PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Cdc42 Pafah1b1 16369480 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Pafah1b1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Arhgap1 18331715 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Iqgap1 16369480 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Dync1h1 15762842 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Pafah1b1 11344260 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Clip1 16369480 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map1b Pafah1b1 15762842 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G Protein Cenpf Pafah1b1 15939891 intact exp, ortho P G G G G G G G G G G G G G G G G Pafah1b1 Pafah1b3 11231056 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Ndel1 15208636,17997972,18331715,12796778,11231056 biogrid,intact,dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Nde1 11163258 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Cstf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Mapre1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Cdk2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Isg15 ortho P Map2 Pafah1b1 ortho P Ap1g1 Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Chid1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Nudcd2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Msn Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Isoc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Dctn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Nudcd3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Pafah1b2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Scly ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Kars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Ntrk1 ortho Pafah1b1 Tuba1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Fh ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Dab1 ortho G G G G G G G G Pafah1b1 Katna1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Disc1 ortho Cops5 Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eif5 Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dync1i1 Pafah1b1 ortho P G G G G G G G G G G G Pafah1b1 Atic ortho P Pafah1b1 Bicd2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Ywhah ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Pde4b Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Csnk2a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Hsph1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nudc Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Dynll1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Pak2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Iqcb1 ortho Capns1 Pafah1b1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Sbds ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Katnb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr5 Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dctn1 Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dcx Pafah1b1 ortho G G G G G Myo1e Pafah1b1 ortho P G G G Pafah1b1 Dnai1 ortho Pafah1b1 Cep135 ortho P Snrpf Pafah1b1 ortho P Pafah1b1 Chmp2b ortho P Ubc Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdia4 Pafah1b1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snrpd2 Pafah1b1 ortho P Pafah1b1 Papss1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhag Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Asns ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc2a4 Pafah1b1 ortho G G G G G G G G G G G G G G G G G G G G Pafah1b1 Tatdn1 ortho Pafah1b1 Cep128 ortho Capn2 Pafah1b1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Tnik ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P43034 P63005 affinity chromatography technology 20360068 physical association X 2 Q05682-3 P63005 affinity chromatography technology 20360068 physical association X 2 Q9GZM8-2 P63005 affinity chromatography technology 20360068 physical association X 2 Q9JHU4 P63005 affinity chromatography technology 15762842 physical association X 2 Q9NYL9 P63005 affinity chromatography technology 20360068 physical association X 2 O43854 P63005 affinity chromatography technology 20360068 physical association X 2 Q6NYC8-3 P63005 affinity chromatography technology 20360068 physical association X 2 P63005 Q16658 affinity chromatography technology 20360068 physical association X 2 Q9JKF1 P63005 affinity chromatography technology 16369480 physical association X 2 Q9JKF1 P63005 affinity chromatography technology 16369480 physical association X 2 Q922J3 P63005 affinity chromatography technology 16369480 physical association X 2 Q9CZA6-2 P63005 pull down 11163258 direct interaction X 2 P0CG63 P63005 pull down 21070969 direct interaction X 2 A2AH25 P63005 affinity chromatography technology 18331715 physical association X 2 P43033 P63005 affinity chromatography technology 11344260 physical association X 2 P60766 P63005 affinity chromatography technology 16369480 physical association X 2 P68402 P63005 affinity chromatography technology 20360068 physical association X 2 P13797-2 P63005 affinity chromatography technology 20360068 physical association X 2 P63005 affinity chromatography technology 20360068 physical association X 2 P62136-3 P63005 affinity chromatography technology 20360068 physical association X 2 Q9BVA0 P63005 two hybrid 16203747 direct interaction X 2 P63005 P63005 affinity chromatography technology 11344260 physical association X 2 P63005 A0A024R0L6 affinity chromatography technology 20360068 physical association X 2 P14873 P63005 affinity chromatography technology 15762842 physical association X 2 P14873 P63005 affinity chromatography technology 15762842 physical association X 2 Q9ERR1 P63005 affinity chromatography technology 15208636 physical association X 2 Q9ERR1 P63005 biochemical 15208636 association X 2 Q9ERR1 P63005 affinity chromatography technology 18331715 physical association X 2 Q9GZM8 P63005 pull down 17997972 direct interaction X 2 Q9ERR1 P63005 pull down 17997972 direct interaction X 2 Q9ERR1 P63005 electron paramagnetic resonance 17997972 direct interaction X 2 P63005 cosedimentation 16615898 colocalization C 1216 Q155P7 P63005 confocal microscopy 15939891 physical association X 2 P63005 tandem affinity purification 20360068 physical association C 15 Q9CZA6 P63005 pull down 11163258 direct interaction X 2 Q61205 P63005 two hybrid 11231056 physical association X 2 Q61205 P63005 pull down 11231056 physical association X 2 Q9ERR1 P63005 two hybrid 11231056 physical association X 2 Q9ERR1 P63005 pull down 11231056 physical association X 2 Q9ERR1 P63005 anti tag coimmunoprecipitation 11231056 physical association X 2 Q9ERR1 P63005 two hybrid 12796778 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Pafah1b1 Arhgap1 MI:0004(affinity chromatography technology) 18331715 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329099 prey bait Pafah1b1 Nde1 MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 11163258 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_160226|BIOGRID_311882 prey|prey bait|bait Pafah1b1 Ndel1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0016(circular dichroism)|MI:0018(two hybrid) 11231056,12796778,15208636,17997972,18331715 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|MI:0465(dip)|(intact) BIOGRID_325298|BIOGRID_329093|UniProt_160079|BIOGRID_325293|UniProt_163349|UniProt_160077|DIP_380|UniProt_160081 prey|prey|prey|prey|prey|bait|-|bait bait|bait|bait|bait|bait|prey|-|prey Pafah1b1 Pafah1b3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 11231056,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_160078|UniProt_160080|UniProt_167130|UniProt_167136|UniProt_167122|UniProt_167134|UniProt_167114 bait|prey|neutral component|neutral component|neutral component|neutral component|neutral component prey|bait|neutral component|neutral component|neutral component|neutral component|neutral component Map1b Pafah1b1 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15762842,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_167115|UniProt_167116|UniProt_167114|BIOGRID_322515|BIOGRID_322514 neutral component|neutral component|neutral component|bait|prey neutral component|neutral component|neutral component|prey|bait Pafah1b1 Iqgap1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 16369480,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_327747|BIOGRID_327745|UniProt_167131|UniProt_167130|UniProt_167133|UniProt_167136|UniProt_167122|UniProt_167134 prey|bait|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component bait|prey|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component Pafah1b1 Dync1h1 MI:0004(affinity chromatography technology)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 15762842,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_322516|UniProt_167131|UniProt_167130|UniProt_167133|UniProt_167136|UniProt_167118|UniProt_167122|UniProt_167134|UniProt_167115|UniProt_167116|UniProt_167114 bait|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component prey|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component Pafah1b1 Clip1 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 16369480,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact) UniProt_167131|UniProt_167130|UniProt_167118|UniProt_167134|BIOGRID_327744|UniProt_167116|UniProt_167114 neutral component|neutral component|neutral component|neutral component|bait|neutral component|neutral component neutral component|neutral component|neutral component|neutral component|prey|neutral component|neutral component Pafah1b1 Cenpf MI:0018(two hybrid) 15939891 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164414 neutral component neutral component

PPI - HINT Gene A Gene B PMID Method Quality YWHAE PAFAH1B1 16615898 0027 LC PAFAH1B1 PAFAH1B1 15274919 0114 LC PAFAH1B1 PAFAH1B3 11231056,11231056 0018,0096 LC PAFAH1B1 NDEL1 17997972,11231056,12796778,12796778,15208636,17997972,15208636,11231056,11231056 0042,0096,0006,0018,0004,0096,0401,0007,0018 LC MAP1B PAFAH1B1 15762842 0004 LC CDC42 PAFAH1B1 16369480 0004 LC PAFAH1B1 PAFAH1B1 11344260 0004 LC PAFAH1B1 CENPF 15939891 0663 LC PAFAH1B1 PAFAH1B3 11231056,11231056 0018,0096 LC PAFAH1B1 ARHGAP1 18331715 0004 LC PAFAH1B1 CLIP1 16369480 0004 LC PAFAH1B1 NDE1 11163258 0096 LC PAFAH1B1 NDEL1 17997972,11231056,18331715,12796778,12796778,15208636,17997972,15208636,11231056,11231056 0042,0096,0004,0006,0018,0004,0096,0401,0007,0018 LC PAFAH1B1 DYNC1H1 15762842 0004 LC PAFAH1B1 IQGAP1 16369480 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5FWK3 P63005 ARHGAP1 PAFAH1B1 0.21 18331715 P63005 P60766 PAFAH1B1 CDC42 0.21 16369480 P63005 P62259 PAFAH1B1 YWHAE 0.081 16615898 P63005 P0CG63 PAFAH1B1 UBI4 0.309 21070969 P63005 O14976 PAFAH1B1 GAK 0.236 26496610 P63005 O43237 PAFAH1B1 DYNC1LI2 0.236 26496610 P63005 O43854 PAFAH1B1 EDIL3 0.236 20360068 P63005 O75746 PAFAH1B1 SLC25A12 0.236 26496610 P63005 P11021 PAFAH1B1 HSPA5 0.236 26496610 P63005 P13797 PAFAH1B1 PLS3 0.236 20360068 P63005 P28066 PAFAH1B1 PSMA5 0.236 26496610 P63005 P43034 PAFAH1B1 PAFAH1B1 0.236 20360068 P63005 P49454 PAFAH1B1 CENPF 0.236 26496610 P63005 P62136 PAFAH1B1 PPP1CA 0.236 20360068 Q08AN1 P63005 ZNF616 PAFAH1B1 0.236 26496610 Q13409 P63005 DYNC1I2 PAFAH1B1 0.236 26496610 Q14204 P63005 DYNC1H1 PAFAH1B1 0.236 26496610 Q155Q3 P63005 DIXDC1 PAFAH1B1 0.236 26496610 Q16658 P63005 FSCN1 PAFAH1B1 0.236 20360068 Q4LE39 P63005 ARID4B PAFAH1B1 0.236 26496610 Q66GS9 P63005 CEP135 PAFAH1B1 0.236 26496610 Q6NYC8 P63005 PPP1R18 PAFAH1B1 0.236 20360068 Q8IXH7 P63005 NELFCD PAFAH1B1 0.236 26496610 Q8TEX9 P63005 IPO4 PAFAH1B1 0.236 26496610 Q96MM7 P63005 HS6ST2 PAFAH1B1 0.236 26496610 Q9H7U1 P63005 CCSER2 PAFAH1B1 0.236 26496610 Q9NP97 P63005 DYNLRB1 PAFAH1B1 0.236 26496610 Q9NYL9 P63005 TMOD3 PAFAH1B1 0.236 20360068 Q9P2X3 P63005 IMPACT PAFAH1B1 0.236 26496610 Q9Y6G9 P63005 DYNC1LI1 PAFAH1B1 0.236 26496610 Q9Y6M0 P63005 PRSS21 PAFAH1B1 0.236 26496610 Q9NXR1 P63005 NDE1 PAFAH1B1 0.416 26496610,20360068 P68402 P63005 PAFAH1B2 PAFAH1B1 0.416 26496610,20360068 Q15102 P63005 PAFAH1B3 PAFAH1B1 0.416 26496610,20360068 Q9GZM8 P63005 NDEL1 PAFAH1B1 0.597 17997972,20360068,26496610 Q9ERR1 P63005 NDEL1 PAFAH1B1 0.872 17997972,12796778,18331715,15208636 Q9BVA0 P63005 KATNB1 PAFAH1B1 0.309 16203747 Q9CZA6 P63005 NDE1 PAFAH1B1 0.309 11163258 P63005 J3KPF0 PAFAH1B1 HECTD4 {ECO:0000313|ENSEMBL:ENSP00000366783} 0.126 26496610 P63005 G3V3R7 PAFAH1B1 ATXN3 {ECO:0000313|ENSEMBL:ENSP00000451385} 0.126 26496610 P63005 P47755 PAFAH1B1 CAPZA2 0.126 20360068 P63005 P07951 PAFAH1B1 TPM2 0.126 20360068 P63005 P14873 PAFAH1B1 MAP1B 0.376 15762842 Q05682 P63005 CALD1 PAFAH1B1 0.126 20360068 P63005 P54252 PAFAH1B1 ATXN3 0.126 26496610 P63005 P63005 PAFAH1B1 PAFAH1B1 0.236 11344260 Q9JKF1 P63005 IQGAP1 PAFAH1B1 0.376 16369480 Q6PJM5 P63005 CALD1 PAFAH1B1 0.126 20360068 Q155P7 P63005 CENPF PAFAH1B1 0.21 15939891 Q922J3 P63005 CLIP1 PAFAH1B1 0.21 16369480 Q9JHU4 P63005 DYNC1H1 PAFAH1B1 0.21 15762842 P63005 P43033 PAFAH1B1 PAFAH1B1 0.21 11344260