PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sh3gl3 Amph 12456676 biogrid,i2d exp G G G G G G Atp6v1a Amph 22707207 intact exp P G G G G G G G G G G Amph Ywhab 16635246 intact exp P G G G G G G G G G G Capn2 Amph 17541403 mint,intact exp P G G G G G G G G G G Ywhae Amph 16615898 intact exp P G G G G G G G G G G Sh3gl2 Amph 12456676 biogrid,i2d exp, ortho P G G G G G G G G G Amph Dnm3 23640057 intact exp, ortho P G G G G G G G G G Amph Sh3glb1 12456676 biogrid,i2d exp, ortho P G G G G G G G G G G Dnm2 Amph 9525921,23640057 biogrid,intact exp, ortho P G G G G G G G G G G Ap2a2 Amph 7730311 mint,intact exp, ortho P G G G G G G G G G G Dnm1 Amph 23640057,16319076 mint,intact exp, ortho P G G G G G G G G G G Manea Amph ortho Amph Scyl1 ortho P G G G G G G G G G G Amph Diras1 ortho P G G G G G G Ap1b1 Amph ortho P G G G G G G G G G G Khdrbs1 Amph ortho P G G G G G G G G G G Amph Nufip1 ortho G G G G G G G G G G Amph Dnaaf2 ortho Amph Tp73 ortho G Amph Sgip1 ortho G G G G G G G Amph Reps2 ortho P Tnk2 Amph ortho G G G G G G G G G G Cdk5 Amph ortho P G G G G G G G G G G Bin1 Amph ortho P G G G G G G G G G G Vtn Amph ortho P G G G G G G G G G G Amph Synj1 ortho P Jun Amph ortho G G G G G G G G G G Amph Pld1 ortho G G G G G G G G Cltc Amph ortho P G G G G G G G G G G Ptk2 Amph ortho P G G G G G G G G G G Amph Amph ortho P G G G G G G G G G G Mapk6 Amph ortho P G G G G G G G G G G Pld2 Amph ortho G G G G G G G G G Amph Ehd1 ortho P G G G G G G G G G G Amph Necap1 ortho P G G G G G G G G G G Ccdc67 Amph ortho Cdk5r1 Amph ortho G G G G G G G G G Ubc Amph ortho P G G G G G G G G G G Syn1 Amph ortho P G G G G G G G G G Dyrk1a Amph ortho P G G G G G G G G G G Vwa5b2 Amph ortho Arl16 Amph ortho G G G G G G G G G Terf1 Amph ortho G G G G G G G G G Cdk1 Amph ortho G G G G G Reps1 Amph ortho P G G G G G G G G G G Amph Paics ortho P G G G G G G G G G G Npas2 Amph ortho G G G Amph Dguok ortho P G G G G G G G G G G Synm Amph ortho P Ap2a1 Amph ortho P G G G G G G G G G G Prop1 Amph ortho G Ppp3cc Amph ortho P G G G Hax1 Amph ortho G G G G G G G G G G Amph Itsn1 ortho P G G G G G G G G G Amph Itsn2 ortho P G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7TQF7 Q62420 - 12456676 - X 2 Q62421 Q7TQF7 - 12456676 - X 2 Q7TQF7 - 12456676 - X 2 Q7TQF7 B4DJ51 affinity chromatography technology 16512683 physical association X 2 Q7TQF7 pull down 9525921 direct interaction X 2 Q7TQF7 cosedimentation through density gradient 16635246 colocalization C 608 Q7TQF7 affinity chromatography technology 16512683 association C 138 O08529 Q7TQF7 enzymatic study 17541403 cleavage reaction X 2 Q7TQF7 P17427 pull down 7730311 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CAPN2 AMPH 17541403 0415 LC YWHAE AMPH 16615898 0027 LC SH3GL2 AMPH 12456676,12456676,12456676 0004,0096,0047 LC SH3GL3 AMPH 12456676,12456676,12456676 0004,0096,0047 LC AMPH YWHAB 16635246 0029 LC AP2A2 AMPH 7730311 0096 LC DNM1 AMPH 23640057,23640057,23640057 0006,0813,0663 LC DNM2 AMPH 23640057,23640057,9525921,23640057 0006,0813,0096,0663 LC ATP6V1A AMPH 22707207 0006 LC SH3GL2 AMPH 12456676,12456676,12456676 0004,0096,0047 LC SH3GL3 AMPH 12456676,12456676,12456676 0004,0096,0047 LC AMPH DNM3 23640057 0006 LC AMPH SH3GLB1 12456676 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JK48 Q7TQF7 SH3GLB1 AMPH 0.309 12456676 Q7TQF7 Q62420 AMPH SH3GL2 0.309 12456676 Q7TQF7 Q62421 AMPH SH3GL3 0.309 12456676 Q7TQF7 O08529 AMPH CAPN2 0.033 17541403 Q7TQF7 P17427 AMPH AP2A2 0.21 7730311 Q8BZ98 Q7TQF7 DNM3 AMPH 0.376 23640057 Q7TQF7 P39054 AMPH DNM2 0.702 23640057,9525921 Q7TQF7 P62158 AMPH CALM3 0.236 16512683 Q9CQV8 Q7TQF7 YWHAB AMPH 0.081 16635246 Q7TQF7 P39053 AMPH DNM1 0.454 23640057 Q7TQF7 P50516 AMPH ATP6V1A 0.126 22707207