PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ccnb1 Fzr1 21241890 biogrid exp G Arhgap35 Fzr1 20530197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Smurf1 Fzr1 22949615 biogrid exp, ortho Skil Fzr1 17215516 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc27 Fzr1 15029244,22014574,25913861,11179223 biogrid exp, ortho G G G G G G Csf3r Fzr1 17001306 biogrid exp, ortho G G G G G G G Sirt2 Fzr1 22014574 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fmr1 Fzr1 25913861 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rrm2 Fzr1 12655059 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G Sox2 Fzr1 ortho G G G G G G G G G G G Fancd2 Fzr1 ortho Psmc3ip Fzr1 ortho G G G G G G G G G Clspn Fzr1 ortho Tk1 Fzr1 ortho G G G G G G G G G G G G G Anapc4 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf34 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdca3 Fzr1 ortho G G G G G G G G G G G G G G G G Arhgap32 Fzr1 ortho Eif3a Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp7 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nop9 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd9 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G Nap1l1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epha4 Fzr1 ortho G G G G G G G G Hecw2 Fzr1 ortho Polr2a Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nek2 Fzr1 ortho G G G G G G G G Senp2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2f1 Fzr1 ortho G G G G G Ccna2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G Moap1 Fzr1 ortho Fzr1 Bex2 ortho G G G G G G G G G G G G G G G G Sdsl Fzr1 ortho G G G G G G G G Emilin1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G Fzr1 Eya4 ortho G Trim33 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Six1 Fzr1 ortho G G G G G G G Mapk8 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct8 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbbp8 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ipo4 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp37 Fzr1 ortho Cdc25a Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccl5 Fzr1 ortho G G G G G G G G G G G G Dkk3 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G Ube4b Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cyp17a1 Fzr1 ortho G G G G Ube2d1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fzr1 Skp2 ortho G G G G G G G G G G G G G Sprtn Fzr1 ortho Cdk5 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pten Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2c Fzr1 ortho G G G G G G G G G G G G G G G G G G Daxx Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc11 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tacc3 Fzr1 ortho G G G G G G G G G G Nat1 Fzr1 ortho G Cdc16 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccnb2 Fzr1 ortho G G G G G G G G G G G G G G G G Dnaja1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ckap2 Fzr1 ortho G G G G G G G G G G G G G G Pim1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cct7 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tpx2 Fzr1 ortho G G G G G G G G G G G G G G Eif3c Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddb1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxm1 Fzr1 ortho G G G G G G G G Mcm3 Fzr1 ortho G G G G G G G G G G G G G G G G G G G Dnm1l Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fzr1 Bub1b ortho G G G G G G G G G G G G Ipo5 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Phf8 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2s Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epsti1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G Setd8 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mak Fzr1 ortho G G G G G G G Hspa9 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Id1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cuedc2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ttk Fzr1 ortho G G G G G G G G Cdc26 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc5 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zc3hc1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tas2r13 Fzr1 ortho Tp53 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc6 Fzr1 ortho G G G G G G G G Gpi Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk5r1 Fzr1 ortho G G G G G G G G G G G G G G G UPF0415 protein C7orf25 homolog Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Cdr2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct3 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc14b Fzr1 ortho Pttg1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aurkb Fzr1 ortho G G G G G G G G G G G G G Ccna1 Fzr1 ortho G Gria1 Fzr1 ortho G G G G G G G G Myc Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G Gmnn Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lrrc46 Fzr1 ortho G G G Brsk2 Fzr1 ortho Cct4 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rb1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc20 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G Cdt1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dcps Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fzr1 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc23 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ist1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G Apc Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Thrsp Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mad2l2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsf2 Fzr1 ortho Fzr1 Cul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cks1b Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ninl Fzr1 ortho Fzr1 Racgap1 ortho G G G G G G G G G G G G G G G G G G G G Cdc14a Fzr1 ortho Fbxo5 Fzr1 ortho E2f3 Fzr1 ortho G G G G G Mdc1 Fzr1 ortho Hspd1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mta3 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fzr1 Stau1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Copb1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc10 Fzr1 ortho Rad17 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Copg2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Plk1 Fzr1 ortho G G G G G G G G G G G G G G Hccs Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9R1K5 Q3TB81 affinity chromatography technology 17215516 physical association X 2 Q9R1K5 P24860 enzymatic study 21241890 direct interaction X 2 Q9R1K5 two hybrid 17001306 direct interaction X 2 P11157 Q9R1K5 affinity chromatography technology 12655059 physical association X 2 Q9D1C1 Q9R1K5 enzymatic study 15029244 direct interaction X 2 B2RTN5 Q9R1K5 affinity chromatography technology 20530197 physical association X 2 B2RTN5 Q9R1K5 affinity chromatography technology 20530197 physical association X 2 B2RTN5 Q9R1K5 enzymatic study 20530197 direct interaction X 2 Q9R1K5 A2A6Q5 affinity chromatography technology 15029244 physical association X 2 Q9R1K5 Q8BSC0 affinity chromatography technology 22949615 physical association X 2 Q9R1K5 A2A6Q5 affinity chromatography technology 22014574 physical association X 2 Q9R1K5 A2A6Q5 affinity chromatography technology 11179223 physical association X 2 Q8VDQ8-3 Q9R1K5 affinity chromatography technology 22014574 physical association X 2 Q8VDQ8-3 Q9R1K5 affinity chromatography technology 22014574 physical association X 2 Q4V8A2 Q9R1K5 affinity chromatography technology 22949615 physical association X 2 Q8VDQ8 Q9R1K5 anti bait coimmunoprecipitation 22014574 physical association X 2 Q8VDQ8 Q9R1K5 anti bait coimmunoprecipitation 22014574 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Fzr1 Cdc27 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11179223,15029244,22014574 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_326213|BIOGRID_321624|BIOGRID_315669 bait|prey|prey prey|bait|bait Smurf1 Fzr1 MI:0004(affinity chromatography technology) 22949615 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323436 prey bait Sirt2 Fzr1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22014574 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_120952|UniProt_174252|UniProt_120951|UniProt_174253|BIOGRID_326210|BIOGRID_326209 prey|bait|bait|prey|prey|bait bait|prey|prey|bait|bait|prey Rrm2 Fzr1 MI:0004(affinity chromatography technology) 12655059 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328650 prey bait Ube2c Fzr1 MI:0004(affinity chromatography technology) 15029244 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321625 bait prey Skil Fzr1 MI:0004(affinity chromatography technology) 17215516 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323495 bait prey Arhgap35 Fzr1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 20530197 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_328693|BIOGRID_328691|BIOGRID_328690 prey|prey|bait bait|bait|prey Ccnb1 Fzr1 MI:0004(affinity chromatography technology) 21241890 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_326103 prey bait Csf3r Fzr1 MI:0004(affinity chromatography technology) 17001306 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_319779 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9R1K5 Q60665 FZR1 SKIL 0.21 17215516 Q9R1K5 Q8VDQ8 FZR1 SIRT2 0.416 22014574 Q9R1K5 Q91YM2 FZR1 ARHGAP35 0.569 20530197 Q9R1K5 P40223 FZR1 CSF3R 0.309 17001306 Q9R1K5 A2A6Q5 FZR1 CDC27 0.569 11179223,15029244,22014574,25913861 Q9R1K5 Q8CFN5 FZR1 MEF2C 0.21 25789873 Q9R1K5 Q4V8A2 FZR1 CDC27 0.21 22949615 Q9R1K5 P11157 FZR1 RRM2 0.21 12655059 Q9R1K5 P24860 FZR1 CCNB1 0.309 21241890 Q9R1K5 Q9CUN6 FZR1 SMURF1 0.21 22949615