PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Cdc27 Fmr1 25913861 biogrid exp G G G G G G Cdc27 Cdc20 22084091,22014574 biogrid exp, ortho G G G G G G Cdc27 Fzr1 15029244,22014574,25913861,11179223 biogrid exp, ortho G G G G G G Cdc27 Anapc7 10922056 biogrid exp, ortho G G G G G G Cdc27 Cdc26 10922056 biogrid exp, ortho G G G G G G Cdc27 Pten 21241890 intact exp, ortho G G G G G G Cdc27 Fbxo43 ortho Cdc27 Anapc2 ortho G G G G G G Cdc27 Cdca5 ortho G G G G G Cdc27 Mad2l1bp ortho G G G G G G Cdc27 Usp37 ortho Cdc27 Ttll1 ortho G G G G G G Cdc27 Sh3kbp1 ortho G G G G G Cdc27 Mib1 ortho G Cdc27 Sirt2 ortho G G G G G G Cdc27 Usp11 ortho G G G G G G Cdc27 Tfdp1 ortho G G G G G G Cdc27 Dcps ortho G G G G G G Cdc27 Cfap97 ortho G Cdc27 Cdkn1a ortho G G G G G G Cdc27 Ube4b ortho G G G G G G Cdc27 Ninl ortho Cdc27 Foxe1 ortho Cdc27 Mad2l2 ortho G G G G G G Cdc27 Snw1 ortho G G G G G G Cdc27 Emilin1 ortho G G G G G Cdc27 Bub1b ortho G G G G G Cdc27 Tp53bp1 ortho G G G G G G Cdc27 Mad2l1 ortho G G G G G G Cdc27 Pik3r1 ortho G G G G G Cdc27 Dclre1c ortho Cdc27 Znf526 ortho Cdc27 Cuedc2 ortho G G G G G G Cdc27 Ddhd2 ortho G G G G G G Cdc27 Cdc16 ortho G G G G G G Cdc27 Smad2 ortho G G G G G G Cdc27 Nck1 ortho G G G G G G Cdc27 Tead2 ortho G G Cdc27 Foxo3 ortho G G G G G G Cdc27 Fbxo5 ortho Cdc27 Mad1l1 ortho G Cdc27 Cdh1 ortho G G G Cdc27 Adnp ortho G G G G G G Cdc27 Ssb ortho G G G G G G Cdc27 Foxm1 ortho G G Cdc27 Cdc5l ortho G G G G G G Cdc27 Cdc23 ortho G G G G G G Cdc27 Anapc10 ortho Cdc27 Foxp3 ortho Cdc27 Rpl5 ortho Cdc27 Rev1 ortho G G G G G G Cdc27 Anapc16 ortho G G G G G G Cdc27 Nrcam ortho G G Cdc27 Mdc1 ortho Cdc27 Notch1 ortho G G G G G Cdc27 Anapc11 ortho G G G G G G Cdc27 Grb2 ortho G G G G G G Cdc27 Ndst2 ortho G G G G G G Cdc27 Skil ortho G G G G G G Cdc27 Vcp ortho G G G G G G Cdc27 Spatc1 ortho Cdc27 Protein Taf4a ortho G G G G G G Cdc27 Gkn1 ortho G G Cdc27 Casp3 ortho G G G G G Cdc27 Smarcad1 ortho G G G G G G Cdc27 Hsf2 ortho Cdc27 Smad3 ortho G G G Cdc27 Pin1 ortho Cdc27 Cdc27 ortho G G G G G G Cdc27 Epn3 ortho G Cdc27 Crebbp ortho G G G G G Cdc27 Ntrk1 ortho Cdc27 Bub3 ortho G G G G G G Cdc27 Rrm2 ortho G G G G G G Cdc27 Xpo1 ortho G G G G G G Cdc27 Sirt6 ortho Cdc27 Aurkb ortho G G G G G Cdc27 Pcna ortho G G G G G G Cdc27 Abl1 ortho G G G G G G Cdc27 Foxq1 ortho G Cdc27 Kras ortho G G G G G G Cdc27 Ncl ortho G G G G G G Cdc27 Chd8 ortho G G G G G G Cdc27 Birc6 ortho G G G G G G Cdc27 Anapc5 ortho G G G G G G Cdc27 Rb1 ortho G G G G G G Cdc27 Cks1b ortho G G G G G G Cdc27 Ctnnb1 ortho G G G G G G Cdc27 Rbpj ortho G G G G G G Cdc27 Ube2s ortho G G G G G G Cdc27 Ppp5c ortho G G G G G G Cdc27 Taf5 ortho Cdc27 Trim33 ortho G G G G G G Cdc27 Anapc4 ortho G G G G G G Cdc27 Ccna2 ortho G G G G G G Cdc27 Magix ortho Cdc27 Hecw2 ortho Cdc27 Fyn ortho G G G G G G Cdc27 Comt ortho G G G G G G Cdc27 Hoxc10 ortho Cdc27 Mcph1 ortho Cdc27 Nf2 ortho G G G G G G Cdc27 Penk ortho G G Cdc27 Nek2 ortho G G G Cdc27 Ccnd1 ortho G G G G G G Cdc27 Grap2 ortho Cdc27 Anapc13 ortho G G G G G G Cdc27 E2f1 ortho G G Cdc27 Phf8 ortho G G G G G G Cdc27 Ttk ortho G G G G Cdc27 Anapc1 ortho G G G G G G Cdc27 Pttg1 ortho G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9R1K5 A2A6Q5 affinity chromatography technology 15029244 physical association X 2 Q9R1K5 A2A6Q5 affinity chromatography technology 22014574 physical association X 2 Q9R1K5 A2A6Q5 affinity chromatography technology 11179223 physical association X 2 A2A6Q5 affinity chromatography technology 20360068 physical association X 2 Q9WVM3 A2A6Q5 affinity chromatography technology 10922056 physical association X 2 Q9JJ66 A2A6Q5 affinity chromatography technology 22084091 physical association X 2 Q9JJ66 A2A6Q5 affinity chromatography technology 22014574 physical association X 2 Q99JP4 A2A6Q5 affinity chromatography technology 10922056 physical association X 2 A2A6Q5 anti bait coimmunoprecipitation 22014574 association C 3 A2A6Q5 anti bait coimmunoprecipitation 22014574 physical association C 3 A2A6Q5 anti bait coimmunoprecipitation 22014574 physical association C 3 A2A6Q5 anti bait coimmunoprecipitation 22014574 physical association C 3 P30260 A2A6Q5 tandem affinity purification 20360068 physical association X 2 O08586 A2A6Q5 fluorescence microscopy 21241890 colocalization X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC27 PTEN 21241890 0416 LC CDC27 FMR1 25913861 0004 LC CDC27 CDC26 10922056 0004 LC CDC27 CDC20 22014574,22084091 0004,0004 LC CDC27 FZR1 11179223,22014574,25913861,15029244 0004,0004,0004,0004 LC CDC27 ANAPC7 10922056 0004 LC