PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Wrnip1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Pgls 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrn Wrnip1 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Wrnip1 18842586 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Pold3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Pin1 ortho P Cdc5l Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sars Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad2 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Abl1 Wrnip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epas1 Wrnip1 ortho G G G G G G G G G G G G G G G G G G G G G Pik3r3 Wrnip1 ortho P Elp2 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Wrnip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Rps6kb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Prkaa2 Wrnip1 ortho P Wrnip1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pold2 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Foxp3 ortho Trim28 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Rnf31 ortho P Ubc Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Mad2l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Xpo1 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Rad18 ortho G G G G G G Wrnip1 Pfdn5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pold1 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G Camk1d Wrnip1 ortho P G G G G G G G G G G G G G G G G G G G G G G G G G G Osbpl6 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fgfr1op Wrnip1 ortho Actg1 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm4a Wrnip1 ortho Wrnip1 Elp3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Wrnip1 ortho Ddx58 Wrnip1 ortho P Nup107 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Hdac11 Wrnip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Srsf4 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcna Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxa3 Wrnip1 ortho G G G G G G Irf3 Wrnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Sars2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Pgm3 ortho P Wrnip1 Pold4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrnip1 Usp11 ortho G G G G G G G G G G G G G G G G G G G G G Esr1 Wrnip1 ortho G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q91XU0 P0CG50 affinity chromatography technology 18842586 physical association X 2 Q91XU0 Q91XU0 two hybrid 18842586 direct interaction X 2 Q91XU0 Q91XU0 affinity chromatography technology 18842586 physical association X 2 Q91XU0 cosedimentation 16615898 colocalization C 1216

PPI - HINT Gene A Gene B PMID Method Quality YWHAE WRNIP1 16615898 0027 LC WRN WRNIP1 11301316,11301316,11301316 0019,0004,0018 LC WRNIP1 WRNIP1 18842586,18842586 0004,0018 LC WRNIP1 PGLS 16615898 0027 LC WRN WRNIP1 11301316,11301316,11301316 0019,0004,0018 LC WRNIP1 WRNIP1 18842586,18842586 0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q91XU0 P62259 WRNIP1 YWHAE 0.081 16615898 Q91XU0 Q91XU0 WRNIP1 WRNIP1 0.49 18842586 Q9CQ60 Q91XU0 PGLS WRNIP1 0.081 16615898 Q91XU0 P45844 WRNIP1 ABCG1 0.21 26296893