortho G G G G G G G G G G G G G G G G G G G G Mdm2 Ddx17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Apex1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nudt9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Dyrk2 ortho Mdm2 Kars ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Map4k4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Anapc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Dnttip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Traf5 ortho G G G G G G G G G G G G G G G G G Mdm2 Smarcc2 ortho Mdm2 Exosc6 ortho Esr2 Mdm2 ortho G Mdm2 Irf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 S100b ortho G G G G G G G G G G G Jun Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nme2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 MCG144734, isoform CRA_a, Protein Zfp420, Zfp420 protein ortho Mdm2 Ube2m ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pot1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Cdkn2b ortho G G G G G G G G G G G G G G G G G G G G Mdm2 Shpk ortho Mdm2 Tsg101 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mdc1 ortho Mdm2 Gnl3l ortho Mdm2 Esyt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Prrc2c ortho Bhlhe40 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Gabra2 ortho G G G G G G Mdm2 Notch1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ryr2 Mdm2 ortho G G G G G G G G Znf335 Mdm2 ortho Mdm2 Gnl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp2a2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Ogdhl Mdm2 ortho Pole2 Mdm2 ortho G G G G G G G G G G G G G G G G Mdm2 Ppard ortho Gata3 Mdm2 ortho G G G G G Mdm2 Pdia3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ppp2r4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Thyn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ehmt1 ortho Mdm2 Hspa8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Trim23 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Arhgef6 ortho Mdm2 Kat2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Gnas ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mydgf ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Cul4a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Tsc22d3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp63 Mdm2 ortho G G G G G G G Mdm2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pfdn6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Noc2l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Dapk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Pgam1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Naca ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Abl2 ortho G G G G G G G G G G G G Erich3 Mdm2 ortho G G G G G G G G Tcap Mdm2 ortho G G G G G G G G G G G Mdm2 Zzz3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rps26 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Aatf ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Daam2 ortho Mdm2 Trrap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Jmy ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ddx5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Znf326 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Trim27 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rbm38 ortho G G G G G G G G G G G G G G G G G G G G G Mdm2 Smc3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Psmd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ubqln4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ier2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Wdr45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Psme3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rnf10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Prpf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Jund Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gcat Mdm2 ortho Parp2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Cwc25 ortho Mdm2 Terf2ip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tpr Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hnf4a ortho G G G G G G G G G G G Mdm2 Itch ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Mars ortho Pcna Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stx1a Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hspa4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Surf2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Hnrnpu ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rpl10a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Runx3 ortho Mdm2 U2af2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr3c1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Top1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Clstn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Actb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Cdkn2aip ortho Mdm2 Sin3b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctbp1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2l3 ortho Mdm2 Csnk1d ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Fbxw7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nlk Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Setdb1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2g2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ppm1d ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Npm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ptk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Brca1 ortho G G G G G G G G G G G G G Psmd4 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Usp10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncl Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dapk3 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Diras1 ortho G G G G G G G G G Rpl27a Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul4b Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Gadd45a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nek9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Erbb4 ortho Lamp2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Slc14a2 ortho G Mdm2 Tuba1c ortho Mdm2 Yeats2 ortho Mdm2 Fez1 ortho G G G G G G G G G G G G G G G G G Mdm2 Tpt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Srek1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Iars ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ilf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ang Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Ercc6 Mdm2 ortho Mdm2 Arih2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Sorbs2 ortho Psmc3 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Family with sequence similarity 171, member A1, Protein Fam171a1 Mdm2 ortho Mdm2 Tfcp2l1 ortho G G G G G G G G G G G G G G Ms4a1 Mdm2 ortho G G G G G G G G G G Mdm2 Rassf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rb1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Chrm3 ortho G Mdm2 Rpl26 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppara Mdm2 ortho G G G G G G G G G G G G G G Cdh1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G Mdm2 MCG2065, isoform CRA_c, PreS1 binding protein, Protein Gltscr2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rnf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Uchl1 ortho G G G G G G G G G G G G G G G G G G Mdm2 Sfpq ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Tab1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Pias1 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Polh ortho Mdm2 Jak1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map2 Mdm2 ortho Mdm2 Stra13 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Nr2f2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Eif3b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ddb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Smarca4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P23804 - 10906133 - X 2 P23804 Q9CXW4 - 15195100 - X 2 P23804 - 15989966 - C 4 P23804 - 15577914 - X 2 P51945 P23804 - 12556559 - X 2 P23804 - 12556559,9653180 - X 2 Q64364 P23804 - 10822382 - X 2 Q64364 P23804 - 11606464 - X 2 Q64364 P23804 - 11718560 - X 2 P23804 - 11697899 - X 2 P19091 P23804 - 12145204 - X 2 P23804 P31750 - 12145204 - X 2 P32121-2 P23804 affinity chromatography technology 19372219 physical association X 2 O35618 P23804 pull down 17616658 direct interaction X 2 O35618 P23804 affinity chromatography technology 19573810 physical association X 2 O35618 P23804 affinity chromatography technology 20697359 physical association X 2 O35618 P23804 affinity chromatography technology 21730132 physical association X 2 O35618 P23804 affinity chromatography technology 22666487 physical association X 2 P70372 P23804 affinity chromatography technology 22095636 physical association X 2 Q91YI4 P23804 affinity chromatography technology 11588219 physical association X 2 Q549C9 P23804 affinity chromatography technology 22805162 physical association X 2 Q549C9 P23804 pull down 22805162 direct interaction X 2 Q549C9 P23804 pull down 10982879 direct interaction X 2 Q549C9 P23804 two hybrid 10982879 direct interaction X 2 Q549C9 P23804 unspecified method 8058315 direct interaction X 2 Q549C9 P23804 affinity chromatography technology 10205143 physical association X 2 Q549C9 P23804 affinity chromatography technology 10205143 physical association X 2 Q549C9 P23804 affinity chromatography technology 21738215 physical association X 2 Q549C9 P23804 affinity chromatography technology 10706102 physical association X 2 Q549C9 P23804 enzymatic study 11953423 direct interaction X 2 Q549C9 P23804 affinity chromatography technology 23580573 physical association X 2 Q549C9 P23804 affinity chromatography technology 18566590 physical association X 2 Q549C9 P23804 affinity chromatography technology 18309296 physical association X 2 Q549C9 P23804 affinity chromatography technology 17936560 physical association X 2 Q549C9 P23804 affinity chromatography technology 17936560 physical association X 2 Q549C9 P23804 affinity chromatography technology 17086174 physical association X 2 Q549C9 P23804 affinity chromatography technology 17086174 physical association X 2 Q549C9 P23804 enzymatic study 17086174 direct interaction X 2 Q549C9 P23804 affinity chromatography technology 20697359 physical association X 2 Q549C9 P23804 affinity chromatography technology 22216266 physical association X 2 Q549C9 P23804 affinity chromatography technology 22216266 physical association X 2 Q549C9 P23804 enzymatic study 22216266 direct interaction X 2 Q549C9 P23804 enzymatic study 21183956 direct interaction X 2 Q549C9 P23804 affinity chromatography technology 20818388 physical association X 2 Q549C9 P23804 affinity chromatography technology 22666487 physical association X 2 Q9WVH4 P23804 affinity chromatography technology 22094330 physical association X 2 Q61216 P23804 affinity chromatography technology 15734743 physical association X 2 P23804 enzymatic study 11983168 direct interaction X 2 Q91ZX6 P23804 affinity chromatography technology 21183956 physical association X 2 Q91ZX6 P23804 affinity chromatography technology 21183956 physical association X 2 Q91ZX6 P23804 enzymatic study 21183956 direct interaction X 2 P23804 P70388 affinity chromatography technology 15734743 physical association X 2 P23804 Q9R207 affinity chromatography technology 15734743 physical association X 2 P23804 Q07864 pull down 10982879 direct interaction X 2 P23804 P04637-7 affinity chromatography technology 11983168 physical association X 2 P23804 Q9CXW4 affinity chromatography technology 15989966 physical association X 2 P23804 Q9CXW4 affinity chromatography technology 15989966 physical association X 2 P23804 P25233 affinity chromatography technology 22905258 physical association X 2 P23804 P25233 affinity chromatography technology 22905258 physical association X 2 P23804 Q3TZM4 affinity chromatography technology 22216266 physical association X 2 P23804 Q3TZM4 pull down 22216266 direct interaction X 2 P23804 Q3TZM4 affinity chromatography technology 22216266 physical association X 2 P53350 P23804 enzymatic study 19833129 direct interaction X 2 Q9WVF7 P23804 pull down 10982879 direct interaction X 2 Q9WVF7 P23804 two hybrid 10982879 direct interaction X 2 P23804 affinity chromatography technology 20697359 physical association X 2 P23804 affinity chromatography technology 18566590 physical association X 2 Q3UKR0 P23804 affinity chromatography technology 15364927 physical association X 2 Q3UKR0 P23804 affinity chromatography technology 18566590 physical association X 2 Q3UKR0 P23804 affinity chromatography technology 18566590 physical association X 2 Q8CH18 P23804 affinity chromatography technology 22905258 physical association X 2 Q8CH18 P23804 affinity chromatography technology 22905258 physical association X 2 P51945 P23804 affinity chromatography technology 11983168 physical association X 2 P51945 P23804 pull down 11983168 direct interaction X 2 P51945 P23804 pull down 11983168 direct interaction X 2 O88904 P23804 affinity chromatography technology 22173032 physical association X 2 P63280 P23804 enzymatic study 21183956 direct interaction X 2 Q9WV60 P23804 affinity chromatography technology 21738215 physical association X 2 Q9WV60 P23804 affinity chromatography technology 21738215 physical association X 2 P23804 affinity chromatography technology 21081496 physical association X 2 P23804 affinity chromatography technology 18566590 physical association X 2 P23804 pull down 18566590 direct interaction X 2 Q9Z172 P23804 affinity chromatography technology 15897463 physical association X 2 P23804 P51480-2 pull down 10713175 direct interaction X 2 P23804 P51480-2 affinity chromatography technology 10713175 physical association X 2 P23804 P51480-2 affinity chromatography technology 10713175 physical association X 2 P23804 P51480-2 imaging technique 10713175 colocalization X 2 P23804 P51480-2 imaging technique 10713175 colocalization X 2 P23804 affinity chromatography technology 9632782 physical association X 2 P23804 pull down 9632782 direct interaction X 2 P23804 affinity chromatography technology 9632782 physical association X 2 P23804 Q15172-2 enzymatic study 11983168 direct interaction X 2 P23804 P0CG50 affinity chromatography technology 12832478 physical association X 2 P23804 P51480-2 affinity chromatography technology 15485902 physical association X 2 P23804 P63166 affinity chromatography technology 15897463 physical association X 2 P23804 P51480-2 affinity chromatography technology 23580573 physical association X 2 P23804 affinity chromatography technology 24167073 physical association X 2 P23804 P0CG50 affinity chromatography technology 18566590 physical association X 2 P23804 P23804 enzymatic study 18566590 direct interaction X 2 P23804 affinity chromatography technology 21849563 physical association X 2 P23804 affinity chromatography technology 17086174 physical association X 2 P23804 pull down 17086174 direct interaction X 2 P23804 affinity chromatography technology 17086174 physical association X 2 P23804 imaging technique 17086174 colocalization X 2 P23804 P23804 enzymatic study 17086174 direct interaction X 2 P23804 affinity chromatography technology 17086174 physical association X 2 P23804 P0CG50 affinity chromatography technology 17086174 physical association X 2 P23804 P63166 affinity chromatography technology 17086174 physical association X 2 P23804 enzymatic study 17086174 direct interaction X 2 P23804 P63166 affinity chromatography technology 21183956 physical association X 2 P23804 P0CG50 affinity chromatography technology 21730132 physical association X 2 P23804 Q60751 affinity chromatography technology 15878855 physical association X 2 P61957 P23804 affinity chromatography technology 15897463 physical association X 2 P23804 coimmunoprecipitation 15989966 association C 4 P23804 tandem affinity purification 19556538 - C 4 O35618 P23804 anti bait coimmunoprecipitation 21730132 physical association X 2 O08918 P23804 coimmunoprecipitation 12167164 physical association X 2 Q549C9 P23804 tandem affinity purification 19556538 physical association X 2 Q549C9 P23804 anti bait coimmunoprecipitation 18695251 physical association X 2 Q549C9 P23804 coimmunoprecipitation 9653180 physical association X 2 Q549C9 P23804 anti bait coimmunoprecipitation 18359851 physical association X 2 Q549C9 P23804 anti bait coimmunoprecipitation 21857681 physical association X 2 P29037 P23804 coimmunoprecipitation 9388200 physical association X 2 P23804 P62984 anti tag coimmunoprecipitation 21730132 physical association X 2 P51945 P23804 affinity chromatography technology 12167164 physical association X 2 P51945 P23804 coimmunoprecipitation 12167164 physical association X 2 Q64364 P23804 coimmunoprecipitation 12167164 physical association X 2 Q64364 P23804 affinity chromatography technology 12167164 physical association X 2 Q64364 P23804 coimmunoprecipitation 9529248 physical association X 2 Q64364 P23804 coimmunoprecipitation 10713175 physical association X 2 Q64364 P23804 coimmunoprecipitation 9653180 physical association X 2 Q9JJP2 P23804 anti bait coimmunoprecipitation 20921405 physical association X 2 P13393 P23804 affinity chromatography technology 9388200 physical association X 2 P21675 P23804 coimmunoprecipitation 9388200 physical association X 2 P21675 P23804 two hybrid 9388200 physical association X 2 P21675 P23804 affinity chromatography technology 9388200 physical association X 2 P23804 P63166 anti bait coimmunoprecipitation 19090619 physical association X 2 P23804 P20226 affinity chromatography technology 9388200 physical association X 2 P23804 P20226 affinity chromatography technology 9388200 physical association X 2 P23804 anti bait coimmunoprecipitation 18566590 association C 4 P23804 anti bait coimmunoprecipitation 19573810 physical association C 3 P23804 anti bait coimmunoprecipitation 20697359 physical association C 3 P23804 anti bait coimmunoprecipitation 25117711 association C 3 O35618 P23804 anti bait coimmunoprecipitation 20697359 physical association X 2 O35618 P23804 anti bait coimmunoprecipitation 20697359 physical association X 2 P02340 P23804 anti bait coimmunoprecipitation 17936560 physical association X 2 P02340 P23804 anti bait coimmunoprecipitation 17936560 physical association X 2 P02340 P23804 anti bait coimmunoprecipitation 20697359 physical association X 2 P02340 P23804 anti bait coimmunoprecipitation 25117711 physical association X 2 P47962 P23804 anti bait coimmunoprecipitation 17936560 physical association X 2 Q62108 P23804 anti bait coimmunoprecipitation 23260144 physical association X 2 Q62108 P23804 confocal microscopy 23260144 colocalization X 2 Q62108 P23804 anti bait coimmunoprecipitation 23260144 physical association X 2 P62830 P23804 anti bait coimmunoprecipitation 20832751 physical association X 2 P23804 Q9CXW4 anti bait coimmunoprecipitation 17936560 physical association X 2 P23804 P62984 anti bait coimmunoprecipitation 17936560 physical association X 2 P23804 Q8BSK8 anti bait coimmunoprecipitation 20657550 physical association X 2 P23804 Q8BSK8 anti bait coimmunoprecipitation 20657550 physical association X 2 P23804 Q9CXW4 anti bait coimmunoprecipitation 20832751 physical association X 2 P23804 anti tag coimmunoprecipitation 22173032 association C 3 P23804 fluorescence microscopy 22173032 colocalization C 3 P23804 anti bait coimmunoprecipitation 20697359 physical association C 3 P23804 anti bait coimmunoprecipitation 22789538 association C 3 P23804 anti bait coimmunoprecipitation 18566590 association C 3 P23804 anti bait coimmunoprecipitation 20832751 association C 6 P10126 P23804 anti bait coimmunoprecipitation 23260144 physical association X 2 P53350 P23804 protein kinase assay 19833129 phosphorylation reaction X 2 P53350 P23804 protein kinase assay 19833129 phosphorylation reaction X 2 Q8BWG8 P23804 two hybrid 15102471 physical association X 2 Q8BWG8 P23804 two hybrid 15102471 physical association X 2 Q8BWG8 P23804 two hybrid 15102471 physical association X 2 Q8BWG8 P23804 two hybrid 15102471 physical association X 2 O88904 P23804 anti bait coimmunoprecipitation 22173032 physical association X 2 Q5EBH1 P23804 fluorescence microscopy 22173032 colocalization X 2 Q5EBH1 P23804 two hybrid 22173032 physical association X 2 Q5EBH1 P23804 pull down 22173032 direct interaction X 2 P23804 P68254 pull down 20086099 association X 2 P02340 P23804 coimmunoprecipitation 11314026 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Mdm2 Arrb2 MI:0004(affinity chromatography technology) 11588219 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_315984 bait prey Hipk1 Mdm2 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 22173032 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0914(association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(intact) UniProt_175709|UniProt_175710|UniProt_122184|BIOGRID_322024|UniProt_175711 neutral component|bait|neutral component|bait|bait neutral component|prey|neutral component|prey|prey Mdm2 Rpl5 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 17936560,20832751,22789538 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact) UniProt_168534|UniProt_172829|UniProt_174352 bait|bait|bait prey|prey|prey Mdm2 Sumo3 MI:0004(affinity chromatography technology) 15897463 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328485 prey bait Mdm2 Igf1r MI:0004(affinity chromatography technology) 15878855 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319891 bait prey Mdm2 Elavl1 MI:0004(affinity chromatography technology) 22095636 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322255 bait prey Mdm2 Rad50 MI:0004(affinity chromatography technology) 15734743 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321626 bait prey Daxx Mdm2 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15364927,18566590 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_169253|MINT_69032|UniProt_95881|BIOGRID_319540|BIOGRID_328906|BIOGRID_312284 bait|bait|bait|prey|bait|bait prey|prey|prey|bait|prey|prey Ubc Mdm2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12832478,17086174,18566590,21730132 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_312277|BIOGRID_319617|BIOGRID_316210|BIOGRID_325186 bait|bait|prey|bait prey|prey|bait|prey Mdm2 Pax3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22216266 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_319416|BIOGRID_319414|BIOGRID_319412 bait|prey|prey prey|bait|bait Eef1a1 Mdm2 MI:0096(pull down) 23260144 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_174747 prey bait Tp53 Mdm2 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0686(unspecified method)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 10205143,10706102,10982879,11953423,17086174,17157790,17936560,18309296,18566590,20697359,20818388,20832751,21183956,21738215,22216266,22666487,22805162,23580573,8058315,9653180 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0465(dip)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_325606|BIOGRID_316209|UniProt_168536|BIOGRID_318823|BIOGRID_312317|UniProt_168533|BIOGRID_319561|BIOGRID_322275|BIOGRID_322276|BIOGRID_328894|BIOGRID_325070|BIOGRID_319793|DIP_272|BIOGRID_323910|BIOGRID_322595|UniProt_108996|BIOGRID_312280|BIOGRID_323909|BIOGRID_319419|BIOGRID_319417|BIOGRID_324067|BIOGRID_320351|BIOGRID_323335|BIOGRID_319415|UniProt_166580|UniProt_166581|BIOGRID_316250|BIOGRID_316214|BIOGRID_322597|BIOGRID_312367|BIOGRID_312366|UniProt_173076|UniProt_172829 prey|prey|bait|bait|bait|prey|prey|bait|bait|prey|bait|bait|-|prey|prey|bait|prey|bait|prey|bait|prey|bait|bait|prey|bait|prey|bait|bait|prey|prey|bait|bait|prey bait|bait|prey|prey|prey|bait|bait|prey|prey|bait|prey|prey|-|bait|bait|null|bait|prey|bait|prey|bait|prey|prey|bait|prey|bait|prey|prey|bait|bait|prey|null|bait Mdm2 Ubb MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 17936560 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_168537|UniProt_93147 bait|bait prey|prey Mdm2 Ywhaq MI:0096(pull down)|MI:0096(pull down) 20086099 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association) (intact)|MI:0471(mint) UniProt_171175|MINT_79308 unspecified role|unspecified role unspecified role|unspecified role Mdm2 Tbp MI:0019(coimmunoprecipitation) 9388200 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) MI:0465(dip) DIP_266 - - Mdm2 Rpl23 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 20832751 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association) (intact)|(intact) UniProt_172830|UniProt_172829 prey|bait bait|prey Mdm2 Arrb1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_162586|UniProt_162587|UniProt_162707|UniProt_162585 prey|prey|prey|prey bait|bait|bait|bait Mdm2 Dlg4 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 21849563,23260144 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid) UniProt_174742|UniProt_174744|UniProt_174746|BIOGRID_316152 neutral component|prey|prey|prey neutral component|bait|bait|bait Mdm2 Usp7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18566590,20697359 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_318825|BIOGRID_319539 prey|bait bait|prey Mdm2 Cdkn2a MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10713175,15485902,20832751,23580573,9653180 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|MI:0465(dip)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid) BIOGRID_322012|DIP_270|BIOGRID_322014|BIOGRID_328176|BIOGRID_322016|BIOGRID_328893|UniProt_172829|BIOGRID_322013|BIOGRID_322015 prey|-|prey|prey|prey|prey|bait|bait|bait bait|-|bait|bait|bait|bait|prey|prey|prey Mdm4 Mdm2 MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 17616658,19573810,20697359,21730132,22666487 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(intact) UniProt_170436|UniProt_108995|UniProt_173075|BIOGRID_320353|BIOGRID_319619|UniProt_173073|BIOGRID_318824|UniProt_173080|UniProt_173079|BIOGRID_322449|UniProt_173074|UniProt_108994|UniProt_108993 bait|prey|prey|prey|bait|bait|bait|bait|bait|prey|bait|bait|bait prey|null|null|bait|prey|null|prey|null|null|bait|null|null|null Mdm2 Eid1 MI:0018(two hybrid) 24167073 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331696 prey bait Mdm2 Rps6kb1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 20657550 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_173730|UniProt_173731 bait|prey prey|bait Mdm2 Ube2i MI:0004(affinity chromatography technology) 21183956 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_319562 prey bait Mdm2 AF366264 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17086174 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_316206|BIOGRID_316208|BIOGRID_316202|BIOGRID_316204|BIOGRID_316249|BIOGRID_316200 prey|bait|prey|prey|prey|prey bait|prey|bait|bait|bait|bait Mdm2 Gsk3b MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21738215 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_324064|BIOGRID_324066 prey|bait bait|prey Mdm2 Rassf5 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22173032 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0914(association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_175709|UniProt_175710|UniProt_122184|UniProt_175701|UniProt_122181|UniProt_175706|UniProt_175705 neutral component|prey|neutral component|bait|neutral component|neutral component|bait neutral component|prey|neutral component|prey|neutral component|neutral component|prey Mdm2 Sumo2 MI:0004(affinity chromatography technology) 15897463 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328483 prey bait Mdm2 Ndn MI:0018(two hybrid)|MI:0018(two hybrid) 22905258 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_329176|BIOGRID_329174 prey|bait bait|prey Mdm2 Foxo3 MI:0004(affinity chromatography technology) 22094330 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318811 prey bait Mdm2 Pole MI:0096(pull down)|MI:0096(pull down) 10982879 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_322598|BIOGRID_322596 bait|bait prey|prey Mdm2 Adrbk1 MI:0004(affinity chromatography technology) 21081496 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321899 prey bait Mdm2 Rassf1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 18566590 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint) BIOGRID_312281|BIOGRID_312279|UniProt_169252|MINT_39736|UniProt_95880|MINT_69025 prey|bait|bait|bait|bait|bait bait|prey|prey|prey|prey|prey Mdm2 Rpl11 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 15989966,17936560,20832751,22789538 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|(intact)|(biogrid)|(intact)|(intact) UniProt_168535|BIOGRID_328924|UniProt_172831|BIOGRID_328921|UniProt_172829|UniProt_174352 bait|prey|bait|bait|bait|bait prey|bait|prey|prey|prey|prey Mdm2 Sumo1 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15897463,17086174,19090619,21183956 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(biogrid)|(biogrid) DIP_711|BIOGRID_319560|BIOGRID_328481|BIOGRID_316211 -|bait|prey|bait -|prey|bait|prey Mdm2 Ccar1 MI:0018(two hybrid)|MI:0018(two hybrid) 22905258 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_329175|BIOGRID_329177 bait|prey prey|bait Mdm2 Nbn MI:0004(affinity chromatography technology) 15734743 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321627 bait prey Mdm2 Ccng1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11983168 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_322659|BIOGRID_322656|BIOGRID_322658 bait|bait|prey prey|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality AF366264 MDM2 17086174,17086174,17086174,17086174 0415,0096,0428,0004 LC CCNG2 MDM2 12167164 0019 LC HIPK1 MDM2 22173032,22173032,22173032,22173032 0007,0416,0006,0004 LC TP53 MDM2 22216266,9653180,10982879,22216266,11314026,21183956,10982879,17086174,17086174,12556559 0004,0019,0018,0415,0019,0415,0096,0004,0415,0019 LC MDM2 MDM2 18566590,17086174 0415,0415 LC MDM2 TBP 9388200 0019 LC MDM2 CCNG1 12556559,12556559,12167164,12167164 0019,0004,0019,0004 LC MDM2 UBE2I 21183956 0415 LC MDM2 RASSF5 22173032,22173032,22173032 0416,0096,0018 LC MDM2 CDKN2A 10713175,12167164,9529248,10713175,9653180,10713175,10713175,12167164 0096,0019,0019,0019,0019,0004,0428,0004 LC MDM2 ARRB1 15102471 0018 LC MDM2 DHCR24 15577914 0019 LC MDM2 ARRB2 11588219,11588219 0004,0415 LC MDM2 SENP2 21183956,21183956 0004,0415 LC MDM2 RPL11 15195100 0019 LC MDM2 POLE 10982879,10982879 0018,0096 LC AF366264 MDM2 17086174,17086174,17086174,17086174 0415,0096,0428,0004 LC DAXX MDM2 18566590,18566590,15364927 0006,0004,0004 LC MDM4 MDM2 17616658,25117711,20697359,20697359,25981963,21730132,22666487,21730132,19573810,19573810 0096,0006,0004,0006,0004,0006,0004,0004,0006,0004 LC HIPK1 MDM2 22173032,22173032,22173032,22173032 0007,0416,0006,0004 LC TP53 MDM2 19556538,17936560,11953423,22216266,20697359,11715018,10982879,21738215,20832751,10205143,22216266,18359851,25117711,10982879,17936560,23580573,20697359,17086174,10706102,22805162,20832751,18695251,25732823,17086174,22805162,20818388,21857681,25732823,9732264,22666487,18309296,18566590 0676,0004,0004,0004,0004,0007,0018,0004,0006,0004,0415,0006,0006,0096,0006,0004,0006,0004,0004,0096,0004,0006,0004,0415,0004,0004,0006,0096,0004,0004,0004,0004 LC UBC MDM2 21730132,17936560,17086174,18566590,21730132 0004,0006,0004,0004,0007 LC EEF1A1 MDM2 23260144 0006 LC IRF8 MDM2 19648273 0007 LC MDM2 PAX3 22216266,22216266 0004,0096 LC MDM2 NDN 22905258 0004 LC MDM2 CEBPB 25720496,25720496 0096,0004 LC MDM2 RPL5 17936560,20832751,22789538 0006,0006,0006 LC MDM2 CCNG1 11983168,12556559,12556559,11983168,12167164,12167164 0096,0019,0004,0004,0019,0004 LC MDM2 UBE2D3 22216266 0096 LC MDM2 UBE2D1 21183956 0096 LC MDM2 SUMO2 15897463 0004 LC MDM2 RPL23 20832751,20832751 0004,0006 LC MDM2 UBA52 17936560,21730132 0006,0007 LC MDM2 SUMO1 21183956,15897463,17086174,19090619 0004,0004,0004,0006 LC MDM2 YWHAQ 20086099 0096 LC MDM2 ELAVL1 22095636 0004 LC MDM2 RAD50 15734743 0004 LC MDM2 RASSF5 22173032,22173032,22173032 0416,0096,0018 LC MDM2 IGF1R 15878855 0004 LC MDM2 EZH2 26748827 0004 LC MDM2 MRE11A 15734743 0004 LC MDM2 DLG4 23260144,23260144,21849563 0006,0663,0004 LC MDM2 CDKN2A 10713175,12167164,11715018,10713175,23580573,15485902,10713175,10713175,20832751,10822382,12167164,20832751 0096,0019,0007,0019,0004,0004,0004,0428,0004,0004,0004,0006 LC MDM2 USP7 20697359,18566590 0004,0004 LC MDM2 RPS6KB1 20657550 0006 LC MDM2 CCAR1 22905258 0004 LC MDM2 ARRB2 11588219,11588219 0004,0415 LC MDM2 SENP2 21183956,21183956 0004,0415 LC MDM2 ADRBK1 21081496 0004 LC MDM2 RASSF1 18566590,18566590,18566590 0096,0006,0004 LC MDM2 RPL11 17936560,22789538,15989966,20832751,20832751 0006,0006,0004,0004,0006 LC MDM2 EID1 24167073 0004 LC MDM2 TP73 20921405 0006 LC MDM2 NBN 15734743 0004 LC MDM2 GSK3B 21738215 0004 LC MDM2 POLE 10982879,10982879 0018,0096 LC MDM2 FOXO3 22094330 0004 LC MDM2 SUMO3 15897463 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61957 P23804 SUMO2 MDM2 0.21 15897463 Q61188 P23804 EZH2 MDM2 0.21 26748827 P23804 O35613 MDM2 DAXX 0.539 18566590,15364927 P23804 O75643 MDM2 SNRNP200 0.126 24980433 P23804 O88904 MDM2 HIPK1 0.569 22173032 P23804 P06748 MDM2 NPM1 0.126 24980433 P23804 P09429 MDM2 HMGB1 0.126 24980433 P23804 P10126 MDM2 EEF1A1 0.21 23260144 P23804 P13010 MDM2 XRCC5 0.126 24980433 P23804 P15311 MDM2 EZR 0.126 24980433 P23804 P15880 MDM2 RPS2 0.126 24980433 P23804 P17987 MDM2 TCP1 0.126 24980433 P23804 P19338 MDM2 NCL 0.126 24980433 P23804 P19474 MDM2 TRIM21 0.126 24980433 P24610 P23804 PAX3 MDM2 0.569 22216266 P25233 P23804 NDN MDM2 0.376 22905258 P26583 P23804 HMGB2 MDM2 0.126 24980433 P27348 P23804 YWHAQ MDM2 0.126 24980433 P28033 P23804 CEBPB MDM2 0.569 25720496 P29037 P23804 TBP MDM2 0.033 9388200 P31943 P23804 HNRNPH1 MDM2 0.126 24980433 P31946 P23804 YWHAB MDM2 0.126 24980433 P32121 P23804 ARRB2 MDM2 0.21 19372219 P32969 P23804 RPL9P9 MDM2 0.126 24980433 P35998 P23804 PSMC2 MDM2 0.126 24980433 P39019 P23804 RPS19 MDM2 0.126 24980433 P39023 P23804 RPL3 MDM2 0.126 24980433 P40939 P23804 HADHA MDM2 0.126 24980433 P46781 P23804 RPS9 MDM2 0.126 24980433 P46783 P23804 RPS10 MDM2 0.126 24980433 P48643 P23804 CCT5 MDM2 0.126 24980433 P50750 P23804 CDK9 MDM2 0.126 24980433 P50991 P23804 CCT4 MDM2 0.126 24980433 P52597 P23804 HNRNPF MDM2 0.126 24980433 P53350 P23804 PLK1 MDM2 0.354 19833129 P61079 P23804 UBE2D3 MDM2 0.309 22216266 P61080 P23804 UBE2D1 MDM2 0.309 21183956 P61247 P23804 RPS3A MDM2 0.126 24980433 P61978 P23804 HNRNPK MDM2 0.126 24980433 P62081 P23804 RPS7 MDM2 0.126 24980433 P62263 P23804 RPS14 MDM2 0.126 24980433 P62753 P23804 RPS6 MDM2 0.126 24980433 P62830 P23804 RPL23 MDM2 0.507 20832751 P62851 P23804 RPS25 MDM2 0.126 24980433 P62913 P23804 RPL11 MDM2 0.126 24980433 P62991 P23804 UBA52 MDM2 0.21 17936560 P78371 P23804 CCT2 MDM2 0.126 24980433 P98175 P23804 RBM10 MDM2 0.126 24980433 Q07864 P23804 POLE MDM2 0.309 10982879 Q15208 P23804 STK38 MDM2 0.126 24980433 Q60751 P23804 IGF1R MDM2 0.21 15878855 Q61216 P23804 MRE11A MDM2 0.21 15734743 Q62108 P23804 DLG4 MDM2 0.569 21849563,23260144 Q6A4J8 P23804 USP7 MDM2 0.309 20697359,18566590 Q7L0Y3 P23804 TRMT10C MDM2 0.126 24980433 Q8BSK8 P23804 RPS6KB1 MDM2 0.21 20657550 Q8BWG8 P23804 ARRB1 MDM2 0.183 15102471 Q8CH18 P23804 CCAR1 MDM2 0.376 22905258 Q8TBX8 P23804 PIP4K2C MDM2 0.126 24980433 Q91YI4 P23804 ARRB2 MDM2 0.21 11588219 Q91ZX6 P23804 SENP2 MDM2 0.569 21183956 Q9BQ67 P23804 GRWD1 MDM2 0.126 24980433 Q9BQA1 P23804 WDR77 MDM2 0.126 24980433 Q9GZR7 P23804 DDX24 MDM2 0.236 24980433 Q9R207 P23804 NBN MDM2 0.21 15734743 Q9WV60 P23804 GSK3B MDM2 0.376 21738215 Q9Y2H1 P23804 STK38L MDM2 0.126 24980433 Q9Y2W1 P23804 THRAP3 MDM2 0.126 24980433 P24941 P23804 CDK2 MDM2 0.309 11983168 Q9WVH4 P23804 FOXO3 MDM2 0.21 22094330 Q9Z172 P23804 SUMO3 MDM2 0.21 15897463 P23804 P13393 MDM2 SPT15 0.033 9388200 P23804 P0CG50 MDM2 UBC 0.376 21730132,17086174 P23804 P04637 MDM2 TP53 0.472 18566590,24980433,11983168 Q99MK9 P23804 RASSF1 MDM2 0.454 18566590 Q9CXW4 P23804 RPL11 MDM2 0.808 22789538,20832751,15989966,17936560 P23804 P23804 MDM2 MDM2 0.472 17086174,18566590 Q9WVF7 P23804 POLE MDM2 0.523 10982879 Q5EBH1 P23804 RASSF5 MDM2 0.583 22173032 P23804 O35618 MDM2 MDM4 0.832 20697359,21730132,25117711,22666487,19573810,25981963,17616658 P51480 P23804 CDKN2A MDM2 0.837 23580573,20832751,10713175,15485902 P23804 P21675 MDM2 TAF1 0.096 9388200 P47962 P23804 RPL5 MDM2 0.507 17936560,22789538,20832751 Q64364 P23804 CDKN2A MDM2 0.884 9653180,23580573,15485902,20832751,9529248,10713175 P23804 P02340 MDM2 TP53 1 10982879,21738215,18359851,18695251,22805162,20697359,25117711,23580573,22666487,22216266,9732264,8058315,20818388,18309296,10706102,25732823,17086174,9653180,18566590,21183956,17936560,20832751,10205143,11953423 Q99MK8 P23804 ADRBK1 MDM2 0.21 21081496 Q9DCR4 P23804 EID1 MDM2 0.21 24167073 P68254 P23804 YWHAQ MDM2 0.21 20086099 P49757 P23804 NUMB MDM2 0.569 9632782 P63166 P23804 SUMO1 MDM2 0.61 15897463,19090619,21183956,17086174 P51945 P23804 CCNG1 MDM2 0.623 11983168 P23804 P20226 MDM2 TBP 0.033 9388200 P63280 P23804 UBE2I MDM2 0.309 21183956 P67775 P23804 PPP2CA MDM2 0.309 11983168