PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mdm2 Sumo2 15897463 biogrid exp Sumo2 Gli3 22549777 biogrid exp Sumo2 Gli2 22549777 biogrid exp Nr5a1 Sumo2 21820362 biogrid exp Sumo2 Nfkbia 21632113 biogrid exp P Mafg Sumo2 16738329 biogrid exp Ccnb1ip1 Sumo2 21779533 biogrid exp Daxx Sumo2 21383010 biogrid exp, ortho Rangap1 Sumo2 19033381 biogrid exp, ortho P Sumo2 Pml 19033381 biogrid exp, ortho P Sumo2 Npm1 15897463 biogrid exp, ortho P Rara Sumo2 19850744 biogrid exp, ortho Sumo2 Hdac9 ortho Sumo2 Rpl4 ortho P Xrcc5 Sumo2 ortho P Cox17 Sumo2 ortho P Sumo2 Rcor2 ortho Exosc10 Sumo2 ortho Sumo2 Topors ortho Sumo2 Top2a ortho Cenpc Sumo2 ortho Hspa9 Sumo2 ortho P Sumo2 Sox10 ortho Sumo2 Usp28 ortho Sumo2 Pias2 ortho Sumo2 Ddx21 ortho P Sumo2 Tubb5 ortho P Traf2 Sumo2 ortho Sumo2 Irf7 ortho P Sumo2 Ddx3x ortho P Sumo2 Eva1a ortho 4732471D19Rik Sumo2 ortho Sumo2 Hnrnpf ortho P Sumo2 Rad51 ortho Ssb Sumo2 ortho P Zmym4 Sumo2 ortho Fos Sumo2 ortho Brca1 Sumo2 ortho Sumo2 Mta1 ortho Sumo2 Chaf1b ortho Sumo2 Champ1 ortho Sumo2 L3mbtl3 ortho Sumo2 Mus81 ortho Sumo2 Zcchc12 ortho Sumo2 Rbbp4 ortho P Sumo2 Atxn7 ortho Sumo2 Chn2 ortho Cks1b Sumo2 ortho Sumo2 Uncharacterized protein C18orf25 homolog ortho Sumo2 Hspa8 ortho P Sumo2 Ube2i ortho P Sumo2 Pafah1b3 ortho P Lef1 Sumo2 ortho Sumo2 Zmym2 ortho P Timp1 Sumo2 ortho Sumo2 Sec23b ortho P Protein Ahnak Sumo2 ortho P Sumo2 Prkdc ortho P Sumo2 Tex10 ortho Sumo2 Tank ortho Sumo2 Senp5 ortho Sumo2 Znf451 ortho Sumo2 Krt5 ortho P Sumo2 Senp3 ortho Sumo2 Atic ortho P Sumo2 Nbn ortho Sumo2 Pogz ortho Sumo2 Senp7 ortho Sumo2 Exosc9 ortho P Sumo2 Tubb6 ortho P Protein Chd3 Sumo2 ortho P Sumo2 Nol9 ortho Tp53 Sumo2 ortho Wrn Sumo2 ortho Zfp295 Sumo2 ortho Jun Sumo2 ortho Sumo2 Kdm1a ortho P Sumo2 Nop58 ortho P Myb Sumo2 ortho Sumo2 Tdp2 ortho Vim Sumo2 ortho P Sumo2 Phf5a ortho P Cad Sumo2 ortho P Sumo2 Setbp1 ortho Sumo2 Tead3 ortho Sumo2 Ndufa4l2 ortho Setdb1 Sumo2 ortho P Sumo2 Creld1 ortho P Sumo2 Atf7ip ortho P Sumo2 Pelp1 ortho P Pias3 Sumo2 ortho Sumo2 Tubb4b ortho P Sumo2 Sae1 ortho P Hsp90ab1 Sumo2 ortho P Parp1 Sumo2 ortho P MCG10049, Protein Zbtb25 Sumo2 ortho Sumo2 Mast2 ortho Sumo2 Ccne2 ortho Eef1a1 Sumo2 ortho P Sumo2 Rnf4 ortho Sumo2 Peo1 ortho Sumo2 Stxbp5 ortho P Sumo2 Ssrp1 ortho P Sumo2 Mdc1 ortho P Sumo2 Nab2 ortho Msh2 Sumo2 ortho P Sumo2 Rbbp7 ortho P Setx Sumo2 ortho Sumo2 Chd4 ortho P Blm Sumo2 ortho Sumo2 Tnip1 ortho Sumo2 Pgd ortho P Ruvbl1 Sumo2 ortho P Eno2 Sumo2 ortho P Baz1a Sumo2 ortho Sumo2 Csnk2b ortho P Sumo2 Zbtb1 ortho Xrcc6 Sumo2 ortho Dchs1 Sumo2 ortho Sumo2 Phf8 ortho Sumo2 Sumo1 ortho P Sumo2 Trim63 ortho Sumo2 Cul3 ortho P Sumo2 Apc ortho P Sumo2 Fkbp6 ortho Traf1 Sumo2 ortho Sox5 Sumo2 ortho Sumo2 Hipk2 ortho Sumo2 Hdac4 ortho Sumo2 Sec23a ortho P Kalrn Sumo2 ortho Sumo2 Bre ortho P Sumo2 Senp2 ortho Sumo2 Nfe2l2 ortho Sumo2 Numa1 ortho P Sumo2 Zhx1 ortho Sumo2 Ddx17 ortho P Sumo2 Smchd1 ortho P Sumo2 Ercc4 ortho Sumo2 Ahcyl1 ortho P Sumo2 Homez ortho Sumo2 Sycp3 ortho Sumo2 Pias4 ortho Sumo2 Rere ortho Sumo2 Hp1bp3 ortho P Efna1 Sumo2 ortho Sumo2 Fam118b ortho Zmat3 Sumo2 ortho P Ep300 Sumo2 ortho P Sumo2 Top2b ortho P Shfm1 Sumo2 ortho Sumo2 Kcna5 ortho Sumo2 Rcor1 ortho Sumo2 Uba2 ortho P Sumo2 Elavl1 ortho P Rpl3 Sumo2 ortho P Sumo2 Senp6 ortho Sumo2 Hnrnpc ortho P Sumo2 Rnf2 ortho P Sumo2 Nop2 ortho P Protein Mdn1 Sumo2 ortho P Sumo2 Alas1 ortho P Sumo2 Npepl1 ortho P Aldoa Sumo2 ortho P Sssca1 Sumo2 ortho P Sumo2 Cmtm6 ortho P Anxa1 Sumo2 ortho P Sumo2 Znf496 ortho Protein Mki67 Sumo2 ortho P Tuba1b Sumo2 ortho P Sumo2 Igbp1 ortho P Sumo2 Mta2 ortho P Sumo2 Hdac2 ortho Sumo2 Trim28 ortho P Ubc Sumo2 ortho P Sumo2 Slx4ip ortho Sumo2 Rad54l2 ortho Hnrnph1 Sumo2 ortho P Sumo2 Supt16h ortho P Hdac1 Sumo2 ortho P Sumo2 Psmd11 ortho P Sumo2 Slx4 ortho Sumo2 Protein Zbtb26, Zinc finger and BTB domain containing 26, Zinc finger and BTB domain containing 26, isoform CRA_b ortho Sumo2 Vcp ortho P Sumo2 Hnrnpk ortho P Ptprs Sumo2 ortho Sumo2 Frs2 ortho Sumo2 Eme1 ortho Plaur Sumo2 ortho Brcc3 Sumo2 ortho P Sumo2 Sdhaf2 ortho Sumo2 Gatad2b ortho P Sumo2 Esrrg ortho Sumo2 Zmym5 ortho Zcchc7 Sumo2 ortho Sumo2 Uimc1 ortho Sumo2 Sobp ortho Sumo2 Bad ortho P Sumo2 Psap ortho P Usp25 Sumo2 ortho Sumo2 Parn ortho Sumo2 Baz1b ortho P Sumo2 Edaradd ortho Sumo2 Atrx ortho Sumo2 Rnf111 ortho Sumo2 Grb10 ortho P Sumo2 Trim26 ortho Sumo2 Zmym3 ortho Senp1 Sumo2 ortho Sumo2 Eef1g ortho P Sumo2 Mef2a ortho Las1l Sumo2 ortho Slc22a2 Sumo2 ortho Sumo2 Tp53bp1 ortho P Sumo2 Lama4 ortho P Sumo2 Chaf1a ortho Sumo2 Casp8ap2 ortho Sumo2 Fam175a ortho Protein Nup153 Sumo2 ortho P Sumo2 Phc1 ortho Sumo2 Gm1103 ortho P Sumo2 Sumo2 ortho P Sumo2 Cars ortho P Protein Triml2 Sumo2 ortho Sumo2 Uspl1 ortho Sumo2 Srrt ortho P Tpr Sumo2 ortho P Sumo2 Kcnb1 ortho Sumo2 Satb1 ortho Ctsa Sumo2 ortho P Msx1 Sumo2 ortho Sumo2 Zbtb6 ortho Sumo2 Mapk1ip1l ortho Sumo2 Rad50 ortho P Sox6 Sumo2 ortho Sumo2 Nck1 ortho P Sumo2 Gmcl1 ortho Sumo2 Erbb2ip ortho P Sumo2 Tp53bp2 ortho P Sumo2 Tmpo ortho P Ctnnd1 Sumo2 ortho P Pias1 Sumo2 ortho Sumo2 Trim23 ortho Hsf2 Sumo2 ortho Sumo2 Ipo5 ortho P Pfkm Sumo2 ortho P Sumo2 Maf1 ortho Sumo2 Mre11a ortho Sumo2 Zbtb33 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O09130 P61957 x-ray crystallography 20077568 association X 2 Q3UKR0 P61957 x-ray crystallography 21383010 association X 2 Q3UKR0 P61957 pull down 21383010 direct interaction X 2 P61957 affinity chromatography technology 19680224 physical association X 2 P61957 P46061 affinity chromatography technology 19033381 physical association X 2 P61957 D3Z3A6 affinity chromatography technology 19033381 physical association X 2 P61957 affinity chromatography technology 15897463 physical association X 2 P61957 O88522 affinity chromatography technology 23825957 physical association X 2 Q9Z1E3 P61957 affinity chromatography technology 21632113 physical association X 2 Q0VGT2 P61957 affinity chromatography technology 22549777 physical association X 2 Q0VGT2 P61957 two hybrid 22549777 direct interaction X 2 O54790 P61957 pull down 16738329 direct interaction X 2 Q3U5E7 P61957 affinity chromatography technology 19850744 physical association X 2 P10687 P61957 affinity chromatography technology 23665500 physical association X 2 P61957 Q61602 affinity chromatography technology 22549777 physical association X 2 P61957 two hybrid 21779533 direct interaction X 2 P61957 P23804 affinity chromatography technology 15897463 physical association X 2 P61957 O55042 affinity chromatography technology 21746851 physical association X 2 P61957 P33242 affinity chromatography technology 21820362 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sumo2 Nfkbia MI:0004(affinity chromatography technology) 21632113 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319553 prey bait Sumo2 Pml MI:0004(affinity chromatography technology) 19033381 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325674 prey bait Nfatc2ip Sumo2 MI:0096(pull down) 20077568 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association) (biogrid) BIOGRID_322021 bait prey Nr5a1 Sumo2 MI:0004(affinity chromatography technology) 21820362 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319630 bait prey Sumo2 Gli2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22549777 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_320434|BIOGRID_320439 prey|prey bait|bait Mafg Sumo2 MI:0096(pull down) 16738329 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322248 bait prey Sumo2 Ccnb1ip1 MI:0018(two hybrid) 21779533 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321675 prey bait Ikbkg Sumo2 MI:0004(affinity chromatography technology) 23825957 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331167 bait prey Snca Sumo2 MI:0096(pull down) 21746851 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319535 prey bait Mdm2 Sumo2 MI:0004(affinity chromatography technology) 15897463 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328483 prey bait Daxx Sumo2 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 21383010 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0914(association) (biogrid)|(biogrid) BIOGRID_319595|BIOGRID_319593 bait|bait prey|prey Rara Sumo2 MI:0096(pull down) 19850744 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332950 prey bait Rangap1 Sumo2 MI:0004(affinity chromatography technology) 19033381 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325673 bait prey Sumo2 Npm1 MI:0004(affinity chromatography technology) 15897463 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328484 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CCNB1IP1 SUMO2 21779533 0018 LC DAXX SUMO2 21383010,21383010 0114,0096 LC SUMO2 GLI2 22549777,22549777 0004,0018 LC DAXX SUMO2 21383010,21383010 0114,0096 LC MAFG SUMO2 16738329 0004 LC SNCA SUMO2 21746851 0004 LC RARA SUMO2 19850744 0004 LC MDM2 SUMO2 15897463 0004 LC NR5A1 SUMO2 21820362 0004 LC RANGAP1 SUMO2 19033381 0004 LC SUMO2 GLI2 22549777,22549777 0004,0018 LC SUMO2 PML 19033381 0004 LC SUMO2 GLI3 22549777 0004 LC SUMO2 NPM1 15897463 0004 LC SUMO2 NFKBIA 21632113 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61957 P11416 SUMO2 RARA 0.376 19850744 P61957 P23804 SUMO2 MDM2 0.21 15897463 Q61937 P61957 NPM1 SUMO2 0.21 15897463 Q60953 P61957 PML SUMO2 0.21 19033381 Q61602 P61957 GLI3 SUMO2 0.21 22549777 P61957 O54790 SUMO2 MAFG 0.21 16738329 Q9Z1E3 P61957 NFKBIA SUMO2 0.21 21632113 P61957 P10687 SUMO2 PLCB1 0.126 23665500 Q0VGT2 P61957 GLI2 SUMO2 0.454 22549777 P61957 O35613 SUMO2 DAXX 0.523 21383010 P61957 P33242 SUMO2 NR5A1 0.21 21820362 P61957 P46061 SUMO2 RANGAP1 0.21 19033381 P61957 D3Z3K2 SUMO2 CCNB1IP1 0.309 21779533